LOCUS       NM_017247               6507 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus sodium voltage-gated channel alpha subunit 10
            (Scn10a), mRNA.
ACCESSION   NM_017247 XM_346840
VERSION     NM_017247.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6507)
  AUTHORS   Blanke,E.N., Ruiz-Velasco,V. and Holmes,G.M.
  TITLE     Spinal cord injury-mediated changes in electrophysiological
            properties of rat gastric nodose ganglion neurons
  JOURNAL   Exp Neurol 348, 113927 (2022)
   PUBMED   34798136
  REMARK    GeneRIF: Spinal cord injury-mediated changes in
            electrophysiological properties of rat gastric nodose ganglion
            neurons.
REFERENCE   2  (bases 1 to 6507)
  AUTHORS   Coskun,C., Ocal,I. and Gunay,I.
  TITLE     A Low-Frequency Pulsed Magnetic Field Reduces Neuropathic Pain by
            Regulating NaV1.8 and NaV1.9 Sodium Channels at the Transcriptional
            Level in Diabetic Rats
  JOURNAL   Bioelectromagnetics 42 (5), 357-370 (2021)
   PUBMED   33998011
  REMARK    GeneRIF: A Low-Frequency Pulsed Magnetic Field Reduces Neuropathic
            Pain by Regulating NaV1.8 and NaV1.9 Sodium Channels at the
            Transcriptional Level in Diabetic Rats.
REFERENCE   3  (bases 1 to 6507)
  AUTHORS   Pryce,K.D., Powell,R., Agwa,D., Evely,K.M., Sheehan,G.D., Nip,A.,
            Tomasello,D.L., Gururaj,S. and Bhattacharjee,A.
  TITLE     Magi-1 scaffolds NaV1.8 and Slack KNa channels in dorsal root
            ganglion neurons regulating excitability and pain
  JOURNAL   FASEB J 33 (6), 7315-7330 (2019)
   PUBMED   30860870
  REMARK    GeneRIF: Magi-1 bound to sequence like a calcium-activated
            potassium channel sodium-activated (Slack) potassium channels,
            demonstrating macrocomplexing with NaV1.8 channels. NaV1.8
            expression decreased after Magi-1 knockdown in vivo.
REFERENCE   4  (bases 1 to 6507)
  AUTHORS   Yan,J., Hu,S., Zou,K., Xu,M., Wang,Q., Miao,X., Yu,S.P. and Xu,G.Y.
  TITLE     Inhibition of cystathionine beta-synthetase suppresses sodium
            channel activities of dorsal root ganglion neurons of rats with
            lumbar disc herniation
  JOURNAL   Sci Rep 6, 38188 (2016)
   PUBMED   27905525
  REMARK    GeneRIF: Treatment of AOAA markedly suppressed expression of NaV1.7
            and NaV1.8 in DRGs of lumbar disc herniation (LDH) rats. These data
            suggest that targeting the CBS-H2S signaling at the DRG level might
            represent a novel therapeutic strategy for chronic pain relief in
            patients with LDH.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6507)
  AUTHORS   Pan,H.L., Liu,B.L., Lin,W. and Zhang,Y.Q.
  TITLE     Modulation of Nav1.8 by Lysophosphatidic Acid in the Induction of
            Bone Cancer Pain
  JOURNAL   Neurosci Bull 32 (5), 445-454 (2016)
   PUBMED   27631681
  REMARK    GeneRIF: This study demonstrated the modulation of Nav1.8 by LPA in
            DRG neurons, and that this probably underlies the peripheral
            mechanism by which bone cancer pain is induced.
REFERENCE   6  (bases 1 to 6507)
  AUTHORS   Benn,S.C., Costigan,M., Tate,S., Fitzgerald,M. and Woolf,C.J.
  TITLE     Developmental expression of the TTX-resistant voltage-gated sodium
            channels Nav1.8 (SNS) and Nav1.9 (SNS2) in primary sensory neurons
  JOURNAL   J Neurosci 21 (16), 6077-6085 (2001)
   PUBMED   11487631
REFERENCE   7  (bases 1 to 6507)
  AUTHORS   Rabert,D.K., Koch,B.D., Ilnicka,M., Obernolte,R.A., Naylor,S.L.,
            Herman,R.C., Eglen,R.M., Hunter,J.C. and Sangameswaran,L.
  TITLE     A tetrodotoxin-resistant voltage-gated sodium channel from human
            dorsal root ganglia, hPN3/SCN10A
  JOURNAL   Pain 78 (2), 107-114 (1998)
   PUBMED   9839820
REFERENCE   8  (bases 1 to 6507)
  AUTHORS   Oaklander,A.L. and Belzberg,A.J.
  TITLE     Unilateral nerve injury down-regulates mRNA for Na+ channel SCN10A
            bilaterally in rat dorsal root ganglia
  JOURNAL   Brain Res Mol Brain Res 52 (1), 162-165 (1997)
   PUBMED   9450690
REFERENCE   9  (bases 1 to 6507)
  AUTHORS   Sangameswaran,L., Delgado,S.G., Fish,L.M., Koch,B.D., Jakeman,L.B.,
            Stewart,G.R., Sze,P., Hunter,J.C., Eglen,R.M. and Herman,R.C.
  TITLE     Structure and function of a novel voltage-gated,
            tetrodotoxin-resistant sodium channel specific to sensory neurons
  JOURNAL   J Biol Chem 271 (11), 5953-5956 (1996)
   PUBMED   8626372
REFERENCE   10 (bases 1 to 6507)
  AUTHORS   Akopian,A.N., Sivilotti,L. and Wood,J.N.
  TITLE     A tetrodotoxin-resistant voltage-gated sodium channel expressed by
            sensory neurons
  JOURNAL   Nature 379 (6562), 257-262 (1996)
   PUBMED   8538791
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Dec 3, 2020 this sequence version replaced NM_017247.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X92184.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-171               JAXUCZ010000008.1  128340128-128340298 c
            172-473             JAXUCZ010000008.1  128314430-128314731 c
            474-592             JAXUCZ010000008.1  128311398-128311516 c
            593-673             JAXUCZ010000008.1  128308032-128308112 c
            674-802             JAXUCZ010000008.1  128293281-128293409 c
            803-894             JAXUCZ010000008.1  128292733-128292824 c
            895-1086            JAXUCZ010000008.1  128291333-128291524 c
            1087-1150           JAXUCZ010000008.1  128290946-128291009 c
            1151-1292           JAXUCZ010000008.1  128287086-128287227 c
            1293-1490           JAXUCZ010000008.1  128286606-128286803 c
            1491-1661           JAXUCZ010000008.1  128285513-128285683 c
            1662-1955           JAXUCZ010000008.1  128281995-128282288 c
            1956-2067           JAXUCZ010000008.1  128279429-128279540 c
            2068-2306           JAXUCZ010000008.1  128271124-128271362 c
            2307-2480           JAXUCZ010000008.1  128268577-128268750 c
            2481-2840           JAXUCZ010000008.1  128256730-128257089 c
            2841-3293           JAXUCZ010000008.1  128255269-128255721 c
            3294-3434           JAXUCZ010000008.1  128253481-128253621 c
            3435-3558           JAXUCZ010000008.1  128251217-128251340 c
            3559-3713           JAXUCZ010000008.1  128249836-128249990 c
            3714-3887           JAXUCZ010000008.1  128246824-128246997 c
            3888-4010           JAXUCZ010000008.1  128242380-128242502 c
            4011-4295           JAXUCZ010000008.1  128241206-128241490 c
            4296-4349           JAXUCZ010000008.1  128239538-128239591 c
            4350-4487           JAXUCZ010000008.1  128238448-128238585 c
            4488-4592           JAXUCZ010000008.1  128237502-128237606 c
            4593-4863           JAXUCZ010000008.1  128232856-128233126 c
            4864-6507           JAXUCZ010000008.1  128228424-128230067 c
FEATURES             Location/Qualifiers
     source          1..6507
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..6507
                     /gene="Scn10a"
                     /gene_synonym="Na(V)1.8; Nav1.8; PN3"
                     /note="sodium voltage-gated channel alpha subunit 10"
                     /db_xref="GeneID:29571"
                     /db_xref="RGD:3629"
     exon            1..171
                     /gene="Scn10a"
                     /gene_synonym="Na(V)1.8; Nav1.8; PN3"
                     /inference="alignment:Splign:2.1.0"
     exon            172..473
                     /gene="Scn10a"
                     /gene_synonym="Na(V)1.8; Nav1.8; PN3"
                     /inference="alignment:Splign:2.1.0"
     CDS             204..6074
                     /gene="Scn10a"
                     /gene_synonym="Na(V)1.8; Nav1.8; PN3"
                     /note="sensory neuron sodium channel; peripheral nerve
                     sodium channel 3; sodium channel protein type X subunit
                     alpha; voltage-gated sodium channel subunit alpha Nav1.8;
                     sodium channel, voltage-gated, type 10, alpha polypeptide;
                     sodium channel, voltage-gated, type X, alpha subunit;
                     sodium channel type X alpha polypeptide; sodium channel
                     voltage-gated type X alpha polypeptide"
                     /codon_start=1
                     /product="sodium channel protein type 10 subunit alpha"
                     /protein_id="NP_058943.2"
                     /db_xref="GeneID:29571"
                     /db_xref="RGD:3629"
                     /translation="MELPFASVGTTNFRRFTPESLAEIEKQIAAHRAAKKARTKHRGQ
                     EDKGEKPRPQLDLKACNQLPKFYGELPAELVGEPLEDLDPFYSTHRTFMVLNKSRTIS
                     RFSATWALWLFSPFNLIRRTAIKVSVHSWFSIFITITILVNCVCMTRTDLPEKVEYVF
                     TVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGAAIDLRGISGLRTFR
                     VLRALKTVSVIPGLKVIVGALIHSVRKLADVTILTVFCLSVFALVGLQLFKGNLKNKC
                     IRNGTDPHKADNLSSEMAEYIFIKPGTTDPLLCGNGSDAGHCPGGYVCLKTPDNPDFN
                     YTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRASGKMYMVFFVLVIFLGSFYLVNLIL
                     AVVTMAYEEQSQATIAEIEAKEKKFQEALEVLQKEQEVLAALGIDTTSLQSHSGSPLA
                     SKNANERRPRVKSRVSEGSTDDNRSPQSDPYNQRRMSFLGLSSGRRRASHGSVFHFRA
                     PSQDISFPDGITDDGVFHGDQESRRGSILLGRGAGQTGPLPRSPLPQSPNPGRRHGEE
                     GQLGVPTGELTAGAPEGPALDTTGQKSFLSAGYLNEPFRAQRAMSVVSIMTSVIEELE
                     ESKLKCPPCLISFAQKYLIWECCPKWRKFKMALFELVTDPFAELTITLCIVVNTVFMA
                     MEHYPMTDAFDAMLQAGNIVFTVFFTMEMAFKIIAFDPYYYFQKKWNIFDCVIVTVSL
                     LELSASKKGSLSVLRTFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTFILAIIVF
                     IFALVGKQLLSEDYGCRKDGVSVWNGEKLRWHMCDFFHSFLVVFRILCGEWIENMWVC
                     MEVSQKSICLILFLTVMVLGNLVVLNLFIALLLNSFSADNLTAPEDDGEVNNLQLALA
                     RIQVLGHRASRAIASYISSHCRFRWPKVETQLGMKPPLTSSEAKNHIATDAVSAAVGN
                     LTKPALSSPKENHGDFITDPNVWVSVPIAEGESDLDELEEDMEQASQSSWQEEDPKGQ
                     QEQLPQVQKCENHQAARSPASMMSSEDLAPYLGESWKRKDSPQVPAEGVDDTSSSEGS
                     TVDCPDPEEILRKIPELADDLDEPDDCFTEGCTRRCPCCNVNTSKSPWATGWQVRKTC
                     YRIVEHSWFESFIIFMILLSSGALAFEDNYLEEKPRVKSVLEYTDRVFTFIFVFEMLL
                     KWVAYGFKKYFTNAWCWLDFLIVNISLTSLIAKILEYSDVASIKALRTLRALRPLRAL
                     SRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFSKCVDTRNNPFS
                     NVNSTMVNNKSECHNQNSTGHFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAV
                     DSGEINSQPNWENNLYMYLYFVVFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDIFM
                     TEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFVFDIVTRQAFDIIIMVLICLNMITM
                     MVETDEQGEEKTKVLGRINQFFVAVFTGECVMKMFALRQYYFTNGWNVFDFIVVILSI
                     GSLLFSAILKSLENYFSPTLFRVIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFN
                     IGLLLFLVMFIYSIFGMASFANVVDEAGIDDMFNFKTFGNSMLCLFQITTSAGWDGLL
                     SPILNTGPPYCDPNLPNSNGSRGNCGSPAVGIIFFTTYIIISFLIVVNMYIAVILENF
                     NVATEESTEPLSEDDFDMFYETWEKFDPEATQFIAFSALSDFADTLSGPLRIPKPNQN
                     ILIQMDLPLVPGDKIHCLDILFAFTKNVLGESGELDSLKTNMEEKFMATNLSKASYEP
                     IATTLRWKQEDLSATVIQKAYRSYMLHRSLTLSNTLHVPRAEEDGVSLPGEGYVTFMA
                     NSGLPDKSETASATSFPPSYDSVTRGLSDRANINPSSSMQNEDEVAAKEGNSPGPQ"
     exon            474..592
                     /gene="Scn10a"
                     /gene_synonym="Na(V)1.8; Nav1.8; PN3"
                     /inference="alignment:Splign:2.1.0"
     exon            593..673
                     /gene="Scn10a"
                     /gene_synonym="Na(V)1.8; Nav1.8; PN3"
                     /inference="alignment:Splign:2.1.0"
     exon            674..802
                     /gene="Scn10a"
                     /gene_synonym="Na(V)1.8; Nav1.8; PN3"
                     /inference="alignment:Splign:2.1.0"
     exon            803..894
                     /gene="Scn10a"
                     /gene_synonym="Na(V)1.8; Nav1.8; PN3"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1086
                     /gene="Scn10a"
                     /gene_synonym="Na(V)1.8; Nav1.8; PN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1150
                     /gene="Scn10a"
                     /gene_synonym="Na(V)1.8; Nav1.8; PN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1292
                     /gene="Scn10a"
                     /gene_synonym="Na(V)1.8; Nav1.8; PN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1490
                     /gene="Scn10a"
                     /gene_synonym="Na(V)1.8; Nav1.8; PN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1661
                     /gene="Scn10a"
                     /gene_synonym="Na(V)1.8; Nav1.8; PN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1955
                     /gene="Scn10a"
                     /gene_synonym="Na(V)1.8; Nav1.8; PN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1956..2067
                     /gene="Scn10a"
                     /gene_synonym="Na(V)1.8; Nav1.8; PN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..2306
                     /gene="Scn10a"
                     /gene_synonym="Na(V)1.8; Nav1.8; PN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2307..2480
                     /gene="Scn10a"
                     /gene_synonym="Na(V)1.8; Nav1.8; PN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2481..2840
                     /gene="Scn10a"
                     /gene_synonym="Na(V)1.8; Nav1.8; PN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2841..3293
                     /gene="Scn10a"
                     /gene_synonym="Na(V)1.8; Nav1.8; PN3"
                     /inference="alignment:Splign:2.1.0"
     exon            3294..3434
                     /gene="Scn10a"
                     /gene_synonym="Na(V)1.8; Nav1.8; PN3"
                     /inference="alignment:Splign:2.1.0"
     exon            3435..3558
                     /gene="Scn10a"
                     /gene_synonym="Na(V)1.8; Nav1.8; PN3"
                     /inference="alignment:Splign:2.1.0"
     exon            3559..3713
                     /gene="Scn10a"
                     /gene_synonym="Na(V)1.8; Nav1.8; PN3"
                     /inference="alignment:Splign:2.1.0"
     exon            3714..3887
                     /gene="Scn10a"
                     /gene_synonym="Na(V)1.8; Nav1.8; PN3"
                     /inference="alignment:Splign:2.1.0"
     exon            3888..4010
                     /gene="Scn10a"
                     /gene_synonym="Na(V)1.8; Nav1.8; PN3"
                     /inference="alignment:Splign:2.1.0"
     exon            4011..4295
                     /gene="Scn10a"
                     /gene_synonym="Na(V)1.8; Nav1.8; PN3"
                     /inference="alignment:Splign:2.1.0"
     exon            4296..4349
                     /gene="Scn10a"
                     /gene_synonym="Na(V)1.8; Nav1.8; PN3"
                     /inference="alignment:Splign:2.1.0"
     exon            4350..4487
                     /gene="Scn10a"
                     /gene_synonym="Na(V)1.8; Nav1.8; PN3"
                     /inference="alignment:Splign:2.1.0"
     exon            4488..4592
                     /gene="Scn10a"
                     /gene_synonym="Na(V)1.8; Nav1.8; PN3"
                     /inference="alignment:Splign:2.1.0"
     exon            4593..4863
                     /gene="Scn10a"
                     /gene_synonym="Na(V)1.8; Nav1.8; PN3"
                     /inference="alignment:Splign:2.1.0"
     exon            4864..6507
                     /gene="Scn10a"
                     /gene_synonym="Na(V)1.8; Nav1.8; PN3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tagcttgctt ctgctaatgc taccccaggc ctttagacag agaacagatg gcagatggag
       61 tttcttattg ccatgcgcaa acgctgagcc cacctcatga tcccggaccc catggttttc
      121 agtagacaac ctgggctaag aagagatctc cgaccttata gagcagcaaa gagtgtaaat
      181 tcttccccaa gaagaatgag aagatggagc tcccctttgc gtccgtggga actaccaatt
      241 tcagacggtt cactccagag tcactggcag agatcgagaa gcagattgct gctcaccgcg
      301 cagccaagaa ggccagaacc aagcacagag gacaggagga caagggcgag aagcccaggc
      361 ctcagctgga cttgaaagcc tgtaaccagc tgcccaagtt ctatggtgag ctcccagcag
      421 aactggtcgg ggagcccctg gaggacctag accctttcta cagcacacac cggacattca
      481 tggtgttgaa taaaagcagg accatttcca gattcagtgc cacttgggcc ctgtggctct
      541 tcagtccctt caacctgatc agaagaacag ccatcaaagt gtctgtccat tcctggttct
      601 ccatattcat caccatcact attttggtca actgcgtgtg catgacccga actgatcttc
      661 cagagaaagt cgagtacgtc ttcactgtca tttacacctt cgaggctctg attaagatac
      721 tggcaagagg gttttgtcta aatgagttca cttatcttcg agatccgtgg aactggctgg
      781 acttcagtgt cattaccttg gcgtatgtgg gtgcagcgat agacctccga ggaatctcag
      841 gcctgcggac attccgagtt ctcagagccc tgaaaactgt ttctgtgatc ccaggactga
      901 aggtcatcgt gggagccctg atccactcag tgaggaagct ggccgacgtg actatcctca
      961 cagtcttctg cctgagcgtc ttcgccttgg tgggcctgca gctctttaag gggaacctta
     1021 agaacaaatg catcaggaac ggaacagatc cccacaaggc tgacaacctc tcatctgaaa
     1081 tggcagaata catcttcatc aagcctggta ctacggatcc cttactgtgc ggcaatgggt
     1141 ctgatgctgg tcactgccct ggaggctatg tctgcctgaa aactcctgac aacccggatt
     1201 ttaactacac cagctttgat tcctttgcgt gggcattcct ctcactgttc cgcctcatga
     1261 cgcaggactc ctgggagcgc ctgtaccagc agacactccg ggcttctggg aaaatgtaca
     1321 tggtcttttt cgtgctggtt attttccttg gatcgttcta cctggtcaat ttgatcttgg
     1381 ccgtggtcac catggcgtat gaagagcaga gccaggcaac aattgcagaa atcgaagcca
     1441 aggaaaaaaa gttccaggaa gcccttgagg tgctgcagaa ggaacaggag gtgctggcag
     1501 ccctggggat tgacacgacc tcgctccagt cccacagtgg atcaccctta gcctccaaaa
     1561 acgccaatga gagaagaccc agggtgaaat caagggtgtc agagggctcc acggatgaca
     1621 acaggtcacc ccaatctgac ccttacaacc agcgcaggat gtctttccta ggcctgtctt
     1681 caggaagacg cagggctagc cacggcagtg tgttccactt ccgagcgccc agccaagaca
     1741 tctcatttcc tgacgggatc acggatgatg gggtctttca cggagaccag gaaagccgtc
     1801 gaggttccat attgctgggc aggggtgctg ggcagacagg tccactcccc aggagcccac
     1861 tgcctcagtc ccccaaccct ggccgtagac atggagaaga gggacagctc ggagtgccca
     1921 ctggtgagct taccgctgga gcgcctgaag gcccggcact cgacactaca gggcagaaga
     1981 gcttcctgtc tgcgggctac ttgaacgaac ctttccgagc acagagggcc atgagcgttg
     2041 tcagtatcat gacttctgtc attgaggagc ttgaagagtc taagctgaag tgcccaccct
     2101 gcttgatcag cttcgctcag aagtatctga tctgggagtg ctgccccaag tggaggaagt
     2161 tcaagatggc gctgttcgag ctggtgactg accccttcgc agagcttacc atcaccctct
     2221 gcatcgtggt gaacaccgtc ttcatggcca tggagcacta ccccatgacc gatgccttcg
     2281 atgccatgct tcaagccggc aacattgtct tcaccgtgtt tttcacaatg gagatggcct
     2341 tcaagatcat tgccttcgac ccctactatt acttccagaa gaagtggaat atcttcgact
     2401 gtgtcatcgt caccgtgagc cttctggagc tgagcgcatc caagaagggc agcctgtctg
     2461 tgctccgtac cttccgcttg ctgcgggtct tcaagctggc caagtcctgg cccaccctga
     2521 acaccctcat caagatcatc gggaactccg tgggggccct gggcaacctg acctttatcc
     2581 tggccatcat cgtcttcatc ttcgccctgg tcggaaagca gcttctctca gaggactacg
     2641 ggtgccgcaa ggacggcgtc tccgtgtgga acggcgagaa gctccgctgg cacatgtgtg
     2701 acttcttcca ttccttcctg gtcgtcttcc gaatcctctg cggggagtgg atcgagaaca
     2761 tgtgggtctg catggaggtc agccagaaat ccatctgcct catcctcttc ttgactgtga
     2821 tggtgctggg caacctagtg gtgctcaacc ttttcatcgc tttactgctg aactccttca
     2881 gcgcggacaa cctcacggct ccagaggatg acggggaggt gaacaacttg cagttagcac
     2941 tggccaggat ccaggtactt ggccatcggg ccagcagggc catcgccagt tacatcagca
     3001 gccactgccg attccgctgg cccaaggtgg agacccagct gggcatgaag cccccactca
     3061 ccagctcaga ggccaagaac cacattgcca ctgatgctgt cagtgctgca gtggggaacc
     3121 tgacaaagcc agctctcagt agccccaagg agaaccacgg ggacttcatc actgatccca
     3181 acgtgtgggt ctctgtgccc attgctgagg gggaatctga cctcgacgag ctcgaggaag
     3241 atatggagca ggcttcgcag agctcctggc aggaagagga ccccaaggga cagcaggagc
     3301 agttgccaca agtccaaaag tgtgaaaacc accaggcagc cagaagccca gcctccatga
     3361 tgtcctctga ggacctggct ccatacctgg gtgagagctg gaagaggaag gatagccctc
     3421 aggtccctgc cgagggagtg gatgacacga gctcctctga gggcagcacg gtggactgcc
     3481 cggacccaga ggaaatcctg aggaagatcc ccgagctggc agatgacctg gacgagcccg
     3541 atgactgttt cacagaaggc tgcactcgcc gctgtccctg ctgcaacgtg aatactagca
     3601 agtctccttg ggccacaggc tggcaggtgc gcaagacctg ctaccgcatc gtggagcaca
     3661 gctggtttga gagtttcatc atcttcatga tcctgctcag cagtggagcg ctggcctttg
     3721 aggataacta cctggaagag aaaccccgag tgaagtccgt gctggagtac actgaccgag
     3781 tgttcacctt catcttcgtc tttgagatgc tgctcaagtg ggtagcctat ggcttcaaaa
     3841 agtatttcac caatgcctgg tgctggctgg acttcctcat tgtgaacatc tccctgacaa
     3901 gcctcatagc gaagatcctt gagtattccg acgtggcgtc catcaaagcc cttcggactc
     3961 tccgtgccct ccgaccgctg cgggctctgt ctcgattcga aggcatgagg gtagtggtgg
     4021 atgccctcgt gggcgccatc ccctccatca tgaacgtcct cctcgtctgc ctcatcttct
     4081 ggctcatctt cagcatcatg ggcgtgaacc tcttcgccgg gaaattttcg aagtgcgtcg
     4141 acaccagaaa taacccattt tccaacgtga attcgacgat ggtgaataac aagtccgagt
     4201 gtcacaatca aaacagcacc ggccacttct tctgggtcaa cgtcaaagtc aacttcgaca
     4261 acgtcgctat gggctacctc gcacttcttc aggtggcaac cttcaaaggc tggatggaca
     4321 taatgtatgc agctgttgat tccggagaga tcaacagtca gcctaactgg gagaacaact
     4381 tgtacatgta cctgtacttc gtcgttttca tcattttcgg tggcttcttc acgctgaatc
     4441 tctttgttgg ggtcataatc gacaacttca accaacagaa aaaaaagcta ggaggccagg
     4501 acatcttcat gacagaagag cagaagaagt actacaatgc catgaagaag ctgggctcca
     4561 agaaacccca gaagcccatc ccacggcccc tgaataagta ccaaggcttc gtgtttgaca
     4621 tcgtgaccag gcaagccttt gacatcatca tcatggttct catctgcctc aacatgatca
     4681 ccatgatggt ggagaccgac gagcagggcg aggagaagac gaaggttctg ggcagaatca
     4741 accagttctt tgtggccgtc ttcacgggcg agtgtgtgat gaagatgttc gccctgcgac
     4801 agtactactt caccaacggc tggaacgtgt tcgacttcat agtggtgatc ctgtccattg
     4861 ggagtctgct gttttctgca atccttaagt cactggaaaa ctacttctcc ccgacgctct
     4921 tccgagtcat ccgtctggcc aggatcggcc gcatcctcag gctgatccga gcagccaagg
     4981 ggattcgcac gctgctcttc gccctcatga tgtccctgcc cgccctcttc aacatcggcc
     5041 tcctcctctt cctcgtcatg ttcatctact ccatcttcgg catggccagc ttcgctaacg
     5101 tcgtggacga ggccggcatc gacgacatgt tcaacttcaa gacctttggc aacagcatgc
     5161 tgtgcctgtt ccagatcacc acctcggccg gctgggacgg cctcctcagc cccatcctca
     5221 acacggggcc tccctactgc gaccccaacc tgcccaacag caacggctcc cgggggaact
     5281 gcgggagccc ggcggtgggc atcatcttct tcaccaccta catcatcatc tctttcctca
     5341 tcgtggtcaa catgtacatc gcagtgattc tggagaactt caacgtggcc accgaggaga
     5401 gcacggagcc cctgagcgag gacgacttcg acatgttcta tgagacctgg gagaagttcg
     5461 acccggaggc cacccagttc attgcctttt ctgccctctc agacttcgcg gacacgctct
     5521 ccggccctct tagaatcccc aaacccaacc agaatatatt aatccagatg gacctgccgt
     5581 tggtccccgg ggataagatc cactgtctgg acatcctttt tgccttcaca aagaacgtct
     5641 tgggagaatc cggggagttg gactccctga agaccaatat ggaagagaag tttatggcga
     5701 ccaatctctc caaagcatcc tatgaaccaa tagccaccac cctccggtgg aagcaggaag
     5761 acctctcagc cacagtcatt caaaaggcct accggagcta catgctgcac cgctccttga
     5821 cactctccaa caccctgcat gtgcccaggg ctgaggagga tggcgtgtca cttcccgggg
     5881 aaggctatgt tacattcatg gcaaacagtg gactcccgga caaatcagaa actgcctctg
     5941 ctacgtcttt cccgccatcc tatgacagtg tcaccagggg tctgagtgac cgggccaaca
     6001 ttaacccatc tagctcaatg caaaatgaag atgaggtcgc tgctaaggaa ggaaacagcc
     6061 ctggacctca gtgaaggcac tcaggcatgc acagggcagg ttccaatgtc tttctctgct
     6121 gtgctaactc cttccctctg gaggtggcac caacctccag cctccaccaa tgcatgtcac
     6181 tggtcatggt gtcagaactg aatggggaca tccttgagaa agcccccacc ccaataggaa
     6241 tcaaaagcca aggatactcc tccattctga cgtcccttcc gagttcccag aagatgtcat
     6301 tgctcccttc tgtttgtgac cagagacgtg attcaccaac ttctcggagc cagagacaca
     6361 tagcaaagac ttttctgctg gtgtcgggca gtcttagaga agtcacgtag gggttggcac
     6421 tgagaattag ggtttgcatg actgcatgct cacagctgcc ggacaatacc tgtgagtcgg
     6481 ccattaaaat taatattttt aaagtta
//
