LOCUS       NM_153740               2319 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus sodium channel and clathrin linker 1 (Sclt1),
            mRNA.
ACCESSION   NM_153740
VERSION     NM_153740.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2319)
  AUTHORS   Ye,X., Zeng,H., Ning,G., Reiter,J.F. and Liu,A.
  TITLE     C2cd3 is critical for centriolar distal appendage assembly and
            ciliary vesicle docking in mammals
  JOURNAL   Proc Natl Acad Sci U S A 111 (6), 2164-2169 (2014)
   PUBMED   24469809
REFERENCE   2  (bases 1 to 2319)
  AUTHORS   Tanos,B.E., Yang,H.J., Soni,R., Wang,W.J., Macaluso,F.P.,
            Asara,J.M. and Tsou,M.F.
  TITLE     Centriole distal appendages promote membrane docking, leading to
            cilia initiation
  JOURNAL   Genes Dev 27 (2), 163-168 (2013)
   PUBMED   23348840
REFERENCE   3  (bases 1 to 2319)
  AUTHORS   Wilson,M.J., Zhang,M.M., Azam,L., Olivera,B.M., Bulaj,G. and
            Yoshikami,D.
  TITLE     Navbeta subunits modulate the inhibition of Nav1.8 by the analgesic
            gating modifier muO-conotoxin MrVIB
  JOURNAL   J Pharmacol Exp Ther 338 (2), 687-693 (2011)
   PUBMED   21586605
  REMARK    GeneRIF: Coexpression of beta-subunits of NaV1.8 strongly
            influences the affinity of the muO-conotoxin MrVIB conopeptide for
            the channel.
REFERENCE   4  (bases 1 to 2319)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   5  (bases 1 to 2319)
  AUTHORS   Liu,C., Cummins,T.R., Tyrrell,L., Black,J.A., Waxman,S.G. and
            Dib-Hajj,S.D.
  TITLE     CAP-1A is a novel linker that binds clathrin and the voltage-gated
            sodium channel Na(v)1.8
  JOURNAL   Mol Cell Neurosci 28 (4), 636-649 (2005)
   PUBMED   15797711
  REMARK    GeneRIF: SAP-1 is the first example of an adapter protein that
            links clathrin and a sodium channel and may regulate Na(v)1.8
            channel density at the cell surface.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF421190.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF421190.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2319
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q26"
     gene            1..2319
                     /gene="Sclt1"
                     /gene_synonym="CAP-1A; Sap1"
                     /note="sodium channel and clathrin linker 1"
                     /db_xref="GeneID:266809"
                     /db_xref="RGD:628721"
     CDS             1..2067
                     /gene="Sclt1"
                     /gene_synonym="CAP-1A; Sap1"
                     /note="clathrin-associated protein 1A; sodium
                     channel-associated protein 1; sodium channel
                     Nav1.8-binding protein"
                     /codon_start=1
                     /product="sodium channel and clathrin linker 1"
                     /protein_id="NP_714962.1"
                     /db_xref="GeneID:266809"
                     /db_xref="RGD:628721"
                     /translation="MATEIDLLRDQNVKLNDILRQHQIEHIFRDPAMQNSMSKGGRGD
                     TLTNSVNDQSALPPLIAEYEKHLEELNRQLTYYQKHMGEMKLQLETVITENERLHSKL
                     KDAVEKQLEALPFGTGIGNDICADDETVRNLQEQLQIANQEKNWAVQLWQTASQELES
                     VQKLYQEHMTEAQIHVFENRKQKDQLNNFQQLTKKLHVANENIEMTNHHFLKTVTEQN
                     MEIEKLRKQLRQAKLDLRVAVTKVEELTKVTEGLQEQMLKKEEDIMSAQGKEEASDRR
                     VQQLQSSIKQLESRLCIAIQEANVLKTGKTQLEKQIKELQAKCSESENEKYEAISRAR
                     DSMQLLEEANIKQNQILLEEKQKEVEREKMKKTISHLIQDAAIKARKEVESTKKQYEV
                     LILQLKEELSALQMDCDEKQGQIDRAIRGKRAVEEELEKIYREGKQDEGDYRKLEEMH
                     QRCLAAERSKDDLQLRLKTAENRIKQLEINSSEEISRSHEMIQKLQTVLESERENCGF
                     VSEQRLKLQQENEQLQKETEDLRKVALEAQKKAKLKVSTMEHQFSIKEHGFEVQLREM
                     EDSNRNSIVELRHLLAAQQKTANRWKEETKKLTESAEMRISSLKSELSRQKLHTQELL
                     SQLEMANEKVAENEKLILEHQEKANRLQRRLSQAEERAASASQQLSVITVQRRKAASM
                     MNLENI"
     exon            1..34
                     /gene="Sclt1"
                     /gene_synonym="CAP-1A; Sap1"
                     /inference="alignment:Splign:2.1.0"
     exon            35..102
                     /gene="Sclt1"
                     /gene_synonym="CAP-1A; Sap1"
                     /inference="alignment:Splign:2.1.0"
     exon            103..161
                     /gene="Sclt1"
                     /gene_synonym="CAP-1A; Sap1"
                     /inference="alignment:Splign:2.1.0"
     exon            162..234
                     /gene="Sclt1"
                     /gene_synonym="CAP-1A; Sap1"
                     /inference="alignment:Splign:2.1.0"
     exon            235..290
                     /gene="Sclt1"
                     /gene_synonym="CAP-1A; Sap1"
                     /inference="alignment:Splign:2.1.0"
     exon            291..426
                     /gene="Sclt1"
                     /gene_synonym="CAP-1A; Sap1"
                     /inference="alignment:Splign:2.1.0"
     exon            427..549
                     /gene="Sclt1"
                     /gene_synonym="CAP-1A; Sap1"
                     /inference="alignment:Splign:2.1.0"
     exon            550..615
                     /gene="Sclt1"
                     /gene_synonym="CAP-1A; Sap1"
                     /inference="alignment:Splign:2.1.0"
     exon            616..686
                     /gene="Sclt1"
                     /gene_synonym="CAP-1A; Sap1"
                     /inference="alignment:Splign:2.1.0"
     exon            687..777
                     /gene="Sclt1"
                     /gene_synonym="CAP-1A; Sap1"
                     /inference="alignment:Splign:2.1.0"
     exon            778..869
                     /gene="Sclt1"
                     /gene_synonym="CAP-1A; Sap1"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1047
                     /gene="Sclt1"
                     /gene_synonym="CAP-1A; Sap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1146
                     /gene="Sclt1"
                     /gene_synonym="CAP-1A; Sap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1218
                     /gene="Sclt1"
                     /gene_synonym="CAP-1A; Sap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1293
                     /gene="Sclt1"
                     /gene_synonym="CAP-1A; Sap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1439
                     /gene="Sclt1"
                     /gene_synonym="CAP-1A; Sap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1632
                     /gene="Sclt1"
                     /gene_synonym="CAP-1A; Sap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1829
                     /gene="Sclt1"
                     /gene_synonym="CAP-1A; Sap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1830..1908
                     /gene="Sclt1"
                     /gene_synonym="CAP-1A; Sap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..2004
                     /gene="Sclt1"
                     /gene_synonym="CAP-1A; Sap1"
                     /inference="alignment:Splign:2.1.0"
     exon            2005..2303
                     /gene="Sclt1"
                     /gene_synonym="CAP-1A; Sap1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggccacag aaatcgactt actgagagac caaaatgtta aactaaatga tattcttagg
       61 cagcatcaaa tcgaacatat tttcagagac ccagctatgc agaacagcat gtccaaagga
      121 ggcagaggtg acacactaac aaactctgta aatgaccaaa gtgctttacc tcctctcatt
      181 gctgagtatg agaaacatct cgaagagcta aacaggcagc tgacctatta ccagaaacac
      241 atgggtgaga tgaaactaca acttgaaacc gtcatcacag aaaatgaaag gttacacagt
      301 aaattaaaag atgctgttga aaagcaattg gaagcccttc cctttggcac agggatagga
      361 aatgacatct gtgcagatga tgagaccgtg aggaatcttc aagaacaatt gcaaatagcc
      421 aatcaagaga aaaattgggc tgttcaactc tggcagactg cgtctcagga gttagaaagt
      481 gttcagaaac tctaccagga acatatgact gaagcccaga ttcatgtatt tgaaaaccgg
      541 aaacaaaaag atcagctgaa caattttcaa caactaacca agaaactcca tgttgctaat
      601 gagaacattg aaatgactaa ccaccacttc ctgaaaacag taactgaaca aaacatggag
      661 attgagaaac ttcgaaaaca acttaggcaa gccaagttag atctgagagt tgcagtaacg
      721 aaagtggaag agttaactaa agtgactgaa ggtcttcaag agcagatgct gaagaaggag
      781 gaagatatta tgtctgcaca aggaaaagag gaagcatcag atagacgtgt gcagcagtta
      841 cagtctagta taaaacagtt agagtcaaga ttgtgtatag caattcaaga agccaatgta
      901 ctaaaaacag ggaaaacaca attggaaaag cagatcaaag agctacaagc aaagtgcagt
      961 gaatcagaaa atgagaaata tgaggctatt tcaagagcca gagatagcat gcagctgtta
     1021 gaagaagcta acattaaaca gaatcagatt ctacttgaag agaagcaaaa agaggttgaa
     1081 agagaaaaaa tgaagaaaac aatttctcat cttatacaag atgccgccat caaagcaagg
     1141 aaagaagttg aaagcacaaa aaaacagtat gaagtactaa ttttgcagtt aaaggaagaa
     1201 ctctcagccc ttcagatgga ctgtgatgaa aagcaaggtc aaattgatcg agccattaga
     1261 gggaaaagag ctgtggaaga agaactcgag aagatttatc gtgaaggcaa acaggatgaa
     1321 ggtgattaca gaaaattgga agaaatgcac caaagatgtc ttgctgcaga gcgttcaaaa
     1381 gatgatcttc agctaagact caagactgca gaaaatagaa taaaacaact tgaaattaat
     1441 tcctcagaag agatatcacg ttcccatgaa atgatccaga aacttcaaac tgtattggag
     1501 tctgagaggg agaactgtgg ctttgtcagc gagcaaaggc tgaagcttca gcaagaaaat
     1561 gagcaactac agaaggagac tgaggatttg agaaaagttg ctctggaggc ccaaaaaaaa
     1621 gcaaaattaa aggtcagtac aatggagcat cagttctcaa taaaggagca tgggtttgaa
     1681 gttcagctga gagagatgga ggacagtaat cggaactcca ttgttgaact gaggcatctt
     1741 ttggcagctc aacaaaagac ggccaatagg tggaaagaag aaaccaagaa actgacggaa
     1801 agtgcagaaa tgaggatcag cagtctaaag agtgagctga gccgacagaa gcttcatacc
     1861 caggagctac tttctcagct ggaaatggca aatgagaagg tagctgagaa tgaaaagtta
     1921 attctggaac atcaagaaaa agccaacaga cttcaaaggc gtttaagtca ggcagaagag
     1981 agagctgctt cagcgtccca gcagctcagt gtgattacag tgcagagaag aaaagcagct
     2041 tccatgatga atctggaaaa tatttaaaca tattcatagt tcactgacag agctgtagag
     2101 ttgggaaagc tgttgtacca accaaagcat cttgatatgg agaaactgcc gagagagaat
     2161 ggtgaaagct tgtgtcgttt gcataagcat tttccattct gtttgcaggg ttattggaaa
     2221 acagaacagt gacagcttcc tgtaagtaaa aactataatc ctatatttga gattcagtgg
     2281 agaataaagc cagctgagaa gaaaaaaaaa aaaaaaaaa
//
