LOCUS       NM_001398998             955 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus SLP adaptor and CSK interacting membrane protein
            (Scimp), mRNA.
ACCESSION   NM_001398998 XM_001080739
VERSION     NM_001398998.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 955)
  AUTHORS   Luo,L., Bokil,N.J., Wall,A.A., Kapetanovic,R., Lansdaal,N.M.,
            Marceline,F., Burgess,B.J., Tong,S.J., Guo,Z., Alexandrov,K.,
            Ross,I.L., Hibbs,M.L., Stow,J.L. and Sweet,M.J.
  TITLE     SCIMP is a transmembrane non-TIR TLR adaptor that promotes
            proinflammatory cytokine production from macrophages
  JOURNAL   Nat Commun 8, 14133 (2017)
   PUBMED   28098138
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 955)
  AUTHORS   Kralova,J., Fabisik,M., Pokorna,J., Skopcova,T., Malissen,B. and
            Brdicka,T.
  TITLE     The Transmembrane Adaptor Protein SCIMP Facilitates Sustained
            Dectin-1 Signaling in Dendritic Cells
  JOURNAL   J Biol Chem 291 (32), 16530-16540 (2016)
   PUBMED   27288407
REFERENCE   3  (bases 1 to 955)
  AUTHORS   Draber,P., Vonkova,I., Stepanek,O., Hrdinka,M., Kucova,M.,
            Skopcova,T., Otahal,P., Angelisova,P., Horejsi,V., Yeung,M.,
            Weiss,A. and Brdicka,T.
  TITLE     SCIMP, a transmembrane adaptor protein involved in major
            histocompatibility complex class II signaling
  JOURNAL   Mol Cell Biol 31 (22), 4550-4562 (2011)
   PUBMED   21930792
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Dec 29, 2021 this sequence version replaced XM_001080739.6.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FM120765.1, SRR22582419.187424.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN16676785,
                                           SAMN16676786 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                JAXUCZ010000010.1  56026271-56026357   c
            88-211              JAXUCZ010000010.1  56015100-56015223   c
            212-275             JAXUCZ010000010.1  56013110-56013173   c
            276-349             JAXUCZ010000010.1  56009878-56009951   c
            350-955             JAXUCZ010000010.1  56006243-56006848   c
FEATURES             Location/Qualifiers
     source          1..955
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..955
                     /gene="Scimp"
                     /note="SLP adaptor and CSK interacting membrane protein"
                     /db_xref="GeneID:691993"
                     /db_xref="RGD:1593299"
     exon            1..87
                     /gene="Scimp"
                     /inference="alignment:Splign:2.1.0"
     exon            88..211
                     /gene="Scimp"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..555
                     /gene="Scimp"
                     /codon_start=1
                     /product="SLP adapter and CSK-interacting membrane
                     protein"
                     /protein_id="NP_001385927.1"
                     /db_xref="GeneID:691993"
                     /db_xref="RGD:1593299"
                     /translation="MSWWRNNFWLILAVTIISISLVLGLILYCVCRWQLRQGRNWEVA
                     KPSIQDGREEDKMYENVLNSSPGRLPALPPRSSPFPEDPAPQESPRQPSAWYSSVKKV
                     KKKNVFDISVSTDPENDYDDVEIPATTEIQHSITPIPLWQAETGLHSSF"
     exon            212..275
                     /gene="Scimp"
                     /inference="alignment:Splign:2.1.0"
     exon            276..349
                     /gene="Scimp"
                     /inference="alignment:Splign:2.1.0"
     exon            350..955
                     /gene="Scimp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaggctctcc ccagctgtgt taagaaacgc cctcatagtc cacagctgtc tccacagcgg
       61 ctttcagcga cacccgggca agtctaggct tccacagcaa tgagttggtg gaggaacaat
      121 ttctggctca tcttagctgt gaccatcatc tccatctcct tggtcctggg tctcatcctg
      181 tactgtgtct gcaggtggca gcttagacaa ggcaggaact gggaagttgc caagccctcg
      241 atacaggacg gaagagaaga ggacaagatg tatgagaatg ttcttaattc ttcaccaggt
      301 cggttacctg ctctgccacc caggagttca ccttttccag aagacccagc cccacaggaa
      361 tctccaagac aaccatcagc ttggtactca tcagtgaaga aagttaaaaa gaagaacgtc
      421 tttgatatct cggtctccac tgatccagaa aatgattacg atgatgttga gattccggca
      481 accactgaaa tccagcactc tataacaccc atacctcttt ggcaagctga aacgggctta
      541 cacagctcat tttagaataa tctagaatgg ctggactgta acataagcac ttcccgatcc
      601 ctagaggaaa ccacctccgc catgtgaaag ctacagcaga ggctaggaca gcttgatgtc
      661 cccagtgctc cagatgtgtc tgttgctcca gatgatgttc ctgatgtttc tcgcactgca
      721 gaagctctgt cctgagactc tgagggtgta gccttggcac ctctgtggag gaagtttcct
      781 ttgtgcagac cactgggcct gtgagaattg actcatttcc ccacattccc ctttgctccc
      841 gtggtgaatg tggctgtaac gtggtgggtc tcaaccttcc tgatgctggg acccttcaat
      901 acagttcttt aggttgtggc gatccccaat tgtaaaatca ttttgttgct acttc
//
