LOCUS       NM_201561               1365 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus secretagogin, EF-hand calcium binding protein
            (Scgn), mRNA.
ACCESSION   NM_201561 XM_225337
VERSION     NM_201561.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1365)
  AUTHORS   Tapia-Gonzalez,S., Insausti,R. and DeFelipe,J.
  TITLE     Differential expression of secretagogin immunostaining in the
            hippocampal formation and the entorhinal and perirhinal cortices of
            humans, rats, and mice
  JOURNAL   J Comp Neurol 528 (4), 523-541 (2020)
   PUBMED   31512254
  REMARK    GeneRIF: Differential expression of secretagogin immunostaining in
            the hippocampal formation and the entorhinal and perirhinal
            cortices of humans, rats, and mice.
REFERENCE   2  (bases 1 to 1365)
  AUTHORS   Kosaka,T., Yasuda,S. and Kosaka,K.
  TITLE     Calcium-binding protein, secretagogin, characterizes novel groups
            of interneurons in the rat striatum
  JOURNAL   Neurosci Res 119, 53-60 (2017)
   PUBMED   28193530
  REMARK    GeneRIF: secretagogin, characterizes novel groups of interneurons
            in the rat striatum
REFERENCE   3  (bases 1 to 1365)
  AUTHORS   Hanics,J., Szodorai,E., Tortoriello,G., Malenczyk,K., Keimpema,E.,
            Lubec,G., Hevesi,Z., Lutz,M.I., Kozsurek,M., Puskar,Z., Toth,Z.E.,
            Wagner,L., Kovacs,G.G., Hokfelt,T.G., Harkany,T. and Alpar,A.
  TITLE     Secretagogin-dependent matrix metalloprotease-2 release from
            neurons regulates neuroblast migration
  JOURNAL   Proc Natl Acad Sci U S A 114 (10), E2006-E2015 (2017)
   PUBMED   28223495
  REMARK    GeneRIF: Secretagogin-dependent MMP2 release from neurons regulates
            neuroblast migration.
REFERENCE   4  (bases 1 to 1365)
  AUTHORS   Shi,T.J., Xiang,Q., Zhang,M.D., Tortoriello,G., Hammarberg,H.,
            Mulder,J., Fried,K., Wagner,L., Josephson,A., Uhlen,M., Harkany,T.
            and Hokfelt,T.
  TITLE     Secretagogin is expressed in sensory CGRP neurons and in spinal
            cord of mouse and complements other calcium-binding proteins, with
            a note on rat and human
  JOURNAL   Mol Pain 8, 80 (2012)
   PUBMED   23102406
  REMARK    GeneRIF: Scgn is a CaBP expressed in a subpopulation of nociceptive
            DRG neurons and their processes in the dorsal horn.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1365)
  AUTHORS   Maj,M., Gartner,W., Ilhan,A., Neziri,D., Attems,J. and Wagner,L.
  TITLE     Expression of TAU in insulin-secreting cells and its interaction
            with the calcium-binding protein secretagogin
  JOURNAL   J Endocrinol 205 (1), 25-36 (2010)
   PUBMED   20061514
  REMARK    GeneRIF: There is an association of TAU and the calcium-binding
            protein SCGN in insulin-secreting cells implicating beta-cells as
            an extra cerebral site of tauopathy.
REFERENCE   6  (bases 1 to 1365)
  AUTHORS   Gartner,W., Vila,G., Daneva,T., Nabokikh,A., Koc-Saral,F.,
            Ilhan,A., Majdic,O., Luger,A. and Wagner,L.
  TITLE     New functional aspects of the neuroendocrine marker secretagogin
            based on the characterization of its rat homolog
  JOURNAL   Am J Physiol Endocrinol Metab 293 (1), E347-E354 (2007)
   PUBMED   17426113
  REMARK    GeneRIF: The sequence homology and the comparable tissue expression
            patterns of human and rat secretagogin indicate conserved
            intracellular functions.
REFERENCE   7  (bases 1 to 1365)
  AUTHORS   Gartner,W., Lang,W., Leutmetzer,F., Domanovits,H., Waldhausl,W. and
            Wagner,L.
  TITLE     Cerebral expression and serum detectability of secretagogin, a
            recently cloned EF-hand Ca(2+)-binding protein
  JOURNAL   Cereb Cortex 11 (12), 1161-1169 (2001)
   PUBMED   11709487
  REMARK    GeneRIF: Characterization of the human secretagogin homolog.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Sep 30, 2022 this sequence version replaced NM_201561.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY513659.1, SRR26643288.57593.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840115, SAMN12840117
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-211               JAXUCZ010000017.1  41534558-41534768
            212-282             JAXUCZ010000017.1  41535812-41535882
            283-375             JAXUCZ010000017.1  41543826-41543918
            376-465             JAXUCZ010000017.1  41546868-41546957
            466-522             JAXUCZ010000017.1  41550181-41550237
            523-600             JAXUCZ010000017.1  41550969-41551046
            601-656             JAXUCZ010000017.1  41562582-41562637
            657-702             JAXUCZ010000017.1  41567611-41567656
            703-762             JAXUCZ010000017.1  41568307-41568366
            763-831             JAXUCZ010000017.1  41570219-41570287
            832-1365            JAXUCZ010000017.1  41575992-41576525
FEATURES             Location/Qualifiers
     source          1..1365
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p11"
     gene            1..1365
                     /gene="Scgn"
                     /note="secretagogin, EF-hand calcium binding protein"
                     /db_xref="GeneID:306942"
                     /db_xref="RGD:1303281"
     exon            1..211
                     /gene="Scgn"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..960
                     /gene="Scgn"
                     /codon_start=1
                     /product="secretagogin"
                     /protein_id="NP_963855.2"
                     /db_xref="GeneID:306942"
                     /db_xref="RGD:1303281"
                     /translation="MDNAHRQTQAHLDAACFWQIWQRFDKDEKGYIKETELDAFFDDL
                     LAKFGIEDTLMEENVQKMKEQLMVGHDISKEGRILMKELASMFLSEDENFLLFFRLET
                     PLDNSVEFMQIWRKYDADSSGFISAAELSNFLRDLFLHHKKVISEAELEEYTSTMMKI
                     FDRNKDGRLDLNDLARILALQENFLLQFKMDASSTEERKRDFEKIFAHYDVSKTGALE
                     GPEVDGFVKDMMELVQPSISGVDLDKFREILLRHCDVNKDGKIQKSELALCLGLKINP
                     "
     exon            212..282
                     /gene="Scgn"
                     /inference="alignment:Splign:2.1.0"
     exon            283..375
                     /gene="Scgn"
                     /inference="alignment:Splign:2.1.0"
     exon            376..465
                     /gene="Scgn"
                     /inference="alignment:Splign:2.1.0"
     exon            466..522
                     /gene="Scgn"
                     /inference="alignment:Splign:2.1.0"
     exon            523..600
                     /gene="Scgn"
                     /inference="alignment:Splign:2.1.0"
     exon            601..656
                     /gene="Scgn"
                     /inference="alignment:Splign:2.1.0"
     exon            657..702
                     /gene="Scgn"
                     /inference="alignment:Splign:2.1.0"
     exon            703..762
                     /gene="Scgn"
                     /inference="alignment:Splign:2.1.0"
     exon            763..831
                     /gene="Scgn"
                     /inference="alignment:Splign:2.1.0"
     exon            832..1365
                     /gene="Scgn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgctcagcg acaccaaaga gctgaaagcc ctagagcctg ctttgcccac tgatacctag
       61 ctagagaggg aggaagtgga ccaacgagtc gggaaatact gctaggcgat tgttactcct
      121 atcagcacca tggacaacgc acacagacaa actcaagctc atttggatgc tgcctgcttc
      181 tggcagatct ggcagcgctt cgacaaggat gaaaaaggtt acataaaaga gacagagctg
      241 gatgcctttt ttgacgattt gctggcaaaa tttggaattg aggacactct tatggaagaa
      301 aatgtgcaga aaatgaaaga acagttaatg gttggccatg acatctctaa ggaaggtcgc
      361 atactgatga aagagcttgc cagtatgttc ttatctgagg acgaaaattt cctcttgttc
      421 tttcgcctgg aaactccctt ggataacagt gtggagttta tgcagatttg gcgcaagtat
      481 gatgcggaca gcagtggctt catatcagct gctgagcttt ctaactttct ccgagatctt
      541 ttcctccacc acaaaaaggt catttccgag gctgagctgg aagagtatac tagcaccatg
      601 atgaagatct ttgacagaaa taaagatggt cgtttggatc ttaatgactt ggcaaggatt
      661 ctggctcttc aggaaaactt ccttcttcag tttaaaatgg atgcttcttc tactgaggaa
      721 aggaagaggg actttgagaa aatctttgcc cattatgatg ttagtaaaac tggagccctg
      781 gaaggcccag aagtggatgg atttgtcaaa gacatgatgg aactggtcca gcctagcatc
      841 agcggtgtgg atcttgataa gttccgggag attctgcttc gacattgcga tgtgaacaag
      901 gatggaaaga tccagaagtc tgagctggcg ctgtgtcttg ggctaaaaat aaacccctga
      961 tccccaactg ccctgctctc tgcttatgtg tctgtgctct tgctgtgaga agtgtgcttg
     1021 tgctttgggg acccacctta atggactttc tccctgacag tttggtactc ttgatagggg
     1081 gaggggccct agggtgctgc ttccagaggc agccatgatt ttatcccacg ggaagccctc
     1141 aaccgcttct tccatgttcg ttccttgacc ttggcctatc acctccaggg cctcagttta
     1201 cctgctggtc ctgctctgtt caactttccc tattacccag tgatccattc taccatctcc
     1261 catttgtctt tgacctttct gctcagttag aatgtcacct gtgtcatgct gtcacttcta
     1321 caaatatgtc ttcttgtaga aataaatcta tggtcaagaa tgaag
//
