LOCUS       NM_001024283             373 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus secretoglobin, family 3A, member 2 (Scgb3a2),
            mRNA.
ACCESSION   NM_001024283 XM_574139
VERSION     NM_001024283.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 373)
  AUTHORS   Kurotani R, Okumura S, Matsubara T, Yokoyama U, Buckley JR, Tomita
            T, Kezuka K, Nagano T, Esposito D, Taylor TE, Gillette WK, Ishikawa
            Y, Abe H, Ward JM and Kimura S.
  TITLE     Secretoglobin 3A2 suppresses bleomycin-induced pulmonary fibrosis
            by transforming growth factor beta signaling down-regulation
  JOURNAL   J Biol Chem 286 (22), 19682-19692 (2011)
   PUBMED   21478551
REFERENCE   2  (bases 1 to 373)
  AUTHORS   Andiappan AK, Yeo WS, Parate PN, Anantharaman R, Suri BK, Wang de Y
            and Chew FT.
  TITLE     Variation in Uteroglobin-Related Protein 1 (UGRP1) gene is
            associated with allergic rhinitis in Singapore Chinese
  JOURNAL   BMC Med Genet 12, 39 (2011)
   PUBMED   21410962
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 373)
  AUTHORS   Lu X, Wang N, Long XB, You XJ, Cui YH and Liu Z.
  TITLE     The cytokine-driven regulation of secretoglobins in normal human
            upper airway and their expression, particularly that of
            uteroglobin-related protein 1, in chronic rhinosinusitis
  JOURNAL   Respir Res 12 (1), 28 (2011)
   PUBMED   21385388
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 373)
  AUTHORS   Kurotani R, Kumaki N, Naizhen X, Ward JM, Linnoila RI and Kimura S.
  TITLE     Secretoglobin 3A2/uteroglobin-related protein 1 is a novel marker
            for pulmonary carcinoma in mice and humans
  JOURNAL   Lung Cancer 71 (1), 42-48 (2011)
   PUBMED   20466451
REFERENCE   5  (bases 1 to 373)
  AUTHORS   Tachihara-Yoshikawa M, Ishida T, Watanabe K, Sugawara A, Kanazawa
            K, Kanno R, Suzuki T, Niimi T, Kimura S and Munakata M.
  TITLE     Expression of secretoglobin3A2 (SCGB3A2) in primary pulmonary
            carcinomas
  JOURNAL   Fukushima J Med Sci 54 (2), 61-72 (2008)
   PUBMED   19418968
REFERENCE   6  (bases 1 to 373)
  AUTHORS   de Burbure C, Pignatti P, Corradi M, Malerba M, Clippe A, Dumont X,
            Moscato G, Mutti A and Bernard A.
  TITLE     Uteroglobin-related protein 1 and clara cell protein in induced
            sputum of patients with asthma and rhinitis
  JOURNAL   Chest 131 (1), 172-179 (2007)
   PUBMED   17218572
REFERENCE   7  (bases 1 to 373)
  AUTHORS   Chiba Y, Kurotani R, Kusakabe T, Miura T, Link BW, Misawa M and
            Kimura S.
  TITLE     Uteroglobin-related protein 1 expression suppresses allergic airway
            inflammation in mice
  JOURNAL   Am J Respir Crit Care Med 173 (9), 958-964 (2006)
   PUBMED   16456148
REFERENCE   8  (bases 1 to 373)
  AUTHORS   Chiba Y, Kusakabe T and Kimura S.
  TITLE     Decreased expression of uteroglobin-related protein 1 in inflamed
            mouse airways is mediated by IL-9
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 287 (6), L1193-L1198 (2004)
   PUBMED   15531759
REFERENCE   9  (bases 1 to 373)
  AUTHORS   Niimi T, Munakata M, Keck-Waggoner CL, Popescu NC, Levitt RC,
            Hisada M and Kimura S.
  TITLE     A polymorphism in the human UGRP1 gene promoter that regulates
            transcription is associated with an increased risk of asthma
  JOURNAL   Am J Hum Genet 70 (3), 718-725 (2002)
   PUBMED   11813133
REFERENCE   10 (bases 1 to 373)
  AUTHORS   Niimi T, Keck-Waggoner CL, Popescu NC, Zhou Y, Levitt RC and Kimura
            S.
  TITLE     UGRP1, a uteroglobin/Clara cell secretory protein-related protein,
            is a novel lung-enriched downstream target gene for the
            T/EBP/NKX2.1 homeodomain transcription factor
  JOURNAL   Mol Endocrinol 15 (11), 2021-2036 (2001)
   PUBMED   11682631
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF439547.1.
            
            On May 27, 2005 this sequence version replaced XM_574139.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF439547.1, CF110360.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676784, SAMN16676785
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..373
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q11"
     gene            1..373
                     /gene="Scgb3a2"
                     /gene_synonym="Pnsp1"
                     /note="secretoglobin, family 3A, member 2"
                     /db_xref="GeneID:498854"
                     /db_xref="RGD:1564790"
     exon            1..102
                     /gene="Scgb3a2"
                     /gene_synonym="Pnsp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..329
                     /gene="Scgb3a2"
                     /gene_synonym="Pnsp1"
                     /note="pneumo secretory protein 1"
                     /codon_start=1
                     /product="secretoglobin family 3A member 2"
                     /protein_id="NP_001019454.1"
                     /db_xref="GeneID:498854"
                     /db_xref="RGD:1564790"
                     /translation="MKVVPIFLLVTIGICGYSATAFLINSVPLPVDKVLPLPLDNLIP
                     LFDPLKMLLKTLGISVEHLVEGLKKCVNELGPEASEAVKKLLEALSHLV"
     exon            103..305
                     /gene="Scgb3a2"
                     /gene_synonym="Pnsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            306..373
                     /gene="Scgb3a2"
                     /gene_synonym="Pnsp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttctgtcta cattccaaag tccaagaaaa catcagagga accagctatg aaggtggtac
       61 ccatctttct gctggtgacg atcggtattt gtggttattc tgccactgcc tttcttatca
      121 acagtgtccc tcttcctgtt gacaaagtgt tacctttacc tttggacaac cttattccct
      181 tatttgatcc cttgaagatg cttctgaaaa ccctgggaat ttctgtagaa catctggtgg
      241 aagggctgaa gaagtgcgtg aatgagctgg ggccagaggc ttcagaggct gtgaagaagc
      301 ttctggaggc tctatcacac ctggtataaa atctgcataa acagatttaa ggtgcgagtg
      361 aagagaagga tgt
//
