LOCUS       NM_013175               1146 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus secretogranin V (Scg5), mRNA.
ACCESSION   NM_013175
VERSION     NM_013175.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1146)
  AUTHORS   Stauber,M., Weidemann,M., Dittrich-Breiholz,O., Lobschat,K.,
            Alten,L., Mai,M., Beckers,A., Kracht,M. and Gossler,A.
  TITLE     Identification of FOXJ1 effectors during ciliogenesis in the foetal
            respiratory epithelium and embryonic left-right organiser of the
            mouse
  JOURNAL   Dev Biol 423 (2), 170-188 (2017)
   PUBMED   27914912
REFERENCE   2  (bases 1 to 1146)
  AUTHORS   Tadros,H., Schmidt,G., Sirois,F. and Mbikay,M.
  TITLE     Regulation of 7B2 mRNA translation: dissecting the role of its
            5'-untranslated region
  JOURNAL   Methods Mol Biol 768, 217-230 (2011)
   PUBMED   21805245
  REMARK    GeneRIF: Acute exposure of MIN6 cells transduced with rat 7B2 to
            high glucose increased endogenous 7B2 biosynthesis without
            affecting the levels of its mRNA.
REFERENCE   3  (bases 1 to 1146)
  AUTHORS   Lee,S.N., Hwang,J.R. and Lindberg,I.
  TITLE     Neuroendocrine protein 7B2 can be inactivated by phosphorylation
            within the secretory pathway
  JOURNAL   J Biol Chem 281 (6), 3312-3320 (2006)
   PUBMED   16286464
  REMARK    GeneRIF: phosphorylation of 7B2 functionally inactivates this
            protein in a manner analogous to the phosphorylating inactivation
            of BiP, which impairs its ability to bind substrate
REFERENCE   4  (bases 1 to 1146)
  AUTHORS   Kwitek,A.E., Gullings-Handley,J., Yu,J., Carlos,D.C., Orlebeke,K.,
            Nie,J., Eckert,J., Lemke,A., Andrae,J.W., Bromberg,S., Pasko,D.,
            Chen,D., Scheetz,T.E., Casavant,T.L., Soares,M.B., Sheffield,V.C.,
            Tonellato,P.J. and Jacob,H.J.
  TITLE     High-density rat radiation hybrid maps containing over 24,000
            SSLPs, genes, and ESTs provide a direct link to the rat genome
            sequence
  JOURNAL   Genome Res 14 (4), 750-757 (2004)
   PUBMED   15060019
REFERENCE   5  (bases 1 to 1146)
  AUTHORS   Mbikay,M., Seidah,N.G. and Chretien,M.
  TITLE     Neuroendocrine secretory protein 7B2: structure, expression and
            functions
  JOURNAL   Biochem J 357 (Pt 2), 329-342 (2001)
   PUBMED   11439082
  REMARK    Review article
REFERENCE   6  (bases 1 to 1146)
  AUTHORS   Muller,L., Zhu,X. and Lindberg,I.
  TITLE     Mechanism of the facilitation of PC2 maturation by 7B2: involvement
            in ProPC2 transport and activation but not folding
  JOURNAL   J Cell Biol 139 (3), 625-638 (1997)
   PUBMED   9348280
REFERENCE   7  (bases 1 to 1146)
  AUTHORS   Braks,J.A. and Martens,G.J.
  TITLE     7B2 is a neuroendocrine chaperone that transiently interacts with
            prohormone convertase PC2 in the secretory pathway
  JOURNAL   Cell 78 (2), 263-273 (1994)
   PUBMED   7913882
REFERENCE   8  (bases 1 to 1146)
  AUTHORS   Martens,G.J., Braks,J.A., Eib,D.W., Zhou,Y. and Lindberg,I.
  TITLE     The neuroendocrine polypeptide 7B2 is an endogenous inhibitor of
            prohormone convertase PC2
  JOURNAL   Proc Natl Acad Sci U S A 91 (13), 5784-5787 (1994)
   PUBMED   8016065
REFERENCE   9  (bases 1 to 1146)
  AUTHORS   Waldbieser,G.C., Aimi,J. and Dixon,J.E.
  TITLE     Cloning and characterization of the rat complementary
            deoxyribonucleic acid and gene encoding the neuroendocrine peptide
            7B2
  JOURNAL   Endocrinology 128 (6), 3228-3236 (1991)
   PUBMED   1709861
REFERENCE   10 (bases 1 to 1146)
  AUTHORS   Iguchi,H., Chan,J.S., Seidah,N.G. and Chretien,M.
  TITLE     Tissue distribution and molecular forms of a novel pituitary
            protein in the rat
  JOURNAL   Neuroendocrinology 39 (5), 453-458 (1984)
   PUBMED   6514132
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Mar 16, 2021 this sequence version replaced NM_013175.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ213100.1, CF976380.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMN12840106 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                JAXUCZ010000003.1  121042729-121042795 c
            68-294              JAXUCZ010000003.1  121041130-121041356 c
            295-444             JAXUCZ010000003.1  121013742-121013891 c
            445-557             JAXUCZ010000003.1  121010509-121010621 c
            558-611             JAXUCZ010000003.1  121002718-121002771 c
            612-1146            JAXUCZ010000003.1  120998420-120998954 c
FEATURES             Location/Qualifiers
     source          1..1146
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     gene            1..1146
                     /gene="Scg5"
                     /gene_synonym="7B2; Sgne1"
                     /note="secretogranin V"
                     /db_xref="GeneID:25719"
                     /db_xref="RGD:3669"
     exon            1..67
                     /gene="Scg5"
                     /gene_synonym="7B2; Sgne1"
                     /inference="alignment:Splign:2.1.0"
     exon            68..294
                     /gene="Scg5"
                     /gene_synonym="7B2; Sgne1"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..707
                     /gene="Scg5"
                     /gene_synonym="7B2; Sgne1"
                     /note="neuroendocrine protein 7B2; secretogranin-5;
                     secretory granule endocrine protein I; Secretory granule
                     neuroendocrine, protein 1 (7B2 protein); secretogranin V
                     (7B2 protein); secretory granule neuroendocrine protein 1"
                     /codon_start=1
                     /product="neuroendocrine protein 7B2 precursor"
                     /protein_id="NP_037307.2"
                     /db_xref="GeneID:25719"
                     /db_xref="RGD:3669"
                     /translation="MTSRMVILSGLLFWLLLEWNPAFAYSPRTPDRVSETDIQRLLHG
                     VMEQLGIARPRVEYPAHQAMNLVGPQSIEGGAHEGLQHLGPFGNIPNIVAELTGDNIP
                     KDFSEDQGYPDPPNPCPLGKTADDGCLENAPDTAEFSREFQLDQHLFDPEHDYPGLGK
                     WNKKLLYEKMKGGQRRKRRSVNPYLQGKRLDNVVAKKSVPHFSEEEKEPE"
     exon            295..444
                     /gene="Scg5"
                     /gene_synonym="7B2; Sgne1"
                     /inference="alignment:Splign:2.1.0"
     exon            445..557
                     /gene="Scg5"
                     /gene_synonym="7B2; Sgne1"
                     /inference="alignment:Splign:2.1.0"
     exon            558..611
                     /gene="Scg5"
                     /gene_synonym="7B2; Sgne1"
                     /inference="alignment:Splign:2.1.0"
     exon            612..1146
                     /gene="Scg5"
                     /gene_synonym="7B2; Sgne1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagctatcc agcacgtcag ctccctgttt tggcccagat tgctagacgc ccgcccgcgg
       61 ccacacggtt aaaaatgacc tcaaggatgg tcatactatc tggtcttttg ttttggctgc
      121 tgcttgagtg gaatccagca ttcgcttata gtccacggac tcctgaccgg gtctcagaga
      181 cagacatcca gaggctgctg catggagtca tggagcagct gggcattgcc aggccacgtg
      241 tggagtaccc agcccaccag gccatgaatc ttgttgggcc gcagagcatc gaagggggag
      301 ctcacgaggg tcttcagcat ctgggtcctt tcggcaacat ccccaacatc gtggcagagt
      361 tgactggcga caatattcct aaggacttca gtgaggacca aggctaccca gaccctccaa
      421 atccctgtcc tcttgggaaa actgcagatg acggatgtct agaaaacgcc cctgacactg
      481 cagagttcag ccgagaattc cagttagacc agcacctttt tgatccagaa catgactacc
      541 caggtttggg caagtggaac aagaaactcc tttatgagaa gatgaaggga ggacagaggc
      601 ggaagcggag gagtgtcaat ccctatctac aaggaaagag gctggacaat gttgtggcaa
      661 agaaatctgt cccccacttc tcagaagagg agaaggagcc agaataaaga gaagacagta
      721 ggtggaaacc catacaatgc ttatgtatgt gcatgttagc agagcccgtg agtgacagca
      781 tgcattttac atatttatgg atgaaaaaca gctgtccttg tctccatagc aatgcctgag
      841 ctttctgcta aattagaata aaagctcctt tccttttggg gattttttga tgtggatctg
      901 caagaaacat tacaattaaa atgtatatgt caagtataat aaaaacacgg atatgaaata
      961 ctctgatttc ttgccgtttt gggttgtgct gtttgggcca agtctgtaaa aagctagcat
     1021 ttgattttga ttatgtagtg tatctagccc ttgggccttg ttacacacca ataaagaagt
     1081 ttgtactcaa ggggaggggc tgacacatct cactctgctg cttcttaata aatgtatgtg
     1141 caagca
//
