LOCUS       NM_053856               2144 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus secretogranin III (Scg3), mRNA.
ACCESSION   NM_053856
VERSION     NM_053856.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2144)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   2  (bases 1 to 2144)
  AUTHORS   Hotta,K., Kitamoto,T., Kitamoto,A., Mizusawa,S., Matsuo,T.,
            Nakata,Y., Kamohara,S., Miyatake,N., Kotani,K., Komatsu,R.,
            Itoh,N., Mineo,I., Wada,J., Yoneda,M., Nakajima,A., Funahashi,T.,
            Miyazaki,S., Tokunaga,K., Masuzaki,H., Ueno,T., Hamaguchi,K.,
            Tanaka,K., Yamada,K., Hanafusa,T., Oikawa,S., Yoshimatsu,H.,
            Sakata,T., Matsuzawa,Y., Nakao,K. and Sekine,A.
  TITLE     Association of variations in the FTO, SCG3 and MTMR9 genes with
            metabolic syndrome in a Japanese population
  JOURNAL   J Hum Genet 56 (9), 647-651 (2011)
   PUBMED   21796137
REFERENCE   3  (bases 1 to 2144)
  AUTHORS   Prasad,P., Yanagihara,A.A., Small-Howard,A.L., Turner,H. and
            Stokes,A.J.
  TITLE     Secretogranin III directs secretory vesicle biogenesis in mast
            cells in a manner dependent upon interaction with chromogranin A
  JOURNAL   J Immunol 181 (7), 5024-5034 (2008)
   PUBMED   18802106
  REMARK    GeneRIF: In mast cells, a secretogranin III-chromogranin A complex
            may play a key role in secretory granule biogenesis.
REFERENCE   4  (bases 1 to 2144)
  AUTHORS   Han,L., Suda,M., Tsuzuki,K., Wang,R., Ohe,Y., Hirai,H.,
            Watanabe,T., Takeuchi,T. and Hosaka,M.
  TITLE     A large form of secretogranin III functions as a sorting receptor
            for chromogranin A aggregates in PC12 cells
  JOURNAL   Mol Endocrinol 22 (8), 1935-1949 (2008)
   PUBMED   18483175
  REMARK    GeneRIF: A small amount of secretogranin III is able to sort
            chromogranin A aggregates together with adrenomedullin to secretory
            granules.
REFERENCE   5  (bases 1 to 2144)
  AUTHORS   Hosaka,M., Watanabe,T., Sakai,Y., Kato,T. and Takeuchi,T.
  TITLE     Interaction between secretogranin III and carboxypeptidase E
            facilitates prohormone sorting within secretory granules
  JOURNAL   J Cell Sci 118 (Pt 20), 4785-4795 (2005)
   PUBMED   16219686
  REMARK    GeneRIF: SgIII and CPE form the separate functional sorting complex
            by anchoring to cholesterol-rich SG membranes, and POMC-derived
            peptides are transferred from CPE to SgIII, and subsequently to
            CgA.
REFERENCE   6  (bases 1 to 2144)
  AUTHORS   Sakai,Y., Hosaka,M., Yoshinaga,A., Hira,Y., Harumi,T. and
            Watanabe,T.
  TITLE     Immunocytochemical localization of secretogranin III in the
            endocrine pancreas of male rats
  JOURNAL   Arch Histol Cytol 67 (1), 57-64 (2004)
   PUBMED   15125023
  REMARK    GeneRIF: SgIII is closely associated with the secretory granule
            membrane, serving to anchor the aggregates of other soluble
            constituents to the membrane.
REFERENCE   7  (bases 1 to 2144)
  AUTHORS   Hosaka,M., Suda,M., Sakai,Y., Izumi,T., Watanabe,T. and Takeuchi,T.
  TITLE     Secretogranin III binds to cholesterol in the secretory granule
            membrane as an adapter for chromogranin A
  JOURNAL   J Biol Chem 279 (5), 3627-3634 (2004)
   PUBMED   14597614
  REMARK    GeneRIF: SgIII directly binds to cholesterol components of the
            secretory granule membrane and targets chromogranin A to secretory
            granules in pituitary and pancreatic endocrine cells
REFERENCE   8  (bases 1 to 2144)
  AUTHORS   Hosaka,M., Watanabe,T., Sakai,Y., Uchiyama,Y. and Takeuchi,T.
  TITLE     Identification of a chromogranin A domain that mediates binding to
            secretogranin III and targeting to secretory granules in pituitary
            cells and pancreatic beta-cells
  JOURNAL   Mol Biol Cell 13 (10), 3388-3399 (2002)
   PUBMED   12388744
REFERENCE   9  (bases 1 to 2144)
  AUTHORS   Dopazo,A., Lovenberg,T.W., Danielson,P.E., Ottiger,H.P. and
            Sutcliffe,J.G.
  TITLE     Primary structure of mouse secretogranin III and its absence from
            deficient mice
  JOURNAL   J Mol Neurosci 4 (4), 225-233 (1993)
   PUBMED   7917832
REFERENCE   10 (bases 1 to 2144)
  AUTHORS   Ottiger,H.P., Battenberg,E.F., Tsou,A.P., Bloom,F.E. and
            Sutcliffe,J.G.
  TITLE     1B1075: a brain- and pituitary-specific mRNA that encodes a novel
            chromogranin/secretogranin-like component of intracellular vesicles
  JOURNAL   J Neurosci 10 (9), 3135-3147 (1990)
   PUBMED   2204688
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U02983.1.
            
            [WARNING] On Oct 8, 2024 this sequence was replaced by NM_053856.3.
            
            On Aug 30, 2012 this sequence version replaced NM_053856.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U02983.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760396, SAMN12840111
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2144              U02983.1           3-2146
FEATURES             Location/Qualifiers
     source          1..2144
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..2144
                     /gene="Scg3"
                     /gene_synonym="SgIII"
                     /note="secretogranin III"
                     /db_xref="GeneID:116635"
                     /db_xref="RGD:621209"
     exon            1..384
                     /gene="Scg3"
                     /gene_synonym="SgIII"
                     /inference="alignment:Splign:2.1.0"
     CDS             294..1709
                     /gene="Scg3"
                     /gene_synonym="SgIII"
                     /note="secretogranin-3; 1B1075"
                     /codon_start=1
                     /product="secretogranin-3 precursor"
                     /protein_id="NP_446308.1"
                     /db_xref="GeneID:116635"
                     /db_xref="RGD:621209"
                     /translation="MGFLWTGSWILVLVLNSGPIQAFPKPEGSQDKSLHNRELSAERP
                     LNEQIAEAEADKIKKTYPSESKPSESNFSSVDNLNLLKAITEKETVEKAKQSIRSSPF
                     DNRLNVDDADSTKNRKLTDEYDSTKSGLDRKVQDDPDGLHQLDGTPLTAEDIVHKIAT
                     RIYEENDRGVFDKIVSKLLNLGLITESQAHTLEDEVAEALQKLISKEANNYEEAPEKP
                     TSRTENQDGKIPEKVTPVAATQDGFTNRENDDTVSNTLTLSNGLERRTNPHRDDDFEE
                     LQYFPNFYALLTSIDSEKEAKEKETLITIMKTLIDFVKMMVKYGTISPEEGVSYLENL
                     DETIALQTKNKLEKNTTDSKSKLFPAPPEKSHEETDSTKEEAAKMEKEYGSLKDSTKD
                     DNSNLGGKTDEAKGKTEAYLEAIRKNIEWLKKHNKKGNKEDYDLSKMRDFINQQADAY
                     VEKGILDKEEANAIKRIYSSL"
     exon            385..437
                     /gene="Scg3"
                     /gene_synonym="SgIII"
                     /inference="alignment:Splign:2.1.0"
     exon            438..483
                     /gene="Scg3"
                     /gene_synonym="SgIII"
                     /inference="alignment:Splign:2.1.0"
     exon            484..699
                     /gene="Scg3"
                     /gene_synonym="SgIII"
                     /inference="alignment:Splign:2.1.0"
     exon            700..842
                     /gene="Scg3"
                     /gene_synonym="SgIII"
                     /inference="alignment:Splign:2.1.0"
     exon            843..992
                     /gene="Scg3"
                     /gene_synonym="SgIII"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1170
                     /gene="Scg3"
                     /gene_synonym="SgIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1287
                     /gene="Scg3"
                     /gene_synonym="SgIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1371
                     /gene="Scg3"
                     /gene_synonym="SgIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1509
                     /gene="Scg3"
                     /gene_synonym="SgIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1590
                     /gene="Scg3"
                     /gene_synonym="SgIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..2144
                     /gene="Scg3"
                     /gene_synonym="SgIII"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtagagtaaa gctacgccca ggcccgcgtc cgcaggcgac gcaggaactt cagcacccgc
       61 ggggcggaca gcgcccgccg cacctgctca cctgctccgg gcgccggaag agcccacatc
      121 ctcctgccag ccccgtgaga ctgccaccgg gggccgccca gatcctctcc cttcctgcac
      181 ccaggctcct gtcccttcca gcttcttact ccccttctca ttcataacaa aagctacagc
      241 tcaggggccc agcgccaagc tctttccagc agagcgcaga ggagcaagaa agaatggggt
      301 tcctttggac aggctcttgg atactggtgt tggtgctcaa cagcggccca attcaagctt
      361 tccccaaacc cgaaggcagc caagacaaat ccctgcataa tagagaattg agtgcagaga
      421 gacccttgaa tgagcagatc gctgaggcag aggcagacaa gattaaaaag acatacccct
      481 cagaaagcaa gccaagtgaa agcaattttt cttcggtcga taacttgaat ctgctaaagg
      541 cgataacgga aaaggaaaca gttgagaaag ccaagcaatc cataagaagc tccccgtttg
      601 ataacagact gaatgtggac gatgccgatt caactaaaaa tcggaagctg accgacgagt
      661 acgactccac taagagtgga ctggaccgca aggttcaaga tgacccagat ggcctccatc
      721 aactggatgg aactccttta actgctgaag acattgtcca taaaattgcc accaggattt
      781 atgaggagaa cgacagagga gtgtttgaca agattgtctc taaactgctg aatctcggcc
      841 taatcactga aagccaggca catactctag aagatgaagt agcagaggct ttacaaaaat
      901 tgatttcaaa agaggccaac aattatgagg aggccccgga aaaacccaca agcaggaccg
      961 agaatcagga tgggaaaata ccggagaaag tgactccagt ggcagcaacc caagatggct
     1021 ttactaaccg tgaaaatgat gacacagtat cgaacacctt gaccttgtcc aacggcttgg
     1081 aaaggagaac gaacccccac agggacgatg actttgagga gctccagtat ttccccaact
     1141 tctatgcact actgacaagc atcgactcag aaaaagaagc aaaagagaaa gaaaccctga
     1201 tcaccatcat gaagacgttg attgactttg tgaaaatgat ggtgaaatac ggtacaatat
     1261 ctccagagga aggcgtttct taccttgaaa acttggatga aaccattgct ctgcagacca
     1321 agaacaagct agaaaaaaat accactgaca gcaaaagcaa gcttttccca gctccgccag
     1381 agaagagtca cgaagaaaca gacagtacca aggaggaagc cgccaagatg gagaaggaat
     1441 acggaagcct caaagactcc acaaaagacg ataactccaa cctcggagga aagacagatg
     1501 aagccaaagg gaaaacagaa gcctacttgg aagccattag aaaaaacatc gagtggctga
     1561 agaagcacaa caagaagggc aacaaagaag attacgacct ttcaaagatg agggacttca
     1621 tcaaccaaca ggctgatgct tatgtggaga aaggcatcct ggataaggaa gaagccaacg
     1681 ccatcaaacg catctacagc agcctgtgaa aacggcaggc aacctgagcc ttccaactgt
     1741 tccagcaaaa acaatatagc ttaaaatcta attcggcggt taaagattta tcagcccagg
     1801 agtcttagga tgtgctgact ttatagtagt taatccctta gaaatgagta aaatagagct
     1861 ctcttgccat aaacacctta tgaaaggtaa agttgtaaag agcctcggtt tttctatgta
     1921 gaatccttaa tccttatttc ctcttggatt tacattttat aatcagagat atgctgttct
     1981 ggaagagact ctgatgggtt gaacatacat ctgaacctac ttcccactgt cgtcagccct
     2041 gtttcggcat gctagacacc tgagcacatc gttggatgtt tgttatttga tgctgtttcc
     2101 agtagttctc tgttgggcac ggaaataaac ccacgtctct tcat
//
