LOCUS       NM_022669               2291 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus secretogranin II (Scg2), mRNA.
ACCESSION   NM_022669
VERSION     NM_022669.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2291)
  AUTHORS   Trebak,F., Dubuc,I., Picot,M., Alaoui,A., Leprince,J., Prevost,G.,
            Anouar,Y., Magoul,R. and Chartrel,N.
  TITLE     Effect of food deprivation on the hypothalamic gene expression of
            the secretogranin II-derived peptide EM66 in rat
  JOURNAL   Neuroreport 28 (16), 1049-1053 (2017)
   PUBMED   28902709
  REMARK    GeneRIF: EM66 (peptide derived from SCG2) gene expression is
            modulated by a negative energy status and suggest interactions
            between EM66 and NPY to regulate food intake through the POMC
            system.
REFERENCE   2  (bases 1 to 2291)
  AUTHORS   Ida-Eto,M., Nomura,M., Ohkawara,T., Narita,N. and Narita,M.
  TITLE     Localization of manserin, a secretogranin II-derived neuropeptide,
            in the oviduct of female rats
  JOURNAL   Acta Histochem 116 (3), 522-526 (2014)
   PUBMED   24360019
  REMARK    GeneRIF: Manserin localizes to secretory cells in the oviduct and
            may be involved in stress-induced gynecological disorders.
REFERENCE   3  (bases 1 to 2291)
  AUTHORS   Ohkawara,T., Oyabu,A., Ida-Eto,M., Tashiro,Y., Narita,N. and
            Narita,M.
  TITLE     Subtype-specific parafollicular localization of the neuropeptide
            manserin in the rat thyroid gland
  JOURNAL   Acta Histochem 115 (2), 190-194 (2013)
   PUBMED   22682498
  REMARK    GeneRIF: Manserin localizes to rat thyroid follicular epithelial
            cells and also to some parafollicular cells
REFERENCE   4  (bases 1 to 2291)
  AUTHORS   Rosjo,H., Stridsberg,M., Florholmen,G., Stenslokken,K.O.,
            Ottesen,A.H., Sjaastad,I., Husberg,C., Dahl,M.B., Oie,E.,
            Louch,W.E., Omland,T. and Christensen,G.
  TITLE     Secretogranin II; a protein increased in the myocardium and
            circulation in heart failure with cardioprotective properties
  JOURNAL   PLoS One 7 (5), e37401 (2012)
   PUBMED   22655045
  REMARK    GeneRIF: The secretogranin II fragment secretoneurin reduces
            ischemia/reperfusion injury in the isolated perfused rat heart.
REFERENCE   5  (bases 1 to 2291)
  AUTHORS   Blanco,E.H., Zuniga,J.P., Andres,M.E., Alvarez,A.R. and Gysling,K.
  TITLE     Corticotropin-releasing factor binding protein enters the regulated
            secretory pathway in neuroendocrine cells and cortical neurons
  JOURNAL   Neuropeptides 45 (4), 273-279 (2011)
   PUBMED   21624661
REFERENCE   6  (bases 1 to 2291)
  AUTHORS   Leitner,B., Schneitler,C., Klocker,H., Volknandt,W., Zimmermann,H.,
            Winkler,H. and Fischer-Colbrie,R.
  TITLE     Formation and sequence analysis of secretoneurin, a neuropeptide
            derived from secretogranin II, in mammalian, bird, reptile,
            amphibian and fish brains
  JOURNAL   Neurosci Lett 248 (2), 105-108 (1998)
   PUBMED   9654353
REFERENCE   7  (bases 1 to 2291)
  AUTHORS   Dunzendorfer,S., Schratzberger,P., Reinisch,N., Kahler,C.M. and
            Wiedermann,C.J.
  TITLE     Secretoneurin, a novel neuropeptide, is a potent chemoattractant
            for human eosinophils
  JOURNAL   Blood 91 (5), 1527-1532 (1998)
   PUBMED   9473216
REFERENCE   8  (bases 1 to 2291)
  AUTHORS   Kakar,S.S., Wei,N., Mulchahey,J.J., LeBoeuf,R.D. and Neill,J.D.
  TITLE     Regulation of expression of secretogranin II mRNA in female rat
            pituitary and hypothalamus
  JOURNAL   Neuroendocrinology 57 (3), 422-431 (1993)
   PUBMED   8321414
REFERENCE   9  (bases 1 to 2291)
  AUTHORS   Kagotani,Y., Picart,R., Barret,A., Wiedenmann,B., Huttner,W.B. and
            Tixier-Vidal,A.
  TITLE     Subcellular localization of secretogranin II and synaptophysin by
            immunoelectron microscopy in differentiated hypothalamic neurons in
            culture
  JOURNAL   J Histochem Cytochem 39 (11), 1507-1518 (1991)
   PUBMED   1918927
REFERENCE   10 (bases 1 to 2291)
  AUTHORS   Gerdes,H.H., Phillips,E. and Huttner,W.B.
  TITLE     The primary structure of rat secretogranin II deduced from a cDNA
            sequence
  JOURNAL   Nucleic Acids Res 16 (24), 11811 (1988)
   PUBMED   3211750
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Nov 26, 2020 this sequence version replaced NM_022669.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M93669.1, X13618.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840110, SAMN12840113
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                JAXUCZ010000009.1  88256851-88256866   c
            17-2291             JAXUCZ010000009.1  88251557-88253831   c
FEATURES             Location/Qualifiers
     source          1..2291
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q34"
     gene            1..2291
                     /gene="Scg2"
                     /gene_synonym="Chcg"
                     /note="secretogranin II"
                     /db_xref="GeneID:24765"
                     /db_xref="RGD:3626"
     exon            1..16
                     /gene="Scg2"
                     /gene_synonym="Chcg"
                     /inference="alignment:Splign:2.1.0"
     exon            17..2291
                     /gene="Scg2"
                     /gene_synonym="Chcg"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..1890
                     /gene="Scg2"
                     /gene_synonym="Chcg"
                     /note="secretogranin-2; sgII; chromogranin-C; Chromogranin
                     C (Secretogranin II); secretogranin II (chromogranin C)"
                     /codon_start=1
                     /product="secretogranin-2 precursor"
                     /protein_id="NP_073160.2"
                     /db_xref="GeneID:24765"
                     /db_xref="RGD:3626"
                     /translation="MAESKAYRFGAVLLLIHLIFLVPGTEAASFQRNQLLQKEPDLRL
                     ENVQKFPSPEMIRALEYIEKLRQQAHREESSPDYNPYQGISVPLQLKENGEESHLAES
                     SRDVLSEDEWMRIILEALRQAENEPPSALKENKPYALNLEKNFPVDTPDDYETQQWPE
                     RKLKHMRFPLMYEENSRENPFKRTNEIVEEQYTPQSLATLESVFQELGKLTGPSNQKR
                     ERVDEEQKLYTDDEDDVYKTNNIAYEDVVGGEDWSPMEEKIETQTQEEVRDSKENTEK
                     NEQINEEMKRSGHLGLPDEGNRKESKDQLSEDASKVITYLRRLVNAVGSGRSQSGQNG
                     DRAARLLERPLDSQSIYQLIEISRNLQIPPEDLIEMLKAGEKPNGLVEPEQDLELAVD
                     LDDIPEADIDRPDMFQSKTLSKGGYPKAPGRGMMEALPDGLSVEDILNVLGMENVANQ
                     KSPYFPNQYSRDKALLRLPYGPGKSRANQIPKVAWIPDVESRQAPYDNLNDKDQELGE
                     YLARMLVKYPELMNTNQLKRVPSPGSSEDDLQEEEQLEQAIKEHLGQGSSQEMEKLAK
                     VSKRIPAGSLKNEDTPNRQYLDEDMLLKVLEYLNQEQAEQGREHLAKRAMENM"
ORIGIN      
        1 acaatataag acagaggaaa attttaagac atggctgaat cgaaggctta ccgatttgga
       61 gcagttctgc ttcttatcca cttaattttc cttgtccctg gaaccgaagc agcttccttc
      121 cagcgaaacc agctgcttca gaaagaacca gacctcagat tggagaatgt ccagaagttt
      181 cctagtccag aaatgatcag ggctttggag tacatagaaa agctcaggca gcaggcccac
      241 agagaagaaa gcagcccaga ctacaatccc taccaaggca tctctgttcc ccttcaactc
      301 aaagaaaacg gagaagaaag tcacttggca gagagctcaa gggatgtctt gagtgaagac
      361 gagtggatgc ggataatact tgaggctttg aggcaggctg aaaatgagcc gccatctgcc
      421 ctcaaggaga acaagcccta tgccttgaat ctggagaaga acttccctgt ggacacgcct
      481 gatgactatg agactcaaca atggcctgag aggaaactca agcacatgcg gttccctctc
      541 atgtatgaag agaattccag ggaaaacccc ttcaaacgca caaacgaaat agtagaagaa
      601 cagtacacac cccaaagtct tgctaccctg gagtctgtgt tccaagagct tgggaaactg
      661 acagggccaa gcaaccagaa gcgtgagagg gttgacgagg aacagaagct ctacacggac
      721 gatgaagatg acgtgtacaa gaccaacaac attgcctatg aagatgtggt cgggggagaa
      781 gactggagtc ctatggagga gaaaatagag actcaaaccc aggaagaggt gagagacagc
      841 aaagagaaca cagaaaaaaa cgaacaaatc aatgaagaga tgaaacggtc agggcacttg
      901 gggctcccag atgaaggtaa ccggaaagag agcaaagacc agctctcaga ggacgcctcc
      961 aaggtcatca cctacttgag aaggttagtg aatgctgtgg gcagtgggag gtcccagagt
     1021 gggcaaaacg gggacagggc agccaggctt cttgagaggc cccttgattc tcagtctatt
     1081 tatcagctga ttgaaatctc caggaatttg cagatacccc ctgaagactt aattgagatg
     1141 ctcaaagctg gggagaaacc aaatgggttg gtggagcccg agcaggatct ggagcttgct
     1201 gttgacctag atgacatccc ggaagctgac atagaccgcc cagacatgtt tcaaagtaag
     1261 acgctctcca agggtgggta tcccaaggca cctggtcgag gtatgatgga ggccttgcca
     1321 gatggcctca gtgttgaaga cattttaaat gttttaggga tggagaatgt agcaaatcag
     1381 aagtccccat atttccccaa ccaatacagc cgagacaagg ctctgctgag gcttccttat
     1441 ggtcctggga aatctagagc caaccagatt cccaaagtag cctggatccc agacgttgaa
     1501 agcagacaag ccccctatga caatctgaat gataaggacc aagaattggg agagtactta
     1561 gccaggatgc tagttaagta ccctgagctc atgaatacca accagctgaa gagagtgccc
     1621 agcccaggct cctcagaaga tgacctccaa gaagaagagc agctcgagca ggccatcaag
     1681 gagcatctgg gtcaaggaag ctcccaggaa atggagaaac tggccaaggt gagcaaaagg
     1741 atccctgcag gatccctgaa gaatgaggat accccaaata gacagtacct ggatgaagat
     1801 atgctcctga aagtgctaga gtatctcaat caagaacagg cagagcaggg aagggaacat
     1861 cttgccaaac gggccatgga aaacatgtaa acagctttaa tgcccaattt cccttctttt
     1921 ccccaagtga atcccctccc tttctcttaa gtgtgttaat ctctatcctg ttaacactgt
     1981 aatatcttta agtgatgtac aagcagatga ctccagatag ttttggggat ctgctttact
     2041 tattctgagc tgttatgttg tgtatggatg tgtataaatg ttatgactct cagatttaaa
     2101 aaatatgtcc tttattcaag aaagatatct atgatagtgt tgactaatgt atccaatggt
     2161 catggtattg acaatgctca catatgatga agagtatcct ataattatct tggaagtttt
     2221 taacatttat tgaattattt tgttactgtc tgtagtgttt tgtggagttc tggagcaaaa
     2281 tcaataaagc a
//
