LOCUS       NM_031841               5046 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus stearoyl-Coenzyme A desaturase 2 (Scd2), mRNA.
ACCESSION   NM_031841
VERSION     NM_031841.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5046)
  AUTHORS   Wang,W., Zhang,Z.Z., Wu,Y., Wang,R.Q., Chen,J.W., Chen,J.,
            Zhang,Y., Chen,Y.J., Geng,M., Xu,Z.D., Dai,M., Li,J.H. and Pan,L.L.
  TITLE     (-)-Epigallocatechin-3-Gallate Ameliorates Atherosclerosis and
            Modulates Hepatic Lipid Metabolic Gene Expression in Apolipoprotein
            E Knockout Mice: Involvement of TTC39B
  JOURNAL   Front Pharmacol 9, 195 (2018)
   PUBMED   29593532
  REMARK    Erratum:[Front Pharmacol. 2018 May 01;9:459. doi:
            10.3389/fphar.2018.00459.. PMID: 29745376]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5046)
  AUTHORS   Green,C.D. and Olson,L.K.
  TITLE     Modulation of palmitate-induced endoplasmic reticulum stress and
            apoptosis in pancreatic beta-cells by stearoyl-CoA desaturase and
            Elovl6
  JOURNAL   Am J Physiol Endocrinol Metab 300 (4), E640-E649 (2011)
   PUBMED   21266672
  REMARK    GeneRIF: Overt type 2 diabetes is associated with diminished islet
            expression of SCD and Elovl6, and this can disrupt desaturation of
            saturated FAs to MUFAs, rendering beta-cells more susceptible to
            saturated FA-induced ER stress and apoptosis.
REFERENCE   3  (bases 1 to 5046)
  AUTHORS   Miyazaki,M., Bruggink,S.M. and Ntambi,J.M.
  TITLE     Identification of mouse palmitoyl-coenzyme A Delta9-desaturase
  JOURNAL   J Lipid Res 47 (4), 700-704 (2006)
   PUBMED   16443825
REFERENCE   4  (bases 1 to 5046)
  AUTHORS   Moreau,C., Froment,P., Tosca,L., Moreau,V. and Dupont,J.
  TITLE     Expression and regulation of the SCD2 desaturase in the rat ovary
  JOURNAL   Biol Reprod 74 (1), 75-87 (2006)
   PUBMED   16207839
REFERENCE   5  (bases 1 to 5046)
  AUTHORS   Saether,T., Tran,T.N., Rootwelt,H., Christophersen,B.O. and
            Haugen,T.B.
  TITLE     Expression and regulation of delta5-desaturase, delta6-desaturase,
            stearoyl-coenzyme A (CoA) desaturase 1, and stearoyl-CoA desaturase
            2 in rat testis
  JOURNAL   Biol Reprod 69 (1), 117-124 (2003)
   PUBMED   12606372
  REMARK    GeneRIF: testicular distribution of Delta5- and Delta6-desaturase
            and stearoyl-CoA desaturase 1 and 2 shows that all four desaturases
            seem to be localized in the Sertoli cells, with far lower
            expression in germ cells
REFERENCE   6  (bases 1 to 5046)
  AUTHORS   Misawa,K., Nosaka,T., Morita,S., Kaneko,A., Nakahata,T., Asano,S.
            and Kitamura,T.
  TITLE     A method to identify cDNAs based on localization of green
            fluorescent protein fusion products
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3062-3066 (2000)
   PUBMED   10716735
REFERENCE   7  (bases 1 to 5046)
  AUTHORS   Garbay,B., Boiron-Sargueil,F., Shy,M., Chbihi,T., Jiang,H.,
            Kamholz,J. and Cassagne,C.
  TITLE     Regulation of oleoyl-CoA synthesis in the peripheral nervous
            system: demonstration of a link with myelin synthesis
  JOURNAL   J Neurochem 71 (4), 1719-1726 (1998)
   PUBMED   9751207
REFERENCE   8  (bases 1 to 5046)
  AUTHORS   Baba,H., Fuss,B., Watson,J.B., Zane,L.T. and Macklin,W.B.
  TITLE     Identification of novel mRNAs expressed in oligodendrocytes
  JOURNAL   Neurochem Res 19 (8), 1091-1099 (1994)
   PUBMED   7800118
REFERENCE   9  (bases 1 to 5046)
  AUTHORS   Mihara,K.
  TITLE     Structure and regulation of rat liver microsomal stearoyl-CoA
            desaturase gene
  JOURNAL   J Biochem 108 (6), 1022-1029 (1990)
   PUBMED   1982442
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031841.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB032243.1, BC061737.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-368               JAXUCZ010000001.1  253118377-253118744
            369-651             JAXUCZ010000001.1  253119241-253119523
            652-782             JAXUCZ010000001.1  253122311-253122441
            783-988             JAXUCZ010000001.1  253124124-253124329
            989-1221            JAXUCZ010000001.1  253125760-253125992
            1222-5046           JAXUCZ010000001.1  253127612-253131436
FEATURES             Location/Qualifiers
     source          1..5046
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..5046
                     /gene="Scd2"
                     /gene_synonym="Scd"
                     /note="stearoyl-Coenzyme A desaturase 2"
                     /db_xref="GeneID:83792"
                     /db_xref="RGD:621177"
     exon            1..368
                     /gene="Scd2"
                     /gene_synonym="Scd"
                     /inference="alignment:Splign:2.1.0"
     CDS             345..1421
                     /gene="Scd2"
                     /gene_synonym="Scd"
                     /EC_number="1.14.19.1"
                     /note="acyl-CoA desaturase 2; delta(9)-desaturase 2; fatty
                     acid desaturase 2; stearoyl-CoA desaturase
                     (delta-9-desaturase)"
                     /codon_start=1
                     /product="stearoyl-CoA desaturase 2"
                     /protein_id="NP_114029.1"
                     /db_xref="GeneID:83792"
                     /db_xref="RGD:621177"
                     /translation="MPAHILQEISGSYSATTTITAPPSGGQQNGGEKFEKNPHHWGAD
                     VRPEIKDDLYDPSYQDEEGPPPKLEYVWRNIILMALLHIGALYGITLVPSCKVYTCLF
                     AYLYYVISALGITAGAHRLWSHRTYKARLPLRLFLIIANTMAFQNDVYEWARDHRAHH
                     KFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYK
                     PGLLLMCFILPTLVPWYCWGETFVNSLCVSTFLRYAVVLNATWLVNSAAHLYGYRPYD
                     KNISSRENILVSMGAVGEGFHNYHHAFPYDYSASEYRWHINFTTFFIDCMALLGLAYD
                     RKRVSKAAVLARIKRTGEESCKSG"
     exon            369..651
                     /gene="Scd2"
                     /gene_synonym="Scd"
                     /inference="alignment:Splign:2.1.0"
     exon            652..782
                     /gene="Scd2"
                     /gene_synonym="Scd"
                     /inference="alignment:Splign:2.1.0"
     exon            783..988
                     /gene="Scd2"
                     /gene_synonym="Scd"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1221
                     /gene="Scd2"
                     /gene_synonym="Scd"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..5046
                     /gene="Scd2"
                     /gene_synonym="Scd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctagggat gggacaatgc ggtgttggtg tctgcagtat tctgactcct ggacaccggt
       61 ggctgcaagc tgcgcttttg gcgtcctctc atttttctat ccttatctcc gtccgcggct
      121 gccttggcca gccagttttt gattttttat ctgttccttg atcgatacaa cgaacctaag
      181 gacatacagg acattaatac ccaactgcca gctctggccc agggcttgta ctgtgcagcg
      241 ggctggctgc agaaacttaa gtcataacac tctttgtcgc tgaggtctga agctctctgc
      301 acgttctcat ccctgggaac gtgaccccag catccgacgc caagatgccg gctcacatac
      361 tgcaagagat ctctggctct tactcggcca ccaccacaat cacagcgcca ccttctgggg
      421 gacagcagaa tggaggagag aagtttgaaa agaatcctca ccactgggga gcagatgttc
      481 gccctgaaat taaagatgac ctatacgacc ccagctacca ggatgaggag gggcccccgc
      541 ccaagctgga gtacgtctgg aggaacatca tcctcatggc cctgctgcac attggagccc
      601 tgtacgggat cacactggtc ccctcctgca aggtctacac ctgcctcttt gcatatttgt
      661 actacgtaat cagcgccctg ggcatcacag ccggggctca tcgcctgtgg agccacagga
      721 cttacaaggc tcggctgccc ctgaggctct ttctcatcat cgccaacacc atggcattcc
      781 agaacgatgt gtacgaatgg gcccgggatc accgcgccca ccacaagttc tcagagacac
      841 acgccgaccc tcacaactcc cgccgtggct ttttcttctc tcacgtgggt tggctgcttg
      901 tgcgcaaaca cccggctgtc aaagagaagg gcggaaagct ggacatgtct gacctgaaag
      961 ctgagaagct ggtgatgttc cagaggaggt attacaagcc cggcctcctg ctcatgtgct
     1021 tcatcctgcc cacgctggtg ccctggtact gctggggtga gacgtttgta aacagcctgt
     1081 gcgtcagcac cttcttacgg tacgctgtgg tgctcaacgc cacctggctg gtgaacagcg
     1141 ccgcccacct ctatggatat cgcccctacg acaagaacat cagctctcgg gagaacatcc
     1201 tggtgtcgat gggagctgtg ggcgagggct tccacaacta ccatcacgcc ttcccctatg
     1261 actactctgc cagtgagtac cgctggcaca tcaacttcac cacgttcttc atcgactgca
     1321 tggccctcct gggcctggct tatgaccgga agagggtgtc caaggccgct gtcttagcca
     1381 ggattaagag aactggggag gagagctgca agagtggctg agttcggggt cttccagttc
     1441 ctgttccaag agccggcttg gcagaggctt actgttctgt taattaacta ctgagtattg
     1501 ctacccagat gctaaaatga tgaagttaac ccattctggt acagtattgt aaaacggaca
     1561 aatatcggaa gtcaacagct ctaccttttg atgctaagct gttctcccct tctatcttct
     1621 tttcccgttg tctttttctt cgctttgtcc ccaatgacct cacccctcat cgcctcccct
     1681 aagccagcag ccactccgct gtagttcaga gttcaccttc cagagcgtac cagcttttca
     1741 agggtctaca gtaaaggttc acgccccagc cccaacttaa cgttgctcca agttacagat
     1801 agaagaaaaa tcttgagaaa tttctcctgt tattttagtc cagactttgc cagatggaat
     1861 gggagaaaaa atagttttat ttggcagaga gcttgcgaag tgggtaaatc ttaaggggcc
     1921 aaattcaaca ctcgggctgt gattcatcaa aattgtggga gagggggatc tcctgtgatc
     1981 aggctccgct ccgtctggcc gaggtgctgg cgtctcttga cacagcgtgc ctcctctcct
     2041 aattctgatt gggtgacagc cgtggaactt tgtgacacta aaatatggca acacatcggt
     2101 atctcagtgt actttaggct aaagatttaa aaaaatagag aagtgaaaaa caatttgtag
     2161 gaaaagtggt ctttcctaaa ataagatttt cttttccttt cataacaagg acctggggcc
     2221 aggcgtcgtg gcacgcgcct caaaacagtt gagaggagag gggcaggtgg gtctctgagt
     2281 ttgaagccag ccagggctag atagtgaggc cttgtctcaa atagaaaagc caacaattag
     2341 caggacacac ggagccgggg gtcctcttgc gaggcgtgtc tggaatccat gagggcggtc
     2401 gctcgtggtt tttgagcttc ctgtgagctg cacccccaga cacttgtaat tcctgttctt
     2461 ccgtctttcg gatgcaggtt gctcccacaa attcaggata gctgtggcgt ttccatgcat
     2521 cccacaatgg aaggagtgta agacttgagc ttgagtcaca gctaaaaccc agaagacaca
     2581 aagtcagtct gtcctggatc ctacaaacac tcaacgagtg cctccctctg gaaaagatgg
     2641 tgaacacctt ccttccactg ttgggcagtg gacagggaag ttggaggtcg ctgtaggcag
     2701 ctccaaggtt tctaggggca ccttgccagg ggacctcaca actttggcgg tctctagtgg
     2761 agcaggttag gttttagctc cctttggtcc cgctgtgctt tgtggtaagg cttttccctg
     2821 ggctgttgcc tcattcctca ctagctctgt gaccaggtag gactctggga tacatggctg
     2881 aaagctcttt gctctaccac atctgcctct ctttccctac ccattttttt gtgtttcggg
     2941 gtggtatttt tgtggtggtt gttttgtttt atttcttctt tcctctttga cgtttagtct
     3001 tgctctaggc agaaacgtcc tggatattta cggtcagtaa agatgtccgg tcccagcaga
     3061 gatacaacct ctatctgcag taggtagaga aggctgtccc tttccggtgg ctttcagatt
     3121 ctccacctct atccctccca ggcctctgat attctttaaa ctttaaagga aaagtttggc
     3181 cgactttcta gaaacatccc tggctcagag aggctctctg tctcctcggt tgttctaaaa
     3241 caaatggtcc gggtggtgtg ggtgctggcc caagactcga ttcctctgag ttagggcaga
     3301 gcatgctccc tgcactcagc aaagcctctc gggctgatca gtgctcctgg gtgatgctgt
     3361 ggtgctttta ggaggaagac agtgttggct ggctggaaag cacgacagtt aaggttgtgt
     3421 tcttaagtgc ctcagtttga aagctttggc tagggtagga gatctgagat gccgtggact
     3481 ttgcagaaga gattttgtgc agcaacgcag aagcctggct gtgttaagat tggctgtaca
     3541 ggatagcgaa tgctgtggtt ggagggcaca gtcttcccgt gttagttaaa tagagaggct
     3601 ttaggacgtc tctgcgccca cttgaaggta gccttatcct ttagctgttc gctaaaatag
     3661 aatccttgag agatgacaat atatttgctg gcctgtcgcc ctattccttg gagaggcctt
     3721 ttgaatggtt ttaattccac tggttatccg gtgcccactt aatcaaatgt gaaaaataaa
     3781 agcagctctc ttcttagcct gccccgtgga tctgaggacc ccgttagata cagctgtcgg
     3841 taagggtgta ccagctcact aagaaacact actgtcaaga ttttaaagct cagaccaagt
     3901 gacacgttaa taagaaacta agatctgatt gaattttcta acagtccttg cctcgtggac
     3961 acgctaaaat tcgacttggg tgccttacct cttttctagc tagtgttact catgggcctg
     4021 cgctcccttc ctctgcggat tccttagaac cggagagcct gtaagtgtga caggctcaaa
     4081 actggcctgg ctggagggtt aggtggactt tgatctgcag tgttccctct ggggtcttcg
     4141 tttggggaat atttcttggg gctgttttgc tgaagtgccc gtagctgatg gatggtggaa
     4201 gtaatttgaa cgtacgcgat ttgtaggttt tgttatttgt tttaagattt aaaggctggt
     4261 tgtagcattt aaagtgaaag ctttttcttc ctggtttgct agtgttctgc gtgtcttctt
     4321 tagttgaaat aggttagtgg agaagttaag aaagcggtgg ccgtgttacg ctggtggtga
     4381 aggccagggc cgcctacaaa ctctcagttt tgttttgttt tgtttttttt ataacagtcc
     4441 cactctgaca ataatgagtt cactccttgg ataaggttgt taatgaggga agagcccttc
     4501 agacctaatc agctcttact ggacccagct gtcaacactg ttgcattggg gattaagttt
     4561 ccaacccgtg aatcatggga cagactcaaa ccgtagcact gggcatgtcg cctaacaata
     4621 taatgtgact cagtattctg tgagacatgg gataatattc ctgacctacc tccacgggta
     4681 ggtgcgagca tgagcaaatg ctctttataa aacatttggg gatcctcagc agaggagtat
     4741 ttaagtcctg cacattttta tagtaaccgt ccaccatgga cttgacacgt gcctatgtcc
     4801 cagacgacat tgttaatcta catcattctt ctcagaggtt gaatggatgc attagataat
     4861 gtatactcat tgctatggaa acctgcagga ctccttttcc ttccttgggt gggatttttt
     4921 tttcctttat tatgtgcaac agtagctatt tgtaatctaa taattttcat taataccaac
     4981 tctgaaagta tttctactca tctgaggttg tgtttgttca taataaaatg aaatggatct
     5041 gactgc
//
