LOCUS       NM_139192               4475 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus stearoyl-CoA desaturase (Scd), mRNA.
ACCESSION   NM_139192
VERSION     NM_139192.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4475)
  AUTHORS   Zhu,Y.L., Meng,L.L., Ma,J.H., Yuan,X., Chen,S.W., Yi,X.R., Li,X.Y.,
            Wang,Y., Tang,Y.S., Xue,M., Zhu,M.Z., Peng,J., Lu,X.J., Huang,J.Z.,
            Song,Z.C., Wu,C., Zheng,K.Z., Dai,Q.Q., Huang,F. and Fang,H.S.
  TITLE     Loss of LBP triggers lipid metabolic disorder through H3K27
            acetylation-mediated C/EBPbeta- SCD activation in non-alcoholic
            fatty liver disease
  JOURNAL   Zool Res 45 (1), 79-94 (2024)
   PUBMED   38114435
  REMARK    GeneRIF: Loss of LBP triggers lipid metabolic disorder through
            H3K27 acetylation-mediated C/EBPbeta- SCD activation in
            non-alcoholic fatty liver disease.
REFERENCE   2  (bases 1 to 4475)
  AUTHORS   Zhang,Y., Gu,Y., Chen,Y., Huang,Z., Li,M., Jiang,W., Chen,J.,
            Rao,W., Luo,S., Chen,Y., Chen,J., Li,L., Jia,Y., Liu,M. and Zhou,F.
  TITLE     Dingxin Recipe IV attenuates atherosclerosis by regulating lipid
            metabolism through LXR-alpha/SREBP1 pathway and modulating the gut
            microbiota in ApoE-/- mice fed with HFD
  JOURNAL   J Ethnopharmacol 266, 113436 (2021)
   PUBMED   33011372
REFERENCE   3  (bases 1 to 4475)
  AUTHORS   Chen,M., Xu,J., Wang,Y., Wang,Z., Guo,L., Li,X. and Huang,L.
  TITLE     Arctium lappa L. polysaccharide can regulate lipid metabolism in
            type 2 diabetic rats through the SREBP-1/SCD-1 axis
  JOURNAL   Carbohydr Res 494, 108055 (2020)
   PUBMED   32535406
REFERENCE   4  (bases 1 to 4475)
  AUTHORS   Gopal Reddy,M.R., Kumar,M.S., Acharya,V., Venkata,S.M., Putcha,U.K.
            and Jeyakumar,S.M.
  TITLE     Vitamin A deficiency increases the oleic acid (C18:1) levels in the
            kidney of high fructose diet-fed rats
  JOURNAL   Indian J Med Res 150 (6), 620-629 (2019)
   PUBMED   32048626
  REMARK    GeneRIF: Feeding of VAD diet either alone or under HFr condition
            increased the kidney oleic acid (C18:1) levels and thus total MUFA,
            which corroborated with elevated SCD1 activity index, without
            affecting its expression status
REFERENCE   5  (bases 1 to 4475)
  AUTHORS   Hao,C.L., Lin,H.L., Ke,L.Y., Yen,H.W. and Shen,K.P.
  TITLE     Pre-germinated brown rice extract ameliorates high-fat diet-induced
            metabolic syndrome
  JOURNAL   J Food Biochem 43 (3), e12769 (2019)
   PUBMED   31353547
REFERENCE   6  (bases 1 to 4475)
  AUTHORS   Sundberg,J.P., Boggess,D., Sundberg,B.A., Eilertsen,K., Parimoo,S.,
            Filippi,M. and Stenn,K.
  TITLE     Asebia-2J (Scd1(ab2J)): a new allele and a model for scarring
            alopecia
  JOURNAL   Am J Pathol 156 (6), 2067-2075 (2000)
   PUBMED   10854228
REFERENCE   7  (bases 1 to 4475)
  AUTHORS   Shanklin,J., Whittle,E. and Fox,B.G.
  TITLE     Eight histidine residues are catalytically essential in a
            membrane-associated iron enzyme, stearoyl-CoA desaturase, and are
            conserved in alkane hydroxylase and xylene monooxygenase
  JOURNAL   Biochemistry 33 (43), 12787-12794 (1994)
   PUBMED   7947684
REFERENCE   8  (bases 1 to 4475)
  AUTHORS   Mihara,K.
  TITLE     Structure and regulation of rat liver microsomal stearoyl-CoA
            desaturase gene
  JOURNAL   J Biochem 108 (6), 1022-1029 (1990)
   PUBMED   1982442
REFERENCE   9  (bases 1 to 4475)
  AUTHORS   Strittmatter,P., Thiede,M.A., Hackett,C.S. and Ozols,J.
  TITLE     Bacterial synthesis of active rat stearyl-CoA desaturase lacking
            the 26-residue amino-terminal amino acid sequence
  JOURNAL   J Biol Chem 263 (5), 2532-2535 (1988)
   PUBMED   2892838
REFERENCE   10 (bases 1 to 4475)
  AUTHORS   Thiede,M.A., Ozols,J. and Strittmatter,P.
  TITLE     Construction and sequence of cDNA for rat liver stearyl coenzyme A
            desaturase
  JOURNAL   J Biol Chem 261 (28), 13230-13235 (1986)
   PUBMED   2428815
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF509569.1.
            
            On Jun 10, 2007 this sequence version replaced NM_139192.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF509568.1, AF509569.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4475
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="F344"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..4475
                     /gene="Scd"
                     /gene_synonym="Scd1"
                     /note="stearoyl-CoA desaturase"
                     /db_xref="GeneID:246074"
                     /db_xref="RGD:621176"
     exon            1..72
                     /gene="Scd"
                     /gene_synonym="Scd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..1125
                     /gene="Scd"
                     /gene_synonym="Scd1"
                     /EC_number="1.14.19.1"
                     /note="delta(9)-desaturase 1; fatty acid desaturase 1;
                     stearoyl-CoA desaturase 1; stearoyl-Coenzyme A desaturase
                     1"
                     /codon_start=1
                     /product="acyl-CoA desaturase 1"
                     /protein_id="NP_631931.2"
                     /db_xref="GeneID:246074"
                     /db_xref="RGD:621176"
                     /translation="MPAHMLQEISSSYTTTTTITEPPSGNLQNGREKMKKVPLYLEED
                     IRPEMREDIHDPSYQDEEGPPPKLEYVWRNIILMALLHVGALYGITLIPSSKVYTLLW
                     GIFYYLISALGITAGAHRLWSHRTYKARLPLRIFLIIANTMAFQNDVYEWARDHRAHH
                     KFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYK
                     PGLLLMCFILPTLVPWYCWGETFLHSLFVSTFLRYTLVLNATWLVNSAAHLYGYRPYD
                     KNIQSRENILVSLGAVGEGFHNYHHAFPYDYSASEYRWHINFTTFFIDCMAALGLAYD
                     RKKVSKAAVLARIKRTGDGSHKSS"
     exon            73..355
                     /gene="Scd"
                     /gene_synonym="Scd1"
                     /inference="alignment:Splign:2.1.0"
     exon            356..486
                     /gene="Scd"
                     /gene_synonym="Scd1"
                     /inference="alignment:Splign:2.1.0"
     exon            487..692
                     /gene="Scd"
                     /gene_synonym="Scd1"
                     /inference="alignment:Splign:2.1.0"
     exon            693..925
                     /gene="Scd"
                     /gene_synonym="Scd1"
                     /inference="alignment:Splign:2.1.0"
     exon            926..4475
                     /gene="Scd"
                     /gene_synonym="Scd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacttgatct cagcgctggg aaagtgaagc gagcaaccga cagccacgat gccggcccac
       61 atgctccaag agatctccag ttcctacacg accaccacta ccatcacaga gcctccttcc
      121 ggaaacctgc agaatggacg agagaagatg aagaaggtgc ccctctatct ggaagaagac
      181 atccgtcctg aaatgagaga agatatccac gaccccagct accaggatga ggaggggccc
      241 ccgcccaagc tggagtacgt ctggaggaac atcatcctca tggccctgct gcacgtggga
      301 gccctgtacg ggatcacact gatcccctcc tccaaggtct acaccttgct ctgggggata
      361 ttttactacc ttatcagtgc cctgggcatc acagccgggg ctcatcgcct gtggagccac
      421 aggacttaca aggctcggct gcccctgagg atcttcctca tcattgccaa caccatggcg
      481 ttccagaacg atgtgtatga atgggcccgg gatcaccgcg cccaccacaa gttctctgag
      541 acacacgccg accctcacaa ctcccgccgt ggctttttct tctctcacgt gggttggctg
      601 cttgtgcgca aacacccggc tgtcaaagag aagggcggaa agctggacat gtctgacctg
      661 aaagctgaga agctggtgat gttccagagg aggtactaca agcctggcct cctgctcatg
      721 tgcttcatcc tgcccacact ggtgccctgg tactgctggg gcgaaacttt cctgcacagc
      781 ctgttcgtca gcaccttctt gagatacact ctggtgctca acgccacctg gctggtgaac
      841 agcgctgccc acctctatgg gtatcgcccc tacgacaaga acattcaatc tcgggagaac
      901 atcctggttt ccctgggtgc cgtgggcgag ggcttccaca actaccatca cgccttcccc
      961 tacgactact ctgccagtga gtaccgctgg cacatcaact tcaccacgtt cttcatcgac
     1021 tgcatggctg ccctgggcct ggcttacgac cggaaaaaag tttctaaggc cgctgtctta
     1081 gccaggatta agagaactgg agatgggagc cacaagagta gctgagttct gggcttctga
     1141 gttcctgttc caaaagtttt ctgggcagag atttaatatt ctgttgatta actactggat
     1201 aatgctatcg gaatgttaat gatgcattta aactattccg gtacagtatt atgagaaagc
     1261 tttgatcatg ttttgaggta atgcatattt taattagcca ggattaacca tgccacaata
     1321 catatatatt tctaagcata catgataaat gcatatacaa ttgtgcacat cagctttaaa
     1381 taataacgat gaatttgaac attctataca gagagtatta aagccaagga acatgctgtt
     1441 ttgatgctag ggcaagcatg gtgctctttc cctgtttgca ctgcatccag cttcgttcct
     1501 tcctctgtca tcaccatctt caggcaaata gctgaccagc cactggcctg tgtccacctt
     1561 ccaaagccca ggcaaccttt ctgctttctg aaatactgat ccttcctcct ggatatgtct
     1621 ttccttgttc tgaactttga gattgctggc tcagacttaa gatagaacaa aaaccttcct
     1681 ggaagttccc actggtgaac ttcactatag gttttgccag agggaatagg gaaattatct
     1741 tgattgtagc aagtagatca ccttgagaga agaattagca cgcacggtgt ggtttgtaag
     1801 taaggatggg agagagctag gaaaaggtag ccatatctaa tggcctactt accaaagccc
     1861 ccaggcctct ctgcatagca tgactccttc cagtccatat tctgaacaac agaaattagt
     1921 gagatttgaa taattaaatt attttcagag tgaagggaat gggaaatgca tggtctgtgc
     1981 taggggcgga gagtggggaa gggttagctt ttggtaactg aagatttctt catggaaaga
     2041 gtcttaatgt taaatgtgcc tagaactggt aactaaacag ctgacatttg gagggaatgt
     2101 ggtgtaaaac tatgtaaata taagcaaaat ctgcacatga aaatatttca cttagaaaaa
     2161 gtgttgctaa agaaaaaaat tcgaaggaca agaggtgttg cctgggttgc cagtttcttt
     2221 cgtggcaggg caggaaatag tgaggttgag aggcagcatc tgtaagtaga tgctaagagg
     2281 tacatttcta aatgaagccc ttggggaaca tctgccaggg atctagagag tgctggtttc
     2341 atccattgtt ttaatttcct ccttggattg agtagaaacg tggcttcttg tggtgttgaa
     2401 ccttccccga cttctttgct ttgttgccat ctagcctgcc cagcactgcc tagggagcgc
     2461 ctacccaccc tgatttcttc tgccagctcc tacccaccct gatttcttct gccacttctt
     2521 tctttggcat tcatttttct ttccctggac aggaagctag ttacccgagt gtatcaggag
     2581 cacctaggct tgcctttgtc caggcccatt cctcctggta tccttgggtg tggaactgct
     2641 ggacagcttc aggaagcaga gccaggtgcc acttttctgt ggcttccaga tcctccctac
     2701 ctccacccct atgtgcctct gccacagtaa tttcagaaaa gcttggtaca ccctctagca
     2761 acatcttggt tcagagagtc tctctggctt gtgagttaac agctcagcca aatgctgtgt
     2821 tgtctcagtg aggcaaccac tgaacgagag ggttggttgt tgggctgtct ctgtgtgagt
     2881 cagagtagac aacatgttca cttcttcctg tctgctttgc aaggtgtctc tgactgatca
     2941 aggcaggcag ggagtggtat agtacttctg aaaggaagaa gttccctatt tatctgttaa
     3001 aagaccagag gcatgggcaa gtgctcagga cctcacttcg ggaagagggt ctgcttcctg
     3061 aagccagtgt ataaggaaaa gcttcgactg aaacctggta tctaaggtac catgaactaa
     3121 cactctatca cacagcccag ggcaaacagt ggtatagaaa agtctagaag aaaacatcac
     3181 atcagtattt tagaaccatc cacctttact gtccctgtag cccaatccag agcctggctt
     3241 ttagatctgg ctgcgtacag tgccaaatgc tcagtttact tgtaagatca gagcctttct
     3301 ttctgtgtta attgaacaca tgctctgagc tgttttgttg aagtagaaaa tctagtagaa
     3361 aatcactgta gatctgatga cctggaaacc tctggaaatg ccttcggggt ggttttattt
     3421 ttccaggtca cagatgcctg atttataaga tgaacaatga aatcagcttt ctttctcttc
     3481 tgatcttatt ccctggattt gatgcagccc atgttccaaa gcaaagctac atagagactt
     3541 caggctgagg tcctggtgtc tttaagcaaa ggacactctt tcagatcctc tcagaggcgg
     3601 atttgtaaca gtttccacat gaatgtacta atcatgttgg gtgccttatc gctttcctaa
     3661 tctacagtgc ctgttagccc agcctcactc cttcccttaa ccctgagatc ccgtagatgg
     3721 agcgggtgta gacaagaggc tggctggagg atcatcagta cagtgatttg cagaaatctt
     3781 ttatgggctt cattttggaa aaatttgttt ttagtaaatg ctcaaatttg gtgggaagta
     3841 atttgaatgt atttgattgt attgtcctca ttacaattgt taattagaca cgttctacat
     3901 gacagtagta ctcaggggag ttttctccct gggctgctaa tatctgggtg taatctctga
     3961 aactgtaggt ccagtgaggc ggcgtgaaaa gttagcaaag ccaccatctg ctggtggttt
     4021 aagccaaggc ctctcttctt cgccactgac ttgctatgtt atcctttctc ttgtaacaaa
     4081 cccatcccag agatgaggcc tttaatcatc ccaagaacct cctgggctaa gtatctgaca
     4141 gtctcacatc tcaacatcgt gtattaagtg tccagaacat cagctcagga ggacacgctg
     4201 aaactctcac tctgggcgag tcctgataaa acaggctcct aatactgacc tacctcaagg
     4261 gcagttctga ggtgattaga gccttttctt tttttaagca agtgtttgga gatgcatggc
     4321 agaggttttc ctgcagactt gtaaagagct agatgtgttc taaagaccat ctttagtcta
     4381 cattgctctt cccagagatc tacaactatg acccagccaa agtgcaagcc tacctactca
     4441 ctgccataaa aactattcag gaaacctttt cctgg
//
