LOCUS       NP_631931                358 aa            linear   ROD 01-JUN-2024
DEFINITION  acyl-CoA desaturase 1 [Rattus norvegicus].
ACCESSION   NP_631931
VERSION     NP_631931.2
DBSOURCE    REFSEQ: accession NM_139192.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 358)
  AUTHORS   Zhu,Y.L., Meng,L.L., Ma,J.H., Yuan,X., Chen,S.W., Yi,X.R., Li,X.Y.,
            Wang,Y., Tang,Y.S., Xue,M., Zhu,M.Z., Peng,J., Lu,X.J., Huang,J.Z.,
            Song,Z.C., Wu,C., Zheng,K.Z., Dai,Q.Q., Huang,F. and Fang,H.S.
  TITLE     Loss of LBP triggers lipid metabolic disorder through H3K27
            acetylation-mediated C/EBPbeta- SCD activation in non-alcoholic
            fatty liver disease
  JOURNAL   Zool Res 45 (1), 79-94 (2024)
   PUBMED   38114435
  REMARK    GeneRIF: Loss of LBP triggers lipid metabolic disorder through
            H3K27 acetylation-mediated C/EBPbeta- SCD activation in
            non-alcoholic fatty liver disease.
REFERENCE   2  (residues 1 to 358)
  AUTHORS   Zhang,Y., Gu,Y., Chen,Y., Huang,Z., Li,M., Jiang,W., Chen,J.,
            Rao,W., Luo,S., Chen,Y., Chen,J., Li,L., Jia,Y., Liu,M. and Zhou,F.
  TITLE     Dingxin Recipe IV attenuates atherosclerosis by regulating lipid
            metabolism through LXR-alpha/SREBP1 pathway and modulating the gut
            microbiota in ApoE-/- mice fed with HFD
  JOURNAL   J Ethnopharmacol 266, 113436 (2021)
   PUBMED   33011372
REFERENCE   3  (residues 1 to 358)
  AUTHORS   Chen,M., Xu,J., Wang,Y., Wang,Z., Guo,L., Li,X. and Huang,L.
  TITLE     Arctium lappa L. polysaccharide can regulate lipid metabolism in
            type 2 diabetic rats through the SREBP-1/SCD-1 axis
  JOURNAL   Carbohydr Res 494, 108055 (2020)
   PUBMED   32535406
REFERENCE   4  (residues 1 to 358)
  AUTHORS   Gopal Reddy,M.R., Kumar,M.S., Acharya,V., Venkata,S.M., Putcha,U.K.
            and Jeyakumar,S.M.
  TITLE     Vitamin A deficiency increases the oleic acid (C18:1) levels in the
            kidney of high fructose diet-fed rats
  JOURNAL   Indian J Med Res 150 (6), 620-629 (2019)
   PUBMED   32048626
  REMARK    GeneRIF: Feeding of VAD diet either alone or under HFr condition
            increased the kidney oleic acid (C18:1) levels and thus total MUFA,
            which corroborated with elevated SCD1 activity index, without
            affecting its expression status
REFERENCE   5  (residues 1 to 358)
  AUTHORS   Hao,C.L., Lin,H.L., Ke,L.Y., Yen,H.W. and Shen,K.P.
  TITLE     Pre-germinated brown rice extract ameliorates high-fat diet-induced
            metabolic syndrome
  JOURNAL   J Food Biochem 43 (3), e12769 (2019)
   PUBMED   31353547
REFERENCE   6  (residues 1 to 358)
  AUTHORS   Sundberg,J.P., Boggess,D., Sundberg,B.A., Eilertsen,K., Parimoo,S.,
            Filippi,M. and Stenn,K.
  TITLE     Asebia-2J (Scd1(ab2J)): a new allele and a model for scarring
            alopecia
  JOURNAL   Am J Pathol 156 (6), 2067-2075 (2000)
   PUBMED   10854228
REFERENCE   7  (residues 1 to 358)
  AUTHORS   Shanklin,J., Whittle,E. and Fox,B.G.
  TITLE     Eight histidine residues are catalytically essential in a
            membrane-associated iron enzyme, stearoyl-CoA desaturase, and are
            conserved in alkane hydroxylase and xylene monooxygenase
  JOURNAL   Biochemistry 33 (43), 12787-12794 (1994)
   PUBMED   7947684
REFERENCE   8  (residues 1 to 358)
  AUTHORS   Mihara,K.
  TITLE     Structure and regulation of rat liver microsomal stearoyl-CoA
            desaturase gene
  JOURNAL   J Biochem 108 (6), 1022-1029 (1990)
   PUBMED   1982442
REFERENCE   9  (residues 1 to 358)
  AUTHORS   Strittmatter,P., Thiede,M.A., Hackett,C.S. and Ozols,J.
  TITLE     Bacterial synthesis of active rat stearyl-CoA desaturase lacking
            the 26-residue amino-terminal amino acid sequence
  JOURNAL   J Biol Chem 263 (5), 2532-2535 (1988)
   PUBMED   2892838
REFERENCE   10 (residues 1 to 358)
  AUTHORS   Thiede,M.A., Ozols,J. and Strittmatter,P.
  TITLE     Construction and sequence of cDNA for rat liver stearyl coenzyme A
            desaturase
  JOURNAL   J Biol Chem 261 (28), 13230-13235 (1986)
   PUBMED   2428815
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF509569.1.
            
            On Jun 10, 2007 this sequence version replaced NP_631931.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF509568.1, AF509569.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..358
                     /organism="Rattus norvegicus"
                     /strain="F344"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     Protein         1..358
                     /product="acyl-CoA desaturase 1"
                     /EC_number="1.14.19.1"
                     /note="delta(9)-desaturase 1; fatty acid desaturase 1;
                     stearoyl-CoA desaturase 1; stearoyl-Coenzyme A desaturase
                     1"
                     /calculated_mol_wt=41336
     Region          8..33
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P07308.2)"
     Site            72..92
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P07308.2)"
     Site            97..117
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P07308.2)"
     Region          99..336
                     /region_name="Delta9-FADS-like"
                     /note="The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like
                     CD includes the delta-9 and delta-11 acyl CoA desaturases
                     found in various eukaryotes including vertebrates,
                     insects, higher plants, and fungi. The delta-9 acyl-lipid
                     desaturases are found in a wide...; cd03505"
                     /db_xref="CDD:239582"
     Site            order(119,124,156,159..160,297,300..301)
                     /site_type="other"
                     /note="Di-iron ligands [ion binding]"
                     /db_xref="CDD:239582"
     Region          119..124
                     /region_name="Histidine box-1. /evidence=ECO:0000305"
                     /note="propagated from UniProtKB/Swiss-Prot (P07308.2)"
     Region          156..160
                     /region_name="Histidine box-2. /evidence=ECO:0000305"
                     /note="propagated from UniProtKB/Swiss-Prot (P07308.2)"
     Site            217..236
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P07308.2)"
     Site            241..262
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P07308.2)"
     Region          297..301
                     /region_name="Histidine box-3. /evidence=ECO:0000305"
                     /note="propagated from UniProtKB/Swiss-Prot (P07308.2)"
     CDS             1..358
                     /gene="Scd"
                     /gene_synonym="Scd1"
                     /coded_by="NM_139192.2:49..1125"
                     /db_xref="GeneID:246074"
                     /db_xref="RGD:621176"
ORIGIN      
        1 mpahmlqeis ssytttttit eppsgnlqng rekmkkvply leedirpemr edihdpsyqd
       61 eegpppkley vwrniilmal lhvgalygit lipsskvytl lwgifyylis algitagahr
      121 lwshrtykar lplrifliia ntmafqndvy ewardhrahh kfsethadph nsrrgfffsh
      181 vgwllvrkhp avkekggkld msdlkaeklv mfqrryykpg lllmcfilpt lvpwycwget
      241 flhslfvstf lrytlvlnat wlvnsaahly gyrpydkniq srenilvslg avgegfhnyh
      301 hafpydysas eyrwhinftt ffidcmaalg laydrkkvsk aavlarikrt gdgshkss
//
