LOCUS       NM_054001               2070 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus scavenger receptor class B, member 2 (Scarb2),
            mRNA.
ACCESSION   NM_054001
VERSION     NM_054001.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2070)
  AUTHORS   Sakane,H., Urabe,J., Nakahira,S., Hino,K., Miyata,N. and Akasaki,K.
  TITLE     Involvement of lysosomal integral membrane protein-2 in the
            activation of autophagy
  JOURNAL   Biochem Biophys Res Commun 533 (4), 976-982 (2020)
   PUBMED   33010890
  REMARK    GeneRIF: Involvement of lysosomal integral membrane protein-2 in
            the activation of autophagy.
REFERENCE   2  (bases 1 to 2070)
  AUTHORS   Fujimoto,K., Uchida,S., Amen,R.N.S., Ishii,Y., Tanaka,Y. and
            Hirota,Y.
  TITLE     Lysosomal integral membrane protein LGP85 (LIMP-2) is ubiquitinated
            at the N-terminal cytoplasmic domain
  JOURNAL   Biochem Biophys Res Commun 524 (2), 424-430 (2020)
   PUBMED   32007273
  REMARK    GeneRIF: Lysosomal integral membrane protein LGP85 (LIMP-2) is
            ubiquitinated at the N-terminal cytoplasmic domain.
REFERENCE   3  (bases 1 to 2070)
  AUTHORS   Conrad,K.S., Cheng,T.W., Ysselstein,D., Heybrock,S., Hoth,L.R.,
            Chrunyk,B.A., Am Ende,C.W., Krainc,D., Schwake,M., Saftig,P.,
            Liu,S., Qiu,X. and Ehlers,M.D.
  TITLE     Lysosomal integral membrane protein-2 as a phospholipid receptor
            revealed by biophysical and cellular studies
  JOURNAL   Nat Commun 8 (1), 1908 (2017)
   PUBMED   29199275
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2070)
  AUTHORS   Jian,J., Tian,Q.Y., Hettinghouse,A., Zhao,S., Liu,H., Wei,J.,
            Grunig,G., Zhang,W., Setchell,K.D.R., Sun,Y., Overkleeft,H.S.,
            Chan,G.L. and Liu,C.J.
  TITLE     Progranulin Recruits HSP70 to beta-Glucocerebrosidase and Is
            Therapeutic Against Gaucher Disease
  JOURNAL   EBioMedicine 13, 212-224 (2016)
   PUBMED   27789271
REFERENCE   5  (bases 1 to 2070)
  AUTHORS   Rothaug,M., Zunke,F., Mazzulli,J.R., Schweizer,M., Altmeppen,H.,
            Lullmann-Rauch,R., Kallemeijn,W.W., Gaspar,P., Aerts,J.M.,
            Glatzel,M., Saftig,P., Krainc,D., Schwake,M. and Blanz,J.
  TITLE     LIMP-2 expression is critical for beta-glucocerebrosidase activity
            and alpha-synuclein clearance
  JOURNAL   Proc Natl Acad Sci U S A 111 (43), 15573-15578 (2014)
   PUBMED   25316793
REFERENCE   6  (bases 1 to 2070)
  AUTHORS   Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
            Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
REFERENCE   7  (bases 1 to 2070)
  AUTHORS   Reczek,D., Schwake,M., Schroder,J., Hughes,H., Blanz,J., Jin,X.,
            Brondyk,W., Van Patten,S., Edmunds,T. and Saftig,P.
  TITLE     LIMP-2 is a receptor for lysosomal mannose-6-phosphate-independent
            targeting of beta-glucocerebrosidase
  JOURNAL   Cell 131 (4), 770-783 (2007)
   PUBMED   18022370
REFERENCE   8  (bases 1 to 2070)
  AUTHORS   Kuronita,T., Hatano,T., Furuyama,A., Hirota,Y., Masuyama,N.,
            Saftig,P., Himeno,M., Fujita,H. and Tanaka,Y.
  TITLE     The NH(2)-terminal transmembrane and lumenal domains of LGP85 are
            needed for the formation of enlarged endosomes/lysosomes
  JOURNAL   Traffic 6 (10), 895-906 (2005)
   PUBMED   16138903
  REMARK    GeneRIF: These results indicate the involvement of distinct domains
            of LGP85 in the targeting to, and biogenesis and maintenance of,
            endosomal/lysosomal compartments.
REFERENCE   9  (bases 1 to 2070)
  AUTHORS   Vega,M.A., Segui-Real,B., Garcia,J.A., Cales,C., Rodriguez,F.,
            Vanderkerckhove,J. and Sandoval,I.V.
  TITLE     Cloning, sequencing, and expression of a cDNA encoding rat LIMP II,
            a novel 74-kDa lysosomal membrane protein related to the surface
            adhesion protein CD36
  JOURNAL   J Biol Chem 266 (25), 16818-16824 (1991)
   PUBMED   1715871
REFERENCE   10 (bases 1 to 2070)
  AUTHORS   Fujita,H., Ezaki,J., Noguchi,Y., Kono,A., Himeno,M. and Kato,K.
  TITLE     Isolation and sequencing of a cDNA clone encoding 85kDa
            sialoglycoprotein in rat liver lysosomal membranes
  JOURNAL   Biochem Biophys Res Commun 178 (2), 444-452 (1991)
   PUBMED   1859403
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC061853.1.
            
            On Feb 9, 2004 this sequence version replaced NM_054001.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061853.1, M68965.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2070
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..2070
                     /gene="Scarb2"
                     /gene_synonym="Cd36l2; LGP85; LimpII"
                     /note="scavenger receptor class B, member 2"
                     /db_xref="GeneID:117106"
                     /db_xref="RGD:621882"
     exon            1..399
                     /gene="Scarb2"
                     /gene_synonym="Cd36l2; LGP85; LimpII"
                     /inference="alignment:Splign:2.1.0"
     CDS             283..1719
                     /gene="Scarb2"
                     /gene_synonym="Cd36l2; LGP85; LimpII"
                     /note="LIMP II; CD36 antigen-like 2; lysosome membrane
                     protein II; 85 kDa lysosomal membrane sialoglycoprotein;
                     CD36 antigen (collagen type I receptor, thrombospondin
                     receptor)-like 2"
                     /codon_start=1
                     /product="lysosome membrane protein 2"
                     /protein_id="NP_446453.1"
                     /db_xref="GeneID:117106"
                     /db_xref="RGD:621882"
                     /translation="MARCCFYTAGTLSLLLLVTSVTLLVARVFQKAVDQTIEKNMVLQ
                     NGTKVFDSWEKPPLPVYIQFYFFNVTNPEEILQGEIPLLEEVGPYTYRELRNKANVQF
                     GENGTTISAVTNKAYIFERNQSVGDPTVDLIRTINIPLLTVVEMAQQPFLREIIEAML
                     KAYQQTLFVTHTVHELLWGYKDEVLSLVHIFRPDVSPNFGLFYERNGTNDGEYVFLTG
                     EDNYLNFTKIVEWNGKTSLDWWTTDTCNMINGTDGDSFHPLISKDETLYIFPSDFCRS
                     VYITFSSFENVEGLPAFRYKVPAEILANSSENAGFCIPEGNCMDAGVLNVSICKNGAP
                     IIMSFPHFYQADEKFVSAIKGMRPNKEEHESFVDINPLTGIILRGAKRFQINTYVKKL
                     DDFVETGNIRTMVFPVMYLNESVLIDKETASQLKSVINTTLIVTNIPYIIMALGVFFG
                     LIFTWLACRGQGSTDEGTADERAPLIRT"
     exon            400..557
                     /gene="Scarb2"
                     /gene_synonym="Cd36l2; LGP85; LimpII"
                     /inference="alignment:Splign:2.1.0"
     exon            558..705
                     /gene="Scarb2"
                     /gene_synonym="Cd36l2; LGP85; LimpII"
                     /inference="alignment:Splign:2.1.0"
     exon            706..894
                     /gene="Scarb2"
                     /gene_synonym="Cd36l2; LGP85; LimpII"
                     /inference="alignment:Splign:2.1.0"
     exon            895..986
                     /gene="Scarb2"
                     /gene_synonym="Cd36l2; LGP85; LimpII"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1106
                     /gene="Scarb2"
                     /gene_synonym="Cd36l2; LGP85; LimpII"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1276
                     /gene="Scarb2"
                     /gene_synonym="Cd36l2; LGP85; LimpII"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1395
                     /gene="Scarb2"
                     /gene_synonym="Cd36l2; LGP85; LimpII"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1469
                     /gene="Scarb2"
                     /gene_synonym="Cd36l2; LGP85; LimpII"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1521
                     /gene="Scarb2"
                     /gene_synonym="Cd36l2; LGP85; LimpII"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1680
                     /gene="Scarb2"
                     /gene_synonym="Cd36l2; LGP85; LimpII"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1983
                     /gene="Scarb2"
                     /gene_synonym="Cd36l2; LGP85; LimpII"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctgcgcgc tccctgcacc tcccgggctg cagcagcccg agaaaacgaa agccaggcga
       61 tcccagcacc cgcgatcgcg cgggctctgt gctccgaggg ccgtgctcgc ctggtgccta
      121 ctccagggct gtgtacaccg cgcgggcggc ggctgagccc gcaccaggag ggcgcgggag
      181 ccgcagggcc ctggagcttt gggcgactgc tacgcggcct tggccgaggc tcttccttgc
      241 tcgccgttct gtcgcgggcc tggcccgtga accgctcaca gtatggcccg atgctgcttc
      301 tacacggcgg ggacactgtc tctgctgctg ctggtgacca gtgtcacgct gctagtggct
      361 cgagtctttc agaaggcagt ggaccagacg atcgagaaga atatggtatt acaaaatggt
      421 accaaggtct ttgattcctg ggagaagccc cctctacctg tgtacatcca gttttatttc
      481 ttcaatgtca ccaatccaga ggagatcctc caaggagaaa tccccctgct agaagaagtg
      541 gggccgtaca cctacaggga gctcaggaac aaggcaaacg ttcagtttgg agaaaatgga
      601 acaaccatat ctgccgtcac caataaggca tatatttttg aacgaaacca gtctgttgga
      661 gaccctaccg ttgacttgat tagaacaata aatattcctc tgttgactgt tgtggaaatg
      721 gcccagcagc ccttcctcag ggagatcatc gaggccatgc tgaaagctta tcagcagacg
      781 ctgtttgtca ctcacactgt acatgaactg ctctggggct acaaagatga ggtcttgtcg
      841 ctcgtccata ttttcagacc tgacgtctcc cctaactttg gcctgttcta tgagagaaat
      901 ggaactaatg atggggagta tgtttttctg actggagagg acaattacct gaactttaca
      961 aaaattgtgg agtggaatgg aaaaacgtcg ctggactggt ggacgacgga cacgtgcaat
     1021 atgatcaacg ggacagacgg agattctttt cacccattaa taagcaagga tgagaccctg
     1081 tacatcttcc catctgactt ctgcaggtcc gtctatataa ctttcagtag ctttgagaac
     1141 gtagaaggac tgcctgcttt tcggtataag gtgcctgcag aaatactagc caattcctcc
     1201 gaaaacgctg gcttctgtat acccgaggga aactgcatgg acgcgggagt gctgaacgtc
     1261 agcatttgca agaatggtgc gcccattatc atgtctttcc cacactttta ccaagccgac
     1321 gagaagttcg tttcggccat aaaaggcatg cgtccaaaca aggaagaaca tgagtcattt
     1381 gtggacatta atcctttgac aggaattatt ttaagagggg ccaagagatt ccaaatcaac
     1441 acgtacgtta agaagctgga tgactttgtg gaaacgggaa acattaggac tatggttttc
     1501 ccagtgatgt atctcaatga gagtgttctc attgacaaag agactgcaag tcaactgaag
     1561 tctgtgatta acacaacttt gattgtcacc aacataccct acatcatcat ggcactgggc
     1621 gtgttctttg gcttgatttt cacgtggctg gcgtgtcgag gacaggggtc tacggatgag
     1681 ggaactgcag atgaaagggc acccctcata cggacctaat gggacttacc tgttgcctga
     1741 gcttggtgag agaatgtgag aactgacctg acctggacca ggacagggaa aagcctgcat
     1801 cctcacgggc tcctggcctg tcaagaaggg agtgaagccg cagcactggc acgcgagaag
     1861 accctcctgg acagagggga ccgagcaggt gacatggctg gcaattacgc tttataaaat
     1921 catgtctctg aaactgtgtc aatgtgtctt agggagtatt taataaattg tgtagaaacc
     1981 tttaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2041 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
