LOCUS       NP_446453                478 aa            linear   ROD 03-APR-2024
DEFINITION  lysosome membrane protein 2 [Rattus norvegicus].
ACCESSION   NP_446453
VERSION     NP_446453.1
DBSOURCE    REFSEQ: accession NM_054001.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 478)
  AUTHORS   Sakane,H., Urabe,J., Nakahira,S., Hino,K., Miyata,N. and Akasaki,K.
  TITLE     Involvement of lysosomal integral membrane protein-2 in the
            activation of autophagy
  JOURNAL   Biochem Biophys Res Commun 533 (4), 976-982 (2020)
   PUBMED   33010890
  REMARK    GeneRIF: Involvement of lysosomal integral membrane protein-2 in
            the activation of autophagy.
REFERENCE   2  (residues 1 to 478)
  AUTHORS   Fujimoto,K., Uchida,S., Amen,R.N.S., Ishii,Y., Tanaka,Y. and
            Hirota,Y.
  TITLE     Lysosomal integral membrane protein LGP85 (LIMP-2) is ubiquitinated
            at the N-terminal cytoplasmic domain
  JOURNAL   Biochem Biophys Res Commun 524 (2), 424-430 (2020)
   PUBMED   32007273
  REMARK    GeneRIF: Lysosomal integral membrane protein LGP85 (LIMP-2) is
            ubiquitinated at the N-terminal cytoplasmic domain.
REFERENCE   3  (residues 1 to 478)
  AUTHORS   Conrad,K.S., Cheng,T.W., Ysselstein,D., Heybrock,S., Hoth,L.R.,
            Chrunyk,B.A., Am Ende,C.W., Krainc,D., Schwake,M., Saftig,P.,
            Liu,S., Qiu,X. and Ehlers,M.D.
  TITLE     Lysosomal integral membrane protein-2 as a phospholipid receptor
            revealed by biophysical and cellular studies
  JOURNAL   Nat Commun 8 (1), 1908 (2017)
   PUBMED   29199275
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 478)
  AUTHORS   Jian,J., Tian,Q.Y., Hettinghouse,A., Zhao,S., Liu,H., Wei,J.,
            Grunig,G., Zhang,W., Setchell,K.D.R., Sun,Y., Overkleeft,H.S.,
            Chan,G.L. and Liu,C.J.
  TITLE     Progranulin Recruits HSP70 to beta-Glucocerebrosidase and Is
            Therapeutic Against Gaucher Disease
  JOURNAL   EBioMedicine 13, 212-224 (2016)
   PUBMED   27789271
REFERENCE   5  (residues 1 to 478)
  AUTHORS   Rothaug,M., Zunke,F., Mazzulli,J.R., Schweizer,M., Altmeppen,H.,
            Lullmann-Rauch,R., Kallemeijn,W.W., Gaspar,P., Aerts,J.M.,
            Glatzel,M., Saftig,P., Krainc,D., Schwake,M. and Blanz,J.
  TITLE     LIMP-2 expression is critical for beta-glucocerebrosidase activity
            and alpha-synuclein clearance
  JOURNAL   Proc Natl Acad Sci U S A 111 (43), 15573-15578 (2014)
   PUBMED   25316793
REFERENCE   6  (residues 1 to 478)
  AUTHORS   Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
            Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
REFERENCE   7  (residues 1 to 478)
  AUTHORS   Reczek,D., Schwake,M., Schroder,J., Hughes,H., Blanz,J., Jin,X.,
            Brondyk,W., Van Patten,S., Edmunds,T. and Saftig,P.
  TITLE     LIMP-2 is a receptor for lysosomal mannose-6-phosphate-independent
            targeting of beta-glucocerebrosidase
  JOURNAL   Cell 131 (4), 770-783 (2007)
   PUBMED   18022370
REFERENCE   8  (residues 1 to 478)
  AUTHORS   Kuronita,T., Hatano,T., Furuyama,A., Hirota,Y., Masuyama,N.,
            Saftig,P., Himeno,M., Fujita,H. and Tanaka,Y.
  TITLE     The NH(2)-terminal transmembrane and lumenal domains of LGP85 are
            needed for the formation of enlarged endosomes/lysosomes
  JOURNAL   Traffic 6 (10), 895-906 (2005)
   PUBMED   16138903
  REMARK    GeneRIF: These results indicate the involvement of distinct domains
            of LGP85 in the targeting to, and biogenesis and maintenance of,
            endosomal/lysosomal compartments.
REFERENCE   9  (residues 1 to 478)
  AUTHORS   Vega,M.A., Segui-Real,B., Garcia,J.A., Cales,C., Rodriguez,F.,
            Vanderkerckhove,J. and Sandoval,I.V.
  TITLE     Cloning, sequencing, and expression of a cDNA encoding rat LIMP II,
            a novel 74-kDa lysosomal membrane protein related to the surface
            adhesion protein CD36
  JOURNAL   J Biol Chem 266 (25), 16818-16824 (1991)
   PUBMED   1715871
REFERENCE   10 (residues 1 to 478)
  AUTHORS   Fujita,H., Ezaki,J., Noguchi,Y., Kono,A., Himeno,M. and Kato,K.
  TITLE     Isolation and sequencing of a cDNA clone encoding 85kDa
            sialoglycoprotein in rat liver lysosomal membranes
  JOURNAL   Biochem Biophys Res Commun 178 (2), 444-452 (1991)
   PUBMED   1859403
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC061853.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061853.1, M68965.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     Protein         1..478
                     /product="lysosome membrane protein 2"
                     /note="LIMP II; CD36 antigen-like 2; lysosome membrane
                     protein II; 85 kDa lysosomal membrane sialoglycoprotein;
                     CD36 antigen (collagen type I receptor, thrombospondin
                     receptor)-like 2"
                     /calculated_mol_wt=53960
     Site            5..27
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P27615.2)"
     Region          28..457
                     /region_name="CD36"
                     /note="CD36 family; pfam01130"
                     /db_xref="CDD:460076"
     Site            45
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P27615.2)"
     Site            68
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P27615.2)"
     Site            105
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P27615.2)"
     Site            122
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0007744|PubMed:24090084; propagated from
                     UniProtKB/Swiss-Prot (P27615.2)"
     Region          155..191
                     /region_name="Important for interaction with GBA1.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P27615.2)"
     Site            206
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P27615.2)"
     Site            224
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P27615.2)"
     Site            249
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P27615.2)"
     Site            304
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P27615.2)"
     Site            325
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P27615.2)"
     Site            412
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0007744|PubMed:24090084; propagated from
                     UniProtKB/Swiss-Prot (P27615.2)"
     Site            430
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P27615.2)"
     Site            434..459
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P27615.2)"
     CDS             1..478
                     /gene="Scarb2"
                     /gene_synonym="Cd36l2; LGP85; LimpII"
                     /coded_by="NM_054001.2:283..1719"
                     /db_xref="GeneID:117106"
                     /db_xref="RGD:621882"
ORIGIN      
        1 marccfytag tlsllllvts vtllvarvfq kavdqtiekn mvlqngtkvf dswekpplpv
       61 yiqfyffnvt npeeilqgei plleevgpyt yrelrnkanv qfgengttis avtnkayife
      121 rnqsvgdptv dlirtinipl ltvvemaqqp flreiieaml kayqqtlfvt htvhellwgy
      181 kdevlslvhi frpdvspnfg lfyerngtnd geyvfltged nylnftkive wngktsldww
      241 ttdtcnming tdgdsfhpli skdetlyifp sdfcrsvyit fssfenvegl pafrykvpae
      301 ilanssenag fcipegncmd agvlnvsick ngapiimsfp hfyqadekfv saikgmrpnk
      361 eehesfvdin pltgiilrga krfqintyvk klddfvetgn irtmvfpvmy lnesvlidke
      421 tasqlksvin ttlivtnipy iimalgvffg liftwlacrg qgstdegtad eraplirt
//
