LOCUS       NM_031541               2476 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus scavenger receptor class B, member 1 (Scarb1),
            mRNA.
ACCESSION   NM_031541
VERSION     NM_031541.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2476)
  AUTHORS   Toma,V.A., Tigu,A.B., Farcas,A.D., Sevastre,B., Taulescu,M.,
            Gherman,A.M.R., Roman,I., Fischer-Fodor,E. and Parvu,M.
  TITLE     New Aspects Towards a Molecular Understanding of the Allicin
            Immunostimulatory Mechanism via Colec12, MARCO, and SCARB1
            Receptors
  JOURNAL   Int J Mol Sci 20 (15), 3627 (2019)
   PUBMED   31344978
  REMARK    GeneRIF: The molecular docking revealed that
            S-allyl-mercapto-glutathione interacting with Colec12, MARCO (class
            A), and SCARB1 (class B) scavenger receptors in in vitro tests
            demonstrates a direct stimulation of immunoglobulin secretion by
            S-allylmercaptoglutathione (GSSA) in CD19+ B lymphocytes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2476)
  AUTHORS   Lu,X., He,L., Zhou,Q., Wang,M., Shen,W.J., Azhar,S., Pan,F., Guo,Z.
            and Hu,Z.
  TITLE     NHERF1 and NHERF2 regulation of SR-B1 stability via ubiquitination
            and proteasome degradation
  JOURNAL   Biochem Biophys Res Commun 490 (4), 1168-1175 (2017)
   PUBMED   28669731
  REMARK    GeneRIF: The results suggest that NHERF1 and NHERF2 down-regulated
            SR-B1 at least in part via the ubiquitin/proteasome pathway.
REFERENCE   3  (bases 1 to 2476)
  AUTHORS   Rotimi,O.A., Rotimi,S.O., Duru,C.U., Ebebeinwe,O.J., Abiodun,A.O.,
            Oyeniyi,B.O. and Faduyile,F.A.
  TITLE     Acute aflatoxin B1 - Induced hepatotoxicity alters gene expression
            and disrupts lipid and lipoprotein metabolism in rats
  JOURNAL   Toxicol Rep 4, 408-414 (2017)
   PUBMED   28959666
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2476)
  AUTHORS   Lee,M.H., Appleton,K.M., El-Shewy,H.M., Sorci-Thomas,M.G.,
            Thomas,M.J., Lopes-Virella,M.F., Luttrell,L.M., Hammad,S.M. and
            Klein,R.L.
  TITLE     S1P in HDL promotes interaction between SR-BI and S1PR1 and
            activates S1PR1-mediated biological functions: calcium flux and
            S1PR1 internalization
  JOURNAL   J Lipid Res 58 (2), 325-338 (2017)
   PUBMED   27881715
  REMARK    GeneRIF: Model recombinant HDL (rHDL) particles formed in vitro
            with S1P incorporated into the particle initiated the
            internalization of S1PR1, whereas rHDL without supplemented S1P did
            not, suggesting that S1P transported in HDL can selectively
            activate S1PR1.
REFERENCE   5  (bases 1 to 2476)
  AUTHORS   Jeyakumar,S.M., Sheril,A. and Vajreswari,A.
  TITLE     Chronic vitamin A-enriched diet feeding regulates
            hypercholesterolaemia through transcriptional regulation of reverse
            cholesterol transport pathway genes in obese rat model of
            WNIN/GR-Ob strain
  JOURNAL   Indian J Med Res 144 (2), 238-244 (2016)
   PUBMED   27934803
  REMARK    GeneRIF: Chronic vitamin A-enriched diet feeding decreased
            hypercholesterolaemia and normalized HDL-C levels, possibly by
            regulating pathways involved in HDL synthesis and degradation,
            independent of hepatic SR-B1 in this glucose-intolerant obese rat
            mode
REFERENCE   6  (bases 1 to 2476)
  AUTHORS   Murao,K., Terpstra,V., Green,S.R., Kondratenko,N., Steinberg,D. and
            Quehenberger,O.
  TITLE     Characterization of CLA-1, a human homologue of rodent scavenger
            receptor BI, as a receptor for high density lipoprotein and
            apoptotic thymocytes
  JOURNAL   J Biol Chem 272 (28), 17551-17557 (1997)
   PUBMED   9211901
REFERENCE   7  (bases 1 to 2476)
  AUTHORS   Xu,S., Laccotripe,M., Huang,X., Rigotti,A., Zannis,V.I. and
            Krieger,M.
  TITLE     Apolipoproteins of HDL can directly mediate binding to the
            scavenger receptor SR-BI, an HDL receptor that mediates selective
            lipid uptake
  JOURNAL   J Lipid Res 38 (7), 1289-1298 (1997)
   PUBMED   9254056
REFERENCE   8  (bases 1 to 2476)
  AUTHORS   Mizutani,T., Sonoda,Y., Minegishi,T., Wakabayashi,K. and
            Miyamoto,K.
  TITLE     Cloning, characterization, and cellular distribution of rat
            scavenger receptor class B type I (SRBI) in the ovary
  JOURNAL   Biochem Biophys Res Commun 234 (2), 499-505 (1997)
   PUBMED   9177301
REFERENCE   9  (bases 1 to 2476)
  AUTHORS   Babitt,J., Trigatti,B., Rigotti,A., Smart,E.J., Anderson,R.G.,
            Xu,S. and Krieger,M.
  TITLE     Murine SR-BI, a high density lipoprotein receptor that mediates
            selective lipid uptake, is N-glycosylated and fatty acylated and
            colocalizes with plasma membrane caveolae
  JOURNAL   J Biol Chem 272 (20), 13242-13249 (1997)
   PUBMED   9148942
REFERENCE   10 (bases 1 to 2476)
  AUTHORS   Dissen,E. and Fossum,S.
  TITLE     Chromosomal localization of the genes encoding rat CD4, CD8alpha,
            and CD8beta
  JOURNAL   Immunogenetics 44 (4), 312-314 (1996)
   PUBMED   8753864
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031541.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB002151.1, BC076504.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-328               JAXUCZ010000012.1  36957496-36957823
            329-486             JAXUCZ010000012.1  36996953-36997110
            487-628             JAXUCZ010000012.1  36998622-36998763
            629-832             JAXUCZ010000012.1  37000806-37001009
            833-928             JAXUCZ010000012.1  37002626-37002721
            929-1044            JAXUCZ010000012.1  37004414-37004529
            1045-1211           JAXUCZ010000012.1  37007640-37007806
            1212-1330           JAXUCZ010000012.1  37012759-37012877
            1331-1404           JAXUCZ010000012.1  37013749-37013822
            1405-1456           JAXUCZ010000012.1  37016759-37016810
            1457-1603           JAXUCZ010000012.1  37017454-37017600
            1604-1732           JAXUCZ010000012.1  37020168-37020296
            1733-2476           JAXUCZ010000012.1  37023239-37023982
FEATURES             Location/Qualifiers
     source          1..2476
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q15"
     gene            1..2476
                     /gene="Scarb1"
                     /gene_synonym="Cd36l1; SR-B1; Srb1"
                     /note="scavenger receptor class B, member 1"
                     /db_xref="GeneID:25073"
                     /db_xref="RGD:2302"
     exon            1..328
                     /gene="Scarb1"
                     /gene_synonym="Cd36l1; SR-B1; Srb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..1732
                     /gene="Scarb1"
                     /gene_synonym="Cd36l1; SR-B1; Srb1"
                     /note="CD36 antigen (collagen type I receptor,
                     thrombospondin receptor)-like 1; SR-BI; scavanger receptor
                     class B type 1; CD36 antigen (collagen type I receptor
                     thrombospondin receptor)-like 1 (scavanger receptor class
                     B type 1); scavenger receptor class B type I"
                     /codon_start=1
                     /product="scavenger receptor class B member 1"
                     /protein_id="NP_113729.1"
                     /db_xref="GeneID:25073"
                     /db_xref="RGD:2302"
                     /translation="MGVSSRARWVALGLGVLGLLCAALGVIMILMVPSLIKQQVLKNV
                     RIDPSSLSFGMWKEIPVPFYLSVYFFEVVNPSEVLNGQKPVVRERGPYVYREFRQKVN
                     ITFNDNDTVSYIENRSLRFQPDRSQGSESDYIVLPNILVLGGAVMMEDKPTSLKLLMT
                     LGLVTMGQRAFMNRTVGEILWGYEDPFVNFLSKYFPDMFPIKGKFGLFVGMNDSSSGV
                     FTVFTGVQNFSKIHLVDKWNGLSEVNYWHSEQCNMINGTAGQMWAPFMTPESSLEFFS
                     PEACRSMKLTYQESRVFEGIPTYRFTAPDTLFANGSVYPPNEGFCPCRESGIQNVSTC
                     RFGAPLFLSQPHFYNADPVLSEAVLGLNPDPKEHSLFLDIHPVTGIPMNCSVKMQLSL
                     YIKSVKGVGQTGKIEPVVLPLLWFEQSGMMGGKTLNTFYTQLVLMPQVLHYAQYVLLG
                     LGGLLLLVPIIYQLRSQEKCFLFWSGSKKGSQDKEAMQAYSESLMSPAAKGTVLQEAK
                     L"
     exon            329..486
                     /gene="Scarb1"
                     /gene_synonym="Cd36l1; SR-B1; Srb1"
                     /inference="alignment:Splign:2.1.0"
     exon            487..628
                     /gene="Scarb1"
                     /gene_synonym="Cd36l1; SR-B1; Srb1"
                     /inference="alignment:Splign:2.1.0"
     exon            629..832
                     /gene="Scarb1"
                     /gene_synonym="Cd36l1; SR-B1; Srb1"
                     /inference="alignment:Splign:2.1.0"
     exon            833..928
                     /gene="Scarb1"
                     /gene_synonym="Cd36l1; SR-B1; Srb1"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1044
                     /gene="Scarb1"
                     /gene_synonym="Cd36l1; SR-B1; Srb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1211
                     /gene="Scarb1"
                     /gene_synonym="Cd36l1; SR-B1; Srb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1330
                     /gene="Scarb1"
                     /gene_synonym="Cd36l1; SR-B1; Srb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1404
                     /gene="Scarb1"
                     /gene_synonym="Cd36l1; SR-B1; Srb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1456
                     /gene="Scarb1"
                     /gene_synonym="Cd36l1; SR-B1; Srb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1603
                     /gene="Scarb1"
                     /gene_synonym="Cd36l1; SR-B1; Srb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1732
                     /gene="Scarb1"
                     /gene_synonym="Cd36l1; SR-B1; Srb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..2476
                     /gene="Scarb1"
                     /gene_synonym="Cd36l1; SR-B1; Srb1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaatcccgc gccgaacacg ggggcgggct gcccgggcca tggcgcataa aacctctggc
       61 cacctgcagg gctactgctg ctctggccac tgtcaggcac acaccttgct gctcggtttc
      121 tgtcatctct gtggcctccg tcgcctctgt cgccgtcccc ttcaggtcct gagcccagcg
      181 actctcggcc gcgcacgcgg acatgggcgt cagctccagg gcacgctggg tggccttggg
      241 gctgggcgtt ctagggctgc tgtgtgctgc gctcggcgtt atcatgattc tcatggtgcc
      301 ctcgctcatc aagcagcagg tgctcaagaa tgtccgcata gaccccagca gcctgtcctt
      361 tgggatgtgg aaggagatcc ctgttccctt ctacttgtcc gtctacttct tcgaggtggt
      421 caaccccagc gaggtcctaa atggccagaa gccagtagtc cgggagcgcg gaccctatgt
      481 ctacagggag ttcagacaaa aggttaacat caccttcaat gacaatgaca cggtgtccta
      541 catagagaac cgaagccttc gtttccagcc agacaggtcc cagggctcag agagtgacta
      601 cattgtactg cctaacatcc tggtcctggg aggggcagtg atgatggagg acaagcccac
      661 aagcctgaag ctgctaatga ccttggggtt ggtcaccatg ggccagcggg cctttatgaa
      721 ccgcacggtt ggtgagatcc tgtggggcta cgaagatccc tttgtgaatt tcctcagcaa
      781 atatttccca gacatgttcc ccatcaaagg caaatttggc ctgttcgttg ggatgaacga
      841 ctcgagttct ggcgtcttca ccgtcttcac aggtgtccag aatttcagca agatccatct
      901 ggtggataag tggaacggcc tcagcgaggt caactattgg cattcggaac agtgcaacat
      961 gatcaatggt actgccgggc agatgtgggc accattcatg acacccgaat cctcactgga
     1021 attcttcagc ccagaagcct gcagatctat gaagctcacc taccaggaat caagggtgtt
     1081 cgaaggcatc cccacttatc gcttcacggc ccccgatact ttgtttgcca acgggtccgt
     1141 ctacccacct aatgaaggct tctgcccgtg ccgcgagtcc ggcattcaga atgtcagcac
     1201 ctgcaggttt ggtgcgcccc tgtttctctc ccagccccac ttctacaatg ctgaccccgt
     1261 gctgtcagaa gctgttcttg gtctgaaccc tgacccaaag gagcattcct tgttcctaga
     1321 catccacccg gtcactggga tccccatgaa ctgttccgtg aagatgcagc tgagtctgta
     1381 catcaaatcc gtcaagggcg tcgggcaaac agggaagatc gagccagtag tcctgccatt
     1441 gctgtggttc gaacagagcg ggatgatggg tggcaagacc ctgaacacgt tctacacgca
     1501 gctggtgctg atgccccagg ttcttcacta cgcgcagtat gtgctgctgg ggcttggagg
     1561 cctcctgctt ctggtgccca tcatttacca actgcgcagc caggagaaat gctttttatt
     1621 ttggagtggt agtaaaaagg gctcgcagga taaggaggcc atgcaggcct actctgagtc
     1681 tctgatgtca ccagctgcca agggcacggt actgcaagaa gccaagctgt agggcccaga
     1741 agacaccacg agccccccaa acctgatagc ttggtcagac cagccgccca gtccctacac
     1801 cccacttctc gaggactctc tcagcggaca acccgccagt gccacgtcct gagcccccag
     1861 atgtcacact gtccacacgg cacatagtgt gcggaaacac tcagggacca gggacagacc
     1921 cgctgctgag tagagcctgt tgggccacag gcgacctctt ctaagtgacc tgtgagccag
     1981 gctgtgggaa ctgtagctgc ccctcctgta ggagctggcg ccgccggggc tcctgacttt
     2041 ctccgtcttt ctccagcagg ctgaaagcct tagttcccac agaggacaca gatctgtcac
     2101 tcctaggggc tgggcaaaca tcggcctctt gcgtcacggc tggacaagca gttccagatc
     2161 ctgaccagtc tgcacacaca ctctggcgct gtatctggcc cttctcctac agtctctgct
     2221 gtcacctgaa cactgaattg gccactgtaa gtggcagcgg tggcaggccc cctcagggtc
     2281 cttatttttc aggcgtgggg tcaaagagag aggtgtgggc cgtctacccc tggcacctag
     2341 tatatctcac cagagggtag ggtatacaga ggcccagcgt cccacaatcg accccttttt
     2401 ttctactgga agagaaattt tatcgtcttt tgaaagaaag tcatgactga agcaataaac
     2461 cttttcacaa attcaa
//
