LOCUS       NM_001100966            4281 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus SREBF chaperone (Scap), mRNA.
ACCESSION   NM_001100966 XM_001077128 XM_217279
VERSION     NM_001100966.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4281)
  AUTHORS   Verdier,V., Csardi,G., de Preux-Charles,A.S., Medard,J.J.,
            Smit,A.B., Verheijen,M.H., Bergmann,S. and Chrast,R.
  TITLE     Aging of myelinating glial cells predominantly affects lipid
            metabolism and immune response pathways
  JOURNAL   Glia 60 (5), 751-760 (2012)
   PUBMED   22337502
REFERENCE   2  (bases 1 to 4281)
  AUTHORS   Chu,Q., Zhang,J., Wu,Y., Zhang,Y., Xu,G., Li,W. and Xu,G.T.
  TITLE     Differential gene expression pattern of diabetic rat retinas after
            intravitreal injection of erythropoietin
  JOURNAL   Clin Exp Ophthalmol 39 (2), 142-151 (2011)
   PUBMED   20973890
REFERENCE   3  (bases 1 to 4281)
  AUTHORS   Cho,K.H., Kim,H.J., Kamanna,V.S. and Vaziri,N.D.
  TITLE     Niacin improves renal lipid metabolism and slows progression in
            chronic kidney disease
  JOURNAL   Biochim Biophys Acta 1800 (1), 6-15 (2010)
   PUBMED   19878707
REFERENCE   4  (bases 1 to 4281)
  AUTHORS   Osborne,T.F. and Espenshade,P.J.
  TITLE     Evolutionary conservation and adaptation in the mechanism that
            regulates SREBP action: what a long, strange tRIP it's been
  JOURNAL   Genes Dev 23 (22), 2578-2591 (2009)
   PUBMED   19933148
  REMARK    Review article
REFERENCE   5  (bases 1 to 4281)
  AUTHORS   Yellaturu,C.R., Deng,X., Cagen,L.M., Wilcox,H.G., Mansbach,C.M.
            2nd, Siddiqi,S.A., Park,E.A., Raghow,R. and Elam,M.B.
  TITLE     Insulin enhances post-translational processing of nascent SREBP-1c
            by promoting its phosphorylation and association with COPII
            vesicles
  JOURNAL   J Biol Chem 284 (12), 7518-7532 (2009)
   PUBMED   19158095
  REMARK    GeneRIF: insulin selectively stimulates the processing of SREBP-1c
            in rat hepatocytes by enhancing the association between the
            SCAP-SREBP-1c complex and COPII proteins and subsequent ER to Golgi
            transport and proteolytic cleavage.
REFERENCE   6  (bases 1 to 4281)
  AUTHORS   Pallottini,V., Martini,C., Cavallini,G., Donati,A., Bergamini,E.,
            Notarnicola,M., Caruso,M.G. and Trentalance,A.
  TITLE     Modified HMG-CoA reductase and LDLr regulation is deeply involved
            in age-related hypercholesterolemia
  JOURNAL   J Cell Biochem 98 (5), 1044-1053 (2006)
   PUBMED   16741953
REFERENCE   7  (bases 1 to 4281)
  AUTHORS   Kuriyama,H., Liang,G., Engelking,L.J., Horton,J.D., Goldstein,J.L.
            and Brown,M.S.
  TITLE     Compensatory increase in fatty acid synthesis in adipose tissue of
            mice with conditional deficiency of SCAP in liver
  JOURNAL   Cell Metab 1 (1), 41-51 (2005)
   PUBMED   16054043
REFERENCE   8  (bases 1 to 4281)
  AUTHORS   Yabe,D., Brown,M.S. and Goldstein,J.L.
  TITLE     Insig-2, a second endoplasmic reticulum protein that binds SCAP and
            blocks export of sterol regulatory element-binding proteins
  JOURNAL   Proc Natl Acad Sci U S A 99 (20), 12753-12758 (2002)
   PUBMED   12242332
REFERENCE   9  (bases 1 to 4281)
  AUTHORS   Rader,D.J.
  TITLE     A new feature on the cholesterol-lowering landscape
  JOURNAL   Nat Med 7 (12), 1282-1284 (2001)
   PUBMED   11726962
REFERENCE   10 (bases 1 to 4281)
  AUTHORS   Matsuda,M., Korn,B.S., Hammer,R.E., Moon,Y.A., Komuro,R.,
            Horton,J.D., Goldstein,J.L., Brown,M.S. and Shimomura,I.
  TITLE     SREBP cleavage-activating protein (SCAP) is required for increased
            lipid synthesis in liver induced by cholesterol deprivation and
            insulin elevation
  JOURNAL   Genes Dev 15 (10), 1206-1216 (2001)
   PUBMED   11358865
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 18, 2021 this sequence version replaced NM_001100966.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC131852.1, SRR26643295.33727.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-140               JAXUCZ010000008.1  119184438-119184577
            141-191             JAXUCZ010000008.1  119203180-119203230
            192-410             JAXUCZ010000008.1  119207181-119207399
            411-540             JAXUCZ010000008.1  119216661-119216790
            541-698             JAXUCZ010000008.1  119226964-119227121
            699-919             JAXUCZ010000008.1  119227736-119227956
            920-1025            JAXUCZ010000008.1  119228139-119228244
            1026-1198           JAXUCZ010000008.1  119228722-119228894
            1199-1325           JAXUCZ010000008.1  119229217-119229343
            1326-1438           JAXUCZ010000008.1  119231179-119231291
            1439-1533           JAXUCZ010000008.1  119232298-119232392
            1534-1632           JAXUCZ010000008.1  119233005-119233103
            1633-1851           JAXUCZ010000008.1  119233238-119233456
            1852-2228           JAXUCZ010000008.1  119234124-119234500
            2229-2417           JAXUCZ010000008.1  119234985-119235173
            2418-2619           JAXUCZ010000008.1  119235256-119235457
            2620-2735           JAXUCZ010000008.1  119235531-119235646
            2736-3249           JAXUCZ010000008.1  119235741-119236254
            3250-3335           JAXUCZ010000008.1  119236330-119236415
            3336-3418           JAXUCZ010000008.1  119237696-119237778
            3419-3585           JAXUCZ010000008.1  119237877-119238043
            3586-3666           JAXUCZ010000008.1  119238205-119238285
            3667-3873           JAXUCZ010000008.1  119238395-119238601
            3874-4281           JAXUCZ010000008.1  119238679-119239086
FEATURES             Location/Qualifiers
     source          1..4281
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..4281
                     /gene="Scap"
                     /note="SREBF chaperone"
                     /db_xref="GeneID:301024"
                     /db_xref="RGD:1309378"
     exon            1..140
                     /gene="Scap"
                     /inference="alignment:Splign:2.1.0"
     exon            141..191
                     /gene="Scap"
                     /inference="alignment:Splign:2.1.0"
     exon            192..410
                     /gene="Scap"
                     /inference="alignment:Splign:2.1.0"
     CDS             289..4119
                     /gene="Scap"
                     /note="SREBP cleavage activating protein"
                     /codon_start=1
                     /product="sterol regulatory element-binding protein
                     cleavage-activating protein"
                     /protein_id="NP_001094436.1"
                     /db_xref="GeneID:301024"
                     /db_xref="RGD:1309378"
                     /translation="MTLTERLREKISQAFYNHGLLCASYPIPIILFTGLCILACCYPL
                     LKLPLPGTGPVEFSTPVKGYSPPPADSDHKQGEPSEQPEWYVGAPVAYIQQIFVKSSV
                     SPWHRNLLAVDVFRSPLSRAFQLVEEIRNHVLRDSSGTKSLEEVCLQVTDLLPGLRKL
                     RSLLPEHGCLLLSPGNFWQNDWERFHADPDIIGTIHQHEPKTLQTSATLKDLLFGVPG
                     KYSGVSLYTRKRMVSYTITLVFQRYHAKFLSSLRARLMLLHPSPNCSLRAENLVHVHF
                     KEEIGIAELIPLVTTYIILFAYIYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLC
                     TLFGLTPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSSESWSI
                     MKNVATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELA
                     DLNKRLPPESCLPSAKPVGRPARYERQLAVRPSTPHTITLQPSSFRNLRLPKRLRVIY
                     FLARTRLAQRLIMAGTVVWIGILVYTDPAGLRTYLAAQVTEQSPLGEGSLGPMPVPSG
                     VLPASHPDPAFSIFPPDAPKLPENQTLPGELPEHAVPAEGVQDSRAPEVTWGPEDEEL
                     WRKLSFRHWPTLFNYYNITLAKRYISLLPVIPVTLHLNPREALEGRHPQDGRTAWAPP
                     EPLPAGLWETGPKGPGGTQTHGDITLYKVAALGLAAGIVLVLLLLCLYRVLCPRNYGQ
                     PGGGAGRRRRGELPCDDYGYAPPETEIVPLVLRGHLMDIECLASDGMLLVSCCLAGQV
                     CVWDAQTGDCLTRIPRPGPRRDSCGGGAFEAQENWERLSDGGKASPEEPGDSPPLRRR
                     PRGPPPPSLFGDQPDLTCLIDTNFSVQLPPEPTQPEPRHRAGCGRSRDSGYDFSRLVQ
                     RVYQEEGLAAVHMSALRPPSPGPPLPQASQEEGTAPEKGSPPLAWAPSTAGSIWSLEL
                     QGSLIVVGRSSGRLEVWDAIEGVLCCSNEEISSGITALVFLDRRIVAARLNGSLDFFS
                     LETHTSLSPLQFRGTPGRGSSPSSPVYSSSNTVACHLTHTVPCAHQKPITALRAAAGR
                     LVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYIDQTMVLASGGQDGAICLWDVLT
                     GSRVSHTFAHRGDVTSLTCTTSCVISSGLDDFINIWDRSTGIKLYSIQQDLGCGASLG
                     VISDNLLVTGGQGCVSFWDLNYGDLLQTVYLGKNSEAQPARQILVLDNAAIVCNFGSE
                     LSLVYVPSVLEKLD"
     exon            411..540
                     /gene="Scap"
                     /inference="alignment:Splign:2.1.0"
     exon            541..698
                     /gene="Scap"
                     /inference="alignment:Splign:2.1.0"
     exon            699..919
                     /gene="Scap"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1025
                     /gene="Scap"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1198
                     /gene="Scap"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1325
                     /gene="Scap"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1438
                     /gene="Scap"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1533
                     /gene="Scap"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1632
                     /gene="Scap"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1851
                     /gene="Scap"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..2228
                     /gene="Scap"
                     /inference="alignment:Splign:2.1.0"
     exon            2229..2417
                     /gene="Scap"
                     /inference="alignment:Splign:2.1.0"
     exon            2418..2619
                     /gene="Scap"
                     /inference="alignment:Splign:2.1.0"
     exon            2620..2735
                     /gene="Scap"
                     /inference="alignment:Splign:2.1.0"
     exon            2736..3249
                     /gene="Scap"
                     /inference="alignment:Splign:2.1.0"
     exon            3250..3335
                     /gene="Scap"
                     /inference="alignment:Splign:2.1.0"
     exon            3336..3418
                     /gene="Scap"
                     /inference="alignment:Splign:2.1.0"
     exon            3419..3585
                     /gene="Scap"
                     /inference="alignment:Splign:2.1.0"
     exon            3586..3666
                     /gene="Scap"
                     /inference="alignment:Splign:2.1.0"
     exon            3667..3873
                     /gene="Scap"
                     /inference="alignment:Splign:2.1.0"
     exon            3874..4281
                     /gene="Scap"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaggggcgg ggagctgcgc gggcgccggg cggccgggag ggagagggcg ggctcgaaac
       61 accggatcgc gggccaggag cgcgcaggcc gctctccgcc gctccgtcgc cgccgcccgg
      121 gagctgcctc gccgccacag gcacctctcc cgtggttgga ggaaacgagg cattctagaa
      181 ggggatagca ggtacctgca gatgatgtgc attgtcattg gtatccagca tcttccaggc
      241 tgatccatgg tcactttccg ggatggcaac aaggtgactt agctgaggat gaccctgact
      301 gaaaggcttc gtgagaagat atctcaggcg ttctacaacc atgggctgct ctgcgcatcc
      361 taccccattc ccatcatcct cttcacagga ctctgcatcc tagcctgctg ctacccgctg
      421 ctgaagcttc ccttgcctgg aacgggaccc gtggaattct ccacgcctgt gaagggttac
      481 tcgcccccgc ctgcggactc tgaccacaaa caaggagagc ccagtgagca gccagagtgg
      541 tatgtgggtg cccccgtggc atacatccag cagatattcg tgaagtcatc agtgtctccc
      601 tggcacagaa accttctggc agtagatgtg ttccggtcac ctctgtcccg agcattccaa
      661 ctggtggaag agatccggaa ccatgtgctg agagacagct cagggaccaa gagcctggag
      721 gaagtttgcc tgcaggtgac agacctgctg ccaggcctca ggaaactccg gagcctactt
      781 cccgaacatg gctgcctgct gctgtcacct gggaacttct ggcagaatga ctgggaaaga
      841 ttccatgctg accctgacat cattggaacc atccatcagc atgagcctaa aaccctacag
      901 acatcagcca cactcaaaga cttgctgttc ggtgttcctg ggaagtacag tggggtcagc
      961 ctctacacga ggaagaggat ggtctcatac accatcaccc tggtcttcca gcgctaccat
     1021 gccaagtttc tgagcagcct ccgtgcccgg ctcatgcttc tgcaccccag ccccaactgc
     1081 agcctccgag cagagaacct ggtgcatgtg cacttcaaag aggagattgg cattgccgag
     1141 ctcatccccc tcgtgaccac ctacatcatc ctgtttgcct acatctactt ctccacacgc
     1201 aagatcgaca tggtcaagtc caagtggggc ctcgccctgg cagccgtggt cacagtgctt
     1261 agctcgctgc tcatgtctgt ggggctctgc actctcttcg gcctgacgcc cacactcaat
     1321 ggcggcgaga ttttcccata tctggtggtg gttattgggc tagagaatgt gttggtgctc
     1381 accaagtcag tggtatcaac tccagtggac cttgaggtga agcttcgaat tgcacaaggc
     1441 ttaagcagtg agagctggtc catcatgaag aacgtagcaa ctgaactggg catcatcctc
     1501 attggctact tcacccttgt gcctgccatc caagagttct gcctctttgc tgtggtgggc
     1561 ctggtgtctg acttcttcct ccagatgctg ttcttcacca ccgtgctgtc catcgacatt
     1621 cgccggatgg agctagcaga cctgaacaag cggctgcccc ctgagtcctg cctgccctca
     1681 gccaagcctg tggggaggcc agcccgatat gagagacagc tagctgtacg gccgtccaca
     1741 ccacacacca tcacattgca accatcttcc ttccgaaacc tgcggcttcc caaaaggctg
     1801 cgtgtcatct acttcctggc ccgcactcgc ctggcacagc gcctcatcat ggctggtaca
     1861 gttgtctgga ttggcatcct ggtatataca gacccggcag ggctgcgcac ctacctcgct
     1921 gcccaggtga cagaacagag cccactgggt gagggttccc tggggcccat gcctgtgcct
     1981 agtggagtgc tgcctgccag ccacccggac cctgccttct ccatcttccc acctgatgct
     2041 cctaaactgc cagagaacca gacgttgcca ggtgagctgc ctgagcatgc cgttccagca
     2101 gagggcgtcc aggacagccg agccccagag gtgacttggg ggcccgagga tgaggagctg
     2161 tggaggaaat tgtccttccg ccactggccc acactcttca actactataa tatcacactg
     2221 gccaaaaggt acatcagcct gctgcctgtc atccctgtca cactacacct gaatccacgg
     2281 gaggctctgg aggggcgaca ccctcaggat ggccgcactg cctgggcccc accagagcct
     2341 ttgcctgctg gcctgtggga gaccggacct aaggggccag gtggaacaca gacccatggc
     2401 gacattacct tgtacaaggt ggctgcactt ggcctggcag cgggcattgt cctagtgctg
     2461 ctgctgctct gcctctaccg ggtgctctgc ccgcgaaact acgggcagcc gggtggtggt
     2521 gcgggcaggc ggaggcgcgg agagctgcct tgcgatgact atggctacgc accgcctgag
     2581 acggagatag tgccgctggt gctgcgaggg cacctcatgg acatcgagtg tctggctagc
     2641 gatgggatgc tcctggtgag ctgctgcctg gctggccaag tctgcgtgtg ggatgcacag
     2701 accggggact gcctcactcg catcccgcgc cctgggccac gccgggacag ctgcggaggc
     2761 ggagcttttg aagctcagga gaactgggaa agactgtctg atgggggcaa agctagcccg
     2821 gaagagcctg gcgacagccc tccgctgcga cgccgccctc gagggcctcc accgccttcc
     2881 ctctttgggg accagccaga cctcacctgc ttaatcgaca ccaacttctc agtgcagctg
     2941 cccccagagc ccactcagcc cgagcctcgg caccgggcgg gctgtggccg ctctagagac
     3001 tctggttacg acttcagccg tctggtgcag cgtgtgtacc aagaggaagg cctggctgct
     3061 gtgcacatgt cggccctgcg cccaccctcc ccgggacctc ccctgcccca ggcctctcaa
     3121 gaagagggga ctgctcccga gaagggctcc ccccctctgg cctgggcccc cagcacagcc
     3181 ggttccatct ggagcttaga gttgcaaggc agtctcatcg tggttgggcg aagcagcggc
     3241 cggctggagg tgtgggatgc cattgagggc gtgctctgct gcagcaatga ggagatctcc
     3301 tcaggcatca cagcccttgt cttcttagac aggaggattg tagctgctcg gctcaacggt
     3361 tccctcgatt tcttttcctt ggagacccac acttccctca gccccctgca gttcagaggg
     3421 accccaggga gaggcagttc tccttcctcg cctgtgtaca gcagcagcaa cactgtggcc
     3481 tgtcacctga cccacacagt cccctgtgca caccagaaac ccatcacagc cctgagagca
     3541 gcagcggggc gcctggtgac agggagccaa gaccatactc tgagagtctt ccgactggag
     3601 gattcgtgtt gcctctttac cctgcagggc cactcggggg caatcacaac tgtgtacatt
     3661 gatcagacca tggtattggc cagtggagga caagatggag ccatctgcct gtgggatgta
     3721 ctaacaggca gccgggtcag ccatacattt gctcaccgtg gagatgtcac ctccctcacc
     3781 tgtaccactt cctgtgttat cagtagtggc ctggatgact tcatcaacat ctgggaccga
     3841 agcacaggca tcaagctgta ctccattcag caggacctgg gctgtggtgc aagcttgggt
     3901 gtcatctctg ataaccttct ggtgaccggc ggccagggat gtgtctcctt ttgggaccta
     3961 aactatgggg acctgttaca gacagtctac ttgggaaaga acagtgaagc ccagcctgcc
     4021 cggcagattt tggtgctgga caatgctgcc attgtctgca actttggcag tgagctcagc
     4081 ctagtgtatg tgccctctgt gctggagaaa ctggactgaa ggcaggtcaa ctgcactatg
     4141 cctttccccc atcccaaggt ggggcactgg ggattgcaac tctttggacc tagactggag
     4201 gcaataggta ggcatctttg cagctgactc agaactgttg tctcctgact gtaataataa
     4261 actttttttt aaaaaaccac a
//
