LOCUS       NM_031726               1147 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus secretory carrier membrane protein 5 (Scamp5),
            mRNA.
ACCESSION   NM_031726
VERSION     NM_031726.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1147)
  AUTHORS   Lee,U., Ryu,S.H. and Chang,S.
  TITLE     SCAMP5 mediates activity-dependent enhancement of NHE6 recruitment
            to synaptic vesicles during synaptic plasticity
  JOURNAL   Mol Brain 14 (1), 47 (2021)
   PUBMED   33663553
  REMARK    GeneRIF: SCAMP5 mediates activity-dependent enhancement of NHE6
            recruitment to synaptic vesicles during synaptic plasticity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1147)
  AUTHORS   Zhao,H., Kim,Y., Park,J., Park,D., Lee,S.E., Chang,I. and Chang,S.
  TITLE     SCAMP5 plays a critical role in synaptic vesicle endocytosis during
            high neuronal activity
  JOURNAL   J Neurosci 34 (30), 10085-10095 (2014)
   PUBMED   25057210
  REMARK    GeneRIF: Knockdown of SCAMP5 severely impairs synaptic vesicle
            endocytosis during stimulation.
REFERENCE   3  (bases 1 to 1147)
  AUTHORS   Noh,J.Y., Lee,H., Song,S., Kim,N.S., Im,W., Kim,M., Seo,H.,
            Chung,C.W., Chang,J.W., Ferrante,R.J., Yoo,Y.J., Ryu,H. and
            Jung,Y.K.
  TITLE     SCAMP5 links endoplasmic reticulum stress to the accumulation of
            expanded polyglutamine protein aggregates via endocytosis
            inhibition
  JOURNAL   J Biol Chem 284 (17), 11318-11325 (2009)
   PUBMED   19240033
  REMARK    GeneRIF: exposure to ER stress increases SCAMP5 in the striatum,
            which positively regulates mtHTT aggregation via the endocytosis
            pathway
REFERENCE   4  (bases 1 to 1147)
  AUTHORS   Han,C., Chen,T., Yang,M., Li,N., Liu,H. and Cao,X.
  TITLE     Human SCAMP5, a novel secretory carrier membrane protein,
            facilitates calcium-triggered cytokine secretion by interaction
            with SNARE machinery
  JOURNAL   J Immunol 182 (5), 2986-2996 (2009)
   PUBMED   19234194
REFERENCE   5  (bases 1 to 1147)
  AUTHORS   Liao,H., Zhang,J., Shestopal,S., Szabo,G., Castle,A. and Castle,D.
  TITLE     Nonredundant function of secretory carrier membrane protein
            isoforms in dense core vesicle exocytosis
  JOURNAL   Am J Physiol Cell Physiol 294 (3), C797-C809 (2008)
   PUBMED   18171723
  REMARK    GeneRIF: SCAMP isoforms regulate membrane fusion and dense core
            vesicle exocytosis in neurons.
REFERENCE   6  (bases 1 to 1147)
  AUTHORS   Lin,P.J., Williams,W.P., Luu,Y., Molday,R.S., Orlowski,J. and
            Numata,M.
  TITLE     Secretory carrier membrane proteins interact and regulate
            trafficking of the organellar (Na+,K+)/H+ exchanger NHE7
  JOURNAL   J Cell Sci 118 (Pt 9), 1885-1897 (2005)
   PUBMED   15840657
REFERENCE   7  (bases 1 to 1147)
  AUTHORS   Fernandez-Chacon,R. and Sudhof,T.C.
  TITLE     Novel SCAMPs lacking NPF repeats: ubiquitous and synaptic
            vesicle-specific forms implicate SCAMPs in multiple
            membrane-trafficking functions
  JOURNAL   J Neurosci 20 (21), 7941-7950 (2000)
   PUBMED   11050114
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            [WARNING] On Apr 15, 2024 this sequence was replaced by
            NM_031726.3.
            
            On Nov 26, 2020 this sequence version replaced NM_031726.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF240784.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMEA5760433 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-99                JAXUCZ010000008.1  66767843-66767941   c
            100-215             JAXUCZ010000008.1  66753179-66753294   c
            216-270             JAXUCZ010000008.1  66751040-66751094   c
            271-399             JAXUCZ010000008.1  66750045-66750173   c
            400-556             JAXUCZ010000008.1  66746093-66746249   c
            557-658             JAXUCZ010000008.1  66745057-66745158   c
            659-776             JAXUCZ010000008.1  66744578-66744695   c
            777-1147            JAXUCZ010000008.1  66742578-66742948   c
FEATURES             Location/Qualifiers
     source          1..1147
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..1147
                     /gene="Scamp5"
                     /note="secretory carrier membrane protein 5"
                     /db_xref="GeneID:65171"
                     /db_xref="RGD:68356"
     exon            1..99
                     /gene="Scamp5"
                     /inference="alignment:Splign:2.1.0"
     exon            100..215
                     /gene="Scamp5"
                     /inference="alignment:Splign:2.1.0"
     exon            216..270
                     /gene="Scamp5"
                     /inference="alignment:Splign:2.1.0"
     CDS             264..971
                     /gene="Scamp5"
                     /codon_start=1
                     /product="secretory carrier-associated membrane protein 5"
                     /protein_id="NP_113914.2"
                     /db_xref="GeneID:65171"
                     /db_xref="RGD:68356"
                     /translation="MAEKVNNFPPLPKFIPLKPCFYQDFEADIPPQHLSLTKRLYYLW
                     MLNSVTLAVNLVGCLAWLIGGGGATNFGLAFLWLILFTPCSYVCWFRPIYKAFKTDSS
                     FSFMAFFFTFMAQLVISIIQAVGIPGWGVCGWIATISFFGTNIGSAVVMLIPTVMFTV
                     VAVFSFIALSMVHKFYRGSGGSFSKAQEEWTTGAWKNPHVQQAAQNAAMGAAQGAMNQ
                     PQTQYSATPNYTYSNEM"
     exon            271..399
                     /gene="Scamp5"
                     /inference="alignment:Splign:2.1.0"
     exon            400..556
                     /gene="Scamp5"
                     /inference="alignment:Splign:2.1.0"
     exon            557..658
                     /gene="Scamp5"
                     /inference="alignment:Splign:2.1.0"
     exon            659..776
                     /gene="Scamp5"
                     /inference="alignment:Splign:2.1.0"
     exon            777..1147
                     /gene="Scamp5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagccgctc gcggccggct ccgcgcctga tcgcctggtg catcgcagct cagtgcagcg
       61 caacgcgact acctttctgc agctaagcgg tcggggctga gaacaaagtg ggtcttttgc
      121 cgcagaccac ccaggggagt gtgtcagcag agggaccaag gcttggattt caggtcgaga
      181 acggattcgg cgtgacagac agacacaaac tcgaggtcag gacaaagagt tgtgagcagg
      241 cttcctgagc tggctggtcc atcatggcag agaaagtgaa caacttccca ccattgccca
      301 aattcatccc cctgaagcca tgtttctacc aagacttcga ggcagacatc cctcctcagc
      361 atctcagctt aaccaagcgc ctctactacc tctggatgtt gaacagcgtc acgctggccg
      421 tgaacctggt gggctgtctc gcgtggctga tcggaggcgg gggagccacc aactttggcc
      481 tggcctttct ctggctcatc ctcttcacac cttgctccta cgtctgctgg tttcggccca
      541 tttacaaggc cttcaagaca gacagctcct tcagcttcat ggcattcttc ttcaccttca
      601 tggctcagct ggtcatcagc atcatccagg ctgtcgggat tccgggctgg ggtgtctgcg
      661 gctggatcgc caccatctcc ttcttcggga caaacatcgg ctcagcggtg gtgatgctca
      721 tccccacggt catgttcacg gttgtggccg tcttttcctt cattgccctt agcatggttc
      781 ataagttcta ccggggcagc gggggcagtt tcagcaaagc ccaggaggag tggaccaccg
      841 gagcgtggaa aaacccacac gtgcagcagg ctgcccagaa cgcagccatg ggggctgctc
      901 agggcgccat gaaccaaccg cagactcagt attctgccac tcccaattac acatactcca
      961 atgagatgtg agccagccaa gcccaccagg aggcagggct gggggccagt gggacagggg
     1021 gctcaagcca catcatctgt gtggtgacca agcagggttc ccccttccct tttctcctcc
     1081 ccaactttgt acaaagaatc agagttatat atatatatat atgtatacgt atatgtatat
     1141 gtctatc
//
