LOCUS       NM_023955               2355 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus secretory carrier membrane protein 2 (Scamp2),
            mRNA.
ACCESSION   NM_023955 XM_343399
VERSION     NM_023955.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2355)
  AUTHORS   Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M and
            Stoorvogel W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   2  (bases 1 to 2355)
  AUTHORS   Liao H, Zhang J, Shestopal S, Szabo G, Castle A and Castle D.
  TITLE     Nonredundant function of secretory carrier membrane protein
            isoforms in dense core vesicle exocytosis
  JOURNAL   Am J Physiol Cell Physiol 294 (3), C797-C809 (2008)
   PUBMED   18171723
  REMARK    GeneRIF: SCAMP isoforms regulate membrane fusion and dense core
            vesicle exocytosis in neurons.
REFERENCE   3  (bases 1 to 2355)
  AUTHORS   Muller HK, Wiborg O and Haase J.
  TITLE     Subcellular redistribution of the serotonin transporter by
            secretory carrier membrane protein 2
  JOURNAL   J Biol Chem 281 (39), 28901-28909 (2006)
   PUBMED   16870614
  REMARK    GeneRIF: SCAMP2 plays an important role in the regulation of the
            subcellular distribution of SERT
REFERENCE   4  (bases 1 to 2355)
  AUTHORS   Liu L, Liao H, Castle A, Zhang J, Casanova J, Szabo G and Castle D.
  TITLE     SCAMP2 interacts with Arf6 and phospholipase D1 and links their
            function to exocytotic fusion pore formation in PC12 cells
  JOURNAL   Mol Biol Cell 16 (10), 4463-4472 (2005)
   PUBMED   16030257
  REMARK    GeneRIF: SCAMP2 couples Arf6-stimulated PLD activity to exocytosis
            and links this process to formation of fusion pores.
REFERENCE   5  (bases 1 to 2355)
  AUTHORS   Lin PJ, Williams WP, Luu Y, Molday RS, Orlowski J and Numata M.
  TITLE     Secretory carrier membrane proteins interact and regulate
            trafficking of the organellar (Na+,K+)/H+ exchanger NHE7
  JOURNAL   J Cell Sci 118 (Pt 9), 1885-1897 (2005)
   PUBMED   15840657
REFERENCE   6  (bases 1 to 2355)
  AUTHORS   Larkin JM, Coleman H, Espinosa A, Levenson A, Park MS, Woo B,
            Zervoudakis A and Tinh V.
  TITLE     Intracellular accumulation of pIgA-R and regulators of transcytotic
            trafficking in cholestatic rat hepatocytes
  JOURNAL   Hepatology 38 (5), 1199-1209 (2003)
   PUBMED   14578858
REFERENCE   7  (bases 1 to 2355)
  AUTHORS   Liu L, Guo Z, Tieu Q, Castle A and Castle D.
  TITLE     Role of secretory carrier membrane protein SCAMP2 in granule
            exocytosis
  JOURNAL   Mol Biol Cell 13 (12), 4266-4278 (2002)
   PUBMED   12475951
  REMARK    GeneRIF: SCAMP2 not only colocalizes with fusion sites but also
            appears to have an essential function in granule exocytosis through
            actions mediated by its E peptide-containing domain
REFERENCE   8  (bases 1 to 2355)
  AUTHORS   Guo Z, Liu L, Cafiso D and Castle D.
  TITLE     Perturbation of a very late step of regulated exocytosis by a
            secretory carrier membrane protein (SCAMP2)-derived peptide
  JOURNAL   J Biol Chem 277 (38), 35357-35363 (2002)
   PUBMED   12124380
  REMARK    GeneRIF: role in perturbation of a very late step of regulated
            exocytosis
REFERENCE   9  (bases 1 to 2355)
  AUTHORS   Fernandez-Chacon R and Sudhof TC.
  TITLE     Novel SCAMPs lacking NPF repeats: ubiquitous and synaptic
            vesicle-specific forms implicate SCAMPs in multiple
            membrane-trafficking functions
  JOURNAL   J Neurosci 20 (21), 7941-7950 (2000)
   PUBMED   11050114
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085862.1.
            
            On Nov 22, 2004 this sequence version replaced XM_343399.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085862.1, SRR8487227.42565.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2355
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..2355
                     /gene="Scamp2"
                     /note="secretory carrier membrane protein 2"
                     /db_xref="GeneID:65168"
                     /db_xref="RGD:68348"
     exon            1..153
                     /gene="Scamp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..1086
                     /gene="Scamp2"
                     /codon_start=1
                     /product="secretory carrier-associated membrane protein 2"
                     /protein_id="NP_076445.1"
                     /db_xref="GeneID:65168"
                     /db_xref="RGD:68348"
                     /translation="MSAFDTNPFADPVDVNPFQDPSVTQLTSAPQSGLAEFNPFSETN
                     AATTVPVTQLPGPSQPAVLQPSVEPAQPSPQAVAAAAQAGLLRQQEELDRKAAELERK
                     ERELQNTAANLHVRENNWPPLPSWCPVKPCFYQDFSTEIPADYQRICKMLYYLWMLHS
                     VTLFLNLLACLAWFTSDAANGTAFGLSILWFLIFTPCAFLCWYRPIYKAFRSDNSFSF
                     FVFFFVFFCQIGIYFIQLIGLPNLGTSGWLAALSTVNKGPLAVTIIMMVVAGFFTLCA
                     GLSLFLLQRVHAFYRRTGASFQQAQEEFSQGIFSSRTFRTAASSAARGTFQGN"
     exon            154..222
                     /gene="Scamp2"
                     /inference="alignment:Splign:2.1.0"
     exon            223..321
                     /gene="Scamp2"
                     /inference="alignment:Splign:2.1.0"
     exon            322..439
                     /gene="Scamp2"
                     /inference="alignment:Splign:2.1.0"
     exon            440..568
                     /gene="Scamp2"
                     /inference="alignment:Splign:2.1.0"
     exon            569..728
                     /gene="Scamp2"
                     /inference="alignment:Splign:2.1.0"
     exon            729..830
                     /gene="Scamp2"
                     /inference="alignment:Splign:2.1.0"
     exon            831..951
                     /gene="Scamp2"
                     /inference="alignment:Splign:2.1.0"
     exon            952..2331
                     /gene="Scamp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctcccggaa gtggagggtt tacactgagt gccgctgggt ctgagtgacc gaaggcagta
       61 gcgttcgcgg agatcgcccg ctggccctcg atcaccatgt cggccttcga cactaacccc
      121 ttcgcggacc cagtggatgt aaaccccttc caggatcctt ctgtgaccca gctgaccagt
      181 gctcctcaga gtggcctggc tgagttcaat cccttctcag agacaaatgc agcgacaaca
      241 gttcctgtca cacaacttcc tgggccctcc cagccagcag ttctccagcc ctcagtggag
      301 ccagcacagc catcgcccca ggctgttgcg gctgcagccc aggcaggcct gcttcggcag
      361 caggaagagt tagacaggaa agctgctgag ctggaacgca aggagcgaga gttgcagaac
      421 actgcggcga atttgcatgt aagagaaaac aactggccgc cactcccctc atggtgccct
      481 gtgaaaccct gcttctatca ggacttctcc acggagatcc ctgccgacta ccagcggata
      541 tgcaagatgc tttactatct gtggatgttg cattcagtga ctctgtttct aaacctgctt
      601 gcatgcctgg cctggttcac aagtgacgca gctaatggaa cagcctttgg cctctccatc
      661 ctttggtttc tgattttcac gccctgtgcc ttcctttgtt ggtaccgacc catctacaag
      721 gctttcaggt ctgacaactc tttcagcttc ttcgtgttct tttttgtatt tttttgtcaa
      781 ataggaatct acttcatcca gttgattggc ttgcctaact tggggaccag tggttggctc
      841 gcagccctct ctacagtgaa taaggggccc ttagctgtga ccatcatcat gatggtagtg
      901 gctggcttct ttaccctctg tgctgggctc tcactcttcc tcctgcagcg ggtccatgcc
      961 ttctaccgcc gaacaggagc cagcttccag caggctcagg aagaattctc ccagggcatc
     1021 ttcagcagca gaaccttccg cactgctgcc tcgtctgctg cccgaggaac cttccagggg
     1081 aattagtctt cctgactctc cttccctcag ccctggcctc tgtcacctgc cttctgagct
     1141 gcactttcca tgggtgcctt agcagtggct gtgcccagca cagaccaggc agggattcgt
     1201 cttgtccctg cactttcctc agtagtcagc tttctcttct acaggaggga aggacaggaa
     1261 gggacaagga cttttttttt taacacatgg gaaaagaaaa aaataacaaa gctgtctttc
     1321 cttttctaac ggtggtttgg taggattttg tctggaagca atgggcctgc ttttcctgaa
     1381 aacaaatgga ctcatgggta tgggatcatg ggccagcctg ggctcactgt accagggatt
     1441 tcccacaggc actttgcatt cctccctcta taggcttcat ctgtactggg gcctccacag
     1501 tcttgccttt catgcttggg cttcatgagc ctccccaggg ctacactcta ggtgaactgt
     1561 gtactgggtg ggtgcacaga agtttcccag attatcttcg ggggtcttca ggtgttcacg
     1621 atagtcacga ccctgtgcct gcttcgactc atggtgtgac cgcaccttgt gtcctcgggg
     1681 ccttccctag cccctcttca gacttctgaa tgtatagtga gtggggttgg ttgggacttg
     1741 gggatgggga gggactgagg acaagtcaat caagtcctgc ccagcctcta gcagtcttct
     1801 gagagggtag gtgtctgctg acctgtttgt tgtggcttct ctcctcccaa gggactctgc
     1861 ccctccgcct taccctggcc cctgcccatc ttcagcaata ctcacctctt acaactctta
     1921 gggtggtttg gaggaaatca gtcctgaact atgtcctgca ggcaggactg ctgagccttc
     1981 tttctgaggg ttcttcccac accctcagtg gagtctaggt tcctatccac tcatcttggg
     2041 gtgctccaca ggtgtcactg cagtggcact taggaagcca ctgtgagaac ctggaccctg
     2101 tgctttgtga gtgttgtaag cactcgccaa gctggccagc ctcctgcctc tgggaactgg
     2161 ggccctcctg aggctaccct catgctgtca gcccatttag ccctagagcc accaaatggt
     2221 aatgacagcc acaagggttt tgtaaactct ctggtattat tttcctccat gtacaaatgt
     2281 atatgtcttg tctcaatttt tgtgctttaa taaaaagatt ttcggacagc aaaaaaaaaa
     2341 aaaaaaaaaa aaaaa
//
