LOCUS       NM_001100636            3651 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus secretory carrier membrane protein 1 (Scamp1),
            mRNA.
ACCESSION   NM_001100636 XM_001059581 XM_001059643 XM_001059698 XM_342174
VERSION     NM_001100636.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3651)
  AUTHORS   Wilhelm,B.G., Mandad,S., Truckenbrodt,S., Krohnert,K., Schafer,C.,
            Rammner,B., Koo,S.J., Classen,G.A., Krauss,M., Haucke,V., Urlaub,H.
            and Rizzoli,S.O.
  TITLE     Composition of isolated synaptic boutons reveals the amounts of
            vesicle trafficking proteins
  JOURNAL   Science 344 (6187), 1023-1028 (2014)
   PUBMED   24876496
REFERENCE   2  (bases 1 to 3651)
  AUTHORS   Zhang,J. and Castle,D.
  TITLE     Regulation of fusion pore closure and compound exocytosis in
            neuroendocrine PC12 cells by SCAMP1
  JOURNAL   Traffic 12 (5), 600-614 (2011)
   PUBMED   21272170
  REMARK    GeneRIF: Data suggest that SCAMP1's apparent dual role in
            facilitating dilation and closure of fusion pores implicates its
            function in exo-endocytic coupling and in the regulation of partial
            secretion.
REFERENCE   3  (bases 1 to 3651)
  AUTHORS   Felkl,M. and Leube,R.E.
  TITLE     Interaction assays in yeast and cultured cells confirm known and
            identify novel partners of the synaptic vesicle protein
            synaptophysin
  JOURNAL   Neuroscience 156 (2), 344-352 (2008)
   PUBMED   18706977
REFERENCE   4  (bases 1 to 3651)
  AUTHORS   Liao,H., Zhang,J., Shestopal,S., Szabo,G., Castle,A. and Castle,D.
  TITLE     Nonredundant function of secretory carrier membrane protein
            isoforms in dense core vesicle exocytosis
  JOURNAL   Am J Physiol Cell Physiol 294 (3), C797-C809 (2008)
   PUBMED   18171723
  REMARK    GeneRIF: SCAMP isoforms regulate membrane fusion and dense core
            vesicle exocytosis in neurons.
REFERENCE   5  (bases 1 to 3651)
  AUTHORS   Castle,A. and Castle,D.
  TITLE     Ubiquitously expressed secretory carrier membrane proteins (SCAMPs)
            1-4 mark different pathways and exhibit limited constitutive
            trafficking to and from the cell surface
  JOURNAL   J Cell Sci 118 (Pt 16), 3769-3780 (2005)
   PUBMED   16105885
  REMARK    GeneRIF: SCAMPs travel between the cell surface and internal
            recycling systems, and form a mosaic with individual isoforms
            marking distinct pathways and functioning as trafficking machinery
            at sites of vesicle formation and fusion.
REFERENCE   6  (bases 1 to 3651)
  AUTHORS   Fernandez-Chacon,R. and Sudhof,T.C.
  TITLE     Novel SCAMPs lacking NPF repeats: ubiquitous and synaptic
            vesicle-specific forms implicate SCAMPs in multiple
            membrane-trafficking functions
  JOURNAL   J Neurosci 20 (21), 7941-7950 (2000)
   PUBMED   11050114
REFERENCE   7  (bases 1 to 3651)
  AUTHORS   Antonin,W., Riedel,D. and von Mollard,G.F.
  TITLE     The SNARE Vti1a-beta is localized to small synaptic vesicles and
            participates in a novel SNARE complex
  JOURNAL   J Neurosci 20 (15), 5724-5732 (2000)
   PUBMED   10908612
REFERENCE   8  (bases 1 to 3651)
  AUTHORS   Fernandez-Chacon,R., Achiriloaie,M., Janz,R., Albanesi,J.P. and
            Sudhof,T.C.
  TITLE     SCAMP1 function in endocytosis
  JOURNAL   J Biol Chem 275 (17), 12752-12756 (2000)
   PUBMED   10777571
REFERENCE   9  (bases 1 to 3651)
  AUTHORS   Fernandez-Chacon,R., Alvarez de Toledo,G., Hammer,R.E. and
            Sudhof,T.C.
  TITLE     Analysis of SCAMP1 function in secretory vesicle exocytosis by
            means of gene targeting in mice
  JOURNAL   J Biol Chem 274 (46), 32551-32554 (1999)
   PUBMED   10551807
REFERENCE   10 (bases 1 to 3651)
  AUTHORS   Brand,S.H. and Castle,J.D.
  TITLE     SCAMP 37, a new marker within the general cell surface recycling
            system
  JOURNAL   EMBO J 12 (10), 3753-3761 (1993)
   PUBMED   8404846
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB740599.1, L22079.1 and BC090322.1.
            
            On or before Oct 28, 2007 this sequence version replaced
            XM_342174.3, XM_001059643.1, XM_001059698.1, XM_001059581.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L22079.1, SRR8487230.78069.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                CB740599.1         54-133
            81-333              L22079.1           1-253
            334-3651            BC090322.1         1-3318
FEATURES             Location/Qualifiers
     source          1..3651
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q12"
     gene            1..3651
                     /gene="Scamp1"
                     /note="secretory carrier membrane protein 1"
                     /db_xref="GeneID:29521"
                     /db_xref="RGD:3625"
     exon            1..166
                     /gene="Scamp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..1126
                     /gene="Scamp1"
                     /note="SCAMP 37"
                     /codon_start=1
                     /product="secretory carrier-associated membrane protein 1"
                     /protein_id="NP_001094106.1"
                     /db_xref="GeneID:29521"
                     /db_xref="RGD:3625"
                     /translation="MSDFDSNPFADPDLNNPFKDPSVTQVTRNVPPGLDEYNPFSDSR
                     TPPPGGVKMPNVPNTQPAIMKPTEEHPAYTQITKEHALAQAELLKRQEELERKAAELD
                     RREREMQNLSQHGRKNNWPPLPSNFPVGPCFYQDFSVDIPVEFQKTVKLMYYLWMFHA
                     VTLFLNIFGCLAWFCVDSSRAVDFGLSILWFLLFTPCSFVCWYRPLYGAFRSDSSFRF
                     FVFFFVYICQFAVHVLQAAGFHNWGNCGWISSLTGLNKNIPVGIMMIIIAALFTASAV
                     ISLVMFKKVHGLYRTTGASFEKAQQEFATGVMSNKTVQTAAANAASTAATSAAQNAFK
                     GNQM"
     exon            167..244
                     /gene="Scamp1"
                     /inference="alignment:Splign:2.1.0"
     exon            245..343
                     /gene="Scamp1"
                     /inference="alignment:Splign:2.1.0"
     exon            344..452
                     /gene="Scamp1"
                     /inference="alignment:Splign:2.1.0"
     exon            453..581
                     /gene="Scamp1"
                     /inference="alignment:Splign:2.1.0"
     exon            582..741
                     /gene="Scamp1"
                     /inference="alignment:Splign:2.1.0"
     exon            742..843
                     /gene="Scamp1"
                     /inference="alignment:Splign:2.1.0"
     exon            844..961
                     /gene="Scamp1"
                     /inference="alignment:Splign:2.1.0"
     exon            962..3622
                     /gene="Scamp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggatctgt gcggcggcgg cggcgacgtg agcgcgcagg ggggcggcgg cctcgcctcg
       61 tctgtgtctc ggcgccgggc tcgggtgggt gacgcgcagt gccggggcaa tgtcggattt
      121 tgacagcaac ccctttgcgg atccggatct caacaacccg ttcaaggacc catctgtcac
      181 acaggtgaca agaaatgtgc caccgggact tgatgaatat aatcctttct ctgattctag
      241 aacgcctcca ccaggtggtg tgaaaatgcc taatgtaccc aacacccagc cagcaataat
      301 gaagccgacc gaggagcatc cggcttacac acagatcaca aaggagcatg ccttggctca
      361 agccgagctt ctcaagcgcc aagaggagct ggagagaaaa gctgcagagt tagatcgtcg
      421 agagcgagag atgcagaacc tgagtcagca cgggagaaaa aataattggc cacctcttcc
      481 tagcaatttc cctgtggggc cttgtttcta tcaagacttt tctgtagaca ttcccgtaga
      541 gttccagaag acagtgaagc ttatgtacta cctatggatg ttccatgcgg taaccctgtt
      601 cctgaacatc ttcggatgcc tggcttggtt ttgtgttgat tcctcaagag cagttgactt
      661 tggactcagc atcctgtggt tcttgctctt taccccctgt tcatttgtct gttggtacag
      721 gccactctat ggggccttca ggagtgacag ttccttcagg ttctttgtgt tcttcttcgt
      781 ctatatttgt cagtttgctg tacatgtgct ccaggctgca ggatttcata actggggaaa
      841 ctgtggttgg atctcatccc tcactggtct caacaagaac attccggtcg ggatcatgat
      901 gatcatcatc gcagcgctct ttacagcgtc cgctgtcatc tcgctcgtca tgtttaaaaa
      961 agtgcatgga ctgtatcgca caacaggtgc tagctttgag aaggcccagc aagagtttgc
     1021 aacgggagtg atgtccaata aaactgttca gacagcagct gcaaatgccg cgtccaccgc
     1081 agcaaccagc gcggcgcaga atgccttcaa gggtaaccag atgtagcgag cctcctcaga
     1141 gcggttctcc attcccttat gactgtgttt ttttctccag ttactgtatt ctacagatat
     1201 ttttatgttg gaaacacaca gtacataaag catgggtatt tcctatccac atgtgcatgg
     1261 tctaaaaacc agagaaactt cctagtctta ttactttgcc taatagtttc ttactatttc
     1321 catgcccctc acagaagaaa actatcatct gcaaaacaaa tattctccat atttttgggg
     1381 gatggtgttc ctcagattat ttcagtggtg acacactgaa atgagtatgt tactgaagat
     1441 ttaaaaggca ctcgatgcta gccacagaag ctcttccaag aggcagtaga gacacagatt
     1501 atacattgca aatgaaacaa cctttgtccc cccccccccc atattagttt ggaaggaaca
     1561 aggtcagcca aggcttgcgg tgttttgaaa ttggcttgct ttatatgcgg ttcagtcagc
     1621 agagaggagc ctgcgtgctc tgtagtagat aatgtatatt ttaccttctt ttattttatt
     1681 tttagactag ttgatatttt gataacaatc tctgatcttg catgggcacc acatctctta
     1741 agtgaaatga attagtattt tgggttctgt actgctatag ttgtaggacc tggggctctt
     1801 tatagaatca gaaatgattt tctgtaatag tttcttttaa gtaaaaattt actggagtat
     1861 aaagacttta atataatgtg cagtgcatta tccaaaagag aggacagtga attgatgagc
     1921 tagtatatag tgataatttc ttttcccctc ctaatttcca gtattcatag agtaaaatgt
     1981 tactgtatgg aactctggtg tattcttctg gctgatcttt ttaattgaac tgggattcgt
     2041 gtttgtagct ctgtgtgggt gtgtgtgtgg gcgtgcgtgt gtgtacgtgt atgtatgtgt
     2101 gtgtgagaga ggggtggaga ttttgacaca ggtgttaaag gctcgcctaa cccttgaata
     2161 aaaagaacac acagtatttg agggatttct ctttcagcct cccactttta gttgcattaa
     2221 aaataaaaga cccttgtgct tctaatgtcc ttggtttctt aatgtacctg tcttctactt
     2281 ttaagacaga ctaaattcat gtgaaacatt gcaccaagca ggggagtgaa acttcaggca
     2341 ctgtgatcat tattgatgtc atcaaattaa catggctgtg atgagcgcac acgatgtggg
     2401 ttcagacttc tgatcatgat gatgattagg tgtctcagga gcgtctgtca ggcagcctgt
     2461 tgtagaagcc tcactggctt tagattgcag aacgctagac tcacccaagc caactttaaa
     2521 tagaggtgga ctgttgaatg cagggcatcc tttcaaaatg aactgaactg gtcgagtcac
     2581 gttatcctct cccaaggctg cagtcagagg gacttgtgtg cagagctggg gtgcagttct
     2641 tggaggtcgg tgggtgctgg gttacacatc cccccatgca gggccacggt aggtttgctt
     2701 gggaattgac tgagtacagt agttcaaaga gctttctttg actcaggaag atggagaact
     2761 cagaaatgaa tttggagttg tgttttagct ccttccaatc agtgaggatc ccctccctcc
     2821 tcaactgccc aggcgttgct gctgcgagcc gtgctcggtc cagtgtggct ttaatggaca
     2881 cggagaccgt taagactgta aaagtgcacg taaacactgg tacttctagt tcaagtccac
     2941 ctttattcct ctctgaggta cagataagag acacatcaga gattcaaaac atgctaatag
     3001 ttttttctaa attggtccct ctccattatg tggaggtccc caaaggtagt gttatcgaat
     3061 gacagagaat agttgtaact cacattatgt ttctgtatga agaacaaaaa agctgttttc
     3121 aatccaattg tttggattct tacaagtttg aaagattatg ttgtgtgaaa acacagggga
     3181 gcattgaagg gatggtggag tctgcagctc agtcaggcag gagcagctcg agacctcctc
     3241 tgctctcctc tcagccacag tctgtcagca atgcactttg gtttcctatt tgataccaat
     3301 gtcaccgcag ccatgaggcg agcatccacg tgacctttca gtttgcaata ttaaatggtg
     3361 actattttat ttaaaactag ggtctgatca ctggaaaatg actgcctggt gacttgtgac
     3421 tcggggcttg gttcattgct ctagggacgt ttgtgtattc tgtaggtgcg tgcactcctg
     3481 cgctgccctg tggtgtgtca cggctctgtg tgaacgccct ccacgtggcc ctctcatgtt
     3541 gcatgttttc agtggtttgg aagttttgta tatttattgt attaaatgca gagtgtcata
     3601 aaataaaata atgtttactg gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
