LOCUS       NM_001399482            1433 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus somatomedin B and thrombospondin, type 1 domain
            containing (Sbspon), mRNA.
ACCESSION   NM_001399482 XM_216317
VERSION     NM_001399482.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1433)
  AUTHORS   Barallobre-Barreiro,J., Gupta,S.K., Zoccarato,A.,
            Kitazume-Taneike,R., Fava,M., Yin,X., Werner,T., Hirt,M.N.,
            Zampetaki,A., Viviano,A., Chong,M., Bern,M., Kourliouros,A.,
            Domenech,N., Willeit,P., Shah,A.M., Jahangiri,M., Schaefer,L.,
            Fischer,J.W., Iozzo,R.V., Viner,R., Thum,T., Heineke,J.,
            Kichler,A., Otsu,K. and Mayr,M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   2  (bases 1 to 1433)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   3  (bases 1 to 1433)
  AUTHORS   Didangelos,A., Yin,X., Mandal,K., Baumert,M., Jahangiri,M. and
            Mayr,M.
  TITLE     Proteomics characterization of extracellular space components in
            the human aorta
  JOURNAL   Mol Cell Proteomics 9 (9), 2048-2062 (2010)
   PUBMED   20551380
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Jan 10, 2022 this sequence version replaced XM_216317.10.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DN948097.1, DN937489.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-281               JAXUCZ010000005.1  8186004-8186284
            282-476             JAXUCZ010000005.1  8197827-8198021
            477-567             JAXUCZ010000005.1  8208679-8208769
            568-744             JAXUCZ010000005.1  8210354-8210530
            745-1433            JAXUCZ010000005.1  8215888-8216576
FEATURES             Location/Qualifiers
     source          1..1433
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q11"
     gene            1..1433
                     /gene="Sbspon"
                     /gene_synonym="RGD1559717; Rpesp"
                     /note="somatomedin B and thrombospondin, type 1 domain
                     containing"
                     /db_xref="GeneID:297757"
                     /db_xref="RGD:1559717"
     exon            1..281
                     /gene="Sbspon"
                     /gene_synonym="RGD1559717; Rpesp"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..862
                     /gene="Sbspon"
                     /gene_synonym="RGD1559717; Rpesp"
                     /note="RPE-spondin"
                     /codon_start=1
                     /product="somatomedin-B and thrombospondin type-1
                     domain-containing protein precursor"
                     /protein_id="NP_001386411.1"
                     /db_xref="GeneID:297757"
                     /db_xref="RGD:1559717"
                     /translation="MRTLWMVLCALARLWPGALAGCAEAGRCCPGRDPACFARGWRLD
                     RVYGTCFCDQACRLTGDCCFDYDRACPARPCFVGEWSPWSGCAGQCQPTMRVRRRSVH
                     QEPLNGGAPCPPLEERAGCLEYSSSQGQDCGHSFVPAFITSSAFNKKRIVQAVSPQWP
                     THTEDAGYCMEFKTESLTAHCALDSRPLTRWMQYLREGYTVCVDCQPPAMNSVSLRCS
                     GDGLDSDGNQTLRWQAIGNPRCQGTWKKVRRAEQCSCPDVHRFIFI"
     exon            282..476
                     /gene="Sbspon"
                     /gene_synonym="RGD1559717; Rpesp"
                     /inference="alignment:Splign:2.1.0"
     exon            477..567
                     /gene="Sbspon"
                     /gene_synonym="RGD1559717; Rpesp"
                     /inference="alignment:Splign:2.1.0"
     exon            568..744
                     /gene="Sbspon"
                     /gene_synonym="RGD1559717; Rpesp"
                     /inference="alignment:Splign:2.1.0"
     exon            745..1433
                     /gene="Sbspon"
                     /gene_synonym="RGD1559717; Rpesp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaggagcag agcgctcgcc cgaggctctg gctgggttgg ctcgcaggtg tggccgcagc
       61 tctggccatg aggaccctgt ggatggtgct gtgcgctctg gcgcggctgt ggcccggggc
      121 cctggctggc tgcgcagagg cgggccgctg ctgtcctggt cgggacccag cctgcttcgc
      181 ccgtggctgg agactggaca gagtctatgg aacttgcttc tgcgatcaag cctgccgtct
      241 caccggggac tgctgcttcg actatgacag ggcgtgccca gctcgccctt gctttgtggg
      301 agaatggagt ccctggagtg gctgcgcagg tcagtgccag cccaccatgc gtgtgcgcag
      361 gcgttcggtc catcaggagc cactgaatgg aggggcgccc tgcccacccc tggaagagag
      421 agccggctgc ctggagtact cctcgtcaca aggccaggat tgcgggcact cctttgttcc
      481 tgccttcata actagctctg ccttcaacaa gaagaggata gtacaagctg tatctccaca
      541 gtggcctaca catactgagg atgctggata ctgtatggag ttcaagactg aatccttgac
      601 tgcccactgt gctctggaca gccgtccgct gactcggtgg atgcagtacc tccgtgaggg
      661 atacacagtg tgtgtggact gccagcctcc agctatgaac tccgtgagcc tgcgctgctc
      721 tggagatggt ctggactctg atggaaatca gactcttcgc tggcaagcca tcgggaatcc
      781 tcgatgccaa ggaacctgga aaaaagtgcg tcgggcagag cagtgctcat gtccagatgt
      841 gcaccgattc atttttatat agagcacctg ggagctactt cggagcacgc atgtgaatgg
      901 gctgagtatc gacaagataa gttccaagct tcagaggcct ccaaaagctg cactaaggac
      961 caggacactt gccattgcta cactttgcca ccaagaaaga aaacttgggg atggttctca
     1021 agatagacca cagtctcttt gcttttattt ttaatgagtt aagtacccat agtaaaagct
     1081 cctgtgactt atagattttg accttacatt tggtctgtac tagaatcact accatgtgct
     1141 ccagttctct ctctctctct ctctctctcc ctccctccct cccgctttta aaatttaaag
     1201 acaggttctc attctatagc ctggggctca ctatgcagac atctgcctgc ctctgcctcc
     1261 tgaatgttgt gactgaaggt gtgtgccacc atgcactgct attctgtgtc tattgttttg
     1321 ggtggggggg catggcaaga cagggtttct ttgtgtagcc tttgccatcc tgaaacttgt
     1381 tcagtagatc aggctggcat caaactcaga gatctgccta tttctgcctc cca
//
