LOCUS       NM_001108068            4826 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus strawberry notch homolog 2 (Sbno2), mRNA.
ACCESSION   NM_001108068 XM_001073102 XM_001073135 XM_234899
VERSION     NM_001108068.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4826)
  AUTHORS   Grill,M., Syme,T.E., Nocon,A.L., Lu,A.Z., Hancock,D., Rose-John,S.
            and Campbell,I.L.
  TITLE     Strawberry notch homolog 2 is a novel inflammatory response factor
            predominantly but not exclusively expressed by astrocytes in the
            central nervous system
  JOURNAL   Glia 63 (10), 1738-1752 (2015)
   PUBMED   25903009
REFERENCE   2  (bases 1 to 4826)
  AUTHORS   Maruyama,K., Uematsu,S., Kondo,T., Takeuchi,O., Martino,M.M.,
            Kawasaki,T. and Akira,S.
  TITLE     Strawberry notch homologue 2 regulates osteoclast fusion by
            enhancing the expression of DC-STAMP
  JOURNAL   J Exp Med 210 (10), 1947-1960 (2013)
   PUBMED   23980096
REFERENCE   3  (bases 1 to 4826)
  AUTHORS   El Kasmi,K.C., Smith,A.M., Williams,L., Neale,G., Panopoulos,A.D.,
            Watowich,S.S., Hacker,H., Foxwell,B.M. and Murray,P.J.
  TITLE     Cutting edge: A transcriptional repressor and corepressor induced
            by the STAT3-regulated anti-inflammatory signaling pathway
  JOURNAL   J Immunol 179 (11), 7215-7219 (2007)
   PUBMED   18025162
  REMARK    Erratum:[J Immunol. 2008 Mar 1;180(5):3612. Panopolous, Athanasia
            [corrected to Panopoulos, Athanasia D]]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474029.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_234899.4, XM_001073102.1, XM_001073135.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760393,
                              SAMEA5760494 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..4826
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..4826
                     /gene="Sbno2"
                     /gene_synonym="RGD1307194; Stno"
                     /note="strawberry notch homolog 2"
                     /db_xref="GeneID:314619"
                     /db_xref="RGD:1307194"
     exon            1..93
                     /gene="Sbno2"
                     /gene_synonym="RGD1307194; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            94..266
                     /gene="Sbno2"
                     /gene_synonym="RGD1307194; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            267..340
                     /gene="Sbno2"
                     /gene_synonym="RGD1307194; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            341..452
                     /gene="Sbno2"
                     /gene_synonym="RGD1307194; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            453..621
                     /gene="Sbno2"
                     /gene_synonym="RGD1307194; Stno"
                     /inference="alignment:Splign:2.1.0"
     CDS             556..4410
                     /gene="Sbno2"
                     /gene_synonym="RGD1307194; Stno"
                     /codon_start=1
                     /product="protein strawberry notch homolog 2"
                     /protein_id="NP_001101538.1"
                     /db_xref="GeneID:314619"
                     /db_xref="RGD:1307194"
                     /translation="MALLGDQNSFTVPCGIPTLGVQDPSCLEDLSNASVFSSSVDSLS
                     DIPDTPDFLPADSLNEVPTIWDVSTTSTTRDKLFLPSVPFSALEDPVTAVSSTPLLVS
                     YQSHSQPEEEEGEDEEEAEELGHAETYADYVPSKSKIGKQHPDRVVETSTLSSVPPPD
                     ITYTLALPTSDNGTLSALQLEAITYACQQHEVLLPSGQRAGFLIGDGAGVGKGRTVAG
                     IIVENYLRGRKKALWFSASNDLKYDAERDLRDIEAPGIAVHALSKIKYGDNTTSEGVL
                     FATYSALIGESQAGGQHRTRLRQILQWCGEAFDGVIVFDECHKAKNASSTKMGKAVLD
                     LQNKLPQARVVYASATGASEPRNMIYMSRLGIWGEGTPFRTFEEFLHAIEKRGVGAME
                     IVAMDMKVSGMYIARQLSFSGVTFRIEEIPLSPVFEQVYNRAARLWAEALSVFQQAAD
                     WIGLESRKSLWGQFWSAHQRFFKYLCIAAKVHRLVELAQQELSRDKCVVIGLQSTGEA
                     RTREVLDENEGRLDCFVSAAEGVFLSLIQKHFPSTRRRRDRGGGKRKRRPRGRGPKAS
                     RLTLEAAGVIRISDGSSTESDAGLDSDFNSSPESLVDDDVVIVDAPTLPTDDRGPLYP
                     LQRDLQGPGVLERVERLKQGLLAKVRALGRELPVNTLDQLIHQLGGPECVAEMTGRKG
                     RVVSRPDGSVVFESRAEQGLSIDHVNLREKQRFMSGEKLVAIISEASSSGVSLQADRR
                     VQNQRRRVHMTLELPWSADRAIQQFGRTHRSNQVSAPEYVFLISELAGERRFASIVAK
                     RLESLGALTHGDRRATESRDLSKYNFENKYGARALSRVLATIMGQTNNRVPLPQGYPG
                     GDAAFFRDMKQGLLSVGIGSRESRSGCLDVEKDCSITKFLNRILGLEVHKQNALFQYF
                     SDTFDHLIEIDKKEGRYDMGILDLAPGINEIHEESQQVFLAPGHPQDGQVVFYKISVD
                     RGMKWEEAFTRSLELKGPYDGFYLSYKVRGSKTSCLLAEQNRGDYFTVYKPNIGRQSQ
                     LETLDNLCRKFHRVTPEEAREPWESSYALSLEHCSHTTWNQRCRLAQEGKCCAQGLRL
                     RHHYMLCGALLRVWGRIAAVMADVSSSSYLQIVRLKTKDKKKQVGIKIPEGCVHRVLQ
                     ELQLMDAEVKRRSAHGLAARPPTPRAITLPCGPGEVLDLTYSPPAEPFPAPPRFAFPS
                     LPPPDPSSLMLGTRDNATNPVELAHQGCDINFREVLEDMLRSLRAGPTETPAPLVGVG
                     GGGGGGTERQSVIHFSPPFPNS"
     exon            622..783
                     /gene="Sbno2"
                     /gene_synonym="RGD1307194; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            784..867
                     /gene="Sbno2"
                     /gene_synonym="RGD1307194; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            868..964
                     /gene="Sbno2"
                     /gene_synonym="RGD1307194; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1119
                     /gene="Sbno2"
                     /gene_synonym="RGD1307194; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1253
                     /gene="Sbno2"
                     /gene_synonym="RGD1307194; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1344
                     /gene="Sbno2"
                     /gene_synonym="RGD1307194; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1488
                     /gene="Sbno2"
                     /gene_synonym="RGD1307194; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1606
                     /gene="Sbno2"
                     /gene_synonym="RGD1307194; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1712
                     /gene="Sbno2"
                     /gene_synonym="RGD1307194; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1866
                     /gene="Sbno2"
                     /gene_synonym="RGD1307194; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..2043
                     /gene="Sbno2"
                     /gene_synonym="RGD1307194; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            2044..2141
                     /gene="Sbno2"
                     /gene_synonym="RGD1307194; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            2142..2221
                     /gene="Sbno2"
                     /gene_synonym="RGD1307194; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            2222..2413
                     /gene="Sbno2"
                     /gene_synonym="RGD1307194; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            2414..2583
                     /gene="Sbno2"
                     /gene_synonym="RGD1307194; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            2584..2715
                     /gene="Sbno2"
                     /gene_synonym="RGD1307194; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            2716..2851
                     /gene="Sbno2"
                     /gene_synonym="RGD1307194; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            2852..2964
                     /gene="Sbno2"
                     /gene_synonym="RGD1307194; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            2965..3036
                     /gene="Sbno2"
                     /gene_synonym="RGD1307194; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            3037..3145
                     /gene="Sbno2"
                     /gene_synonym="RGD1307194; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            3146..3220
                     /gene="Sbno2"
                     /gene_synonym="RGD1307194; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            3221..3364
                     /gene="Sbno2"
                     /gene_synonym="RGD1307194; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            3365..3459
                     /gene="Sbno2"
                     /gene_synonym="RGD1307194; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            3460..3552
                     /gene="Sbno2"
                     /gene_synonym="RGD1307194; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            3553..3684
                     /gene="Sbno2"
                     /gene_synonym="RGD1307194; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            3685..3761
                     /gene="Sbno2"
                     /gene_synonym="RGD1307194; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            3762..3952
                     /gene="Sbno2"
                     /gene_synonym="RGD1307194; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            3953..4826
                     /gene="Sbno2"
                     /gene_synonym="RGD1307194; Stno"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgccaagatg gcgtccagaa cccggaagtg agcggcggcc gctgagaggc tccgggaaac
       61 tgaggcgtcg cgggctcagc gaccaggtct gaggatatga cattacaact gctgccagca
      121 ccacagagtg agcagcctcg atagccgcca cccgagggtg gcggagcgcc gcctccacct
      181 gcctgatgct ggcagtggaa cccaccatgg atggggactt ccctccacat gagctccctc
      241 cccccggagg tggcatccag ctccagaacc gactcctgca ctgtccttgg tggggcagtt
      301 tctcaccgcc attgtacccc accttctcca gtgaaaatca acagttcgtg agctccaccc
      361 cattccttgg tggccagtct tgccctgaaa ccagctaccc caccacagcc accgtcccca
      421 gcttcttctc caagagcagc gactttcctc agctagcccc agccctcgac ctcctgcttc
      481 tccgaggaca gggcccgtgc actcctggtc tgccctccat ctctggtggc atggaacccc
      541 ttcccatggg ctctgatggc cctgcttggt gaccagaaca gcttcacagt cccctgtggg
      601 atacccaccc tgggcgtgca ggatccttca tgcctcgagg acctctccaa tgcctctgtc
      661 ttctcctcgt ctgtggattc cctgtcagat atcccagaca cacccgactt cctgccggcc
      721 gacagcctca acgaggtgcc taccatctgg gatgtcagca ccacctccac cacccgggac
      781 aagctgttcc taccgagtgt gccattctcg gctctggaag acccggtgac cgcagtttcc
      841 agtaccccgc ttctcgtcag ctatcagtca cacagccagc ctgaggagga ggaaggcgaa
      901 gacgaggagg aggctgagga actgggccat gctgagacct atgccgacta tgtaccttcc
      961 aagtccaaga ttggaaagca gcacccagac cgtgtagtgg agaccagcac actgtccagc
     1021 gttccgcccc cagacatcac ctacaccctg gcactaccca cctcagacaa cgggaccctg
     1081 tctgccctac agctggaagc catcacctat gcctgccagc aacacgaggt cctgctgccc
     1141 agtgggcagc gtgctggttt cctgattggg gatggggccg gcgtgggcaa gggccgcacg
     1201 gtggctggca tcatagtgga gaattacctg cggggccgga agaaggcttt gtggttcagt
     1261 gcctccaatg acctcaagta tgatgcagaa cgggacctga gagacatcga ggcccccggc
     1321 attgcggtgc atgcactaag caagatcaag tacggtgaca acactacctc agagggtgtc
     1381 ctctttgcca cctactctgc cctgattgga gaaagccagg cgggtgggca gcatcgcaca
     1441 cgtctacgcc agatcctgca gtggtgtgga gaggcctttg atggtgtgat tgtgtttgac
     1501 gagtgtcaca aagccaagaa tgccagctcc accaagatgg gcaaggccgt gctggacctg
     1561 cagaacaagc tgccccaggc cagggtggtg tatgccagcg ccacaggcgc ctctgagccc
     1621 cgcaacatga tatacatgag ccgcttgggc atctggggcg agggcacacc cttccggacc
     1681 ttcgaggagt tcctgcatgc cattgagaag aggggcgtgg gtgccatgga gattgtggcc
     1741 atggacatga aggtcagtgg catgtacatc gcccgccagc tcagcttctc aggggtcaca
     1801 ttccgaatcg aggagatccc actgtctcct gtcttcgagc aggtctataa tcgggcagcc
     1861 cggctgtggg ccgaggccct gagtgtgttc cagcaggcgg ctgactggat cggtctggag
     1921 tctcggaagt ccctgtgggg tcagttctgg tccgcacacc agcgcttctt taaatacctg
     1981 tgcattgcgg ccaaggtgca ccggctggtg gagctggcac agcaggagct gagcagggac
     2041 aagtgcgtgg tcatcgggct gcagtccaca ggggaggcgc ggacccgaga ggtgctagac
     2101 gagaatgagg gccgcctgga ctgcttcgtc tctgcagcag aaggcgtctt cctgtccctg
     2161 atccagaagc acttcccttc caccaggagg aggcgtgacc ggggaggagg aaagaggaaa
     2221 cggcggcctc ggggtcgtgg tcccaaggct tccagactga cactggaggc agcaggagtt
     2281 atccgtatta gtgatggcag cagcacagag tcagatgctg gcctggatag cgacttcaat
     2341 tcatccccag agtccctggt agatgatgat gtggtcatcg tagacgcccc cacgctcccc
     2401 acagatgacc gaggtcccct gtacccactt cagagagacc tacagggccc tggtgtcctg
     2461 gagcgggtgg aacggctgaa acagggcctg ctggcaaagg tgcgagcact gggccgggag
     2521 ctgcctgtga acacattgga ccagctcatc caccagcttg ggggcccgga gtgtgtggct
     2581 gagatgactg gcaggaaagg ccgagtggta tcgaggcccg acgggtcagt ggtctttgag
     2641 tccagagcag agcagggcct gtccatcgac catgtgaacc tcagggagaa gcagcgtttc
     2701 atgagcggcg agaagctcgt ggctattatc tctgaggcct ccagctctgg tgtctccctc
     2761 caagccgacc ggcgagtcca gaaccagaga cgccgggtac acatgacctt ggagctgcct
     2821 tggagcgcag accgagccat ccaacagttt ggccgcaccc acagatccaa ccaggtctca
     2881 gcgcccgagt atgtcttcct tatctccgag ctggcagggg agcgcaggtt cgcctccatt
     2941 gtggccaagc ggctggagag tctgggtgct ctgacccacg gagatcgacg ggccactgag
     3001 tcccgggacc tgagcaagta taacttcgag aacaagtatg gcgcccgtgc gctcagccgt
     3061 gtccttgcca caatcatggg ccagacaaac aacagggtgc ccctgcccca gggctatcca
     3121 ggaggggatg ctgccttttt tcgggacatg aagcagggcc tgctgtctgt gggcatcggt
     3181 agccgggagt cacgctctgg ctgcttggat gtggagaagg actgctccat caccaagttt
     3241 ctgaaccgca tccttgggct ggaggtgcac aagcagaacg cgctgttcca gtatttctcc
     3301 gacacgtttg accacctcat cgagatcgac aagaaggagg gcagatacga catgggcatt
     3361 ctggacctgg cccccggcat caatgaaata catgaagaga gccagcaggt gttcctggca
     3421 cccgggcacc cacaggacgg gcaggtggtc ttctacaaga ttagcgtgga ccgcggtatg
     3481 aagtgggaag aggcattcac taggtcgctg gagctaaaag gcccctatga cggcttctac
     3541 ctctcctaca aggtacgagg cagcaaaacg agctgccttc tggcagaaca gaatcgaggc
     3601 gattatttca ccgtgtacaa gccaaacatt ggccggcaga gccagctgga gaccctggac
     3661 aacctgtgcc ggaagttcca ccgggtcacc ccggaagagg cgcgggaacc ctgggagagc
     3721 agctatgcgc tgtcgctgga gcactgcagc cacactacct ggaaccagcg ctgccgactg
     3781 gcacaggagg gcaagtgctg tgcccagggc ctgcgcctcc gccaccacta catgctgtgc
     3841 ggggcgctgc tgcgcgtgtg gggccgcatc gctgctgtca tggcggacgt cagcagtagc
     3901 agctacctac agatcgtgcg cctcaagacc aaggacaaaa agaagcaagt gggcatcaag
     3961 atcccggagg gctgcgttca ccgcgtactg caggaactgc agctcatgga tgcagaagtg
     4021 aagcgccgca gcgctcatgg gttggctgcg cgcccaccta ctcctcgtgc gattacactt
     4081 ccatgcggtc ctggtgaggt gctggacttg acctacagtc ccccggccga gcctttccca
     4141 gcgcctccac gcttcgcctt cccttcgttg ccacccccag accccagctc tctgatgctg
     4201 ggtaccaggg acaacgctac caaccctgtg gagctggcac accagggctg cgacatcaat
     4261 ttcagggaag tgctggagga catgctccgc tctttgcgcg cggggcccac tgagacccct
     4321 gcgcctctgg tgggcgtggg cggcggcgga ggcggtggca cagagcggca gagcgttatc
     4381 cacttcagtc cacccttccc aaactcttag gctgctacat cagcctctgg attacactgc
     4441 actgggcagt aaggcctatg ggctcctctg ctagcagggg ttcccatgac tactgagggt
     4501 gactggccac ggtgccttcc ccaccagtag ggcgtggggc ccctgtgcct cccctgctac
     4561 agccatgccc agcctagaag ccgtggggct tggttgtccc agagagctgg taactcagga
     4621 aatcggtgct cgggccccgc tggctatggg ggctccacgg ggtagacccc gttaatatat
     4681 gcaatcccct gccccctaaa ttattgtcac ctgcccctcc ccagccccgg aatctgtggg
     4741 cagccggcag gccctggttt ctatgtattt ataacgaact gtgtacatat gtaaagacct
     4801 tttctaaaat atacatgcct ttgcct
//
