LOCUS       NP_001128442            1826 aa            linear   ROD 24-JUN-2024
DEFINITION  myotubularin-related protein 13 [Rattus norvegicus].
ACCESSION   NP_001128442 XP_001076611
VERSION     NP_001128442.1
DBSOURCE    REFSEQ: accession NM_001134970.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1826)
  AUTHORS   Yoshimura,S., Gerondopoulos,A., Linford,A., Rigden,D.J. and
            Barr,F.A.
  TITLE     Family-wide characterization of the DENN domain Rab GDP-GTP
            exchange factors
  JOURNAL   J Cell Biol 191 (2), 367-381 (2010)
   PUBMED   20937701
REFERENCE   2  (residues 1 to 1826)
  AUTHORS   Berger,P., Berger,I., Schaffitzel,C., Tersar,K., Volkmer,B. and
            Suter,U.
  TITLE     Multi-level regulation of myotubularin-related protein-2
            phosphatase activity by myotubularin-related protein-13/set-binding
            factor-2
  JOURNAL   Hum Mol Genet 15 (4), 569-579 (2006)
   PUBMED   16399794
REFERENCE   3  (residues 1 to 1826)
  AUTHORS   Robinson,F.L. and Dixon,J.E.
  TITLE     The phosphoinositide-3-phosphatase MTMR2 associates with MTMR13, a
            membrane-associated pseudophosphatase also mutated in type 4B
            Charcot-Marie-Tooth disease
  JOURNAL   J Biol Chem 280 (36), 31699-31707 (2005)
   PUBMED   15998640
REFERENCE   4  (residues 1 to 1826)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC168698.1.
            
            On Sep 15, 2008 this sequence version replaced XP_001076611.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168698.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1826
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q33"
     Protein         1..1826
                     /product="myotubularin-related protein 13"
                     /calculated_mol_wt=205440
     Region          1..>47
                     /region_name="uDENN"
                     /note="uDENN domain; cl04085"
                     /db_xref="CDD:470944"
     Region          69..251
                     /region_name="DENN"
                     /note="DENN (AEX-3) domain; pfam02141"
                     /db_xref="CDD:460461"
     Region          305..373
                     /region_name="dDENN"
                     /note="Domain always found downstream of DENN domain,
                     found in a variety of signalling proteins; smart00801"
                     /db_xref="CDD:129037"
     Region          483..706
                     /region_name="SBF2"
                     /note="Myotubularin protein; pfam12335"
                     /db_xref="CDD:463536"
     Region          834..952
                     /region_name="PH-GRAM_MTMR13"
                     /note="Myotubularian (MTM) related 13 protein Pleckstrin
                     Homology-Glucosyltransferases, Rab-like GTPase activators
                     and Myotubularins (PH-GRAM) domain; cd13339"
                     /db_xref="CDD:275416"
     Region          1090..1462
                     /region_name="PTP_DSP_cys"
                     /note="cys-based protein tyrosine phosphatase and
                     dual-specificity phosphatase superfamily; cl28904"
                     /db_xref="CDD:475123"
     Region          1719..1824
                     /region_name="PH_Sbf1_hMTMR5"
                     /note="Set binding factor 1 (also called Human MTMR5)
                     Pleckstrin Homology (PH) domain; cd01235"
                     /db_xref="CDD:269941"
     CDS             1..1826
                     /gene="Sbf2"
                     /gene_synonym="Mtmr13; RGD1559442"
                     /coded_by="NM_001134970.1:89..5569"
                     /db_xref="GeneID:691042"
                     /db_xref="RGD:1588657"
ORIGIN      
        1 marladyfiv vgydhekpgp geglgkiiqr fpqqdwddtp fpqgielgtk keeiegeevs
       61 aliqpaevfa pkslvlvsrl dypeifracl gliytvyvds lsvsleslia nlcaclvpaa
      121 ggsqklfslg agdrqliqtp lhdslpvtgt svallfqqlg iqnvlnlfca vltenkvlfh
      181 sasfqrlsda craleslmfp lkysypyipi lpaqllevls sptpfiigvh sifktdvhel
      241 ldviiadldg gtikipecih lsslpepllh qtqaalslil hpdlevadha fppprtalsh
      301 skmldkevra vflrlfaqlf qgyrsclqli rihaepvihf hktaflgqrg lvendfltkv
      361 lngmafagfv sergppyrac dlfdelvafe verikveenn plkmikhire laeqlfknen
      421 pnphmafqkv prptegshlr vhilpfpkin earvqeliqe nlaknqnatp atrtekkciv
      481 pagppvvsim dkvitvfnsa qrlevvrnci sfifenktle tektlpaalr alkgkaarqc
      541 ltdelglhvq qnraildhqq fdyiirmmnc tlqdcsslee yniaaallpl tsafyrrlap
      601 gvsqfaytcv qdhpiwtnqq fwettfysav qeqvrslyls akednhtphq kqkelpdgqy
      661 qertamdlaa eqlrlwptls katqqelvqh eestvfsqai hfanlmvnll vpldtsknkl
      721 lrasapgdwe sgsnsivtns iagsvaesfd tesgfedsen ndvansvvrf iarfidkvct
      781 esgvtqdhir slhcmipgiv amhietleav hresrrlppi qkpkilrpal lpgeeivceg
      841 lrvlldpdgr eeatggllgg pqllpaegal flttyrilfr gtphdqlvge qtvvrsfpia
      901 sitkekkitm qnqlqqnmqe glqitsasfq likvafdeev spevvdifkk qlmkfrypqs
      961 ifstfafaag qttpqiilpk qkekntsfrt fsktivkgak kagkmtigrq yllkkrtgti
     1021 veeranrpgw needdisvsd dcelptsttl kasekstmeq lvekacfrdy qrlglgtisg
     1081 sssrskpeyf rvtasnrlys lcrsypgllv ipqavqdssl prvarcyrhn rlpvvcwkns
     1141 rsgtlllrsg gfhgkgvvgl fksqnspqav stsslessss ieqekylqal ltavivhqkl
     1201 rgnstltvrp tlalspvhgy rdkcftqsns kssakepvhn qgvwaslrss trlissptsl
     1261 idvgarlagk dhsasfsnst ylqnqlskrq aalyifgeks qlrsskvefa fncefvpvef
     1321 heirqvkasf kklmracips tiptdsevtf lkaledsewf pqlhrimqla vvvsevleng
     1381 ssvwvcleeg wdittqvtsl vqllsdpfyr tiegfrmlve kewlsfghkf sqrsslalns
     1441 qgsgfapifl qfldcvhqvh nqyptefefn lyylkflafh yvsnrfktfl ldsdyerleh
     1501 gtlfddkgdk hakkgvciwe cidkmhkrsp vffnylyspv eiealkpnvn vsslkkwdyy
     1561 teetlsagps ydwmmltpkh fpyeesdvag gagpqsqrkt vwpcyddvtc sqpdaltrlf
     1621 seieklehkl nqtpekwhql wekitmdlke eprtdhslrh ssrspgiast nvpsyqkrpa
     1681 lhalhrspte dqstttapsn gvehraatly sqytsknden rsfegtlykr gallkgwkpr
     1741 wfvldvtkhq lryydsgedt sckghidlae vemvvpagps mgapkytsdk affdlktskr
     1801 vynfcaqdgq saqqwmdriq scisda
//
