LOCUS       NP_001258102            1893 aa            linear   ROD 29-MAR-2024
DEFINITION  myotubularin-related protein 5 [Rattus norvegicus].
ACCESSION   NP_001258102 XP_001054780 XP_003750440 XP_217021
VERSION     NP_001258102.1
DBSOURCE    REFSEQ: accession NM_001271173.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1893)
  AUTHORS   Liska,F., Chylikova,B., Janku,M., Seda,O., Vernerova,Z.,
            Pravenec,M. and Kren,V.
  TITLE     Splicing mutation in Sbf1 causes nonsyndromic male infertility in
            the rat
  JOURNAL   Reproduction 152 (3), 215-223 (2016)
   PUBMED   27335132
  REMARK    GeneRIF: Splicing mutation in Sbf1 causes nonsyndromic male
            infertility.
REFERENCE   2  (residues 1 to 1893)
  AUTHORS   Yoshimura,S., Gerondopoulos,A., Linford,A., Rigden,D.J. and
            Barr,F.A.
  TITLE     Family-wide characterization of the DENN domain Rab GDP-GTP
            exchange factors
  JOURNAL   J Cell Biol 191 (2), 367-381 (2010)
   PUBMED   20937701
REFERENCE   3  (residues 1 to 1893)
  AUTHORS   Lorenzo,O., Urbe,S. and Clague,M.J.
  TITLE     Systematic analysis of myotubularins: heteromeric interactions,
            subcellular localisation and endosome related functions
  JOURNAL   J Cell Sci 119 (Pt 14), 2953-2959 (2006)
   PUBMED   16787938
REFERENCE   4  (residues 1 to 1893)
  AUTHORS   Firestein,R., Nagy,P.L., Daly,M., Huie,P., Conti,M. and Cleary,M.L.
  TITLE     Male infertility, impaired spermatogenesis, and azoospermia in mice
            deficient for the pseudophosphatase Sbf1
  JOURNAL   J Clin Invest 109 (9), 1165-1172 (2002)
   PUBMED   11994405
REFERENCE   5  (residues 1 to 1893)
  AUTHORS   Cui,X., De Vivo,I., Slany,R., Miyamoto,A., Firestein,R. and
            Cleary,M.L.
  TITLE     Association of SET domain and myotubularin-related proteins
            modulates growth control
  JOURNAL   Nat Genet 18 (4), 331-337 (1998)
   PUBMED   9537414
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On or before Sep 7, 2012 this sequence version replaced
            XP_001054780.2, XP_003750440.1, XP_217021.6.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.29810.1,
                                           SRR26643429.28442.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1893
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     Protein         1..1893
                     /product="myotubularin-related protein 5"
                     /calculated_mol_wt=211277
     Region          1..86
                     /region_name="uDENN"
                     /note="Domain always found upstream of DENN domain, found
                     in a variety of signalling proteins; smart00800"
                     /db_xref="CDD:214824"
     Region          129..310
                     /region_name="DENN"
                     /note="Domain found in a variety of signalling proteins,
                     always encircled by uDENN and dDENN; smart00799"
                     /db_xref="CDD:214823"
     Region          364..432
                     /region_name="dDENN"
                     /note="Domain always found downstream of DENN domain,
                     found in a variety of signalling proteins; smart00801"
                     /db_xref="CDD:129037"
     Region          542..764
                     /region_name="SBF2"
                     /note="Myotubularin protein; pfam12335"
                     /db_xref="CDD:463536"
     Region          893..1011
                     /region_name="PH-like"
                     /note="Pleckstrin homology-like domain; cl17171"
                     /db_xref="CDD:473070"
     Region          1150..1522
                     /region_name="PTP_DSP_cys"
                     /note="cys-based protein tyrosine phosphatase and
                     dual-specificity phosphatase superfamily; cl28904"
                     /db_xref="CDD:475123"
     Region          1786..1891
                     /region_name="PH_Sbf1_hMTMR5"
                     /note="Set binding factor 1 (also called Human MTMR5)
                     Pleckstrin Homology (PH) domain; cd01235"
                     /db_xref="CDD:269941"
     CDS             1..1893
                     /gene="Sbf1"
                     /coded_by="NM_001271173.1:129..5810"
                     /db_xref="GeneID:300147"
                     /db_xref="RGD:1307090"
ORIGIN      
        1 marladyfvl vafgphprgs gegqgqilqr fpekdwednp fpqgielfcq psgwqlcper
       61 npptffvavl tdinserhyc acltfwepve stqevmcted atekeeeahg ggqaqlssta
      121 paqpgqlfap ktlvlvsrld hadvfrnslg liytihvegl nvnlenvign lltctvplag
      181 gsqrtislga gdrqviqtpl vdslpvsrcs vallfrqlgi tnvlslfcaa ltehkvlfls
      241 rsyqrladac rgllallfpl rysftyvpil paqllevlst ptpfiigvna afqaetqell
      301 dvivadldgg tvtvpecvhi pplpeplqsq thnvlsmvld peleladlaf pppttsassl
      361 kmqdkelrav flrlfaqllq gyrwclhivr ihpepvirfh kaaflgqrgl veddflmkvl
      421 egmafagfvs ergvpyrstd lfdelvahev armradenhp hrvlrhvqel aeqlyknenp
      481 ypavamhkvq rpgeashlrr thrpfprlde gtvqwivdqa aakmqgappa vkaerrttvp
      541 sgppmtaile rcsgphinsa rrlevvrnci syvfegkmle akkllpavlr alkgraarrc
      601 lahelhlhvq qnravldhqq fdfvvrmmnc clqdctslde hgiaaallpl vtafcrklsp
      661 gvtqfayscv qehvvwstpq fweamfygdv qthiralyle psdgvsptqe tgeaqsqdde
      721 rsaldvaseq rrlwptlsre kqqelvqkee stvfsqaihy anrmsylllp ldssksrllr
      781 eraglgdles asnslvtnsm agsvaesydt esgfedaetc dvagavvrfi nrfvdkvcte
      841 sgvtsdhlkg lhvmvpdivq mhietleavh reskrlppiq kpkllrprll pgeecvldgl
      901 rvyllpdgre egvggsgggp allpaegavf lttyrviftg mptdplvgeq vvvrsfpvaa
      961 ltkekrisvq tpvdqllqdg lqlrsctfql lkmafdeevg sdsaelfrkq lhklryppdi
     1021 ratfaftlgs altpgrpprv tkdkgpsfrt lsrnlvknak ktigrqyvtr kkynppgweh
     1081 rgqpppedqe deisvseele pstltpssal kpsdrmtmss lveraccrdy qrlglgtlss
     1141 slsraksepf rispvnrmya icrsypglli vpqsiqdnal qrvsrcyrqn rfpvvcwrsg
     1201 rskavllrsg glhgkgvvgl fkaqntpspg qaqadsssle qekylqavvs smpryadssg
     1261 rntlssfssa hmgghvpspr arvttlsnpl aasasrwtas rgkwssvras grssglgadv
     1321 gsrlagrdll stphtngapp dsgflrpqra alyiigdkaq lkgvrpdplq qwelvpievf
     1381 earqvkasfk kllkacvpgc patepspasf lrsledsewl iqihkllqis vlvvelldsg
     1441 ssvlvsledg wdittqvvsl vqllsdpfyr tlegfrllve kewlsfghrf shrgahtlag
     1501 qssgftpvfl qfldcvhqvh lqfpmefefs qfylkflgyh htsrrfrtfl ldsdyeriel
     1561 gllyeekger rgqlacksvw eyvdrlskrt pmfynytyap edtevlrpys nvsnlkvwdf
     1621 yteetlaegp pydwelaqgp peppeeerpd ggapqsrrrv vwpcydsrpr vqpdaisrll
     1681 eelqrletel grpserwket wdrvkaaqrl egrqdgrgtp ssllvsavph hrrslgvylq
     1741 egpvgstlsl sldsdqssgs ttsssrqaar rststlysqf qtaesenrsy egtlykkgaf
     1801 mkpwkarwfv ldktkhqlry ydhrvdteck gvidlaevea vapgtptiga pktvdekaff
     1861 dvkttrrvyn fcaqdvpsaq qwvdriqscl sda
//
