LOCUS       NM_001097581            2047 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus salvador family WW domain containing protein 1
            (Sav1), mRNA.
ACCESSION   NM_001097581 XM_001080429 XM_216725
VERSION     NM_001097581.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2047)
  AUTHORS   Park,B.H., Kim,D.S., Won,G.W., Jeon,H.J., Oh,B.C., Lee,Y., Kim,E.G.
            and Lee,Y.H.
  TITLE     Mammalian ste20-like kinase and SAV1 promote 3T3-L1 adipocyte
            differentiation by activation of PPARgamma
  JOURNAL   PLoS One 7 (1), e30983 (2012)
   PUBMED   22292086
  REMARK    Erratum:[PLoS One. 2015 Mar 18;10(3):e0119098. doi:
            10.1371/journal.pone.0119098.. PMID: 25785583]
REFERENCE   2  (bases 1 to 2047)
  AUTHORS   Heallen,T., Zhang,M., Wang,J., Bonilla-Claudio,M., Klysik,E.,
            Johnson,R.L. and Martin,J.F.
  TITLE     Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte
            proliferation and heart size
  JOURNAL   Science 332 (6028), 458-461 (2011)
   PUBMED   21512031
REFERENCE   3  (bases 1 to 2047)
  AUTHORS   Lu,L., Li,Y., Kim,S.M., Bossuyt,W., Liu,P., Qiu,Q., Wang,Y.,
            Halder,G., Finegold,M.J., Lee,J.S. and Johnson,R.L.
  TITLE     Hippo signaling is a potent in vivo growth and tumor suppressor
            pathway in the mammalian liver
  JOURNAL   Proc Natl Acad Sci U S A 107 (4), 1437-1442 (2010)
   PUBMED   20080689
REFERENCE   4  (bases 1 to 2047)
  AUTHORS   Luo,X., Li,Z., Yan,Q., Li,X., Tao,D., Wang,J., Leng,Y., Gardner,K.,
            Judge,S.I., Li,Q.Q., Hu,J. and Gong,J.
  TITLE     The human WW45 protein enhances MST1-mediated apoptosis in vivo
  JOURNAL   Int J Mol Med 23 (3), 357-362 (2009)
   PUBMED   19212654
REFERENCE   5  (bases 1 to 2047)
  AUTHORS   Lee,J.H., Kim,T.S., Yang,T.H., Koo,B.K., Oh,S.P., Lee,K.P.,
            Oh,H.J., Lee,S.H., Kong,Y.Y., Kim,J.M. and Lim,D.S.
  TITLE     A crucial role of WW45 in developing epithelial tissues in the
            mouse
  JOURNAL   EMBO J 27 (8), 1231-1242 (2008)
   PUBMED   18369314
REFERENCE   6  (bases 1 to 2047)
  AUTHORS   Hwang,E., Ryu,K.S., Paakkonen,K., Guntert,P., Cheong,H.K.,
            Lim,D.S., Lee,J.O., Jeon,Y.H. and Cheong,C.
  TITLE     Structural insight into dimeric interaction of the SARAH domains
            from Mst1 and RASSF family proteins in the apoptosis pathway
  JOURNAL   Proc Natl Acad Sci U S A 104 (22), 9236-9241 (2007)
   PUBMED   17517604
REFERENCE   7  (bases 1 to 2047)
  AUTHORS   Callus,B.A., Verhagen,A.M. and Vaux,D.L.
  TITLE     Association of mammalian sterile twenty kinases, Mst1 and Mst2,
            with hSalvador via C-terminal coiled-coil domains, leads to its
            stabilization and phosphorylation
  JOURNAL   FEBS J 273 (18), 4264-4276 (2006)
   PUBMED   16930133
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AM261215.1.
            
            On or before May 24, 2007 this sequence version replaced
            XM_216725.4, XM_001080429.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AM261215.1, BC161803.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2047
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Rowett"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..2047
                     /gene="Sav1"
                     /note="salvador family WW domain containing protein 1"
                     /db_xref="GeneID:299116"
                     /db_xref="RGD:1307253"
     exon            1..265
                     /gene="Sav1"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..1335
                     /gene="Sav1"
                     /function="control of proliferation and apoptosis"
                     /note="Salvador homolog 1 protein; rWW45; 45 kDa WW domain
                     protein"
                     /codon_start=1
                     /product="protein salvador homolog 1"
                     /protein_id="NP_001091050.1"
                     /db_xref="GeneID:299116"
                     /db_xref="RGD:1307253"
                     /translation="MLSRKKTKNEVSKPAEVQGKYVKKETSPLLRNLMPSFIRHGPTI
                     PRRTDLCLPESSASAFSASGDGVVSRNQSFLRTPVQRTPHEVMRRESNRLSAPSSYLV
                     RSLADVPREYGSSQSFLTEVNFAVENGDSGSRYFYSDNFFDGQRRRPLGDRAQEDYRY
                     YEYNHDLFQRMPQNQGRHTSGIGRVTATSLGNLTNHGSEDLPLPPGWSVDWTMRGRKY
                     YIDHNTNTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKRAQYRHPCAPSVPRYD
                     QPPPITYQPQQTERNQSLLVPANPYHTAEIPDWLQVYARAPVKYDHILKWELFQLADL
                     DTYQGMLKLLFMKELEQIVKLYEAYRQALVTELENRKQRQQWYAQHHGKKFLS"
     exon            266..712
                     /gene="Sav1"
                     /inference="alignment:Splign:2.1.0"
     exon            713..983
                     /gene="Sav1"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1127
                     /gene="Sav1"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..2047
                     /gene="Sav1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgagcggcg gcgggcgcgc ttagcgccgc caacatgcgg cggagcctgc gggcgggcgc
       61 gggcggcgga gacccgaggc gaaggcggcg ccggcccggg aggcggcggc gggcggcggg
      121 ctcgcggccc tagcgaggct gctggggcag cggcgggcga cgtccgcgag gatgctgtcc
      181 cgcaagaaaa ccaaaaacga ggtgtctaag ccggccgagg ttcagggcaa gtacgtgaag
      241 aaggagacgt cgcccctgct gcggaatctc atgccttcat tcattcggca cggtccaaca
      301 attccaagac ggactgacct ctgtcttcca gagtcaagcg ctagtgcttt ctcagcttct
      361 ggagatggcg tagtttcaag aaaccagagt ttcctgagaa ctccagttca aaggacgcct
      421 catgaagtaa tgagaagaga aagcaacaga ctgtccgcac cgtcttctta ccttgtcagg
      481 agcctagcgg atgtccctcg ggaatacggc tcatcacagt catttttaac agaagttaat
      541 tttgctgttg aaaatggaga ctctggttcc cgatattttt attcagataa cttttttgat
      601 ggtcagagaa ggaggccact tggagatcgt gcacaagaag actatagata ttatgaatac
      661 aaccatgatc tcttccaaag aatgccacag aatcagggga ggcacacatc aggtattggg
      721 agagtcactg ctacatcttt aggaaattta actaaccatg gatctgaaga tttacccctt
      781 cctcctggct ggtctgtgga ctggacaatg agagggagaa aatactacat agatcataac
      841 acaaacacaa ctcattggag tcatcctctt gaacgagaag gacttcctcc tgggtgggag
      901 cgagtggaat catcagaatt tggaacctat tatgtggatc acacaaataa aagggctcag
      961 tacaggcacc cctgtgctcc cagtgtgcct cggtatgatc agcctccacc catcacgtat
     1021 cagccacagc aaactgaaag aaatcagtct ctcctggtcc ctgcaaaccc ctaccatact
     1081 gcagaaattc ctgactggct tcaggtttat gcccgagccc ctgtgaaata cgaccacatt
     1141 ctgaagtggg agctcttcca gctggctgac ctggacacgt accagggaat gctgaagctg
     1201 ctcttcatga aggagctgga gcagattgtc aagttgtatg aggcctacag acaggctctt
     1261 gtcaccgagc tggaaaaccg caagcagagg cagcagtggt atgcccagca ccatggcaag
     1321 aagtttttaa gttaactttc cacaagccag gttttgtaag agctttaaaa tattttcaga
     1381 taaatgactg caaacaagtt ctttggttaa taaaggcaac ttactatttg gaattacaaa
     1441 attctagttt tacatatatt atcaactttt tcttttattg aaccaagaaa gttttatcac
     1501 ttaaaaagcc aatatggcat atactaccaa atgctgttag gaaactgctt tggagactgt
     1561 ggatggaaag gagtacagga agagactgtc ataaatggca ttaaacagga gtggacacac
     1621 ccttcttgtt ccgaaaagga agcggacgag agcacactgt gaacagcggc tccttgtggt
     1681 gtcaggtgtt ttctggaatg agatggtgtg accattgcca tgggtatagt tcagaataaa
     1741 aacagggcat ggagccttta tggggacaaa cgtgtatatg gtgtgtgtgg tcatctactc
     1801 ccacctcctc cctatgtgag ggacaccttt gaaggaggga gataaagcct ttcaggaata
     1861 gagtcaggaa tacgggaata taataaatac gggcctcagt tggtgcgaaa ctgttgctaa
     1921 tactgcttcc ttccttcctt tgagccagag cacatgagta cagtcagcaa ggctctggtg
     1981 agacacagca cgggcttcct gaccacaggg aatactgtct tccatcaggc tgggctacgt
     2041 gccaaaa
//
