LOCUS       NM_001109306            3005 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus SATB homeobox 2 (Satb2), mRNA.
ACCESSION   NM_001109306 XM_001067518 XM_576570
VERSION     NM_001109306.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3005)
  AUTHORS   Kong J, Wan LP, Liu ZM and Gao ST.
  TITLE     MiR-1301 promotes adipogenic and osteogenic differentiation of
            BMSCs by targeting Satb2
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (7), 3501-3508 (2020)
   PUBMED   32329823
  REMARK    GeneRIF: MiR-1301 promotes adipogenic and osteogenic
            differentiation of BMSCs by targeting Satb2.
REFERENCE   2  (bases 1 to 3005)
  AUTHORS   Chen JR, Zhao H, Lazarenko OP, Blackburn ML and Shankar K.
  TITLE     Maternal regulation of SATB2 in osteo-progeniters impairs skeletal
            development in offspring
  JOURNAL   FASEB J 34 (2), 2511-2523 (2020)
   PUBMED   31908011
  REMARK    GeneRIF: Maternal regulation of SATB2 in osteo-progeniters impairs
            skeletal development in offspring.
REFERENCE   3  (bases 1 to 3005)
  AUTHORS   Li JY, Wei X, Sun Q, Zhao XQ, Zheng CY, Bai CX, Du J, Zhang Z, Zhu
            LG and Jia YS.
  TITLE     MicroRNA-449b-5p promotes the progression of osteoporosis by
            inhibiting osteogenic differentiation of BMSCs via targeting Satb2
  JOURNAL   Eur Rev Med Pharmacol Sci 23 (15), 6394-6403 (2019)
   PUBMED   31378877
  REMARK    GeneRIF: MicroRNA-449b-5p promotes the progression of osteoporosis
            by inhibiting osteogenic differentiation of BMSCs via targeting
            Satb2.
REFERENCE   4  (bases 1 to 3005)
  AUTHORS   Wu G, Xu R, Zhang P, Xiao T, Fu Y, Zhang Y, Du Y, Ye J, Cheng J and
            Jiang H.
  TITLE     Estrogen regulates stemness and senescence of bone marrow stromal
            cells to prevent osteoporosis via ERbeta-SATB2 pathway
  JOURNAL   J Cell Physiol 233 (5), 4194-4204 (2018)
   PUBMED   29030963
  REMARK    GeneRIF: bone marrow stromal cells from the OVX rats displayed
            increased senescence and weaker SATB2 expression, stemness, and
            osteogenic differentiation, while estrogen could rescue these
            phenotypes. Inhibition of ERb or ERa confirmed that SATB2 was
            associated with ERb in estrogen-mediated pluripotency and
            senescence of BMSCs.
REFERENCE   5  (bases 1 to 3005)
  AUTHORS   Hao J, Zhang L, Cong G, Ren L and Hao L.
  TITLE     MicroRNA-34b/c inhibits aldosterone-induced vascular smooth muscle
            cell calcification via a SATB2/Runx2 pathway
  JOURNAL   Cell Tissue Res 366 (3), 733-746 (2016)
   PUBMED   27503378
  REMARK    GeneRIF: miR-34b/c participates in aldosterone-induced vascular
            smooth muscle cell calcification via a SATB2/Runx2 pathway.
REFERENCE   6  (bases 1 to 3005)
  AUTHORS   Arnold SJ, Huang GJ, Cheung AF, Era T, Nishikawa S, Bikoff EK,
            Molnar Z, Robertson EJ and Groszer M.
  TITLE     The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in
            the cortical subventricular zone
  JOURNAL   Genes Dev 22 (18), 2479-2484 (2008)
   PUBMED   18794345
REFERENCE   7  (bases 1 to 3005)
  AUTHORS   Britanova O, de Juan Romero C, Cheung A, Kwan KY, Schwark M, Gyorgy
            A, Vogel T, Akopov S, Mitkovski M, Agoston D, Sestan N, Molnar Z
            and Tarabykin V.
  TITLE     Satb2 is a postmitotic determinant for upper-layer neuron
            specification in the neocortex
  JOURNAL   Neuron 57 (3), 378-392 (2008)
   PUBMED   18255031
REFERENCE   8  (bases 1 to 3005)
  AUTHORS   Britanova O, Depew MJ, Schwark M, Thomas BL, Miletich I, Sharpe P
            and Tarabykin V.
  TITLE     Satb2 haploinsufficiency phenocopies 2q32-q33 deletions, whereas
            loss suggests a fundamental role in the coordination of jaw
            development
  JOURNAL   Am J Hum Genet 79 (4), 668-678 (2006)
   PUBMED   16960803
REFERENCE   9  (bases 1 to 3005)
  AUTHORS   Dobreva G, Chahrour M, Dautzenberg M, Chirivella L, Kanzler B,
            Farinas I, Karsenty G and Grosschedl R.
  TITLE     SATB2 is a multifunctional determinant of craniofacial patterning
            and osteoblast differentiation
  JOURNAL   Cell 125 (5), 971-986 (2006)
   PUBMED   16751105
REFERENCE   10 (bases 1 to 3005)
  AUTHORS   Britanova O, Akopov S, Lukyanov S, Gruss P and Tarabykin V.
  TITLE     Novel transcription factor Satb2 interacts with matrix attachment
            region DNA elements in a tissue-specific manner and demonstrates
            cell-type-dependent expression in the developing mouse CNS
  JOURNAL   Eur J Neurosci 21 (3), 658-668 (2005)
   PUBMED   15733084
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473965.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_576570.2, XM_001067518.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760393,
                              SAMN16418986 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3005
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q31"
     gene            1..3005
                     /gene="Satb2"
                     /gene_synonym="RGD1562369"
                     /note="SATB homeobox 2"
                     /db_xref="GeneID:501145"
                     /db_xref="RGD:1562369"
     exon            1..222
                     /gene="Satb2"
                     /gene_synonym="RGD1562369"
                     /inference="alignment:Splign:2.1.0"
     exon            223..450
                     /gene="Satb2"
                     /gene_synonym="RGD1562369"
                     /inference="alignment:Splign:2.1.0"
     CDS             282..2483
                     /gene="Satb2"
                     /gene_synonym="RGD1562369"
                     /note="special AT-rich sequence binding protein 2"
                     /codon_start=1
                     /product="DNA-binding protein SATB2"
                     /protein_id="NP_001102776.1"
                     /db_xref="GeneID:501145"
                     /db_xref="RGD:1562369"
                     /translation="MERRSESPCLRDSPDRRSGSPDVKGPPPVKVARLEQNGSPMGAR
                     GRPNGAVAKAVGGLMIPVFCVVEQLDGSLEYDNREEHAEFVLVRKDVLFSQLVETALL
                     ALGYSHSSAAQAQGIIKLGRWNPLPLSYVTDAPDATVADMLQDVYHVVTLKIQLQSCS
                     KLEDLPAEQWNHATVRNALKELLKEMNQSTLAKECPLSQSMISSIVNSTYYANVSATK
                     CQEFGRWYKKYKKIKVERVERENLSDYCVLGQRPMHLPNMNQLASLGKTNEQSPHSQI
                     HHSTPIRNQVPALQPIMSPGLLSPQLSPQLVRQQIAMAHLINQQIAVSRLLAHQHPQA
                     INQQFLNHPPIPRAVKPEPTNSSVEVSPDIYQQVRDELKRASVSQAVFARVAFNRTQG
                     LLSEILRKEEDPRTASQSLLVNLRAMQNFLNLPEVERDRIYQDERERSMNPNVSMVSS
                     ASSSPSSSRTPQAKTSTPTTDLPIKVDGANVNITAAIYDEIQQEMKRAKVSQALFAKV
                     AANKSQGWLCELLRWKENPSPENRTLWENLCTIRRFLNLPQHERDVIYEEESRHHHSE
                     RMQHVVQLPPEPVQVLHRQQSQPTKESSPPREEAPPPPPPTEDSCAKKPRSRTKISLE
                     ALGILQSFIHDVGLYPDQEAIHTLSAQLDLPKHTIIKFFQNQRYHVKHHGKLKEHLGS
                     AVDVAEYKDEELLTESEENDSEEGSDEMYKVEAEEESAEKNKVAPAETDQR"
     exon            451..627
                     /gene="Satb2"
                     /gene_synonym="RGD1562369"
                     /inference="alignment:Splign:2.1.0"
     exon            628..754
                     /gene="Satb2"
                     /gene_synonym="RGD1562369"
                     /inference="alignment:Splign:2.1.0"
     exon            755..878
                     /gene="Satb2"
                     /gene_synonym="RGD1562369"
                     /inference="alignment:Splign:2.1.0"
     exon            879..981
                     /gene="Satb2"
                     /gene_synonym="RGD1562369"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1454
                     /gene="Satb2"
                     /gene_synonym="RGD1562369"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1667
                     /gene="Satb2"
                     /gene_synonym="RGD1562369"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1823
                     /gene="Satb2"
                     /gene_synonym="RGD1562369"
                     /inference="alignment:Splign:2.1.0"
     exon            1824..2021
                     /gene="Satb2"
                     /gene_synonym="RGD1562369"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..3005
                     /gene="Satb2"
                     /gene_synonym="RGD1562369"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccccatcat cataacaacc atctccgaac cagaagaaga caccctgacc caggacctta
       61 aacgctagga acggggaaga ggaaaaggaa aggggaagga ggaaagagaa aggaagacag
      121 ggacagcact gcaaatcatc cagaaacttt ccaccctgga ttctctactt ttgctccatg
      181 gacagagtcc cagccagcca agtttcagac agaccgtaag cagtccctgc gcgttttatt
      241 gcgacctgcc ggtgggaact ttgtctccaa atcggagcag catggagcgg cggagcgaga
      301 gcccgtgtct tcgggacagc cccgaccgaa ggagcggcag ccccgacgtc aaggggcctc
      361 ccccggtgaa ggtggcccgg ctggagcaga acggcagccc catgggagcc cgcgggaggc
      421 ccaacggcgc cgtggccaag gccgtgggag gtctgatgat tccggtcttc tgtgtggtgg
      481 agcagttgga tggctctctt gagtacgaca acagagaaga gcatgctgag ttcgtcttgg
      541 tgcgaaaaga tgtgcttttt agccagctgg tggagacggc gctcctggcc ctgggctatt
      601 cccacagctc tgcagctcag gcccaaggaa taatcaagct ggggaggtgg aaccctctcc
      661 ctctcagtta tgtgacagac gcccctgatg ccaccgtggc cgacatgctg caagatgtct
      721 atcacgttgt gacgctgaag atccaattac aaagttgttc aaagttggaa gacttgcctg
      781 cagagcaatg gaaccacgcc accgtccgca atgccttaaa ggagctgctc aaagaaatga
      841 accagagcac attagccaaa gaatgccctc tctcccagag tatgatttca tccattgtaa
      901 atagcacata ctatgccaat gtgtcagcaa ccaagtgcca ggagtttggg agatggtaca
      961 aaaagtataa gaagataaaa gtggaaagag tggagcgaga gaacctttca gactattgtg
     1021 ttctgggcca gcggccaatg catttaccaa atatgaacca gctggcatcc ctgggaaaaa
     1081 ccaacgaaca gtctcctcat agccaaatcc accacagtac tccaatccgg aaccaagtgc
     1141 ccgcactgca gcccatcatg agccctggtc ttctctcacc gcagctcagc ccacagctgg
     1201 tcaggcagca aatagctatg gctcatctga taaaccagca gatcgccgtt agccgacttc
     1261 tggctcacca gcatcctcaa gccatcaacc agcagttcct gaaccatcca cccattccca
     1321 gagcagttaa gccagagcca acaaactcct ctgtggaagt ctctcctgat atctaccagc
     1381 aagttagaga tgagctgaag agggctagcg tgtctcaagc tgtcttcgca agagtggcat
     1441 tcaaccgcac acagggatta ttgtcagaga tactgcgtaa ggaagaagac cccaggactg
     1501 catctcagtc tcttctagta aacctgaggg ccatgcagaa cttcctcaac ctgcctgaag
     1561 tggagcgtga ccgcatttac caggatgagc gagagcggag catgaacccc aatgtgagca
     1621 tggtgtcctc tgcctctagc agtcccagct cctcccgaac cccacaggcc aaaacctcga
     1681 caccgacaac agacctccct attaaggtgg acggagccaa cgtcaacatc acagctgcca
     1741 tttatgacga gatccaacag gagatgaaaa gagccaaggt gtctcaagcc ctgtttgcca
     1801 aagtggctgc aaacaaaagt cagggctggc tctgtgaact gcttcgttgg aaggagaacc
     1861 ccagtccaga aaaccgcacc ctttgggaga atctctgcac cattcgccgt ttcctgaatc
     1921 ttccccagca tgagagggat gtgatctatg aggaagaatc tcgacatcac cacagtgagc
     1981 gcatgcaaca cgtggtccag ctcccacctg agcccgtgca ggtccttcat cgacagcagt
     2041 cccagccaac taaggagagc tcccctccca gagaagaagc acccccacca cctcctccaa
     2101 cagaagacag ttgtgccaaa aaacctcggt ctcgcacaaa gatctccttg gaagcactgg
     2161 gcatccttca aagcttcatc catgatgtag gcctctatcc tgaccaagaa gccatccaca
     2221 cactctcagc ccagttggat ctccctaaac acaccatcat caagttcttc cagaaccaga
     2281 ggtaccatgt gaagcatcat gggaagctga aggagcatct gggctccgcg gtggacgtgg
     2341 cggagtataa ggacgaggag ctgctgacag agtctgagga gaacgacagc gaggaaggct
     2401 cggacgagat gtacaaggtg gaggccgagg aggagagcgc agagaagaac aaggtggccc
     2461 ctgctgaaac tgaccagaga taatgtgagc tccacaggca gcgcaataca tgggtccaag
     2521 gactttccgc tttagtttct tttaaagttc ctctcggctt tgttttattt tgttttttat
     2581 tttatgtctg ttttattttt cttaccctta atggcattcc tctgttacac aggatagcct
     2641 atagactgag tgaactcaga gtttctgaat cagacgtcgc cttggcaaag acactaagtg
     2701 ttaaactttt acaattgact ggaccatagt aattctagtc acgggagacc ctgccatcat
     2761 tcttggacct acgaagagac accagacaag ttccaggatg ggaagaccca ggaaataaat
     2821 gaaggaagct acgagtgtgt gtgtatatgt atatgtacat atctctatat ttacatatat
     2881 atattaaaaa ttgcatggga cagagaactt tacaatttga aggactagac tgtgaaatga
     2941 gttcttaaac aaaagactcg tgtatgtata aaaaataata ccacttcaca gtgagtcgct
     3001 ttgac
//
