LOCUS       NP_001102776             733 aa            linear   ROD 23-MAR-2023
DEFINITION  DNA-binding protein SATB2 [Rattus norvegicus].
ACCESSION   NP_001102776 XP_001067518 XP_576570
VERSION     NP_001102776.1
DBSOURCE    REFSEQ: accession NM_001109306.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 733)
  AUTHORS   Kong J, Wan LP, Liu ZM and Gao ST.
  TITLE     MiR-1301 promotes adipogenic and osteogenic differentiation of
            BMSCs by targeting Satb2
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (7), 3501-3508 (2020)
   PUBMED   32329823
  REMARK    GeneRIF: MiR-1301 promotes adipogenic and osteogenic
            differentiation of BMSCs by targeting Satb2.
REFERENCE   2  (residues 1 to 733)
  AUTHORS   Chen JR, Zhao H, Lazarenko OP, Blackburn ML and Shankar K.
  TITLE     Maternal regulation of SATB2 in osteo-progeniters impairs skeletal
            development in offspring
  JOURNAL   FASEB J 34 (2), 2511-2523 (2020)
   PUBMED   31908011
  REMARK    GeneRIF: Maternal regulation of SATB2 in osteo-progeniters impairs
            skeletal development in offspring.
REFERENCE   3  (residues 1 to 733)
  AUTHORS   Li JY, Wei X, Sun Q, Zhao XQ, Zheng CY, Bai CX, Du J, Zhang Z, Zhu
            LG and Jia YS.
  TITLE     MicroRNA-449b-5p promotes the progression of osteoporosis by
            inhibiting osteogenic differentiation of BMSCs via targeting Satb2
  JOURNAL   Eur Rev Med Pharmacol Sci 23 (15), 6394-6403 (2019)
   PUBMED   31378877
  REMARK    GeneRIF: MicroRNA-449b-5p promotes the progression of osteoporosis
            by inhibiting osteogenic differentiation of BMSCs via targeting
            Satb2.
REFERENCE   4  (residues 1 to 733)
  AUTHORS   Wu G, Xu R, Zhang P, Xiao T, Fu Y, Zhang Y, Du Y, Ye J, Cheng J and
            Jiang H.
  TITLE     Estrogen regulates stemness and senescence of bone marrow stromal
            cells to prevent osteoporosis via ERbeta-SATB2 pathway
  JOURNAL   J Cell Physiol 233 (5), 4194-4204 (2018)
   PUBMED   29030963
  REMARK    GeneRIF: bone marrow stromal cells from the OVX rats displayed
            increased senescence and weaker SATB2 expression, stemness, and
            osteogenic differentiation, while estrogen could rescue these
            phenotypes. Inhibition of ERb or ERa confirmed that SATB2 was
            associated with ERb in estrogen-mediated pluripotency and
            senescence of BMSCs.
REFERENCE   5  (residues 1 to 733)
  AUTHORS   Hao J, Zhang L, Cong G, Ren L and Hao L.
  TITLE     MicroRNA-34b/c inhibits aldosterone-induced vascular smooth muscle
            cell calcification via a SATB2/Runx2 pathway
  JOURNAL   Cell Tissue Res 366 (3), 733-746 (2016)
   PUBMED   27503378
  REMARK    GeneRIF: miR-34b/c participates in aldosterone-induced vascular
            smooth muscle cell calcification via a SATB2/Runx2 pathway.
REFERENCE   6  (residues 1 to 733)
  AUTHORS   Arnold SJ, Huang GJ, Cheung AF, Era T, Nishikawa S, Bikoff EK,
            Molnar Z, Robertson EJ and Groszer M.
  TITLE     The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in
            the cortical subventricular zone
  JOURNAL   Genes Dev 22 (18), 2479-2484 (2008)
   PUBMED   18794345
REFERENCE   7  (residues 1 to 733)
  AUTHORS   Britanova O, de Juan Romero C, Cheung A, Kwan KY, Schwark M, Gyorgy
            A, Vogel T, Akopov S, Mitkovski M, Agoston D, Sestan N, Molnar Z
            and Tarabykin V.
  TITLE     Satb2 is a postmitotic determinant for upper-layer neuron
            specification in the neocortex
  JOURNAL   Neuron 57 (3), 378-392 (2008)
   PUBMED   18255031
REFERENCE   8  (residues 1 to 733)
  AUTHORS   Britanova O, Depew MJ, Schwark M, Thomas BL, Miletich I, Sharpe P
            and Tarabykin V.
  TITLE     Satb2 haploinsufficiency phenocopies 2q32-q33 deletions, whereas
            loss suggests a fundamental role in the coordination of jaw
            development
  JOURNAL   Am J Hum Genet 79 (4), 668-678 (2006)
   PUBMED   16960803
REFERENCE   9  (residues 1 to 733)
  AUTHORS   Dobreva G, Chahrour M, Dautzenberg M, Chirivella L, Kanzler B,
            Farinas I, Karsenty G and Grosschedl R.
  TITLE     SATB2 is a multifunctional determinant of craniofacial patterning
            and osteoblast differentiation
  JOURNAL   Cell 125 (5), 971-986 (2006)
   PUBMED   16751105
REFERENCE   10 (residues 1 to 733)
  AUTHORS   Britanova O, Akopov S, Lukyanov S, Gruss P and Tarabykin V.
  TITLE     Novel transcription factor Satb2 interacts with matrix attachment
            region DNA elements in a tissue-specific manner and demonstrates
            cell-type-dependent expression in the developing mouse CNS
  JOURNAL   Eur J Neurosci 21 (3), 658-668 (2005)
   PUBMED   15733084
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473965.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_576570.1, XP_001067518.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760393,
                              SAMN16418986 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..733
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q31"
     Protein         1..733
                     /product="DNA-binding protein SATB2"
                     /note="special AT-rich sequence binding protein 2"
                     /calculated_mol_wt=82457
     Region          58..156
                     /region_name="ULD"
                     /note="Ubiquitin-like oligomerization domain of SATB;
                     pfam16534"
                     /db_xref="CDD:465165"
     Site            order(61,63,80..84,86,118,120,123..124,130..133,141..142,
                     145..147,149..150)
                     /site_type="other"
                     /note="tetramer interface [polypeptide binding]"
                     /db_xref="CDD:211426"
     Region          162..233
                     /region_name="CUTL"
                     /note="CUT1-like DNA-binding domain of SATB; pfam16557"
                     /db_xref="CDD:435427"
     Region          355..433
                     /region_name="CUT"
                     /note="CUT domain; pfam02376"
                     /db_xref="CDD:460543"
     Region          477..556
                     /region_name="CUT"
                     /note="CUT domain; pfam02376"
                     /db_xref="CDD:460543"
     Region          614..671
                     /region_name="HOX"
                     /note="Homeodomain; smart00389"
                     /db_xref="CDD:197696"
     Site            order(615..619,621,639,645,658,660..661,664..665,667..669,
                     671..672)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     Site            order(617,620,661,664..665,668)
                     /site_type="other"
                     /note="specific DNA base contacts [nucleotide binding]"
                     /db_xref="CDD:238039"
     CDS             1..733
                     /gene="Satb2"
                     /gene_synonym="RGD1562369"
                     /coded_by="NM_001109306.1:282..2483"
                     /db_xref="GeneID:501145"
                     /db_xref="RGD:1562369"
ORIGIN      
        1 merrsespcl rdspdrrsgs pdvkgpppvk varleqngsp mgargrpnga vakavgglmi
       61 pvfcvveqld gsleydnree haefvlvrkd vlfsqlveta llalgyshss aaqaqgiikl
      121 grwnplplsy vtdapdatva dmlqdvyhvv tlkiqlqscs kledlpaeqw nhatvrnalk
      181 ellkemnqst lakecplsqs missivnsty yanvsatkcq efgrwykkyk kikververe
      241 nlsdycvlgq rpmhlpnmnq laslgktneq sphsqihhst pirnqvpalq pimspgllsp
      301 qlspqlvrqq iamahlinqq iavsrllahq hpqainqqfl nhppipravk peptnssvev
      361 spdiyqqvrd elkrasvsqa vfarvafnrt qgllseilrk eedprtasqs llvnlramqn
      421 flnlpeverd riyqderers mnpnvsmvss assspsssrt pqaktstptt dlpikvdgan
      481 vnitaaiyde iqqemkrakv sqalfakvaa nksqgwlcel lrwkenpspe nrtlwenlct
      541 irrflnlpqh erdviyeees rhhhsermqh vvqlppepvq vlhrqqsqpt kessppreea
      601 ppppppteds cakkprsrtk islealgilq sfihdvglyp dqeaihtlsa qldlpkhtii
      661 kffqnqryhv khhgklkehl gsavdvaeyk deelltesee ndseegsdem ykveaeeesa
      721 eknkvapaet dqr
//
