LOCUS       NM_001012129            3001 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus SATB homeobox 1 (Satb1), mRNA.
ACCESSION   NM_001012129 XM_236849
VERSION     NM_001012129.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3001)
  AUTHORS   Guo J, Chen Z, Xiao Y, Yu G and Li Y.
  TITLE     SATB1 promotes osteogenic differentiation of diabetic rat BMSCs
            through MAPK signalling activation
  JOURNAL   Oral Dis 29 (8), 3610-3619 (2023)
   PUBMED   35608610
  REMARK    GeneRIF: SATB1 promotes osteogenic differentiation of diabetic rat
            BMSCs through MAPK signalling activation.
REFERENCE   2  (bases 1 to 3001)
  AUTHORS   Kubota K, Iqbal K and Soares MJ.
  TITLE     SATB1 promotion of trophoblast stem cell renewal through regulation
            of threonine dehydrogenase
  JOURNAL   Biochim Biophys Acta Gen Subj 1865 (1), 129757 (2021)
   PUBMED   33011339
  REMARK    GeneRIF: SATB1 promotion of trophoblast stem cell renewal through
            regulation of threonine dehydrogenase.
REFERENCE   3  (bases 1 to 3001)
  AUTHORS   Delic Jukic IK, Kostic S, Filipovic N, Gudelj Ensor L, Ivandic M,
            Dukic JJ, Vitlov Uljevic M, Ferhatovic Hamzic L, Puljak L and
            Vukojevic K.
  TITLE     Changes in expression of special AT-rich sequence binding protein 1
            and phosphatase and tensin homologue in kidneys of diabetic rats
            during ageing
  JOURNAL   Nephrol Dial Transplant 33 (10), 1734-1741 (2018)
   PUBMED   29506055
  REMARK    GeneRIF: High SATB1 expression is associated with diabetes.
            Erratum:[Nephrol Dial Transplant. 2018 Jun 1;33(6):1075. PMID:
            29617880]
REFERENCE   4  (bases 1 to 3001)
  AUTHORS   Liu HW, Bi WT, Huang HT, Li RX, Xi Q, Feng L, Bo W, Hu M and Wen
            WS.
  TITLE     Satb1 promotes Schwann cell viability and migration via activation
            of PI3K/AKT pathway
  JOURNAL   Eur Rev Med Pharmacol Sci 22 (13), 4268-4277 (2018)
   PUBMED   30024617
  REMARK    GeneRIF: Study in primary rat Schwann cells found that knock-out of
            Satb1 significantly inhibited cell viability and migration and
            promoted Schwann cells apoptosis. Over-expression of Satb1 promoted
            cell viability, migration, and inhibited apoptosis. Satb1 activates
            the PI3K/AKT signaling pathway by inhibiting the expression of
            SHIP1 by recruiting HDAC1.
REFERENCE   5  (bases 1 to 3001)
  AUTHORS   He J, Gong J, Ding Q, Tan Q, Han P, Liu J, Zhou Z, Tu W, Xia Y, Yan
            W and Tian D.
  TITLE     Suppressive effect of SATB1 on hepatic stellate cell activation and
            liver fibrosis in rats
  JOURNAL   FEBS Lett 589 (12), 1359-1368 (2015)
   PUBMED   25896016
  REMARK    GeneRIF: Data suggest that SATB1 expression is down-regulated
            during activation of hepatic stellate cell in liver fibrosis;
            up-regulation of SATB1 expression appears to reduce such cell
            activation, cell proliferation, cell migration, and collagen
            synthesis.
REFERENCE   6  (bases 1 to 3001)
  AUTHORS   Seo J, Lozano MM and Dudley JP.
  TITLE     Nuclear matrix binding regulates SATB1-mediated transcriptional
            repression
  JOURNAL   J Biol Chem 280 (26), 24600-24609 (2005)
   PUBMED   15851481
REFERENCE   7  (bases 1 to 3001)
  AUTHORS   Nie H, Maika SD, Tucker PW and Gottlieb PD.
  TITLE     A role for SATB1, a nuclear matrix association region-binding
            protein, in the development of CD8SP thymocytes and peripheral T
            lymphocytes
  JOURNAL   J Immunol 174 (8), 4745-4752 (2005)
   PUBMED   15814699
REFERENCE   8  (bases 1 to 3001)
  AUTHORS   Cai S, Han HJ and Kohwi-Shigematsu T.
  TITLE     Tissue-specific nuclear architecture and gene expression regulated
            by SATB1
  JOURNAL   Nat Genet 34 (1), 42-51 (2003)
   PUBMED   12692553
REFERENCE   9  (bases 1 to 3001)
  AUTHORS   Alvarez JD, Yasui DH, Niida H, Joh T, Loh DY and Kohwi-Shigematsu
            T.
  TITLE     The MAR-binding protein SATB1 orchestrates temporal and spatial
            expression of multiple genes during T-cell development
  JOURNAL   Genes Dev 14 (5), 521-535 (2000)
   PUBMED   10716941
REFERENCE   10 (bases 1 to 3001)
  AUTHORS   Nakagomi K, Kohwi Y, Dickinson LA and Kohwi-Shigematsu T.
  TITLE     A novel DNA-binding motif in the nuclear matrix attachment
            DNA-binding protein SATB1
  JOURNAL   Mol Cell Biol 14 (3), 1852-1860 (1994)
   PUBMED   8114718
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085814.1.
            
            On Aug 30, 2012 this sequence version replaced NM_001012129.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085814.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3001              BC085814.1         2-3002
FEATURES             Location/Qualifiers
     source          1..3001
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q11"
     gene            1..3001
                     /gene="Satb1"
                     /note="SATB homeobox 1"
                     /db_xref="GeneID:316164"
                     /db_xref="RGD:1305561"
     exon            1..230
                     /gene="Satb1"
                     /inference="alignment:Splign:2.1.0"
     exon            231..475
                     /gene="Satb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             265..2559
                     /gene="Satb1"
                     /note="special AT-rich sequence binding protein 1"
                     /codon_start=1
                     /product="DNA-binding protein SATB1"
                     /protein_id="NP_001012129.1"
                     /db_xref="GeneID:316164"
                     /db_xref="RGD:1305561"
                     /translation="MDHLNETTQGKEHSEMSNNVSDPKGPPAKIARLEQNGSPLGRGR
                     LGSTGGKMQGVPLKHSGHLMKTNLRKGTMLPVFCVVEHYENAIEYDCKEEHAEFVLVR
                     KDMLFNQLIEMALLSLGYSHSSAAQAKGLIQVGKWNPVPLSYVTDAPDATVADMLQDV
                     YHVVTLKIQLHSCPKLEDLPPEQWSHTTVRNALKDLLKDMNQSSLAKECPLSQSMISS
                     IVNSTYYANVSAAKCQEFGRWYKHFKKTKDMMVEMDSLSELSQQGANHVNFGQQPVPG
                     NTAEQPPSPAQLSHGSQPSVRTPLPNLHPGLVSTPISPQLVNQQLVMAQLLNQQYAVN
                     RLLAQQSLNQQYLNHPPPVSRSMNKPLEQQVSTNTEVSSEIYQWVRDELKRAGISQAV
                     FARVAFNRTQGLLSEILRKEEDPKTASQSLLVNLRAMQNFLQLPEAERDRIYQDERER
                     SLNAASAMGPAPLLSTPPSRPPQVKTATLATERNGKPENNTMNINASIYDEIQQEMKR
                     AKVSQALFAKVAATKSQGWLCELLRWKEDPSPENRTLWENLSMIRRFLSLPQPERDAI
                     YEQESNAVHHHGDRPPHIIHVPAEQLQQQQQQQQQQQQQQQPPPPPPQPQPQPQAGPR
                     LPPRQPTVASSAESDEENRQKTRPRTKISVEALGILQSFIQDVGLYPDEEAIQTLSAQ
                     LDLPKYTIIKFFQNQRYYLKHHGKLKDNSGLEVDVAEYKDEELLKDLEESVQDKNANT
                     LFSVKLEEELSVEGSTDINADLKD"
     exon            476..652
                     /gene="Satb1"
                     /inference="alignment:Splign:2.1.0"
     exon            653..779
                     /gene="Satb1"
                     /inference="alignment:Splign:2.1.0"
     exon            780..903
                     /gene="Satb1"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1015
                     /gene="Satb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1470
                     /gene="Satb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1683
                     /gene="Satb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1839
                     /gene="Satb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..2043
                     /gene="Satb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2044..2979
                     /gene="Satb1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttttgccct tcccccgcct agcggggcgc ggggtaaggg aagagaaaat aatacaattt
       61 caggggaagt cgccttcagg tctgctgcct tttttttttt ttttttaaac aataataata
      121 ataataaaaa ggacatagaa aacaccagtc ttgaacttca cttcaggaac cccggctgca
      181 aaggaaatct cctttgtttt gttatttata tgctgtcaag ttttgaagtg ttctggcagg
      241 tgatctgtaa gacagtgact gagtatggat catttgaacg agacaactca ggggaaagag
      301 cattccgaaa tgtctaacaa tgtgagtgat ccgaagggtc cgccggccaa gattgcccgc
      361 ctggagcaga acgggagccc actaggaaga ggaaggcttg ggagcacagg tggaaagatg
      421 cagggagtgc ctttaaaaca ctcgggccac ctcatgaaaa ccaaccttag gaaaggaacc
      481 atgttacccg ttttctgtgt ggtggaacat tatgaaaacg ccatcgagta tgattgcaag
      541 gaggagcatg cggaatttgt gttggtgagg aaggatatgc ttttcaacca gctcatagag
      601 atggcgttgc tgtctctggg ctattcacac agctctgctg cccaagccaa agggctcatc
      661 caggttggga agtggaatcc agttccactg tcgtatgtga cagatgcccc tgatgccaca
      721 gtggcagaca tgcttcagga tgtgtaccat gtggtcactc tgaaaatcca gctgcacagt
      781 tgccccaaac tagaagactt gcctcctgaa caatggtccc acaccacagt aaggaatgct
      841 ctgaaggact tactgaaaga catgaaccag agttcgttgg ccaaggagtg ccccctctca
      901 cagagcatga tctcctccat cgtgaacagc acgtactatg caaatgtctc agcagcaaaa
      961 tgtcaagagt ttggaaggtg gtacaaacat ttcaagaaga caaaggatat gatggttgag
     1021 atggatagtc tgtctgagct atcccagcaa ggcgccaacc atgtcaattt tggccagcag
     1081 cctgtcccag gaaacacagc tgagcagcct ccgtcccctg cacagctctc ccacggcagc
     1141 cagccctctg tccggacccc tcttccgaac ctgcaccctg ggcttgtgtc aacacctatc
     1201 agtcctcagc tggtcaacca gcagctggtg atggcccagt tgctgaacca gcagtatgca
     1261 gtgaacagac tcttggccca gcagtcctta aaccaacagt acttgaacca ccctccccct
     1321 gtcagtaggt ctatgaacaa gcctttggag cagcaagttt ccaccaacac cgaggtctct
     1381 tccgaaatct accagtgggt gcgggatgaa ctgaaacgag ccggaatctc acaggcagtg
     1441 tttgcacgag tggcttttaa cagaactcag ggattgcttt ctgaaatcct ccgcaaggaa
     1501 gaggacccca agactgcatc ccagtctctg ctggtaaacc ttcgggctat gcagaatttc
     1561 ttacagttgc cagaagctga aagagaccgg atataccagg atgagaggga aaggagcttg
     1621 aacgcagcct ccgccatggg gcctgccccg ctgctgagca cgccacccag ccgccctcct
     1681 caggtgaaaa cagctaccct cgccactgag aggaatggga agccagagaa caatactatg
     1741 aacattaacg cctccattta tgacgagatt cagcaggaaa tgaagcgtgc taaagtgtcc
     1801 caagcactgt ttgcaaaggt tgctgccaca aaaagccagg gatggctgtg cgagctgctg
     1861 cgctggaaag aagacccttc tccagaaaac agaaccctgt gggagaacct gtcaatgatc
     1921 cgaagattcc tcagtctgcc tcagcctgag cgcgatgcca tctatgagca ggagagcaat
     1981 gccgtgcatc accatggcga caggcctccc cacatcatcc atgttccagc ggaacagctt
     2041 cagcagcagc agcagcagca gcagcaacag cagcagcaac agcagccacc gccaccacct
     2101 ccacagccac agccacagcc ccaggcaggc cccaggctcc caccccggca gcccaccgtg
     2161 gcctcctctg cagagtccga tgaggaaaac cggcagaaga ccaggccacg aaccaaaatt
     2221 tccgtggaag ccctgggcat ccttcagagt ttcatccaag atgtcggcct gtacccggat
     2281 gaagaggcca tccagaccct gtcggcgcag ctggacctcc cgaagtacac catcatcaag
     2341 ttctttcaga accagcggta ctaccttaag caccacggca agctgaagga caactccggc
     2401 ttggaggtgg atgtggctga gtacaaagat gaggagttgc ttaaggattt ggaggagagc
     2461 gtccaggata aaaacgccaa cacccttttt tcggtgaaac tagaggaaga gctatccgtg
     2521 gaagggagca cagacattaa tgccgacctg aaagactgag agaacagtac tgtttccagc
     2581 cgcgccactg gtatttccta ccaacatgag aagtcagtcc accttgtgtt cgctcagaaa
     2641 aaccttcatc gtttatcgtt tggccaatga atcttcggaa acttgcacaa acaggaagtc
     2701 agaaggacag gacagactgc actcgaggtt ttactctgtt ttacaaactg cttggcggcc
     2761 ccaggtgaag cgtcaaggat tgttgggtag aatttgtgtt caagggctgc acccaggtgt
     2821 tgtaccctgt cagcatgata ccagaaattg gttttccttt tggttattat tctggagcct
     2881 caaataagca ttataacttc tgtgattatg attgcctttt ctttaattat ttctgtaaca
     2941 ctccacacta gtctttggaa accggcccct tattttaaaa aaaaaaaaaa aaaaaaaaaa
     3001 a
//
