LOCUS       NM_001108278             870 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus spermidine/spermine N1-acetyltransferase family
            member 2 (Sat2), mRNA.
ACCESSION   NM_001108278 XM_001079461 XM_340825
VERSION     NM_001108278.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 870)
  AUTHORS   Fragoza R, Das J, Wierbowski SD, Liang J, Tran TN, Liang S, Beltran
            JF, Rivera-Erick CA, Ye K, Wang TY, Yao L, Mort M, Stenson PD,
            Cooper DN, Wei X, Keinan A, Schimenti JC, Clark AG and Yu H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 870)
  AUTHORS   He W, Liu Y, Geng H and Li Y.
  TITLE     The regulation effect of ulinastatin on the expression of SSAT2 and
            AQP4 in myocardial tissue of rats after cardiopulmonary
            resuscitation
  JOURNAL   Int J Clin Exp Pathol 8 (9), 10792-10799 (2015)
   PUBMED   26617791
  REMARK    GeneRIF: Ulinastatin can effectively reduce the cardiac function
            damage caused by cardiopulmonary resuscitation, which could be
            related with the increased SSAT2 and decreased AQP4.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 870)
  AUTHORS   Blot A, Billups D, Bjorkmo M, Quazi AZ, Uwechue NM, Chaudhry FA and
            Billups B.
  TITLE     Functional expression of two system A glutamine transporter
            isoforms in rat auditory brainstem neurons
  JOURNAL   Neuroscience 164 (3), 998-1008 (2009)
   PUBMED   19751803
  REMARK    GeneRIF: Our results indicate that both isoforms are expressed in
            MNTB principal neurons, and demonstrate that functional system A
            transporters are present in the plasma membrane of neurons.
REFERENCE   4  (bases 1 to 870)
  AUTHORS   Jenstad M, Quazi AZ, Zilberter M, Haglerod C, Berghuis P, Saddique
            N, Goiny M, Buntup D, Davanger S, S Haug FM, Barnes CA, McNaughton
            BL, Ottersen OP, Storm-Mathisen J, Harkany T and Chaudhry FA.
  TITLE     System A transporter SAT2 mediates replenishment of dendritic
            glutamate pools controlling retrograde signaling by glutamate
  JOURNAL   Cereb Cortex 19 (5), 1092-1106 (2009)
   PUBMED   18832333
  REMARK    GeneRIF: SAT2 maintains a key metabolic glutamine/glutamate balance
            underpinning retrograde signaling by dendritic release of the
            neurotransmitter glutamate
REFERENCE   5  (bases 1 to 870)
  AUTHORS   Gammelsaeter R, Jenstad M, Bredahl MK, Gundersen V and Chaudhry FA.
  TITLE     Complementary expression of SN1 and SAT2 in the islets of
            Langerhans suggests concerted action of glutamine transport in the
            regulation of insulin secretion
  JOURNAL   Biochem Biophys Res Commun 381 (3), 378-382 (2009)
   PUBMED   19233140
  REMARK    GeneRIF: pronounced expression of SN1 and SAT2 in B-cells and
            A-cells, respectively, was shown suggesting pronounced expression
            of SN1 and SAT2 in B-cells and A-cells, respectively.
REFERENCE   6  (bases 1 to 870)
  AUTHORS   Semenza GL.
  TITLE     Regulation of oxygen homeostasis by hypoxia-inducible factor 1
  JOURNAL   Physiology (Bethesda) 24, 97-106 (2009)
   PUBMED   19364912
  REMARK    Review article
REFERENCE   7  (bases 1 to 870)
  AUTHORS   Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta
            R, Wang NS and Knepper MA.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   8  (bases 1 to 870)
  AUTHORS   Chen Y, Vujcic S, Liang P, Diegelman P, Kramer DL and Porter CW.
  TITLE     Genomic identification and biochemical characterization of a second
            spermidine/spermine N1-acetyltransferase
  JOURNAL   Biochem J 373 (Pt 3), 661-667 (2003)
   PUBMED   12803540
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473948.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_340825.3, XM_001079461.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: FM088604.1, FM130688.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMD00132261, SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..870
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..870
                     /gene="Sat2"
                     /note="spermidine/spermine N1-acetyltransferase family
                     member 2"
                     /db_xref="GeneID:360547"
                     /db_xref="RGD:1307869"
     exon            1..217
                     /gene="Sat2"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..664
                     /gene="Sat2"
                     /EC_number="2.3.1.57"
                     /note="diamine N-acetyltransferase 2; diamine
                     acetyltransferase 2; spermidine/spermine N1-acetyl
                     transferase 2"
                     /codon_start=1
                     /product="thialysine N-epsilon-acetyltransferase"
                     /protein_id="NP_001101748.1"
                     /db_xref="GeneID:360547"
                     /db_xref="RGD:1307869"
                     /translation="MASTRIREAKESDCGDIMRMIRELAEFEKLSHQVKISEEALRAD
                     GFGENPFFHCLVAEIIPAPGEPQGSLVVGYGLYYFIYSTWTGRNIYLEDIYVMPKYRG
                     QGIGTKIIKKVAEVALRKGCSQFRLAVLNWNKKAVNLYKFLGAQDLTESEGWLSFRFE
                     GEAMRELAGC"
     exon            218..269
                     /gene="Sat2"
                     /inference="alignment:Splign:2.1.0"
     exon            270..353
                     /gene="Sat2"
                     /inference="alignment:Splign:2.1.0"
     exon            354..455
                     /gene="Sat2"
                     /inference="alignment:Splign:2.1.0"
     exon            456..496
                     /gene="Sat2"
                     /inference="alignment:Splign:2.1.0"
     exon            497..870
                     /gene="Sat2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggttggtg ccataatcct gtctgggagc tcccaacatt tcttctgccc cttgctccca
       61 accctttgag acctgagctg taggtccttt ctgcggttct acagacatgg gaattgtctt
      121 tgatctttga tttttgacag tgaggcttag gatggcttcc acgcgaatcc gagaggccaa
      181 ggagagcgat tgtggagaca ttatgaggat gattcgggaa ctggcagagt tcgagaaact
      241 gtcccatcag gtgaagatca gtgaagaagc cctgagagca gatggctttg gagagaaccc
      301 tttctttcac tgtttggtgg cagagattat tccagcccct ggggagccac aagggtccct
      361 tgtggtgggc tacgggctct actacttcat ctacagcaca tggaccggac gaaacattta
      421 tctggaagac atctatgtga tgccgaaata tcggggtcaa gggattggta ccaaaataat
      481 caaaaaggtg gctgaggtcg ctctgcgtaa ggggtgctcc cagttccgcc tggcagttct
      541 gaactggaac aagaaggccg tgaacttgta caagtttcta ggggctcaag atctgaccga
      601 atcggaaggc tggctctcct ttcgatttga aggagaggca atgagggagt tggccggatg
      661 ctgacttatc ccccctctct ctcttctttg gggttaccat ctggagttcc taagattcac
      721 aggcactgac ctggacagac actcactcag agcctcccag gatgcagatt tctaaagtat
      781 agaaagagtg gaagcaagcg ggggaagcct tgttggggac cacaaataaa atacctactt
      841 taccctgatg ggtagaggat atgctgctgc
//
