LOCUS       NM_001007667            1162 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus spermidine/spermine N1-acetyl transferase 1
            (Sat1), mRNA.
ACCESSION   NM_001007667 XM_217609
VERSION     NM_001007667.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1162)
  AUTHORS   Fiori,L.M., Wanner,B., Jomphe,V., Croteau,J., Vitaro,F.,
            Tremblay,R.E., Bureau,A. and Turecki,G.
  TITLE     Association of polyaminergic loci with anxiety, mood disorders, and
            attempted suicide
  JOURNAL   PLoS One 5 (11), e15146 (2010)
   PUBMED   21152090
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1162)
  AUTHORS   Blot,A., Billups,D., Bjorkmo,M., Quazi,A.Z., Uwechue,N.M.,
            Chaudhry,F.A. and Billups,B.
  TITLE     Functional expression of two system A glutamine transporter
            isoforms in rat auditory brainstem neurons
  JOURNAL   Neuroscience 164 (3), 998-1008 (2009)
   PUBMED   19751803
  REMARK    GeneRIF: Our results indicate that both isoforms are expressed in
            MNTB principal neurons, and demonstrate that functional system A
            transporters are present in the plasma membrane of neurons.
REFERENCE   3  (bases 1 to 1162)
  AUTHORS   Krick,W., Schnedler,N., Burckhardt,G. and Burckhardt,B.C.
  TITLE     Ability of sat-1 to transport sulfate, bicarbonate, or oxalate
            under physiological conditions
  JOURNAL   Am J Physiol Renal Physiol 297 (1), F145-F154 (2009)
   PUBMED   19369292
  REMARK    GeneRIF: Sat-1 preferentially works as an electroneutral
            sulfate-bicarbonate or oxalate-bicarbonate exchanger.
REFERENCE   4  (bases 1 to 1162)
  AUTHORS   Semenza,G.L.
  TITLE     Regulation of oxygen homeostasis by hypoxia-inducible factor 1
  JOURNAL   Physiology (Bethesda) 24, 97-106 (2009)
   PUBMED   19364912
  REMARK    Review article
REFERENCE   5  (bases 1 to 1162)
  AUTHORS   Ryu,J.H., Cho,Y.S., Chun,Y.S. and Park,J.W.
  TITLE     Myocardial SSAT induction via AMPK signaling and its implication
            for ischemic injury
  JOURNAL   Biochem Biophys Res Commun 366 (2), 438-444 (2008)
   PUBMED   18062919
  REMARK    GeneRIF: These results suggest that myocardial SSAT is induced by
            AMPK signaling and function as a cardioprotectant under
            ATP-depleted conditions.
REFERENCE   6  (bases 1 to 1162)
  AUTHORS   Wang,Z., Zahedi,K., Barone,S., Tehrani,K., Rabb,H., Matlin,K.,
            Casero,R.A. and Soleimani,M.
  TITLE     Overexpression of SSAT in kidney cells recapitulates various
            phenotypic aspects of kidney ischemia-reperfusion injury
  JOURNAL   J Am Soc Nephrol 15 (7), 1844-1852 (2004)
   PUBMED   15213272
  REMARK    GeneRIF: SSAT has a role in kidney ischemia-reperfusion injury
REFERENCE   7  (bases 1 to 1162)
  AUTHORS   Wallace,H.M., Fraser,A.V. and Hughes,A.
  TITLE     A perspective of polyamine metabolism
  JOURNAL   Biochem J 376 (Pt 1), 1-14 (2003)
   PUBMED   13678416
  REMARK    Review article
REFERENCE   8  (bases 1 to 1162)
  AUTHORS   Aitkenhead,M., Wang,S.J., Nakatsu,M.N., Mestas,J., Heard,C. and
            Hughes,C.C.
  TITLE     Identification of endothelial cell genes expressed in an in vitro
            model of angiogenesis: induction of ESM-1, (beta)ig-h3, and NrCAM
  JOURNAL   Microvasc Res 63 (2), 159-171 (2002)
   PUBMED   11866539
REFERENCE   9  (bases 1 to 1162)
  AUTHORS   Nagesh Babu,G., Sailor,K.A., Sun,D. and Dempsey,R.J.
  TITLE     Spermidine/spermine N1-acetyl transferase activity in rat brain
            following transient focal cerebral ischemia and reperfusion
  JOURNAL   Neurosci Lett 300 (1), 17-20 (2001)
   PUBMED   11172929
REFERENCE   10 (bases 1 to 1162)
  AUTHORS   Eloranta,T.O., Khomutov,A.R., Khomutov,R.M. and Hyvonen,T.
  TITLE     Aminooxy analogues of spermidine as inhibitors of spermine synthase
            and substrates of hepatic polyamine acetylating activity
  JOURNAL   J Biochem 108 (4), 593-598 (1990)
   PUBMED   2292587
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC060588.1.
            
            On Mar 18, 2021 this sequence version replaced NM_001007667.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060588.1, FQ229984.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132263
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1162              BC060588.1         3-1164
FEATURES             Location/Qualifiers
     source          1..1162
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq21"
     gene            1..1162
                     /gene="Sat1"
                     /gene_synonym="Ab2-402; Sat; SSAT"
                     /note="spermidine/spermine N1-acetyl transferase 1"
                     /db_xref="GeneID:302642"
                     /db_xref="RGD:1586174"
     exon            1..358
                     /gene="Sat1"
                     /gene_synonym="Ab2-402; Sat; SSAT"
                     /inference="alignment:Splign:2.1.0"
     CDS             293..808
                     /gene="Sat1"
                     /gene_synonym="Ab2-402; Sat; SSAT"
                     /EC_number="2.3.1.57"
                     /note="Spermidine / spermine N1-acyltransferase (diamine
                     acetyltransferase); diamine N-acetyltransferase 1"
                     /codon_start=1
                     /product="diamine acetyltransferase 1"
                     /protein_id="NP_001007668.1"
                     /db_xref="GeneID:302642"
                     /db_xref="RGD:1586174"
                     /translation="MAKFKIRPATASDCSDILRLIKELAKYEYMEDQVVLTEKDLLED
                     GFGEHPFYHCLVAEVPKEHWTPEGHSIVGFAMYYFTYDPWIGKLLYLEDFFVMSDYRG
                     FGIGSEILKNLSQVAMKCRCSSMHFLVAEWNEPSINFYKRRGASDLSSEEGWRLFKID
                     KEYLLKMAAEE"
     exon            359..410
                     /gene="Sat1"
                     /gene_synonym="Ab2-402; Sat; SSAT"
                     /inference="alignment:Splign:2.1.0"
     exon            411..494
                     /gene="Sat1"
                     /gene_synonym="Ab2-402; Sat; SSAT"
                     /inference="alignment:Splign:2.1.0"
     exon            495..596
                     /gene="Sat1"
                     /gene_synonym="Ab2-402; Sat; SSAT"
                     /inference="alignment:Splign:2.1.0"
     exon            597..637
                     /gene="Sat1"
                     /gene_synonym="Ab2-402; Sat; SSAT"
                     /inference="alignment:Splign:2.1.0"
     exon            638..1162
                     /gene="Sat1"
                     /gene_synonym="Ab2-402; Sat; SSAT"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaacagagg gcggtgcttc ctcaggcttg catctttact ggtcgagatc tctatgtctc
       61 ttagtccggg gaggagcttc tgcatactta aaaggcactg tcttgccact gtagctgcgc
      121 agctccccag agtaagtctg ccagttttct gtcttctact gaggttcgcc gggtcatggt
      181 gccagcctga ctgagaagag gacgctcccg ggaaacgaat gaggaaccac ctcctcctgc
      241 tgttcaagta caggggcctg gtgcgcaaag ggaagaaaag caaaagacga aaatggctaa
      301 atttaagatc cgtccagcca ctgcctctga ctgcagtgac atcctgcgac tgatcaagga
      361 actggctaaa tatgaataca tggaagatca agtagtttta actgagaaag atctcttaga
      421 ggatggtttt ggagagcacc ccttctacca ctgcctggtt gcagaagtgc ctaaagagca
      481 ctggacccct gaaggacaca gcattgttgg ttttgccatg tactatttta cctatgaccc
      541 atggattggc aagttactgt atcttgaaga cttctttgtg atgagtgatt accgaggctt
      601 tggtatagga tcagaaattt tgaagaatct aagccaggtt gctatgaagt gtcgctgcag
      661 cagtatgcac ttcttggtag cagagtggaa tgaaccatct atcaacttct acaaaagaag
      721 aggtgcttcg gatctgtcca gtgaagaggg atggagacta ttcaagattg acaaagaata
      781 cttgctaaaa atggcagcag aggagtgagg tgtgccggta tagacaatga ccacctccat
      841 tgtgctttag aataaattct caacttccct tgctttctat ctcgtttgta gtgaaataat
      901 agagtgagca tccattccaa agctttatta ccagtggcgt tgttgcatgt ttgaaattcg
      961 gtctgtttaa aatggcagtc atgtatgtgg tttggaggca gaattcttga acatcttttg
     1021 atgaagaaca aggtggtatc atctttatat atgaaaaaca aaacttcatt cttgtgagtc
     1081 atttaaatgt gtacaatgta cacactggta cttagagttt ctgttttgat tcttttttaa
     1141 aaaaataaac tactctttga tt
//
