LOCUS       NM_001107156            3605 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus spliceosome associated factor 3, U4/U6 recycling
            protein (Sart3), mRNA.
ACCESSION   NM_001107156 XM_001080462 XM_222279
VERSION     NM_001107156.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3605)
  AUTHORS   Long L, Thelen JP, Furgason M, Haj-Yahya M, Brik A, Cheng D, Peng J
            and Yao T.
  TITLE     The U4/U6 recycling factor SART3 has histone chaperone activity and
            associates with USP15 to regulate H2B deubiquitination
  JOURNAL   J Biol Chem 289 (13), 8916-8930 (2014)
   PUBMED   24526689
REFERENCE   2  (bases 1 to 3605)
  AUTHORS   Zhang L, Li X and Zhao R.
  TITLE     Structural analyses of the pre-mRNA splicing machinery
  JOURNAL   Protein Sci 22 (6), 677-692 (2013)
   PUBMED   23592432
  REMARK    Review article
REFERENCE   3  (bases 1 to 3605)
  AUTHORS   Baltz AG, Munschauer M, Schwanhausser B, Vasile A, Murakawa Y,
            Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E,
            Bonneau R, Selbach M, Dieterich C and Landthaler M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 3605)
  AUTHORS   Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein
            C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J and
            Hentze MW.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 3605)
  AUTHORS   Liu Y, Timani K, Mantel C, Fan Y, Hangoc G, Cooper S, He JJ and
            Broxmeyer HE.
  TITLE     TIP110/p110nrb/SART3/p110 regulation of hematopoiesis through CMYC
  JOURNAL   Blood 117 (21), 5643-5651 (2011)
   PUBMED   21447833
REFERENCE   6  (bases 1 to 3605)
  AUTHORS   Song EJ, Werner SL, Neubauer J, Stegmeier F, Aspden J, Rio D,
            Harper JW, Elledge SJ, Kirschner MW and Rape M.
  TITLE     The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control
            reversible ubiquitination at the spliceosome
  JOURNAL   Genes Dev 24 (13), 1434-1447 (2010)
   PUBMED   20595234
REFERENCE   7  (bases 1 to 3605)
  AUTHORS   Medenbach J, Schreiner S, Liu S, Luhrmann R and Bindereif A.
  TITLE     Human U4/U6 snRNP recycling factor p110: mutational analysis
            reveals the function of the tetratricopeptide repeat domain in
            recycling
  JOURNAL   Mol Cell Biol 24 (17), 7392-7401 (2004)
   PUBMED   15314151
REFERENCE   8  (bases 1 to 3605)
  AUTHORS   Damianov A, Schreiner S and Bindereif A.
  TITLE     Recycling of the U12-type spliceosome requires p110, a component of
            the U6atac snRNP
  JOURNAL   Mol Cell Biol 24 (4), 1700-1708 (2004)
   PUBMED   14749385
REFERENCE   9  (bases 1 to 3605)
  AUTHORS   Stanek D, Rader SD, Klingauf M and Neugebauer KM.
  TITLE     Targeting of U4/U6 small nuclear RNP assembly factor SART3/p110 to
            Cajal bodies
  JOURNAL   J Cell Biol 160 (4), 505-516 (2003)
   PUBMED   12578909
REFERENCE   10 (bases 1 to 3605)
  AUTHORS   Bell M, Schreiner S, Damianov A, Reddy R and Bindereif A.
  TITLE     p110, a novel human U6 snRNP protein and U4/U6 snRNP recycling
            factor
  JOURNAL   EMBO J 21 (11), 2724-2735 (2002)
   PUBMED   12032085
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473973.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_222279.4, XM_001080462.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3605
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..3605
                     /gene="Sart3"
                     /note="spliceosome associated factor 3, U4/U6 recycling
                     protein"
                     /db_xref="GeneID:304582"
                     /db_xref="RGD:1311646"
     exon            1..323
                     /gene="Sart3"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..2897
                     /gene="Sart3"
                     /codon_start=1
                     /product="squamous cell carcinoma antigen recognized by
                     T-cells 3"
                     /protein_id="NP_001100626.1"
                     /db_xref="GeneID:304582"
                     /db_xref="RGD:1311646"
                     /translation="MATATASSASEPEVEPQARPEAEGEEDEAKPAGVGRKVLSSAET
                     AKAKGPEREVHQEGVSESDGDEEDAAMASSAESSAGEDEWEYDEEEEKNQLEIERLEE
                     QLSINGYDYNCHVGLIRLLRLEGELNKVRMARQKMSEIFPLTEELWLEWLHDEISMAV
                     DGLDRERVYELFERAVKDYICPNIWLEYGQYSVGGIGQKGGLEKVRSVFERALSSVGL
                     HMTKGLAIWEAYREFESAIVEAARLERVHSLFRRQLAIPLYEMEATFAEYEEWSEEPI
                     PESVLQSYQKALGQLEKYKPYEEALLQAEAPRLAEYQAYIDFEMKVGDPARIQLIFER
                     ALVENCLVPDLWIRYSQYLDRQLKVKDLVLSVHSRAVRNCPWTVALWSRYLLAMERHG
                     LDHQMISATFENALSAGFIQATDYVEIWQVYLDYLRRRVDFRQDSSKELEELRSMFTR
                     ALEYLQQEVEERFSESGDPSCLIMQSWARVEARLCNNMQKARELWDSIMTRGNAKYAN
                     MWLEYYNLERAHGDTQHCRKALHRAVQCTSDYPEHVCEVLLTMERTEGTLEDWDLAIQ
                     KTETRLARVNEQRMKAAEKEAALVQQEEEKAEQRKKVRAEKKALKKKKTRGADKRKAG
                     EDDDERECGEEEEEQPSKRRRMENSLASGVASAKEEETKLSGKCLTIDVAPPSKQKEK
                     AASLKRDMPKVAHDSSKDSVTVFVSNLPYSIEEPEVKLRPLFEACGEVVQIRPIFSNR
                     GDFRGYCYVEFKEEKSAQQALDLDRKNVEGRPMFVSPCVDKSKNPDFKMFRYSTTLEK
                     HKLFISGLPFSCTKEELEGICKAHGTVKDLRLVTNRAGKPKGLAYVEYENESQASQAV
                     LKMDGMTIKENVIKVAISNPPQRKVPEKPEVRTAPGAPMVPRQMYGARGKGRTQLSLL
                     PRALQRQGAAPQAENGPAPGLAATTSVATEAPKMSNADFAKLLLRK"
     exon            324..450
                     /gene="Sart3"
                     /inference="alignment:Splign:2.1.0"
     exon            451..555
                     /gene="Sart3"
                     /inference="alignment:Splign:2.1.0"
     exon            556..740
                     /gene="Sart3"
                     /inference="alignment:Splign:2.1.0"
     exon            741..792
                     /gene="Sart3"
                     /inference="alignment:Splign:2.1.0"
     exon            793..917
                     /gene="Sart3"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1073
                     /gene="Sart3"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1212
                     /gene="Sart3"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1320
                     /gene="Sart3"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1398
                     /gene="Sart3"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1457
                     /gene="Sart3"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1567
                     /gene="Sart3"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1680
                     /gene="Sart3"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1757
                     /gene="Sart3"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..1926
                     /gene="Sart3"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..2378
                     /gene="Sart3"
                     /inference="alignment:Splign:2.1.0"
     exon            2379..2531
                     /gene="Sart3"
                     /inference="alignment:Splign:2.1.0"
     exon            2532..2722
                     /gene="Sart3"
                     /inference="alignment:Splign:2.1.0"
     exon            2723..3605
                     /gene="Sart3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgggctgcg caagatggcg acggcgactg catcctcggc gtccgagccg gaggttgagc
       61 cccaggcccg gcctgaggct gagggagagg aggatgaggc gaagccggcg ggtgtgggca
      121 ggaaggtgct gtccagcgcg gagacagcca aagccaaggg ccctgagcgg gaggtgcacc
      181 aggaaggtgt gagcgagagc gatggggatg aggaggacgc cgccatggct tcctccgccg
      241 agagctccgc cggggaggac gagtgggagt acgacgagga ggaggagaag aaccagttgg
      301 agatcgagcg gctggaggag cagctgtcca tcaatggcta tgattacaac tgccacgtgg
      361 gactcatcag gctgttgcgg ctggaaggcg agctcaacaa agtgaggatg gcccgacaga
      421 agatgagcga gatcttcccc ttgactgaag agctctggct ggagtggctc cacgatgaga
      481 tcagcatggc tgtggacggc ctggaccgcg agcgtgtcta cgagctcttt gagagagccg
      541 tgaaggacta catctgtccg aacatttggc tagaatatgg ccagtactca gttggtggca
      601 ttggtcagaa aggtggccta gagaaagttc gctctgtgtt tgaacgagcc ctgtcatctg
      661 ttggcctaca catgacaaaa ggtctggcca tctgggaggc ctaccgggag tttgaaagtg
      721 ccattgtgga agctgctcgg ctggagagag tgcacagcct cttccggcgg cagctggcga
      781 tcccactgta cgagatggag gccacctttg cagagtatga agaatggtca gaagagccca
      841 tacctgagtc cgtacttcag agctatcaga aggcactggg gcagctggag aagtacaagc
      901 cttacgagga agcactgttg caagcagagg ctccacggct ggcggagtac caagcttaca
      961 tcgactttga gatgaaagtt ggggatcctg ctcgcattca gttgatcttt gagcgtgccc
     1021 tggtggagaa ctgcctggtg ccagacttat ggatccgcta cagtcagtac ctagatcgac
     1081 agctgaaagt aaaggatttg gttttatctg tacacagccg agctgtgagg aactgcccat
     1141 ggacagttgc cctgtggagt cggtacctcc tggccatgga gcgacacgga ctggaccatc
     1201 aaatgatttc cgcgaccttc gagaatgctc tgagtgccgg attcatccag gccactgatt
     1261 atgtggagat ctggcaggtg tacctagact acctgaggag aagggttgac ttcagacaag
     1321 actctagcaa agagctggaa gagctgcggt ccatgttcac gcgtgctctg gagtatctgc
     1381 agcaggaggt tgaggagcgt ttcagcgaga gcggagatcc aagctgcctg atcatgcaga
     1441 gctgggcccg ggttgaggct cgcctgtgca ataacatgca gaaagctcga gaactctggg
     1501 acagcatcat gaccagaggg aatgccaagt acgccaacat gtggctggag tactacaacc
     1561 tggaaagggc acacggtgac acacagcact gtcggaaggc tctgcaccga gctgtgcagt
     1621 gcacgagcga ctaccctgag catgtctgtg aagtgctgct caccatggag aggacagaag
     1681 ggaccttgga agattgggac ctagccattc agaagacaga gacgcgcttg gctcgtgtga
     1741 acgagcaaag gatgaaggct gcagagaagg aagcagctct tgtgcagcag gaagaagaaa
     1801 aggctgagca gcggaagaag gtgcgggcgg agaagaaagc cctgaaaaag aagaagacgc
     1861 gaggtgcaga caagcgcaag gcaggcgagg acgatgatga gagagagtgc ggtgaagagg
     1921 aggaagaaca gccttccaaa cgcagaagga tggagaacag cttggcctct ggagtggctt
     1981 cagctaagga ggaagaaaca aaactttccg ggaaatgctt aacaatagac gttgctcctc
     2041 cttccaagca gaaagagaag gccgcctccc ttaagcggga catgcccaag gtggctcacg
     2101 acagcagcaa ggacagtgtc actgtctttg tcagcaacct gccctacagc atagaagaac
     2161 cagaggtgaa gctcaggccg ctctttgagg cctgtgggga agtggtccag atcaggccaa
     2221 tcttcagcaa ccgtggggac ttccggggct actgctatgt ggagtttaaa gaggagaagt
     2281 cagcccagca ggccctggat ctagacagga agaatgtgga aggaaggccg atgtttgtgt
     2341 ccccctgtgt ggataagagc aagaaccccg attttaagat gttcagatac agcaccaccc
     2401 tggagaaaca caaactcttc atctcgggcc tgcccttttc ctgcaccaaa gaggaacttg
     2461 aaggcatttg taaggctcat ggcactgtta aggacctcag gctggttact aacagggccg
     2521 gcaagccaaa gggcttggcg tacgtggagt atgagaatga gtcccaggcc tctcaggcag
     2581 tgctgaagat ggatggcatg accatcaaag agaacgtcat caaagtggcg atcagcaacc
     2641 cccctcagcg gaaagttcca gagaagccag aagtgaggac agccccagga gcccccatgg
     2701 ttccccggca gatgtatgga gcgcgcggga agggacggac ccagctctcg cttcttcctc
     2761 gggctctgca gcgccagggt gctgctcctc aggctgagaa cggcccagct ccggggctgg
     2821 cagccaccac ctctgtggcc actgaggctc ctaagatgtc caatgccgat tttgcgaagt
     2881 tactcctgag aaagtgagca ggactctgag atggaatgcc ttacctgctc cttcatgctg
     2941 gccaggctgg ctgctgtggg ccctgggcac agaagggctg ggcactcaaa cctgcgtgcc
     3001 caccgatttc tcctccggtg tagatgggaa gggagagcct atgttgagca tggcggtgag
     3061 gagtgttccc tcacattgag ggcggaggcc gactgctcta cgggctgtcc cacggtacgt
     3121 tagtgtccta acaaggaggg actcagcttt cgaggcctac ttgtcctgat actttcaccg
     3181 cctctggccc tttttctacg aaccccctcc ccggccctgc acagcacgcg tgcccatcac
     3241 tctttagtgt gaaaggtgga gtggaggagc cgcactcatc agagtggcct gttcagtgaa
     3301 gtgcccgagg gacatcacag aaggctcgct tgatgggttt tgtccaaaga gcctatgagt
     3361 ttttctatta tgtatttgta attgacattt tgactgtttt atgttcccta aacgtgggga
     3421 gtctgcaaca cttgttccta ggaattgtgt gtgccacccg ctgtgtgtgc cacccactgt
     3481 ggcccatttt ctttgcctga tgactgaaga cctacgccct ctgctcaaac actcatgcct
     3541 ggtgccgtgt ccagtgcaga gtgagttccc atttagttct gtttattaaa ctgaagttct
     3601 tacag
//
