LOCUS       NM_031596               2532 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus spliceosome associated factor 1, recruiter of
            U4/U6.U5 tri-snRNP (Sart1), mRNA.
ACCESSION   NM_031596
VERSION     NM_031596.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2532)
  AUTHORS   Bertram,K., Agafonov,D.E., Dybkov,O., Haselbach,D., Leelaram,M.N.,
            Will,C.L., Urlaub,H., Kastner,B., Luhrmann,R. and Stark,H.
  TITLE     Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for
            Activation
  JOURNAL   Cell 170 (4), 701-713 (2017)
   PUBMED   28781166
REFERENCE   2  (bases 1 to 2532)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 2532)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 2532)
  AUTHORS   Lemm,I., Girard,C., Kuhn,A.N., Watkins,N.J., Schneider,M.,
            Bordonne,R. and Luhrmann,R.
  TITLE     Ongoing U snRNP biogenesis is required for the integrity of Cajal
            bodies
  JOURNAL   Mol Biol Cell 17 (7), 3221-3231 (2006)
   PUBMED   16687569
REFERENCE   5  (bases 1 to 2532)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   6  (bases 1 to 2532)
  AUTHORS   Kikuchi,M., Nakao,M., Inoue,Y., Matsunaga,K., Shichijo,S.,
            Yamana,H. and Itoh,K.
  TITLE     Identification of a SART-1-derived peptide capable of inducing
            HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes
  JOURNAL   Int J Cancer 81 (3), 459-466 (1999)
   PUBMED   10209962
REFERENCE   7  (bases 1 to 2532)
  AUTHORS   Gotoh,M., Shichijo,S., Hoshino,T., Imai,Y., Imaizumi,T., Inoue,Y.,
            Takasu,H., Yamaoka,T. and Itoh,K.
  TITLE     Sequence analysis of genes encoding rodent homologues of the human
            tumor-rejection antigen SART-1
  JOURNAL   Jpn J Cancer Res 89 (8), 849-854 (1998)
   PUBMED   9765622
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB014722.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB014722.1, BC083551.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2532
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..2532
                     /gene="Sart1"
                     /note="spliceosome associated factor 1, recruiter of
                     U4/U6.U5 tri-snRNP"
                     /db_xref="GeneID:29678"
                     /db_xref="RGD:61930"
     exon            1..371
                     /gene="Sart1"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..2479
                     /gene="Sart1"
                     /note="SART-1; rSART-1; squamous cell carcinoma antigen
                     recognized by T cells 1; SART1, U4/U6.U5
                     tri-snRNP-associated protein 1"
                     /codon_start=1
                     /product="U4/U6.U5 tri-snRNP-associated protein 1"
                     /protein_id="NP_113784.1"
                     /db_xref="GeneID:29678"
                     /db_xref="RGD:61930"
                     /translation="MGSSKKHRGEKEAAGTTAAAGTGGTTEQPPRHREHKKHKHRSSG
                     GGSSGGERRKRSRERGAERGSGRRGAEAEARSGAHGRERSQAEPSERRVKREKRDEGY
                     EAAASSKASSGDASSLSIEETNKLRAKLGLKPLEVNAVKKEAGTKEEPVAADVINPMA
                     LRQREELREKLAAAKEKRLLNQKLGKIKTLGEDDPWLDDTAAWIERSRQLQKEKDLAE
                     KRAKLLEEMDQEFGVSTLVEEEFEQRRQDLYSARDLQGLTVEHAIDSFREGETVVLTL
                     KDKGVLQEGEDVLVNVNMVDKERADKNVELRKKKPDYLPYVEDESVDDLAQQKPRSIL
                     AKYDEELEGERPHSFRLEQGGMADGLRERELEEIRTKLRLQAQSLNTVGPRLASEYLS
                     PEEMVTFKKTKRRVKKIRKKEKEVIMRADDLLPLGEDQTQDGDFGSRLRGRGRRRVPE
                     VEEEALEDEEKDPVAQPPPSDDTRVENMDISDEEDGGALPSGPPELEEDEAELELQKQ
                     LEKGRRLRQLQQLQQLRDSGEKVLEIVKKLESRQRGWEEEEDPERKGTIVFNATSEFC
                     RTLGEIPTYGLAGNREEQEELMDFERDEERSANGGSESDGEENIGWSTVNLDEEKQHQ
                     DFSASSTTILDEEPIVNRGLAAALLLCQNKGLLETTVQKVARVKAPNKSLPSAVYCIE
                     DKMAIDDKYSRREEYRGFTQDFKEKDGYKPDVKIEYVDETGRKLTPKEAFRQLSHRFH
                     GKGSGKMKTERRMKKLDEEALLKKMSSSDTPLGTVALLQEKQKAQKTPYIVLSGSGKS
                     MNANTITK"
     exon            372..429
                     /gene="Sart1"
                     /inference="alignment:Splign:2.1.0"
     exon            430..485
                     /gene="Sart1"
                     /inference="alignment:Splign:2.1.0"
     exon            486..612
                     /gene="Sart1"
                     /inference="alignment:Splign:2.1.0"
     exon            613..718
                     /gene="Sart1"
                     /inference="alignment:Splign:2.1.0"
     exon            719..796
                     /gene="Sart1"
                     /inference="alignment:Splign:2.1.0"
     exon            797..896
                     /gene="Sart1"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1039
                     /gene="Sart1"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1246
                     /gene="Sart1"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1374
                     /gene="Sart1"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1648
                     /gene="Sart1"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1822
                     /gene="Sart1"
                     /inference="alignment:Splign:2.1.0"
     exon            1823..1933
                     /gene="Sart1"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..2021
                     /gene="Sart1"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2112
                     /gene="Sart1"
                     /inference="alignment:Splign:2.1.0"
     exon            2113..2248
                     /gene="Sart1"
                     /inference="alignment:Splign:2.1.0"
     exon            2249..2338
                     /gene="Sart1"
                     /inference="alignment:Splign:2.1.0"
     exon            2339..2460
                     /gene="Sart1"
                     /inference="alignment:Splign:2.1.0"
     exon            2461..2531
                     /gene="Sart1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccattttgc gtcgtctggg ttcgggtggc ggcccggctc caggcggacg cactaatcat
       61 ggggtcgtca aagaagcacc gtggagagaa ggaggcagcc gggactacgg ctgcggccgg
      121 taccgggggc actaccgagc agccgccacg gcatcgagag cacaagaaac acaagcatcg
      181 gagcagcggc ggcggcagca gcggcggcga acgacggaag cggagccgcg agcgtggggc
      241 cgagcgcggg agcgggaggc gcggggccga agccgaggcc cgcagcggcg cgcatggtcg
      301 tgaacgaagc caagcggaac cctcggagcg gcgcgtgaag cgggagaaac gcgatgaagg
      361 ctatgaggcc gctgccagct ccaaagccag ctctggagat gcctcatcac tcagcatcga
      421 ggagaccaat aaactccgag caaagttggg gttgaagccc ttggaagtca atgctgttaa
      481 gaaagaggcg ggcaccaagg aggagcccgt ggcagccgat gttatcaacc ccatggcctt
      541 gcgacagcgt gaagaactac gggagaagct ggcagctgcc aaggaaaagc gcttgctgaa
      601 ccaaaaattg gggaaaataa agacactggg ggaggatgac ccctggcttg atgacactgc
      661 agcctggata gagaggagcc ggcagctaca gaaagagaag gacttggcgg agaagcgggc
      721 caagctgcta gaagagatgg accaagagtt tggtgtgagc actttagtgg aggaggagtt
      781 tgagcagagg cgacaggacc tgtacagcgc ccgggacttg caaggcctca ccgtggaaca
      841 tgcaatcgat tcctttcgag aaggggagac tgtggtcctc actctcaagg acaaaggggt
      901 tctgcaggag ggggaggatg tgctggtgaa tgtgaacatg gtggacaagg agcgagcaga
      961 caagaacgtg gaacttcgga agaagaagcc tgactacctg ccctatgtgg aggacgagag
     1021 tgtggatgac ttggcacagc aaaaacctcg ctctatcctg gccaaatatg atgaggaact
     1081 ggagggcgag cggccacatt ccttccgttt agagcagggt ggcatggccg atggcctgag
     1141 agaacgagag ctcgaagaaa tccggaccaa gctacggctg caggctcagt ctctgaacac
     1201 tgtagggccc cggcttgcct ctgagtacct cagtccggag gagatggtga ctttcaaaaa
     1261 gaccaaacgg agagtgaaga aaatccgaaa gaaggagaag gaggtaataa tgcgggcaga
     1321 tgacttgctg ccccttggcg aagaccagac tcaggacggg gactttggat ccaggcttcg
     1381 gggccggggt cggcgccgag ttcctgaagt ggaggaggag gcccttgagg atgaagagaa
     1441 ggaccctgtg gcccagccgc caccatcaga tgacactcgc gtagagaaca tggacatcag
     1501 tgatgaggag gatggggggg ctcttccctc ggggccccca gagctggagg aggacgaagc
     1561 ggagctggag ctgcagaagc agctggagaa ggggcgccgg ctgcggcagc tgcagcaact
     1621 gcagcagctg cgggacagcg gtgagaaggt gctggagatt gtgaagaaac tggagtctcg
     1681 ccaacgtggc tgggaagagg aagaggatcc tgagcggaag gggaccatcg tgttcaatgc
     1741 cacttctgag ttctgtcgca ctctggggga aatccccact tacggattag ctggcaaccg
     1801 agaggagcag gaggagctca tggactttga aagggatgaa gagcgctcgg ccaatggtgg
     1861 ctctgaatca gatggcgaag agaacattgg ctggagcacc gtcaacctgg atgaggagaa
     1921 gcaacatcag gatttctccg cttcctctac caccatcctg gatgaagagc ccattgtgaa
     1981 cagagggctg gcggctgccc tgctcctgtg tcagaacaaa ggactgttgg agaccacggt
     2041 acaaaaggtg gcccgagtaa aggctcccaa taagtcactg ccttcagcag tgtactgcat
     2101 cgaggataag atggccattg atgacaagta cagccgacgt gaggagtaca ggggcttcac
     2161 ccaggacttc aaggagaagg atggctacaa gcccgatgtt aagattgaat atgtggatga
     2221 gacgggcagg aaactgactc ccaaggaggc attccggcag ctgtcccacc gcttccatgg
     2281 gaagggctca gggaagatga agactgagcg gcggatgaag aagctggatg aggaggcgct
     2341 cctaaagaaa atgagttcca gtgacacgcc cctgggaacc gtggcactgc tccaggagaa
     2401 gcagaaggct caaaagacac cgtacatcgt gctcagtggc agtggcaaga gcatgaatgc
     2461 gaacaccatc accaaatgaa gcacctccct gtcccagatg taatgttaaa taaagttccc
     2521 gccttatttt ta
//
