LOCUS       NP_113784                806 aa            linear   ROD 03-APR-2024
DEFINITION  U4/U6.U5 tri-snRNP-associated protein 1 [Rattus norvegicus].
ACCESSION   NP_113784
VERSION     NP_113784.1
DBSOURCE    REFSEQ: accession NM_031596.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 806)
  AUTHORS   Bertram,K., Agafonov,D.E., Dybkov,O., Haselbach,D., Leelaram,M.N.,
            Will,C.L., Urlaub,H., Kastner,B., Luhrmann,R. and Stark,H.
  TITLE     Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for
            Activation
  JOURNAL   Cell 170 (4), 701-713 (2017)
   PUBMED   28781166
REFERENCE   2  (residues 1 to 806)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (residues 1 to 806)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (residues 1 to 806)
  AUTHORS   Lemm,I., Girard,C., Kuhn,A.N., Watkins,N.J., Schneider,M.,
            Bordonne,R. and Luhrmann,R.
  TITLE     Ongoing U snRNP biogenesis is required for the integrity of Cajal
            bodies
  JOURNAL   Mol Biol Cell 17 (7), 3221-3231 (2006)
   PUBMED   16687569
REFERENCE   5  (residues 1 to 806)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   6  (residues 1 to 806)
  AUTHORS   Kikuchi,M., Nakao,M., Inoue,Y., Matsunaga,K., Shichijo,S.,
            Yamana,H. and Itoh,K.
  TITLE     Identification of a SART-1-derived peptide capable of inducing
            HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes
  JOURNAL   Int J Cancer 81 (3), 459-466 (1999)
   PUBMED   10209962
REFERENCE   7  (residues 1 to 806)
  AUTHORS   Gotoh,M., Shichijo,S., Hoshino,T., Imai,Y., Imaizumi,T., Inoue,Y.,
            Takasu,H., Yamaoka,T. and Itoh,K.
  TITLE     Sequence analysis of genes encoding rodent homologues of the human
            tumor-rejection antigen SART-1
  JOURNAL   Jpn J Cancer Res 89 (8), 849-854 (1998)
   PUBMED   9765622
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB014722.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB014722.1, BC083551.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..806
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     Protein         1..806
                     /product="U4/U6.U5 tri-snRNP-associated protein 1"
                     /note="SART-1; rSART-1; squamous cell carcinoma antigen
                     recognized by T cells 1; SART1, U4/U6.U5
                     tri-snRNP-associated protein 1"
                     /calculated_mol_wt=90908
     Region          1..121
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5XIW8.1)"
     Region          118..137
                     /region_name="HIND"
                     /note="HIND motif; pfam19252"
                     /db_xref="CDD:466011"
     Region          165..759
                     /region_name="SART-1"
                     /note="SART-1 family; pfam03343"
                     /db_xref="CDD:460888"
     Site            189
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9Z315; propagated from
                     UniProtKB/Swiss-Prot (Q5XIW8.1)"
     Site            321
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O43290; propagated from
                     UniProtKB/Swiss-Prot (Q5XIW8.1)"
     Site            348
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O43290; propagated from
                     UniProtKB/Swiss-Prot (Q5XIW8.1)"
     Region          418..505
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5XIW8.1)"
     Site            431
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:O43290; propagated from
                     UniProtKB/Swiss-Prot (Q5XIW8.1)"
     Site            481
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q5XIW8.1)"
     Site            527
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O43290; propagated from
                     UniProtKB/Swiss-Prot (Q5XIW8.1)"
     Region          578..610
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5XIW8.1)"
     Site            597
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q5XIW8.1)"
     Site            602
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q5XIW8.1)"
     Site            604
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q5XIW8.1)"
     Site            627
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O43290; propagated from
                     UniProtKB/Swiss-Prot (Q5XIW8.1)"
     Site            701
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:O43290; propagated from
                     UniProtKB/Swiss-Prot (Q5XIW8.1)"
     Site            767
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O43290; propagated from
                     UniProtKB/Swiss-Prot (Q5XIW8.1)"
     Site            770
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:O43290; propagated from
                     UniProtKB/Swiss-Prot (Q5XIW8.1)"
     Site            795
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O43290; propagated from
                     UniProtKB/Swiss-Prot (Q5XIW8.1)"
     CDS             1..806
                     /gene="Sart1"
                     /coded_by="NM_031596.1:59..2479"
                     /db_xref="GeneID:29678"
                     /db_xref="RGD:61930"
ORIGIN      
        1 mgsskkhrge keaagttaaa gtggtteqpp rhrehkkhkh rssgggssgg errkrsrerg
       61 aergsgrrga eaearsgahg rersqaepse rrvkrekrde gyeaaasska ssgdasslsi
      121 eetnklrakl glkplevnav kkeagtkeep vaadvinpma lrqreelrek laaakekrll
      181 nqklgkiktl geddpwlddt aawiersrql qkekdlaekr aklleemdqe fgvstlveee
      241 feqrrqdlys ardlqgltve haidsfrege tvvltlkdkg vlqegedvlv nvnmvdkera
      301 dknvelrkkk pdylpyvede svddlaqqkp rsilakydee legerphsfr leqggmadgl
      361 rereleeirt klrlqaqsln tvgprlasey lspeemvtfk ktkrrvkkir kkekevimra
      421 ddllplgedq tqdgdfgsrl rgrgrrrvpe veeealedee kdpvaqppps ddtrvenmdi
      481 sdeedggalp sgppeleede aelelqkqle kgrrlrqlqq lqqlrdsgek vleivkkles
      541 rqrgweeeed perkgtivfn atsefcrtlg eiptyglagn reeqeelmdf erdeersang
      601 gsesdgeeni gwstvnldee kqhqdfsass ttildeepiv nrglaaalll cqnkgllett
      661 vqkvarvkap nkslpsavyc iedkmaiddk ysrreeyrgf tqdfkekdgy kpdvkieyvd
      721 etgrkltpke afrqlshrfh gkgsgkmkte rrmkkldeea llkkmsssdt plgtvallqe
      781 kqkaqktpyi vlsgsgksmn antitk
//
