LOCUS       NM_001106240            1859 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus seryl-tRNA synthetase 2, mitochondrial (Sars2),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001106240 XM_001078462 XM_214884
VERSION     NM_001106240.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1859)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   2  (bases 1 to 1859)
  AUTHORS   Belostotsky,R., Ben-Shalom,E., Rinat,C., Becker-Cohen,R.,
            Feinstein,S., Zeligson,S., Segel,R., Elpeleg,O., Nassar,S. and
            Frishberg,Y.
  TITLE     Mutations in the mitochondrial seryl-tRNA synthetase cause
            hyperuricemia, pulmonary hypertension, renal failure in infancy and
            alkalosis, HUPRA syndrome
  JOURNAL   Am J Hum Genet 88 (2), 193-200 (2011)
   PUBMED   21255763
REFERENCE   3  (bases 1 to 1859)
  AUTHORS   Gibbons,W.J. Jr., Yan,Q., Li,R., Li,X. and Guan,M.X.
  TITLE     Genomic organization, expression, and subcellular localization of
            mouse mitochondrial seryl-tRNA synthetase
  JOURNAL   Biochem Biophys Res Commun 317 (3), 774-778 (2004)
   PUBMED   15081407
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473979.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_214884.4, XM_001078462.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ212522.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132262, SAMD00132263
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1859
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1859
                     /gene="Sars2"
                     /note="seryl-tRNA synthetase 2, mitochondrial"
                     /db_xref="GeneID:292759"
                     /db_xref="RGD:1309456"
     exon            1..287
                     /gene="Sars2"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..1577
                     /gene="Sars2"
                     /EC_number="6.1.1.11"
                     /note="seryl-aminoacyl-tRNA synthetase 2; seryl-tRNA
                     synthetase, mitochondrial"
                     /codon_start=1
                     /product="serine--tRNA ligase, mitochondrial"
                     /protein_id="NP_001099710.1"
                     /db_xref="GeneID:292759"
                     /db_xref="RGD:1309456"
                     /translation="MAASMARLLWPFLARQGLRFRGRCVCNQNPRRSFATEKRVRNLL
                     YEHAREGYSELPYLDMESVCACPEKAARSLELRKGELRPADLPAIISTWQELRQLREQ
                     IQSLEAEKEAVAEAVRALLAKQDSNQVQKDPQYQGLRTRGREIRKQLTPLYPRETQLE
                     EEFYQQALRLPNQTHPDTPVGDESQARVLRVVGDKPAFSFQPRGHLEIGEKLDIIRQK
                     RLSHVSGHRSYYLRGAGALLQHGLVNFTLSKLVSRGFTPMTVPDLLRGAVFEGCGMTP
                     NANPSQIYNIDPSRFEDLNLAGTAEVGLAGYFMDHAVASRDLPVRMVCASTCYRAETD
                     TGKEPWGLYRVHHFAKVEMFGVTGPGLEQSSQLLEEFLSLQVEILTELGLHFRVLDMP
                     TQELGLPAYRKFDIEAWMPGRGRYGEVTSASNCTDFQSRRLYIMFETETGELQFAHTV
                     NATACAVPRVLIALLESNQQKDGSVLVPAALQPYLGTDRITAPTHVPLQYIGPNQPQK
                     PRLPGQSAAR"
     exon            288..383
                     /gene="Sars2"
                     /inference="alignment:Splign:2.1.0"
     exon            384..413
                     /gene="Sars2"
                     /inference="alignment:Splign:2.1.0"
     exon            414..554
                     /gene="Sars2"
                     /inference="alignment:Splign:2.1.0"
     exon            555..609
                     /gene="Sars2"
                     /inference="alignment:Splign:2.1.0"
     exon            610..673
                     /gene="Sars2"
                     /inference="alignment:Splign:2.1.0"
     exon            674..779
                     /gene="Sars2"
                     /inference="alignment:Splign:2.1.0"
     exon            780..827
                     /gene="Sars2"
                     /inference="alignment:Splign:2.1.0"
     exon            828..936
                     /gene="Sars2"
                     /inference="alignment:Splign:2.1.0"
     exon            937..982
                     /gene="Sars2"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1070
                     /gene="Sars2"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1180
                     /gene="Sars2"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1274
                     /gene="Sars2"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1367
                     /gene="Sars2"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1433
                     /gene="Sars2"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1859
                     /gene="Sars2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttcttgttt ccagtccaag atggctgcgt ccatggcacg gctcttgtgg cctttcctgg
       61 ctcgccaggg gctccggttc cgaggacgct gcgtgtgcaa ccagaaccca aggaggagtt
      121 tcgctacaga aaaacgagtt cggaacctcc tgtacgaaca cgcacgcgag gggtacagcg
      181 agcttcctta cttagacatg gagtcggtgt gcgcatgccc agaaaaggcc gcgcgctccc
      241 tggagctccg caagggggag ctgcggccgg ccgacctgcc tgcgattatc tccacgtggc
      301 aggagttgag gcagcttcgg gagcagatcc agagcctgga ggcagagaag gaggctgtgg
      361 cagaggcagt gcgggccctg ctggcaaagc aagacagcaa ccaagtgcag aaggaccccc
      421 aatatcaggg ccttcggacc cgtggccggg aaatccggaa gcagctcaca cccttgtacc
      481 ccagagagac ccagctggag gaagagttct accagcaggc actgaggctg cccaaccaga
      541 cccacccgga cacgcctgtt ggggatgaga gccaggctag agtgctccgt gtggtgggtg
      601 acaagccggc tttctccttc caaccccgag gccacctgga aattggcgag aaactggaca
      661 tcattcgaca gaagcgcctg tctcacgtgt ctggccaccg gtcttattac ctgcgcgggg
      721 ctggagccct cttacagcac ggcctggtca actttaccct cagcaagctt gtcagcaggg
      781 gcttcacacc catgacggtt ccagaccttc tgagaggagc tgtgtttgaa ggctgtggaa
      841 tgacaccaaa tgccaaccca tcccagattt acaatattga cccctcccgc ttcgaagacc
      901 tcaacctggc tgggacagca gaggtggggc tggcaggata cttcatggac cacgcagtgg
      961 cttccaggga ccttccagtc aggatggtct gtgccagcac ctgctaccgg gcagagacag
     1021 acaccgggaa ggagccttgg gggctgtacc gagtccatca cttcgctaag gtggagatgt
     1081 ttggggtgac aggccctggg ctggagcaga gctcgcagct gctggaggag ttcctgtctc
     1141 tgcaggtgga gatcttgaca gagctgggct tgcacttccg ggtgctggac atgcccaccc
     1201 aggaactggg ccttcctgct taccgcaagt tcgacattga ggcctggatg cctggccgag
     1261 gccgctatgg ggaggtcacc agcgcctcca actgcacaga cttccagagc cgccgtctgt
     1321 acatcatgtt tgagacagag actggggagc tgcagttcgc acacacggtg aatgccaccg
     1381 cttgtgctgt tccccgagtc ctcattgccc tcctggagag caaccagcaa aaggatggtt
     1441 cagtcctcgt acctgccgct ctccagccct acctaggcac tgaccggatc acagccccca
     1501 cccacgtgcc tctccagtac attggcccca atcagcccca gaagcccagg ctccccggcc
     1561 agtctgctgc cagatgacag cggtctgctc cagaggctgg ccttctagag gtccctgatg
     1621 ctgagagcct ttcccctgca gctggtcctg atgtctctgt acttgtcatc tcccctcctg
     1681 gactcctgaa tctatctctg tcccttccct gccggtgaat cattgtcagt gacccctacc
     1741 atcactgggg ctgtcagcca gagtcatgtc tcagcccctg acaggaagaa ggccatccca
     1801 cttcctcttc cacctcagcg ccgagcagaa tgcccacaat aaatggtcat gagaacaga
//
