LOCUS       NM_001007606            1920 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus seryl-tRNA synthetase 1 (Sars1), mRNA.
ACCESSION   NM_001007606 XM_342319
VERSION     NM_001007606.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1920)
  AUTHORS   Musante,L., Puttmann,L., Kahrizi,K., Garshasbi,M., Hu,H., Stehr,H.,
            Lipkowitz,B., Otto,S., Jensen,L.R., Tzschach,A., Jamali,P.,
            Wienker,T., Najmabadi,H., Ropers,H.H. and Kuss,A.W.
  TITLE     Mutations of the aminoacyl-tRNA-synthetases SARS and WARS2 are
            implicated in the etiology of autosomal recessive intellectual
            disability
  JOURNAL   Hum Mutat 38 (6), 621-636 (2017)
   PUBMED   28236339
REFERENCE   2  (bases 1 to 1920)
  AUTHORS   Wang,C., Guo,Y., Tian,Q., Jia,Q., Gao,Y., Zhang,Q., Zhou,C. and
            Xie,W.
  TITLE     SerRS-tRNASec complex structures reveal mechanism of the first step
            in selenocysteine biosynthesis
  JOURNAL   Nucleic Acids Res 43 (21), 10534-10545 (2015)
   PUBMED   26433229
REFERENCE   3  (bases 1 to 1920)
  AUTHORS   Shi,Y., Xu,X., Zhang,Q., Fu,G., Mo,Z., Wang,G.S., Kishi,S. and
            Yang,X.L.
  TITLE     tRNA synthetase counteracts c-Myc to develop functional vasculature
  JOURNAL   Elife 3, e02349 (2014)
   PUBMED   24940000
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1920)
  AUTHORS   Ikromov,O., Alkamal,I., Magheli,A., Ratert,N., Sendeski,M.,
            Miller,K., Krause,H. and Kempkensteffen,C.
  TITLE     Functional Epigenetic Analysis of Prostate Carcinoma: A Role for
            Seryl-tRNA Synthetase?
  JOURNAL   J Biomark 2014, 362164 (2014)
   PUBMED   26317032
REFERENCE   5  (bases 1 to 1920)
  AUTHORS   Xu,X., Shi,Y. and Yang,X.L.
  TITLE     Crystal structure of human Seryl-tRNA synthetase and Ser-SA complex
            reveals a molecular lever specific to higher eukaryotes
  JOURNAL   Structure 21 (11), 2078-2086 (2013)
   PUBMED   24095058
REFERENCE   6  (bases 1 to 1920)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   7  (bases 1 to 1920)
  AUTHORS   Miseta,A., Woodley,C.L., Greenberg,J.R. and Slobin,L.I.
  TITLE     Mammalian seryl-tRNA synthetase associates with mRNA in vivo and
            has homology to elongation factor 1 alpha
  JOURNAL   J Biol Chem 266 (29), 19158-19161 (1991)
   PUBMED   1918033
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC061765.1.
            
            On Nov 29, 2004 this sequence version replaced XM_342319.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061765.1, SRR8487227.99464.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760434
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1920
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1920
                     /gene="Sars1"
                     /gene_synonym="Sars"
                     /note="seryl-tRNA synthetase 1"
                     /db_xref="GeneID:266975"
                     /db_xref="RGD:628813"
     exon            1..194
                     /gene="Sars1"
                     /gene_synonym="Sars"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..1597
                     /gene="Sars1"
                     /gene_synonym="Sars"
                     /EC_number="6.1.1.11"
                     /note="seryl-tRNA synthetase, cytoplasmic; serRS;
                     seryl-tRNA(Ser/Sec) synthetase; seryl-aminoacyl-tRNA
                     synthetase 1"
                     /codon_start=1
                     /product="serine--tRNA ligase, cytoplasmic"
                     /protein_id="NP_001007607.1"
                     /db_xref="GeneID:266975"
                     /db_xref="RGD:628813"
                     /translation="MVLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWR
                     RCRFRADNLNKLKNLCSKTIGEKMKKKEPVGEDESIPEDVLNFDDLTADTLAALKVSQ
                     IKKVRLLVDEAIQKCDGERVKLEAERFENLREIGNLLHPSVPISNDEDADNKVERIWG
                     DCTVRKKYSHVDLVVMVDGFEGEKGAVVAGSRGYFLKGVLVFLEQALIQYALRTLGSR
                     GYTPIYTPFFMRKEVMQEVAQLSQFDEELYKVIGKGSEKSDDSSYDEKYLIATSEQPI
                     AALHRDEWLRPEDLPIKYAGFSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHD
                     NKSWEMFDEMITTAEEFYQSLGIPYHIVNIVSGSLNHAASKKLDLEAWFPGSGAFREL
                     VSCSNCTDYQARRLRIRYGQTKKMMDKVEFVHMLNATMCATTRTICAILENYQTEKGI
                     VVPEKLREFMPPGLQELIPFVKPAPIDQEPSKKQKKQHEGSKKKAKEVTLENQLQNME
                     VTEA"
     exon            195..265
                     /gene="Sars1"
                     /gene_synonym="Sars"
                     /inference="alignment:Splign:2.1.0"
     exon            266..346
                     /gene="Sars1"
                     /gene_synonym="Sars"
                     /inference="alignment:Splign:2.1.0"
     exon            347..505
                     /gene="Sars1"
                     /gene_synonym="Sars"
                     /inference="alignment:Splign:2.1.0"
     exon            506..649
                     /gene="Sars1"
                     /gene_synonym="Sars"
                     /inference="alignment:Splign:2.1.0"
     exon            650..805
                     /gene="Sars1"
                     /gene_synonym="Sars"
                     /inference="alignment:Splign:2.1.0"
     exon            806..1027
                     /gene="Sars1"
                     /gene_synonym="Sars"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1157
                     /gene="Sars1"
                     /gene_synonym="Sars"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1315
                     /gene="Sars1"
                     /gene_synonym="Sars"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1445
                     /gene="Sars1"
                     /gene_synonym="Sars"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1859
                     /gene="Sars1"
                     /gene_synonym="Sars"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccactcgccg cttactgcgg tacagtccac tcatagtgtt aactcgtgag gcagaaggat
       61 ggtgctggac ctggacttgt ttcgggtgga taaaggaggg gacccagccc tcattcgaga
      121 gacgcaggag aagcgcttca aagatccggg gctggtggac cagctggtga aggcagacag
      181 cgagtggcga cgatgcagat ttcgggcaga caacttgaac aagctgaaga atttatgcag
      241 caaaactatt ggggagaaaa tgaagaaaaa agagccagtg ggagaggacg agtccatccc
      301 agaggatgtg ctgaattttg acgacctcac tgcagacacg ttagctgccc tgaaagtctc
      361 acaaattaag aaagtccgac tcctcgttga tgaagccatc cagaagtgtg atggggagcg
      421 ggtaaagctg gaagcagagc gatttgagaa cctccgagag attgggaacc ttctacaccc
      481 ctctgtgccc attagtaacg atgaggatgc agacaacaaa gtagagcgta tttggggtga
      541 ttgtacagtc agaaagaagt attcccatgt ggacctggtg gtgatggtgg atggctttga
      601 aggcgaaaag ggagccgtgg tggctggtag tcgggggtac ttcctgaagg gggtcctggt
      661 gttcctggag caggcactta tccagtatgc actgcgcacc ttgggaagcc gaggctacac
      721 tccaatctac acccccttct tcatgaggaa agaggtcatg caggaagtgg cccagctcag
      781 ccagtttgat gaagaactct ataaggtgat tggcaagggc agcgaaaaga gcgatgacag
      841 ctcctatgac gagaagtact tgattgccac ctcagaacag cccatcgcag ctctgcaccg
      901 ggacgagtgg ctgcggccag aggatctgcc catcaagtac gccggcttct ccacctgctt
      961 tcggcaggaa gtgggttcgc atggccgtga tacccgtggt atctttcgag tccatcagtt
     1021 tgagaagatt gaacagttcg tgtactcatc acctcatgac aacaagtcat gggagatgtt
     1081 tgatgagatg atcaccaccg cagaagaatt ctatcagtct ttgggaatcc cttaccacat
     1141 tgtgaatatt gtctcaggct ctttgaatca tgctgccagc aagaagcttg acctggaggc
     1201 ctggttcccg ggctccggtg ccttccgtga gttggtttcc tgttctaact gcacggatta
     1261 ccaggctcgt cggctccgaa tccgatacgg gcagaccaag aagatgatgg acaaggtgga
     1321 gtttgtccat atgcttaatg ccacaatgtg tgccaccacc cggaccatct gcgccatcct
     1381 ggagaactac cagacagaga agggcatcgt cgtgccagag aagttgaggg agttcatgcc
     1441 cccaggactc caagaactga tcccatttgt gaagccagca cctattgacc aggagccatc
     1501 taagaagcag aagaagcaac atgaaggcag caaaaagaaa gcaaaagagg tcaccctgga
     1561 gaaccagctg cagaacatgg aggtcactga ggcctgaaca ctgcctcctc ccagtttgcc
     1621 agacttactt gctgcctgct gggatcccag gtctgccctg gaacagagag gccgagtacc
     1681 actcctcacc ctgtcccatc tgactgcaca gcatctgggt ccatctgccg ggtactgcgc
     1741 gggtgttccc atcatctcga atgggcccag ggtctcctca ctgatgactg gtgaagccac
     1801 gcaataaagc atctctgggg agggcacaag acttccccag tctcctcccc aggcttgaaa
     1861 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
