LOCUS       NP_001007740             198 aa            linear   ROD 09-JUN-2024
DEFINITION  GTP-binding protein SAR1a [Rattus norvegicus].
ACCESSION   NP_001007740 XP_342137
VERSION     NP_001007740.1
DBSOURCE    REFSEQ: accession NM_001007739.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 198)
  AUTHORS   Chen,X.W., Wang,H., Bajaj,K., Zhang,P., Meng,Z.X., Ma,D., Bai,Y.,
            Liu,H.H., Adams,E., Baines,A., Yu,G., Sartor,M.A., Zhang,B., Yi,Z.,
            Lin,J., Young,S.G., Schekman,R. and Ginsburg,D.
  TITLE     SEC24A deficiency lowers plasma cholesterol through reduced PCSK9
            secretion
  JOURNAL   Elife 2, e00444 (2013)
   PUBMED   23580231
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 198)
  AUTHORS   Nakagawa,H., Ishizaki,M., Miyazaki,S., Abe,T., Nishimura,K.,
            Komori,M. and Matsuo,S.
  TITLE     Sar1 translocation onto the ER-membrane for vesicle budding has
            different pathways for promotion and suppression of ER-to-Golgi
            transport mediated through H89-sensitive kinase and ER-resident G
            protein
  JOURNAL   Mol Cell Biochem 366 (1-2), 175-182 (2012)
   PUBMED   22484643
  REMARK    GeneRIF: Sar1 recruitment to the endoplasmic reticulum-membrane is
            sensitive to H89-sensitive kinase activation, indicating the first
            step in transport vesicle formation occurs under kinase regulation
REFERENCE   3  (residues 1 to 198)
  AUTHORS   Nakagawa,H., Miyazaki,S., Abe,T., Umadome,H., Tanaka,K.,
            Nishimura,K., Komori,M. and Matsuo,S.
  TITLE     H89 sensitive kinase regulates the translocation of Sar1 onto the
            ER membrane through phosphorylation of ER-coupled beta-tubulin
  JOURNAL   Int J Biochem Cell Biol 43 (3), 423-430 (2011)
   PUBMED   21111843
  REMARK    GeneRIF: beta-tubulin is one of downstream effectors of
            H89-sensitive kinase and suppression of endoplasmic reticulum
            (ER)-coupled beta-tubulin phosphorylation decreases Sar1
            translocation onto the ER.
REFERENCE   4  (residues 1 to 198)
  AUTHORS   Bhalla-Gehi,R., Penuela,S., Churko,J.M., Shao,Q. and Laird,D.W.
  TITLE     Pannexin1 and pannexin3 delivery, cell surface dynamics, and
            cytoskeletal interactions
  JOURNAL   J Biol Chem 285 (12), 9147-9160 (2010)
   PUBMED   20086016
REFERENCE   5  (residues 1 to 198)
  AUTHORS   Merte,J., Jensen,D., Wright,K., Sarsfield,S., Wang,Y., Schekman,R.
            and Ginty,D.D.
  TITLE     Sec24b selectively sorts Vangl2 to regulate planar cell polarity
            during neural tube closure
  JOURNAL   Nat Cell Biol 12 (1), 41-6 (2010)
   PUBMED   19966784
REFERENCE   6  (residues 1 to 198)
  AUTHORS   Mancias,J.D. and Goldberg,J.
  TITLE     Structural basis of cargo membrane protein discrimination by the
            human COPII coat machinery
  JOURNAL   EMBO J 27 (21), 2918-2928 (2008)
   PUBMED   18843296
REFERENCE   7  (residues 1 to 198)
  AUTHORS   Mancias,J.D. and Goldberg,J.
  TITLE     The transport signal on Sec22 for packaging into COPII-coated
            vesicles is a conformational epitope
  JOURNAL   Mol Cell 26 (3), 403-414 (2007)
   PUBMED   17499046
REFERENCE   8  (residues 1 to 198)
  AUTHORS   Nori,A., Bortoloso,E., Frasson,F., Valle,G. and Volpe,P.
  TITLE     Vesicle budding from endoplasmic reticulum is involved in
            calsequestrin routing to sarcoplasmic reticulum of skeletal muscles
  JOURNAL   Biochem J 379 (Pt 2), 505-512 (2004)
   PUBMED   14728599
REFERENCE   9  (residues 1 to 198)
  AUTHORS   Shen,K.A., Hammond,C.M. and Moore,H.P.
  TITLE     Molecular analysis of SAR1-related cDNAs from a mouse pituitary
            cell line
  JOURNAL   FEBS Lett 335 (3), 380-385 (1993)
   PUBMED   8262187
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079228.1.
            
            On Nov 29, 2004 this sequence version replaced XP_342137.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079228.1, EV774872.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..198
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q11"
     Protein         1..198
                     /product="GTP-binding protein SAR1a"
                     /EC_number="3.6.5.2"
                     /note="SAR1 gene homolog A; SAR1a gene homolog 1; SAR1
                     homolog A"
                     /calculated_mol_wt=22268
     Region          3..197
                     /region_name="Sar1"
                     /note="Sar1 is an essential component of COPII vesicle
                     coats; cd00879"
                     /db_xref="CDD:206645"
     Site            3..5
                     /site_type="active"
                     /note="STAR motif [active]"
                     /db_xref="CDD:206645"
     Site            32..39
                     /site_type="other"
                     /note="G1 box"
                     /db_xref="CDD:206645"
     Site            order(34..40,56,78,134..135,137,179..181)
                     /site_type="other"
                     /note="GTP/Mg2+ binding site [chemical binding]"
                     /db_xref="CDD:206645"
     Site            order(34..35,39,43,50..62,84,89)
                     /site_type="other"
                     /note="GAP interaction site [polypeptide binding]"
                     /db_xref="CDD:206645"
     Site            44..59
                     /site_type="other"
                     /note="Switch I region"
                     /db_xref="CDD:206645"
     Site            order(56..60,65,75,79,85,87..89)
                     /site_type="other"
                     /note="putative GEF interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:206645"
     Site            56
                     /site_type="other"
                     /note="G2 box"
                     /db_xref="CDD:206645"
     Site            order(57..64,74,85,88..89)
                     /site_type="active"
                     /note="putative effector interaction site [active]"
                     /db_xref="CDD:206645"
     Site            60..74
                     /site_type="active"
                     /note="interswitch region [active]"
                     /db_xref="CDD:206645"
     Site            75..92
                     /site_type="other"
                     /note="Switch II region"
                     /db_xref="CDD:206645"
     Site            75..78
                     /site_type="other"
                     /note="G3 box"
                     /db_xref="CDD:206645"
     Site            134..137
                     /site_type="other"
                     /note="G4 box"
                     /db_xref="CDD:206645"
     Site            179..181
                     /site_type="other"
                     /note="G5 box"
                     /db_xref="CDD:206645"
     CDS             1..198
                     /gene="Sar1a"
                     /gene_synonym="Sara1"
                     /coded_by="NM_001007739.1:140..736"
                     /db_xref="GeneID:361842"
                     /db_xref="RGD:1359540"
ORIGIN      
        1 msfifewiyn gfssvlqflg lykksgklvf lgldnagktt llhmlkddrl gqhvptlhpt
       61 seeltiagmt fttfdlgghe qarrvwknyl paingivflv dcadhsrlme skvelnalmt
      121 detisnvpil ilgnkidrtd aiseeklrei fglygqttgk gnvtlkelna rpmevfmcsv
      181 lkrqgygegf rwlsqyid
//
