LOCUS       NM_001191743            2327 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus SAM and HD domain containing deoxynucleoside
            triphosphate triphosphohydrolase 1 (Samhd1), mRNA.
ACCESSION   NM_001191743 XM_230789
VERSION     NM_001191743.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2327)
  AUTHORS   Deutschmann,J., Schneider,A., Gruska,I., Vetter,B., Thomas,D.,
            Kiessling,M., Wittmann,S., Herrmann,A., Schindler,M., Milbradt,J.,
            Ferreiros,N., Winkler,T.H., Wiebusch,L. and Gramberg,T.
  TITLE     A viral kinase counteracts in vivo restriction of murine
            cytomegalovirus by SAMHD1
  JOURNAL   Nat Microbiol 4 (12), 2273-2284 (2019)
   PUBMED   31548683
REFERENCE   2  (bases 1 to 2327)
  AUTHORS   Thientosapol,E.S., Bosnjak,D., Durack,T., Stevanovski,I., van
            Geldermalsen,M., Holst,J., Jahan,Z., Shepard,C., Weninger,W.,
            Kim,B., Brink,R. and Jolly,C.J.
  TITLE     SAMHD1 enhances immunoglobulin hypermutation by promoting
            transversion mutation
  JOURNAL   Proc Natl Acad Sci U S A 115 (19), 4921-4926 (2018)
   PUBMED   29669924
REFERENCE   3  (bases 1 to 2327)
  AUTHORS   Coquel,F., Silva,M.J., Techer,H., Zadorozhny,K., Sharma,S.,
            Nieminuszczy,J., Mettling,C., Dardillac,E., Barthe,A.,
            Schmitz,A.L., Promonet,A., Cribier,A., Sarrazin,A., Niedzwiedz,W.,
            Lopez,B., Costanzo,V., Krejci,L., Chabes,A., Benkirane,M., Lin,Y.L.
            and Pasero,P.
  TITLE     SAMHD1 acts at stalled replication forks to prevent interferon
            induction
  JOURNAL   Nature 557 (7703), 57-61 (2018)
   PUBMED   29670289
REFERENCE   4  (bases 1 to 2327)
  AUTHORS   Buzovetsky,O., Tang,C., Knecht,K.M., Antonucci,J.M., Wu,L., Ji,X.
            and Xiong,Y.
  TITLE     The SAM domain of mouse SAMHD1 is critical for its activation and
            regulation
  JOURNAL   Nat Commun 9 (1), 411 (2018)
   PUBMED   29379009
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2327)
  AUTHORS   Kodigepalli,K.M., Li,M., Bonifati,S., Panfil,A.R., Green,P.L.,
            Liu,S.L. and Wu,L.
  TITLE     SAMHD1 inhibits epithelial cell transformation in vitro and affects
            leukemia development in xenograft mice
  JOURNAL   Cell Cycle 17 (23), 2564-2576 (2018)
   PUBMED   30474474
REFERENCE   6  (bases 1 to 2327)
  AUTHORS   White,T.E., Brandariz-Nunez,A., Valle-Casuso,J.C., Amie,S.,
            Nguyen,L.A., Kim,B., Tuzova,M. and Diaz-Griffero,F.
  TITLE     The retroviral restriction ability of SAMHD1, but not its
            deoxynucleotide triphosphohydrolase activity, is regulated by
            phosphorylation
  JOURNAL   Cell Host Microbe 13 (4), 441-451 (2013)
   PUBMED   23601106
REFERENCE   7  (bases 1 to 2327)
  AUTHORS   Goncalves,A., Karayel,E., Rice,G.I., Bennett,K.L., Crow,Y.J.,
            Superti-Furga,G. and Burckstummer,T.
  TITLE     SAMHD1 is a nucleic-acid binding protein that is mislocalized due
            to aicardi-goutieres syndrome-associated mutations
  JOURNAL   Hum Mutat 33 (7), 1116-1122 (2012)
   PUBMED   22461318
REFERENCE   8  (bases 1 to 2327)
  AUTHORS   Powell,R.D., Holland,P.J., Hollis,T. and Perrino,F.W.
  TITLE     Aicardi-Goutieres syndrome gene and HIV-1 restriction factor SAMHD1
            is a dGTP-regulated deoxynucleotide triphosphohydrolase
  JOURNAL   J Biol Chem 286 (51), 43596-43600 (2011)
   PUBMED   22069334
REFERENCE   9  (bases 1 to 2327)
  AUTHORS   Goldstone,D.C., Ennis-Adeniran,V., Hedden,J.J., Groom,H.C.,
            Rice,G.I., Christodoulou,E., Walker,P.A., Kelly,G., Haire,L.F.,
            Yap,M.W., de Carvalho,L.P., Stoye,J.P., Crow,Y.J., Taylor,I.A. and
            Webb,M.
  TITLE     HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate
            triphosphohydrolase
  JOURNAL   Nature 480 (7377), 379-382 (2011)
   PUBMED   22056990
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 2327)
  AUTHORS   Rice,G.I., Bond,J., Asipu,A., Brunette,R.L., Manfield,I.W.,
            Carr,I.M., Fuller,J.C., Jackson,R.M., Lamb,T., Briggs,T.A., Ali,M.,
            Gornall,H., Couthard,L.R., Aeby,A., Attard-Montalto,S.P.,
            Bertini,E., Bodemer,C., Brockmann,K., Brueton,L.A., Corry,P.C.,
            Desguerre,I., Fazzi,E., Cazorla,A.G., Gener,B., Hamel,B.C.,
            Heiberg,A., Hunter,M., van der Knaap,M.S., Kumar,R., Lagae,L.,
            Landrieu,P.G., Lourenco,C.M., Marom,D., McDermott,M.F., van der
            Merwe,W., Orcesi,S., Prendiville,J.S., Rasmussen,M., Shalev,S.A.,
            Soler,D.M., Shinawi,M., Spiegel,R., Tan,T.Y., Vanderver,A.,
            Wakeling,E.L., Wassmer,E., Whittaker,E., Lebon,P., Stetson,D.B.,
            Bonthron,D.T. and Crow,Y.J.
  TITLE     Mutations involved in Aicardi-Goutieres syndrome implicate SAMHD1
            as regulator of the innate immune response
  JOURNAL   Nat Genet 41 (7), 829-832 (2009)
   PUBMED   19525956
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB806058.1, FN801895.1 and JAXUCZ010000003.1.
            
            On Sep 6, 2012 this sequence version replaced XM_230789.6.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.16860.1,
                                           SRR26643298.19857.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMN12840106 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-270               CB806058.1         1-270
            271-1000            FN801895.1         1-730
            1001-1040           JAXUCZ010000003.1  166194994-166195033 c
            1041-1167           JAXUCZ010000003.1  166193574-166193700 c
            1168-1259           JAXUCZ010000003.1  166191823-166191914 c
            1260-1375           JAXUCZ010000003.1  166190875-166190990 c
            1376-1512           JAXUCZ010000003.1  166189198-166189334 c
            1513-1605           JAXUCZ010000003.1  166188136-166188228 c
            1606-1710           JAXUCZ010000003.1  166186584-166186688 c
            1711-1848           JAXUCZ010000003.1  166184358-166184495 c
            1849-2327           JAXUCZ010000003.1  166181588-166182066 c
FEATURES             Location/Qualifiers
     source          1..2327
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..2327
                     /gene="Samhd1"
                     /note="SAM and HD domain containing deoxynucleoside
                     triphosphate triphosphohydrolase 1"
                     /db_xref="GeneID:311580"
                     /db_xref="RGD:1308369"
     exon            1..295
                     /gene="Samhd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..1953
                     /gene="Samhd1"
                     /note="SAM domain and HD domain-containing protein 1; SAM
                     domain and HD domain, 1"
                     /codon_start=1
                     /product="deoxynucleoside triphosphate triphosphohydrolase
                     SAMHD1"
                     /protein_id="NP_001178672.1"
                     /db_xref="GeneID:311580"
                     /db_xref="RGD:1308369"
                     /translation="MQRPDSEQPAKRSRCDGSPRTPPSTRPAAANESADPESSDLRTW
                     GPEDVCSFLEKRGFREKKVLDIFRENKISGSFLPFLDENLLESLGVSSLEQRKKMIEC
                     IQKLNQSRIDLMKVFNDPIHGHIEFHPLLIRIIDTPQFQRLRYIKQLGGGYYVFPGAS
                     HNRFEHSLGVGYLAGCLVRALAEKQPELQISERDMLCVQIAGLCHDLGHGPFSHMFDG
                     RFIPLARPDIKWRHEQGSVEMFEHLVNSNELKLVMKNYGLVPEEDITFIKEQIMGPPV
                     SPVKDCLWPYKGRPAKKSFLYEIVANKRNGIDVDKWDYFARDCHHLGIQNNFDYKRFI
                     KFARICEVDDETRAHKVKHICTREKEVGNLYDMFHTRNCLHRRAYQHKIGNLIDIMIT
                     EAFLKADPHVEITGTEGKKFRISTAIHDMEAFSKLTDNIFLEILYSTDPQLSEARNIL
                     RNIECRNLYKYLGETQPKREKIKKAEYDKLAQEVANAKPEIAPDVELKAEDFIVDVIN
                     MDYGMEDKNPIDNVHFYCKSDSRQAVTITKDQVSQLLPQKFAEQLIRVYYKKKDKKSL
                     DAAGKHFIQWCALRDFTKPQDGDIIAPLITPLKWNKKTSSCIEEVSKVKTCLKF"
     exon            296..362
                     /gene="Samhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            363..435
                     /gene="Samhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            436..596
                     /gene="Samhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            597..712
                     /gene="Samhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            713..783
                     /gene="Samhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            784..939
                     /gene="Samhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1040
                     /gene="Samhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1167
                     /gene="Samhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1259
                     /gene="Samhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1375
                     /gene="Samhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1512
                     /gene="Samhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1605
                     /gene="Samhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1710
                     /gene="Samhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1848
                     /gene="Samhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..2327
                     /gene="Samhd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcgccttcg gggctgcaga gtcagtgcgg ctgcgcgcca agcgggtgcc gcggtacttg
       61 acttagcagc gccgggtgtc ggaggtagcc atgcagagac cagactcgga gcaacctgct
      121 aagcggtccc gctgcgatgg cagcccaagg acgccaccga gcacccgtcc tgcagcagcg
      181 aacgagtctg cagatcccga aagcagcgac ctccgaacct ggggtcccga ggacgtgtgc
      241 tccttcttag agaaacgtgg tttccgagag aaaaaagtgc tggacatctt cagagaaaat
      301 aaaatcagtg gttcatttct gccctttttg gatgagaatc ttctcgaaag tctgggagta
      361 agttccttgg agcagaggaa gaagatgata gaatgtatcc agaagctgaa tcagtctcgg
      421 attgatctaa tgaaggtatt taacgatcct attcatggcc atattgaatt ccaccccctc
      481 ctcatccgaa tcattgacac acctcagttc cagcggcttc gctacatcaa gcagctggga
      541 ggcggttact acgtcttccc tggcgcgtca cacaatcggt ttgaacacag tctcggagtg
      601 gggtacctag caggctgcct cgtgcgagcg cttgccgaaa aacagccaga gctgcagatc
      661 agtgaacgag atatgctctg tgttcagatc gcggggctct gccatgacct tggtcatggg
      721 ccattctccc atatgtttga tggaagattt attccacttg ctcgcccaga cataaagtgg
      781 aggcatgaac agggctcagt tgagatgttt gagcatctgg ttaactccaa tgaactcaaa
      841 cttgtcatga agaactatgg tctcgtccct gaagaagaca ttacctttat caaggaacaa
      901 attatgggac cacctgtatc accagtcaaa gactgcttgt ggccgtataa ggggcgcccc
      961 gccaagaaga gcttcctgta cgagatagtg gctaacaaaa gaaatggcat tgatgtggac
     1021 aaatgggact attttgccag agactgtcac catcttggaa tccaaaataa ttttgattac
     1081 aagcgcttca ttaagtttgc ccgtatctgt gaagtggacg acgagacccg ggcacataag
     1141 gtgaagcaca tttgtaccag agaaaaggag gttggaaacc tgtacgacat gttccacaca
     1201 cgcaactgct tacaccgcag agcttatcag cacaaaatcg gcaacctcat cgatataatg
     1261 attaccgaag ctttcctcaa agcagacccc cacgtggaga ttaccgggac cgaagggaag
     1321 aagtttcgaa tttccacagc cattcatgac atggaagcct tcagtaagct gacagataac
     1381 atctttctgg agattttata ctccacggat ccacagttgt ctgaggcccg gaatatttta
     1441 aggaacattg aatgccgtaa tctgtacaag tatttgggtg agacccagcc gaagcgtgag
     1501 aagattaaaa aggcagagta tgacaagctt gcccaagaag ttgctaatgc caaacctgaa
     1561 attgccccgg atgttgaact aaaggctgaa gatttcatcg ttgatgttat caatatggat
     1621 tacgggatgg aagacaagaa cccaattgat aatgttcact tctattgtaa gagtgacagc
     1681 aggcaagcgg tcacgatcac taaagaccag gtgtcccaac tgctgccaca gaaattcgca
     1741 gagcagctca tccgcgtgta ctataagaag aaggacaaga agagcttgga cgccgccggg
     1801 aagcacttca ttcagtggtg tgcgctcagg gacttcacca agccacagga tggtgacatt
     1861 atagcgcctc tcataacgcc tctgaaatgg aataaaaaga cttcatcttg catcgaagaa
     1921 gtatccaaag taaaaacgtg tctcaagttt taagggaatg tctacagtta gttcttttca
     1981 aaatcctctt tgcctcttca caattaagtt tggaaacaga atcagaggcc acctgtgatt
     2041 tttacttagt atcttgaatg tacgctcatg ttgggggttg gggggaggtc gttttttatt
     2101 ctcaacaaaa aatggtaata ttaacaaatg ttccctatct gtcctgtggt gatttgaata
     2161 agaatggccc cagaagctca tgattcaatg cttagtcacc ggggagtgca actgtttgaa
     2221 aggattacaa ggatcagaac gtgtagcctt gttggaggag gtgtgtcacc ggaggtgtgc
     2281 tttgaggttt cagaaaccca tgccagatcc agtgtgtctc tgtctgt
//
