LOCUS       NM_001012040            5678 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus sterile alpha motif domain containing 8 (Samd8),
            transcript variant 1, mRNA.
ACCESSION   NM_001012040 XM_223784
VERSION     NM_001012040.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5678)
  AUTHORS   Bickert,A., Ginkel,C., Kol,M., vom Dorp,K., Jastrow,H., Degen,J.,
            Jacobs,R.L., Vance,D.E., Winterhager,E., Jiang,X.C., Dormann,P.,
            Somerharju,P., Holthuis,J.C. and Willecke,K.
  TITLE     Functional characterization of enzymes catalyzing ceramide
            phosphoethanolamine biosynthesis in mice
  JOURNAL   J Lipid Res 56 (4), 821-835 (2015)
   PUBMED   25667419
  REMARK    Erratum:[J Lipid Res. 2017 Apr;58(4):820. PMID: 28365667]
REFERENCE   2  (bases 1 to 5678)
  AUTHORS   Ding,T., Kabir,I., Li,Y., Lou,C., Yazdanyar,A., Xu,J., Dong,J.,
            Zhou,H., Park,T., Boutjdir,M., Li,Z. and Jiang,X.C.
  TITLE     All members in the sphingomyelin synthase gene family have ceramide
            phosphoethanolamine synthase activity
  JOURNAL   J Lipid Res 56 (3), 537-545 (2015)
   PUBMED   25605874
REFERENCE   3  (bases 1 to 5678)
  AUTHORS   Vacaru,A.M., Tafesse,F.G., Ternes,P., Kondylis,V., Hermansson,M.,
            Brouwers,J.F., Somerharju,P., Rabouille,C. and Holthuis,J.C.
  TITLE     Sphingomyelin synthase-related protein SMSr controls ceramide
            homeostasis in the ER
  JOURNAL   J Cell Biol 185 (6), 1013-1027 (2009)
   PUBMED   19506037
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Mar 18, 2021 this sequence version replaced NM_001012040.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.35863.1,
                                           SRR26360181.533916.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-228               JAXUCZ010000015.1  2606825-2607052     c
            229-821             JAXUCZ010000015.1  2581844-2582436     c
            822-917             JAXUCZ010000015.1  2577452-2577547     c
            918-1035            JAXUCZ010000015.1  2574313-2574430     c
            1036-1186           JAXUCZ010000015.1  2566316-2566466     c
            1187-5678           JAXUCZ010000015.1  2561435-2565926     c
FEATURES             Location/Qualifiers
     source          1..5678
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p16"
     gene            1..5678
                     /gene="Samd8"
                     /note="sterile alpha motif domain containing 8"
                     /db_xref="GeneID:305684"
                     /db_xref="RGD:1306447"
     exon            1..228
                     /gene="Samd8"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..1491
                     /gene="Samd8"
                     /EC_number="2.7.8.48"
                     /note="isoform 1 is encoded by transcript variant 1;
                     sphingomyelin synthase-related protein 1"
                     /codon_start=1
                     /product="sphingomyelin synthase-related protein 1 isoform
                     1"
                     /protein_id="NP_001012040.1"
                     /db_xref="GeneID:305684"
                     /db_xref="RGD:1306447"
                     /translation="MPARSRAGSRQRSGSLPRPSRLPLEALSSAYAPRTPDSDGAIDT
                     GSELGPGSPAPTAEEVEEEMAGPSQLCIRRWTPRHVAVWLKEEGFFEYVDILCNKHRL
                     DGVTLLTLTEYDLRSPPLEIKVLGDIKRLMLSVRKLQKTHIDVLEEMGYNSDSPISPM
                     TPFISALQSADWLCNGEPAHSCDGPIPDLSSDQYQYMNGKNKHCARRLDPEYWKTVLS
                     CVYVFIVFGFTSFIMVIVHERVPDMQTYPPLPDIFLDSVPRIPWAFSMTEVCGMILCY
                     IWILVLLLHKHRSILLRRLCSLMGTVFLLRCFTMFVTSLSVPGQHLQCTGKVYGSVWE
                     KLHRAFAIWSGFGMTLTGVHTCGDYMFSGHTVVLTMLNFFVTEYTPRSWNFLHTLSWV
                     LNLFGIFFILAAHEHYSIDVFIAFYITTRLFLYYHTLANTRAYHQSRRARIWFPMFSF
                     FECNVNGTVPNEYCWPFSKPAIMKRLIG"
     exon            229..821
                     /gene="Samd8"
                     /inference="alignment:Splign:2.1.0"
     exon            822..917
                     /gene="Samd8"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1035
                     /gene="Samd8"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1186
                     /gene="Samd8"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..5678
                     /gene="Samd8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttccggtt cggctggccg ctactggcgg cacggctccg acggggccgg agcgatgccc
       61 gcgcgtagcc gagccggctc ccgccagcgc tccggctccc tgccccggcc ttcgcgtctg
      121 cctcttgagg cgctgagctc cgcctacgcg ccgaggaccc cggactccga cggcgccata
      181 gacaccggct ccgagctggg tcccggcagc ccggctccca ccgcggagga agtagaagag
      241 gaaatggcag gccctagtca actctgcatt cgccgctgga ctcccaggca tgtggccgtg
      301 tggctgaagg aggaggggtt ttttgagtat gtggacatct tatgtaacaa gcaccgtctg
      361 gatggagtca cactgctcac gctcaccgag tatgatctcc gctctcctcc tctggaaatc
      421 aaagtcctag gagacattaa acggctaatg ctctcagtcc gaaaactgca gaaaacacac
      481 attgatgttt tggaagagat gggttacaac agtgacagtc ccataagtcc catgacgcca
      541 ttcatcagtg cccttcagag tgcagactgg ctctgtaatg gagagcctgc acacagctgt
      601 gatgggccca tccctgatct gagctctgat cagtaccaat acatgaatgg caagaacaag
      661 cactgtgccc gaagactgga ccccgagtac tggaagaccg tcctgagctg tgtatatgtc
      721 tttatagtat ttgggttcac ctctttcatt atggtcattg ttcacgagcg agtgcctgac
      781 atgcagacct acccaccact cccagatata ttcttagaca gtgttcctag gatcccgtgg
      841 gccttctcca tgactgaagt gtgtggcatg atcctgtgct acatctggat cctggtcctc
      901 ctccttcaca agcacaggtc aatccttctg cgaaggctct gtagtctgat gggcactgta
      961 ttcttgcttc gctgctttac catgtttgtg acctccctct ccgtgccagg acagcacctg
     1021 cagtgtactg gaaaggtgta tggaagtgtg tgggagaaac tgcatcgggc gtttgccatt
     1081 tggagtggct tcggcatgac tctgacgggc gtgcacactt gtggggatta catgttcagt
     1141 ggccacaccg ttgtcctaac catgctgaat ttctttgtca cagaatatac gccaagaagc
     1201 tggaatttct tgcacactct ctcgtgggtt ctcaacctct ttggaatctt cttcatcttg
     1261 gctgcccatg aacattattc cattgacgtg tttattgcct tttatatcac aacaagactc
     1321 tttttgtact accacactct ggctaatacc agagcgtatc accagagcag gagagcgaga
     1381 atttggttcc ctatgttttc tttctttgaa tgcaatgtta atggcacagt acctaatgaa
     1441 tattgttggc cattttctaa accagcaata atgaaaagac taattggatg aagactctct
     1501 ctctgtaatg agtttgttgt taaatataca gtagttatgg aatgaaaacg aataccgttg
     1561 ctttgtcccc aggttcctgg atatgttgca ttttggcttc tgtgttgaca ggcttcccgt
     1621 tgtgagtaag gctgtgaccg tgaaactcga gaaagagaac acaagactcc gtctctagct
     1681 gtttgaatgg agaggccaag gagagagttt ctgcccctca ctgtaggaag acccagtgtg
     1741 tgggttatgt caggccatta cctgtgcatg ttgagtattt gcttactgaa ctcaagcaca
     1801 tcagcttggg ctggttgaag aatttttact gatttccaat aggactcaag tcaagaagta
     1861 ttttttgaag ctggtgttcc ttacctagtg agctgttctc acatgttcat tgaactaatc
     1921 tgtctgtctg caaagtgagt gtcctactgg taaataggtt ttaccttttg agccatttta
     1981 aagaaaaaca cattgaacat agcagttttt gtgaaacaag agaatgcaag gggcagtgtg
     2041 ggaggtgaca ggctgatcag gggtcgctgg ccttcccact aatgcaggta tgggggtcag
     2101 catttagaac aggtgcagcc tcagttgccg tccctgatct gtttggaagt ctcagtgtga
     2161 acacagaaag gattcatgag gggaaatggc tgtgttccta atagtaaagt ggtgtcattt
     2221 tagtgctgta agtatctgga ataaatactg ttgtgttagt taggcagatg acagcccagt
     2281 ataatgcttt tttaataatg tgacttaagt gaaacaaatg agtgttttac cagattttaa
     2341 agttcttacg tcagtgagtg agtaagtgtg catgcaaaga attcttttct tctggggaaa
     2401 aaaaaacaaa aacaaaacaa aaaaaagaac aagttgtagg cgtactgttc attaactctg
     2461 ggggattcct ctttctgctt tccctcaaag ttctcattct caccatcgaa gtaaaccgtc
     2521 taagacacac ttagacagaa gaaaagcttc atacttttta ttttaaaaaa taactgtatg
     2581 catacattct ttctatagtc ttaacttggc agttagaact aatgctttag ctgctgttta
     2641 cattagaaaa ctaccctccg tgactactgt cacttctcca gtaccacgtg tcactttatt
     2701 ttttattggt tgtacataac agtttaacct tagcctgatg gtaggattgg aatactgatt
     2761 gtatagtttt tacgttccat taagacaagg actctggagc tgcaggcaca ctgcagtcac
     2821 aagtttattc cttctctgtc tgggtgacat gttcgttttc acagttggag tcctagtccc
     2881 accccctcgg aagccactga gtggattagg caggaagggg atgttagaca gacaggtgtg
     2941 ggcctgtgct gagggagcct gctgggagtg tggaggtatg ctggggcacc cctcatttct
     3001 cacccaaagc cactcaagct caatcatgtt tttaaatttc atacttcaaa atatgtgcag
     3061 tattttaaat tattgattct gttacaagcc aggatcaaaa atgccaatat ctcatctaaa
     3121 gaaactgcat aatcatggag cagaggtcgc catgctcctt tgagtagttc gtcaggaata
     3181 ttactgccac cccgtcttat tacctgacac ccccacatag caggatccag tttacctggg
     3241 gggatggaga caggtagtgt tggcttttgg gaaaatgttc caaaaacatg tgtctacatt
     3301 aattttaaac tgctagctat atcaatggta aatatcttaa tgataaacat caggcctctc
     3361 tgtcacagag agagcagtag gtgcagccag ctttgccctt gcagggctgt aagtggggct
     3421 cccggccaca gctgcagcac agattgacgg ttctgagggt gaagggaagc tgggtctgta
     3481 acctagtatc tctgacaaga cagtgtttac atgagctaat cctcttcaag actcagagct
     3541 gagacaaagt catttttctt tcagtttttg ttgtcacacc tttttttatt ttattgtatt
     3601 aaaacctagc cataatgaag atagaatttc tgtttacatt ttgggcatga tgtggctgca
     3661 tgcagaggct tcatgctttt gaaccctgta tttgattgtg ctgcatggga ggcttttatt
     3721 cttgacagct tagtacagaa gcaggagaag gtttgagttc ttggggatgc aaaggacgga
     3781 tggcctatat tctaaagaca gtgtcatcgc ccttcctgtg tgctgaccca gggctgtgtg
     3841 tgtgctaggc gagtgctgtt gaaaggtaga cacgctggtg gagagaaaca agctgctctc
     3901 atcaccacac acttctgcag agcctttgtg ctgcagctcc ccgtgaggct gtcctccagt
     3961 tctctccagc cagaattgct gtggcaacaa tatttttata aagcagtggg cttcatctta
     4021 ggaccagtca attaataagc gtggccgtag ctgagaagag ccacttccaa gagcgcacca
     4081 gacacagtga gtggtgatca gcccccttct gcctgcctgt atgattgaga atcccaaaac
     4141 tctgtaattc ataaatgggg aacagaggca ccgatccttc tatagcagag aggaagtggg
     4201 ctttaggaac atttgtgcaa aaggtttttt ggggggttgg gggaggttcg ttgttcattt
     4261 gtttgtttgt ttttgttttg ctttttggag acagggtttc tggaactcag ggttccacct
     4321 gtctttccct tccatgctgg gattaaaggt atacaccata tgcacctttt tgtaaaactt
     4381 aattcatata aatttagatt catgacaaac gtgttctctt tatattcagt gaaaagcagt
     4441 cttgtcattg aaagattcta gatccagcgt gcttaacaat gtttacaata ttcttgactt
     4501 aaactctctg atttagtata tgtaattgtt tgtgggtgaa atcccatggc agaaagcaga
     4561 tagtagagtc acctgtcagc cctctcagct ctcagactgg aagacaagaa agatcttaga
     4621 agagttcatt tgctttcctt catacagtgt gaaagccacc aaagcatgtc aggggttttg
     4681 tttggttggt ttgggagttt ttgttgttgt tgttgttact gttttgtttt tgttgttttg
     4741 agtattttgt ttttgagaca gggtttctca gtatagccct ggctgtcctg gagcgcacag
     4801 catgtgggtt ttaatggcaa ctttacacga ccgtctgtgt ctattaccag tgagcgcatc
     4861 cccagccacc ccacacctgt gcagctgagg aggaaagtcc catcaatgat gcttcgagca
     4921 accaagggga agagaagggc ttttgtttgt ctcttcttct tatgaatagc ttttaatgac
     4981 taacattatt gtaaaagcag gtgttggctt gctggtaaat tcagtggcac taatttcaca
     5041 tgactaatat gatgaattac tgtatcaaga tcagtacaga tgtctatgaa gtctaagcta
     5101 tttctccggc tacactaagt tgaggataca ttgtactctg tgttaatcaa aggactcttt
     5161 gttctgtgtg ttccctgtgt ctgcataagg aagcctgtgc tttgatggga gaaggaatgt
     5221 tctattgttt tttgtttttt ttttttcatt gttactttac atctctttta atctgaacta
     5281 ctggattgtc tgaagaacta aacggagcct gttattaaca tctttaaagt gtttaatttt
     5341 aataattttt cattgaattc atggattgtt aggataatga aatatttctg atatggaaca
     5401 aaggaaatga aactggtact caatgaggaa gcaggttgct tggactaaac caggcatgtt
     5461 cagttttgag aattctacct agaggtctcc tgcccacaga gaaactagtg ttacttgaag
     5521 atatgaaagt ccctgtggta gccatgcctt gaagcacagt gttgtacata agtaaatacc
     5581 tgattctaaa ttaaatccag atctactaat atattatttt ataactttgt tgtattaaaa
     5641 cgttttaaac actaaagaat aaagcatttg aaagttga
//
