LOCUS       NM_013023               1483 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus S-antigen visual arrestin (Sag), mRNA.
ACCESSION   NM_013023 XM_001057784
VERSION     NM_013023.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1483)
  AUTHORS   Papal,S., Cortese,M., Legendre,K., Sorusch,N., Dragavon,J.,
            Sahly,I., Shorte,S., Wolfrum,U., Petit,C. and El-Amraoui,A.
  TITLE     The giant spectrin betaV couples the molecular motors to
            phototransduction and Usher syndrome type I proteins along their
            trafficking route
  JOURNAL   Hum Mol Genet 22 (18), 3773-3788 (2013)
   PUBMED   23704327
REFERENCE   2  (bases 1 to 1483)
  AUTHORS   Daiger,S.P., Sullivan,L.S. and Bowne,S.J.
  TITLE     Genes and mutations causing retinitis pigmentosa
  JOURNAL   Clin Genet 84 (2), 132-141 (2013)
   PUBMED   23701314
  REMARK    Review article
REFERENCE   3  (bases 1 to 1483)
  AUTHORS   Mockel,A., Obringer,C., Hakvoort,T.B., Seeliger,M., Lamers,W.H.,
            Stoetzel,C., Dollfus,H. and Marion,V.
  TITLE     Pharmacological modulation of the retinal unfolded protein response
            in Bardet-Biedl syndrome reduces apoptosis and preserves light
            detection ability
  JOURNAL   J Biol Chem 287 (44), 37483-37494 (2012)
   PUBMED   22869374
REFERENCE   4  (bases 1 to 1483)
  AUTHORS   Arshavsky,V.Y. and Burns,M.E.
  TITLE     Photoreceptor signaling: supporting vision across a wide range of
            light intensities
  JOURNAL   J Biol Chem 287 (3), 1620-1626 (2012)
   PUBMED   22074925
  REMARK    Review article
REFERENCE   5  (bases 1 to 1483)
  AUTHORS   Gurevich,V.V., Hanson,S.M., Song,X., Vishnivetskiy,S.A. and
            Gurevich,E.V.
  TITLE     The functional cycle of visual arrestins in photoreceptor cells
  JOURNAL   Prog Retin Eye Res 30 (6), 405-430 (2011)
   PUBMED   21824527
  REMARK    Review article
REFERENCE   6  (bases 1 to 1483)
  AUTHORS   Fuchs,S., Nakazawa,M., Maw,M., Tamai,M., Oguchi,Y. and Gal,A.
  TITLE     A homozygous 1-base pair deletion in the arrestin gene is a
            frequent cause of Oguchi disease in Japanese
  JOURNAL   Nat Genet 10 (3), 360-362 (1995)
   PUBMED   7670478
REFERENCE   7  (bases 1 to 1483)
  AUTHORS   Craft,C.M., Whitmore,D.H. and Donoso,L.A.
  TITLE     Differential expression of mRNA and protein encoding retinal and
            pineal S-antigen during the light/dark cycle
  JOURNAL   J Neurochem 55 (5), 1461-1473 (1990)
   PUBMED   2213004
REFERENCE   8  (bases 1 to 1483)
  AUTHORS   Abe,T. and Shinohara,T.
  TITLE     S-antigen from the rat retina and pineal gland have identical
            sequences
  JOURNAL   Exp Eye Res 51 (1), 111-112 (1990)
   PUBMED   2373176
REFERENCE   9  (bases 1 to 1483)
  AUTHORS   Abe,T., Yamaki,K., Tsuda,M., Singh,V.K., Suzuki,S., McKinnon,R.,
            Klein,D.C., Donoso,L.A. and Shinohara,T.
  TITLE     Rat pineal S-antigen: sequence analysis reveals presence of
            alpha-transducin homologous sequence
  JOURNAL   FEBS Lett 247 (2), 307-311 (1989)
   PUBMED   2714438
REFERENCE   10 (bases 1 to 1483)
  AUTHORS   McKechnie,N.M., Al-Mahdawi,S., Dutton,G. and Forrester,J.V.
  TITLE     Ultrastructural localization of retinal S antigen in the human
            retina
  JOURNAL   Exp Eye Res 42 (5), 479-487 (1986)
   PUBMED   3720866
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Nov 27, 2020 this sequence version replaced NM_013023.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: X15353.1, M60737.1 [ECO:0000331]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-98                JAXUCZ010000009.1  95917197-95917294
            99-203              JAXUCZ010000009.1  95918608-95918712
            204-264             JAXUCZ010000009.1  95923344-95923404
            265-309             JAXUCZ010000009.1  95925951-95925995
            310-503             JAXUCZ010000009.1  95927674-95927867
            504-563             JAXUCZ010000009.1  95930254-95930313
            564-640             JAXUCZ010000009.1  95934206-95934282
            641-776             JAXUCZ010000009.1  95935486-95935621
            777-861             JAXUCZ010000009.1  95935906-95935990
            862-934             JAXUCZ010000009.1  95939784-95939856
            935-1072            JAXUCZ010000009.1  95944200-95944337
            1073-1150           JAXUCZ010000009.1  95946604-95946681
            1151-1174           JAXUCZ010000009.1  95949196-95949219
            1175-1230           JAXUCZ010000009.1  95953466-95953521
            1231-1240           JAXUCZ010000009.1  95955824-95955833
            1241-1483           JAXUCZ010000009.1  95956399-95956641
FEATURES             Location/Qualifiers
     source          1..1483
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q35"
     gene            1..1483
                     /gene="Sag"
                     /gene_synonym="SAGMR; SANTI"
                     /note="S-antigen visual arrestin"
                     /db_xref="GeneID:25539"
                     /db_xref="RGD:3619"
     exon            1..98
                     /gene="Sag"
                     /gene_synonym="SAGMR; SANTI"
                     /inference="alignment:Splign:2.1.0"
     exon            99..203
                     /gene="Sag"
                     /gene_synonym="SAGMR; SANTI"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..1349
                     /gene="Sag"
                     /gene_synonym="SAGMR; SANTI"
                     /note="S-AG; 48 kDa protein; rod photoreceptor arrestin;
                     retinal S-antigen; S-antigen; retina and pineal gland
                     (arrestin)"
                     /codon_start=1
                     /product="S-arrestin"
                     /protein_id="NP_037155.2"
                     /db_xref="GeneID:25539"
                     /db_xref="RGD:3619"
                     /translation="MAACVKTNKSHVIFKKVSRDKSVTIYLGKRDYIDHVSQVEPVDG
                     VVLVDPELVKGKKVYVTLTCAFRYGQEDIDVIGLTFRRDLYFSRVQVYPPVGAMSAPT
                     QLQLSLLKKLGDNTYPFLLTFPDYLPCSVMLQPAPQDVGKSCGVDFEVKAFATDITDA
                     EEDKIPKKSSVRLLIRKVQHAPPEMGPQPCAEASWQFFMSDKPLHLSVSLSKEIYFHG
                     EPIPVTVTVTNNTEKVVKKIKVSVEQIANVVLYSSDYYVKPVASEETQEKVQPNSTLT
                     KTLVLVPLLANNRERRGIALDGKIKHEDTNLASSTIIKEGIDRTVMGILVSYHIKVKL
                     TVSGFLGELTSSEVATEVPFRLMHPQPEDPAKESVQDENLVFEEFARQNLKDTGENTE
                     GKKDEDAGQDE"
     exon            204..264
                     /gene="Sag"
                     /gene_synonym="SAGMR; SANTI"
                     /inference="alignment:Splign:2.1.0"
     exon            265..309
                     /gene="Sag"
                     /gene_synonym="SAGMR; SANTI"
                     /inference="alignment:Splign:2.1.0"
     exon            310..503
                     /gene="Sag"
                     /gene_synonym="SAGMR; SANTI"
                     /inference="alignment:Splign:2.1.0"
     exon            504..563
                     /gene="Sag"
                     /gene_synonym="SAGMR; SANTI"
                     /inference="alignment:Splign:2.1.0"
     exon            564..640
                     /gene="Sag"
                     /gene_synonym="SAGMR; SANTI"
                     /inference="alignment:Splign:2.1.0"
     exon            641..776
                     /gene="Sag"
                     /gene_synonym="SAGMR; SANTI"
                     /inference="alignment:Splign:2.1.0"
     exon            777..861
                     /gene="Sag"
                     /gene_synonym="SAGMR; SANTI"
                     /inference="alignment:Splign:2.1.0"
     exon            862..934
                     /gene="Sag"
                     /gene_synonym="SAGMR; SANTI"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1072
                     /gene="Sag"
                     /gene_synonym="SAGMR; SANTI"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1150
                     /gene="Sag"
                     /gene_synonym="SAGMR; SANTI"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1174
                     /gene="Sag"
                     /gene_synonym="SAGMR; SANTI"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1230
                     /gene="Sag"
                     /gene_synonym="SAGMR; SANTI"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1240
                     /gene="Sag"
                     /gene_synonym="SAGMR; SANTI"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1483
                     /gene="Sag"
                     /gene_synonym="SAGMR; SANTI"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagccagggg cctcaccctt gccctgtgag gttatctgat aggattttac cagttccctc
       61 agcgcacggg gctagctgct caccatctga aagcacagcc attcggcctt ggacatacat
      121 cccaagggac agacaacatg gcagcctgtg tgaagaccaa taaatcccat gtcatcttca
      181 agaaggtctc ccgggacaag tcggtgacca tctacctggg gaagagagac tatatagatc
      241 acgtcagcca agtagagcct gtagatggtg ttgtattggt ggatcctgag ctcgtgaagg
      301 ggaagaaagt gtatgtcacc ctgacctgcg ccttccgcta tggccaagag gacattgatg
      361 tgattggcct gaccttccgc agggacctgt atttctctcg ggtccaggta tatcctcctg
      421 ttggggccat gagtgcccca acccagctcc agttgagcct gctcaagaaa ctgggagata
      481 acacgtaccc atttctgctc acgttccctg actacctacc ctgctcagtg atgttgcagc
      541 cagctccaca agatgtaggg aagagctgtg gggttgactt tgaggttaaa gcatttgcca
      601 cagacatcac agatgctgaa gaggacaaga tccccaagaa gagctctgtg cggttactga
      661 tccggaaggt gcagcatgcc ccacctgaga tgggtcccca gccctgtgct gaagcctcct
      721 ggcagttctt catgtctgac aagcccctgc acctctcagt ctccctcagc aaagagatat
      781 atttccatgg ggagcccatc cctgtgaccg tgactgtgac caataacacg gagaaggttg
      841 tgaagaagat taaagtgtca gtggaacaaa tagccaatgt ggttctctac tcgagtgatt
      901 attacgtcaa gcctgtggcc tcggaggaaa cacaggaaaa agtgcagcca aacagcactt
      961 tgaccaagac gctggtgctg gtgcccctcc tggctaacaa cagagaaaga agaggcatcg
     1021 cgctggatgg gaagatcaag catgaggaca caaacctggc ctccagcacc attatcaagg
     1081 agggcatcga tcggaccgtc atgggcatcc tggtgtcata ccatatcaaa gtgaagctca
     1141 cggtgtcagg ctttctagga gagctcacat ccagtgaagt ggctactgag gtgccgttcc
     1201 gtctgatgca cccccagcct gaggacccag caaaagaaag tgtccaggat gaaaatctgg
     1261 tttttgaaga gtttgctcga caaaatctga aagatactgg agagaataca gaagggaaga
     1321 aagatgagga tgcaggccag gatgagtgaa gacttagcct tgatgcctag aaactgcttg
     1381 tagtcctggt tgccttgtgg gaaacccctg gtaacctttc agagttatgc taaatacgaa
     1441 agctcgagca ttcttcccag aaataaagtc tgtgggtcct ccc
//
