LOCUS       NM_001012063            1914 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus SUMO1 activating enzyme subunit 1 (Sae1), mRNA.
ACCESSION   NM_001012063 XM_218333
VERSION     NM_001012063.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1914)
  AUTHORS   Hasson,S.A., Kane,L.A., Yamano,K., Huang,C.H., Sliter,D.A.,
            Buehler,E., Wang,C., Heman-Ackah,S.M., Hessa,T., Guha,R.,
            Martin,S.E. and Youle,R.J.
  TITLE     High-content genome-wide RNAi screens identify regulators of parkin
            upstream of mitophagy
  JOURNAL   Nature 504 (7479), 291-295 (2013)
   PUBMED   24270810
REFERENCE   2  (bases 1 to 1914)
  AUTHORS   Jang,C.Y., Shin,H.S., Kim,H.D., Kim,J.W., Choi,S.Y. and Kim,J.
  TITLE     Ribosomal protein S3 is stabilized by sumoylation
  JOURNAL   Biochem Biophys Res Commun 414 (3), 523-527 (2011)
   PUBMED   21968017
REFERENCE   3  (bases 1 to 1914)
  AUTHORS   Olsen,S.K., Capili,A.D., Lu,X., Tan,D.S. and Lima,C.D.
  TITLE     Active site remodelling accompanies thioester bond formation in the
            SUMO E1
  JOURNAL   Nature 463 (7283), 906-912 (2010)
   PUBMED   20164921
REFERENCE   4  (bases 1 to 1914)
  AUTHORS   Sigal,A., Milo,R., Cohen,A., Geva-Zatorsky,N., Klein,Y., Alaluf,I.,
            Swerdlin,N., Perzov,N., Danon,T., Liron,Y., Raveh,T.,
            Carpenter,A.E., Lahav,G. and Alon,U.
  TITLE     Dynamic proteomics in individual human cells uncovers widespread
            cell-cycle dependence of nuclear proteins
  JOURNAL   Nat Methods 3 (7), 525-531 (2006)
   PUBMED   16791210
REFERENCE   5  (bases 1 to 1914)
  AUTHORS   Lois,L.M. and Lima,C.D.
  TITLE     Structures of the SUMO E1 provide mechanistic insights into SUMO
            activation and E2 recruitment to E1
  JOURNAL   EMBO J 24 (3), 439-451 (2005)
   PUBMED   15660128
REFERENCE   6  (bases 1 to 1914)
  AUTHORS   Desterro,J.M., Rodriguez,M.S., Kemp,G.D. and Hay,R.T.
  TITLE     Identification of the enzyme required for activation of the small
            ubiquitin-like protein SUMO-1
  JOURNAL   J Biol Chem 274 (15), 10618-10624 (1999)
   PUBMED   10187858
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079411.1.
            
            On Feb 11, 2005 this sequence version replaced XM_218333.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079411.1, SRR8487231.54383.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840111, SAMN12840115
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1914
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1914
                     /gene="Sae1"
                     /gene_synonym="Uble1a"
                     /note="SUMO1 activating enzyme subunit 1"
                     /db_xref="GeneID:308384"
                     /db_xref="RGD:1306098"
     exon            1..147
                     /gene="Sae1"
                     /gene_synonym="Uble1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..1090
                     /gene="Sae1"
                     /gene_synonym="Uble1a"
                     /note="ubiquitin-like 1-activating enzyme E1A;
                     ubiquitin-like 1 (sentrin) activating enzyme E1A"
                     /codon_start=1
                     /product="SUMO-activating enzyme subunit 1"
                     /protein_id="NP_001012063.1"
                     /db_xref="GeneID:308384"
                     /db_xref="RGD:1306098"
                     /translation="MVEKEEVSGGGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLI
                     VGMKGLGAEIAKNLILAGVKGLTMLDHEQVSPEDLGAQFLIRTGSVGQNRAEASLERA
                     QNLNPMVDVKVDTEDIEKKPESFFTEFDAVCLTCCSKDVIIKVDQICHRNSIKFFTGD
                     VFGYHGYTFANLGEHEFVEEKTKVTKVSQGVEDGPDAKRAKLDSSETTMVKKKVLFCP
                     VKEALAVDWSGEKAQAALKRTAPDYFLLQVLLKFRTDKGRDPTSDSYSEDAELLLQIR
                     NDVFDSLGVSPDLLPDDFVRYCFSEMAPVCAVVGGILAQEIVKALSQRDPPHNNFFFF
                     DGMKGSGIVECLGPQ"
     exon            148..259
                     /gene="Sae1"
                     /gene_synonym="Uble1a"
                     /inference="alignment:Splign:2.1.0"
     exon            260..433
                     /gene="Sae1"
                     /gene_synonym="Uble1a"
                     /inference="alignment:Splign:2.1.0"
     exon            434..576
                     /gene="Sae1"
                     /gene_synonym="Uble1a"
                     /inference="alignment:Splign:2.1.0"
     exon            577..676
                     /gene="Sae1"
                     /gene_synonym="Uble1a"
                     /inference="alignment:Splign:2.1.0"
     exon            677..782
                     /gene="Sae1"
                     /gene_synonym="Uble1a"
                     /inference="alignment:Splign:2.1.0"
     exon            783..927
                     /gene="Sae1"
                     /gene_synonym="Uble1a"
                     /inference="alignment:Splign:2.1.0"
     exon            928..997
                     /gene="Sae1"
                     /gene_synonym="Uble1a"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1888
                     /gene="Sae1"
                     /gene_synonym="Uble1a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttagcgaga gcgggatcgg gtgagctgaa agccggcgcc atggtggaga aggaggaggt
       61 cagcggcggc ggcggcggca tcagcgagga ggaggcagcg cagtatgacc gacagatccg
      121 cctgtgggga ctggaggctc agaagcggct tcgagcttct cgggtactga ttgtcggcat
      181 gaaaggactt ggggctgaaa tcgccaagaa ccttatcctg gcaggagtga aagggctcac
      241 catgctggac catgaacagg tatctccaga agaccttgga gctcagttct tgattcgaac
      301 tgggtctgtg ggccaaaaca gggccgaggc ctctttggaa cgagcccaga atctcaaccc
      361 catggtggat gtaaaggtgg acactgagga tatagagaag aagccagagt ccttcttcac
      421 agagtttgat gcggtgtgcc tgacttgctg ctccaaagat gtcatcatta aagtcgacca
      481 gatctgtcac agaaatagca tcaagttctt cacaggagat gtctttgggt accatgggta
      541 cacctttgca aatcttggag agcatgaatt tgtagaagag aaaaccaaag ttaccaaagt
      601 cagccaagga gtggaagatg gacctgatgc caagagagca aagcttgact catcggagac
      661 caccatggtc aaaaagaaag tgcttttctg ccctgtaaag gaagcgctag cagtggactg
      721 gagtggagag aaagcccagg ctgccctgaa gcgcactgcc ccagactact ttctgctgca
      781 agtgttgctg aagttccgca cggataaagg gagagaccct acttctgaca gctacagcga
      841 ggatgccgag ctgctgctgc agatacgcaa tgacgtgttt gactcgctgg gcgtcagtcc
      901 tgacctgctt cccgatgact ttgtcaggta ctgcttctct gagatggccc cagtatgtgc
      961 tgtggttgga ggaatcttgg cacaggaaat tgtgaaggcc ctgtctcaaa gggaccctcc
     1021 tcacaacaac ttcttcttct tcgatggcat gaaggggagt ggaattgtgg agtgccttgg
     1081 tccccagtga gcctgaggtg tgtgcaacgc cactgagtca cctatcctct ctatgaaggc
     1141 atgtctggat cgtttttttc tagagcaaga agacgaggtt tcatcccaag tttgtcctag
     1201 cagctatcgg ggacctgctg gctcccgcgt gtgatagtca caaggctccc ctctggcact
     1261 ggggactgac aacacctggg aagagcatca tgcttcgtgg tgtcagagtt tcttctcacc
     1321 ctttggactt ctttctatag gtcaacagag aggagcagga catgggtggg gaccccaggc
     1381 ccagagactc tgaaacccaa tggattatac ttctgcctgg agaactgaga gcagccctct
     1441 tcttggccct tcctcagtct gtatcctggg ttttgtaagg gacgcaccca gttgtcatgt
     1501 cttttggttg tcagccttta atgaccaagc tgtcttttca ccccaaacag tttatttcta
     1561 aaaggtagat ttaatgctag gggccgttat gcagcttgta atcctagaaa ttgggatgcc
     1621 agggcaggag ggttgctgta aatcaaggcc aacaggtcta taaaatgtac cgagaacccc
     1681 tctcagaata taatcaaaga catattccag agttagggtg ggccactatc accatgtccc
     1741 ccagttcctc atattgggag ccaggtcctc tgaggggagg gccgagttgg cttggtcttc
     1801 cttctagggt atgggggcaa cgcgtctaga ttgtagattc ccttggttgt tcataaggaa
     1861 tgataataaa gtgcatcctc tcaagcttaa aaaaaaaaaa aaaaaaaaaa aaaa
//
