LOCUS       NM_021775               2171 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus sphingosine-1-phosphate receptor 5 (S1pr5), mRNA.
ACCESSION   NM_021775
VERSION     NM_021775.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2171)
  AUTHORS   Kihara,Y., Maceyka,M., Spiegel,S. and Chun,J.
  TITLE     Lysophospholipid receptor nomenclature review: IUPHAR Review 8
  JOURNAL   Br J Pharmacol 171 (15), 3575-3594 (2014)
   PUBMED   24602016
  REMARK    Review article
REFERENCE   2  (bases 1 to 2171)
  AUTHORS   Khalid,A.M., Asano,A., Hosaka,Y.Z., Ohyama,K., Ohta,M. and
            Yamano,Y.
  TITLE     Expression of a novel sphingosine 1-phosphate receptor motif
            protein gene in maturing rat testes
  JOURNAL   Biosci Biotechnol Biochem 76 (9), 1769-1773 (2012)
   PUBMED   22972346
  REMARK    GeneRIF: The LOC290876-encoded gene product (EDG-8) has distinct
            roles in the nucleus during the processes of spermatocyte
            maturation and spermatid production in meiosis.
REFERENCE   3  (bases 1 to 2171)
  AUTHORS   Chiyo,M., Iwata,T., Webb,T.J., Vasko,M.R., Thompson,E.L.,
            Heidler,K.M., Cummings,O.W., Yoshida,S., Fujisawa,T., Brand,D.D.
            and Wilkes,D.S.
  TITLE     Silencing S1P1 receptors regulates collagen-V reactive
            lymphocyte-mediated immunobiology in the transplanted lung
  JOURNAL   Am J Transplant 8 (3), 537-546 (2008)
   PUBMED   18294150
  REMARK    GeneRIF: These data demonstrate novel roles of S1P(1R,) which
            include regulating emigration and modulating lymphocyte activation.
REFERENCE   4  (bases 1 to 2171)
  AUTHORS   Jolly,P.S., Bektas,M., Watterson,K.R., Sankala,H., Payne,S.G.,
            Milstien,S. and Spiegel,S.
  TITLE     Expression of SphK1 impairs degranulation and motility of RBL-2H3
            mast cells by desensitizing S1P receptors
  JOURNAL   Blood 105 (12), 4736-4742 (2005)
   PUBMED   15741218
  REMARK    GeneRIF: SphK1 has a role in regulating degranulation and motility
            of rat mast cells by desensitizing S1P receptors
REFERENCE   5  (bases 1 to 2171)
  AUTHORS   Jaillard,C., Harrison,S., Stankoff,B., Aigrot,M.S., Calver,A.R.,
            Duddy,G., Walsh,F.S., Pangalos,M.N., Arimura,N., Kaibuchi,K.,
            Zalc,B. and Lubetzki,C.
  TITLE     Edg8/S1P5: an oligodendroglial receptor with dual function on
            process retraction and cell survival
  JOURNAL   J Neurosci 25 (6), 1459-1469 (2005)
   PUBMED   15703400
  REMARK    GeneRIF: Edg8/S1P5 activation on oligodendroglial cells modulates
            two distinct functional pathways mediating either process
            retraction or cell survival and that these effects depend on the
            developmental stage of the cell.
REFERENCE   6  (bases 1 to 2171)
  AUTHORS   Niedernberg,A., Scherer,C.R., Busch,A.E. and Kostenis,E.
  TITLE     Comparative analysis of human and rat S1P(5) (edg8): differential
            expression profiles and sensitivities to antagonists
  JOURNAL   Biochem Pharmacol 64 (8), 1243-1250 (2002)
   PUBMED   12234605
  REMARK    GeneRIF: differences between hS1P(5) and rS1P(5) will be an
            important point to be considered in the development of selective
            receptor antagonists.
REFERENCE   7  (bases 1 to 2171)
  AUTHORS   Brinkmann,V., Davis,M.D., Heise,C.E., Albert,R., Cottens,S.,
            Hof,R., Bruns,C., Prieschl,E., Baumruker,T., Hiestand,P.,
            Foster,C.A., Zollinger,M. and Lynch,K.R.
  TITLE     The immune modulator FTY720 targets sphingosine 1-phosphate
            receptors
  JOURNAL   J Biol Chem 277 (24), 21453-21457 (2002)
   PUBMED   11967257
  REMARK    GeneRIF: The immune modulator FTY720 targets sphingosine
            1-phosphate receptors.
REFERENCE   8  (bases 1 to 2171)
  AUTHORS   Malek,R.L., Toman,R.E., Edsall,L.C., Wong,S., Chiu,J.,
            Letterle,C.A., Van Brocklyn,J.R., Milstien,S., Spiegel,S. and
            Lee,N.H.
  TITLE     Nrg-1 belongs to the endothelial differentiation gene family of G
            protein-coupled sphingosine-1-phosphate receptors
  JOURNAL   J Biol Chem 276 (8), 5692-5699 (2001)
   PUBMED   11069896
REFERENCE   9  (bases 1 to 2171)
  AUTHORS   Im,D.S., Heise,C.E., Ancellin,N., O'Dowd,B.F., Shei,G.J.,
            Heavens,R.P., Rigby,M.R., Hla,T., Mandala,S., McAllister,G.,
            George,S.R. and Lynch,K.R.
  TITLE     Characterization of a novel sphingosine 1-phosphate receptor, Edg-8
  JOURNAL   J Biol Chem 275 (19), 14281-14286 (2000)
   PUBMED   10799507
REFERENCE   10 (bases 1 to 2171)
  AUTHORS   Glickman,M., Malek,R.L., Kwitek-Black,A.E., Jacob,H.J. and Lee,N.H.
  TITLE     Molecular cloning, tissue-specific expression, and chromosomal
            localization of a novel nerve growth factor-regulated G-protein-
            coupled receptor, nrg-1
  JOURNAL   Mol Cell Neurosci 14 (2), 141-152 (1999)
   PUBMED   10532805
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF115249.1.
            
            On Jun 4, 2003 this sequence version replaced NM_021775.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF115249.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2171
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..2171
                     /gene="S1pr5"
                     /gene_synonym="Edg-8; Edg8"
                     /note="sphingosine-1-phosphate receptor 5"
                     /db_xref="GeneID:60399"
                     /db_xref="RGD:620566"
     exon            1..35
                     /gene="S1pr5"
                     /gene_synonym="Edg-8; Edg8"
                     /inference="alignment:Splign:2.1.0"
     exon            36..182
                     /gene="S1pr5"
                     /gene_synonym="Edg-8; Edg8"
                     /inference="alignment:Splign:2.1.0"
     exon            183..2171
                     /gene="S1pr5"
                     /gene_synonym="Edg-8; Edg8"
                     /inference="alignment:Splign:2.1.0"
     CDS             258..1460
                     /gene="S1pr5"
                     /gene_synonym="Edg-8; Edg8"
                     /note="S1P5; NRG-1; S1P receptor 5; S1P receptor Edg-8;
                     sphingosine 1-phosphate receptor Edg-8; endothelial
                     differentiation G-protein-coupled receptor 8; nerve growth
                     factor-regulated G-protein-coupled receptor 1; endothelial
                     differentiation, sphingolipid G-protein-coupled receptor,
                     8"
                     /codon_start=1
                     /product="sphingosine 1-phosphate receptor 5"
                     /protein_id="NP_068543.2"
                     /db_xref="GeneID:60399"
                     /db_xref="RGD:620566"
                     /translation="MESGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAAVCL
                     AVCAFIVLENLAVLLVLGRHPRFHAPMFLLLGSLTLSDLLAGAAYATNILLSGPLTLR
                     LSPALWFAREGGVFVALAASVLSLLAIAIERHLTMARRGPAPAASRARTLAMAVAAWG
                     LLLTLGLLPALGWNCLGRLEACSTVLPVYAKAYVLFCVLAFLGILAAICALYARIYCQ
                     VRANARRLRAGPGSRRATSSSRSRHTPRSLALLRTLSVVLLAFVACWGPLFLLLLLDV
                     ACPARACPVLLQADPFLGLAMANSLLNPIIYTFTNRDLRHALLRLLCCGRGPCNQDSS
                     NSLQRSPSAVGPSGGGLRRCLPPTLDRSSSPSEHSCPQRDGMDTSCSTGSPGAATANR
                     TLVPDATD"
ORIGIN      
        1 ccgcctaggg cgcacgaccg gacctaggcg caaggttcgc atatagacca gtgcacaaat
       61 gccaagcaga ggggttgatc ccttggtgct gaagttgcag gcggttttga gttgtctgat
      121 gtgggtcctg ggagctaaac ccgagtcctc tggaatagtg gcaagagatc ttaatcgtta
      181 agacttttgc acagtgctcc cgtggacatc tggcaggata cagctgcgac atctccgcgg
      241 cgggcggcgg gcagcccatg gagtccgggc tactgcggcc agcgccggtg agcgaggtca
      301 tcgtccttca ctacaactac actggcaagc tccggggagc gcgctaccag cccggtgccg
      361 gcctgcgtgc ggacgccgca gtgtgcttgg ctgtgtgcgc tttcatcgtg ctggagaacc
      421 tggctgtgct cttggtgctg ggccgccatc ctcgcttcca tgcacccatg ttcctgctcc
      481 tgggtagtct taccttgtcg gacctgctcg ctggggcggc ctacgccacc aacatcctgc
      541 tgtccgggcc gctcacattg cgcctgtcgc ctgcgctctg gtttgcgcgc gaagggggtg
      601 tcttcgtggc gctcgcagcg tcggtgctga gcctcctggc cattgctata gagcgccacc
      661 ttaccatggc ccgtcgtgga cccgcgcctg ccgccagtcg cgctcgcacg ctggcgatgg
      721 cggtggccgc ctggggcttg ttgttgacgc tggggctgct gcccgcgctg ggctggaact
      781 gcttgggacg cctggaagcc tgctccaccg tgttgccggt gtacgccaag gcctatgtgc
      841 tcttctgcgt gctggccttc ctgggcatcc tggctgccat ctgtgcgctc tatgcaagga
      901 tttactgtca ggtgcgggcc aacgcgcgtc gcctgcgggc cggtcctggg tcccgtaggg
      961 ccacgtcctc ctcgcgatcc cggcacacgc cacggtcgtt ggccctgctc cgcacgctta
     1021 gcgtggtgct cctggccttc gtggcctgct ggggacctct atttctcttg ctattactgg
     1081 atgtcgcgtg cccagcccgc gcgtgtcctg tgcttctgca agccgatccc ttcctgggtc
     1141 tagccatggc taactcgctg ctgaatccta tcatctacac cttcaccaac cgagacctgc
     1201 gccacgcgct cctgaggctg ctctgctgtg gccgcggacc ctgcaaccaa gactcctcca
     1261 acagtttgca gcgatcccca agtgctgttg ggccttccgg tggaggcctg cgacgctgcc
     1321 tgccaccaac cctggatcgc agctctagcc catcagaaca ctcgtgtccc cagcgggacg
     1381 ggatggacac cagctgctcc actggcagtc ccggagcagc aaccgccaac cggaccctgg
     1441 tgcctgatgc tacagactga cgcttcccaa cctgctgtcg ccctttgcaa gagcagactg
     1501 actgtccaaa taagcgcatc atctgtagga aatagccaat aacagagggg acatacaaga
     1561 aagaagggaa atggtttgac caccccataa caggaacaga cgaaaatgca cgtggggtct
     1621 ggcatggaca acaacaaaac gaaagtgatg ggaaggtatc cgggtagtga tgtaacctga
     1681 gctgggaacc cctgagggag gaccattcgg tgtggcagca gcagaaattg aggagcagca
     1741 gagcagggtg acaggagatg aaagggcggg ttgtgggaag tcttgttggt tctgagggag
     1801 gccttcggtt tggctctgag tgaagtggga gccgtagaga attctaaaca aaggagggac
     1861 tcgcctagat tcagacctcc acaggtaccc tgtgactact ggagttcaag gggaaacgct
     1921 ggaagacaca gggataaagg ggaggctcca aatattctca aaagcaggtg aagtctgaat
     1981 agagtgcgct aagggctggc agaaggagtg gctggctaca gagtgaggca gagccgtggg
     2041 aaggcaggac cgtaagccta ggtccaaaaa tttggctctg gagactttgc cagatatcag
     2101 ctaccaaact tccagagtgt ggacaggctc tttatacaaa ctacaaccac aataaaaaca
     2161 attcaagcgg c
//
