LOCUS       NM_001271143            3606 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus sphingosine-1-phosphate receptor 3 (S1pr3), mRNA.
ACCESSION   NM_001271143 XM_002725237 XM_225216
VERSION     NM_001271143.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3606)
  AUTHORS   Dong,Y.F., Guo,R.B., Ji,J., Cao,L.L., Zhang,L., Chen,Z.Z.,
            Huang,J.Y., Wu,J., Lu,J. and Sun,X.L.
  TITLE     S1PR3 is essential for phosphorylated fingolimod to protect
            astrocytes against oxygen-glucose deprivation-induced
            neuroinflammation via inhibiting TLR2/4-NFkappaB signalling
  JOURNAL   J Cell Mol Med 22 (6), 3159-3166 (2018)
   PUBMED   29536648
  REMARK    GeneRIF: this study reveals that pFTY720 depends on S1PR3 to
            protect astrocytes against OGD-induced neuroinflammation, due to
            inhibiting TLR2/4-PI3K-NFkappaB signalling pathway.
REFERENCE   2  (bases 1 to 3606)
  AUTHORS   Yin,J., Guo,Y.M., Chen,P., Xiao,H., Wang,X.H., DiSanto,M.E. and
            Zhang,X.H.
  TITLE     Testosterone regulates the expression and functional activity of
            sphingosine-1-phosphate receptors in the rat corpus cavernosum
  JOURNAL   J Cell Mol Med 22 (3), 1507-1516 (2018)
   PUBMED   29266713
  REMARK    GeneRIF: Testosterone regulates the expression and functional
            activity of sphingosine-1-phosphate receptors in the rat corpus
            cavernosum.
REFERENCE   3  (bases 1 to 3606)
  AUTHORS   Xu,D., Liu,Z., Wang,S., Peng,Y. and Sun,X.
  TITLE     Astrocytes regulate the expression of Sp1R3 on oligodendrocyte
            progenitor cells through Cx47 and promote their proliferation
  JOURNAL   Biochem Biophys Res Commun 490 (3), 670-675 (2017)
   PUBMED   28634078
  REMARK    GeneRIF: Astrocytes regulate the expression of S1pR3 in
            oligodendrocyte progenitor cells via Cx47, which could be a
            valuable approach for promoting oligodendrocyte progenitor cells
            proliferation.
REFERENCE   4  (bases 1 to 3606)
  AUTHORS   Zhu,C., Cao,C., Dai,L., Yuan,J. and Li,S.
  TITLE     Corticotrophin-releasing factor participates in S1PR3-dependent
            cPLA2 expression and cell motility in vascular smooth muscle cells
  JOURNAL   Vascul Pharmacol 71, 116-126 (2015)
   PUBMED   25869501
  REMARK    GeneRIF: A pro-migratory role was determined for S1PR3 in vascular
            smooth muscle cells.
REFERENCE   5  (bases 1 to 3606)
  AUTHORS   Ni,X., Epshtein,Y., Chen,W., Zhou,T., Xie,L., Garcia,J.G. and
            Jacobson,J.R.
  TITLE     Interaction of integrin beta4 with S1P receptors in S1P- and
            HGF-induced endothelial barrier enhancement
  JOURNAL   J Cell Biochem 115 (6), 1187-1195 (2014)
   PUBMED   24851274
REFERENCE   6  (bases 1 to 3606)
  AUTHORS   Wamhoff,B.R., Lynch,K.R., Macdonald,T.L. and Owens,G.K.
  TITLE     Sphingosine-1-phosphate receptor subtypes differentially regulate
            smooth muscle cell phenotype
  JOURNAL   Arterioscler Thromb Vasc Biol 28 (8), 1454-1461 (2008)
   PUBMED   18535287
  REMARK    GeneRIF: S1P (sphingosine-1-phosphate receptor)1 and S1P3 receptors
            promote, whereas S1P2 receptors antagonize, smooth muscle cell
            proliferation and phenotypic modulation in vitro in response to
            sphingosine-1-phosphate (S1P), or in vivo after vascular injury
            Erratum:[Arterioscler Thromb Vasc Biol. 2011 Jan;31(1):e3]
REFERENCE   7  (bases 1 to 3606)
  AUTHORS   Niessen,F., Schaffner,F., Furlan-Freguia,C., Pawlinski,R.,
            Bhattacharjee,G., Chun,J., Derian,C.K., Andrade-Gordon,P., Rosen,H.
            and Ruf,W.
  TITLE     Dendritic cell PAR1-S1P3 signalling couples coagulation and
            inflammation
  JOURNAL   Nature 452 (7187), 654-658 (2008)
   PUBMED   18305483
REFERENCE   8  (bases 1 to 3606)
  AUTHORS   Ishii,I., Friedman,B., Ye,X., Kawamura,S., McGiffert,C.,
            Contos,J.J., Kingsbury,M.A., Zhang,G., Brown,J.H. and Chun,J.
  TITLE     Selective loss of sphingosine 1-phosphate signaling with no obvious
            phenotypic abnormality in mice lacking its G protein-coupled
            receptor, LP(B3)/EDG-3
  JOURNAL   J Biol Chem 276 (36), 33697-33704 (2001)
   PUBMED   11443127
REFERENCE   9  (bases 1 to 3606)
  AUTHORS   Ikeda,H., Yatomi,Y., Yanase,M., Satoh,H., Maekawa,H., Ogata,I.,
            Ozaki,Y., Takuwa,Y., Mochida,S. and Fujiwara,K.
  TITLE     Biological activities of novel lipid mediator sphingosine
            1-phosphate in rat hepatic stellate cells
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 279 (2), G304-G310 (2000)
   PUBMED   10915638
  REMARK    Erratum:[Am J Physiol Gastrointest Liver Physiol 2000
            Nov;279(5):section G, following table of contents]
REFERENCE   10 (bases 1 to 3606)
  AUTHORS   An,S., Bleu,T. and Zheng,Y.
  TITLE     Transduction of intracellular calcium signals through G
            protein-mediated activation of phospholipase C by recombinant
            sphingosine 1-phosphate receptors
  JOURNAL   Mol Pharmacol 55 (5), 787-794 (1999)
   PUBMED   10220556
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FN805905.1 and JAXUCZ010000017.1.
            
            On or before Sep 5, 2012 this sequence version replaced
            XM_225216.6, XM_002725237.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.1060912.1,
                                           SRR26360186.1909580.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840108, SAMN12840111
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-740               FN805905.1         1-740
            741-3606            JAXUCZ010000017.1  13932773-13935638   c
FEATURES             Location/Qualifiers
     source          1..3606
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..3606
                     /gene="S1pr3"
                     /gene_synonym="Edg3; Edg3l; lpb3"
                     /note="sphingosine-1-phosphate receptor 3"
                     /db_xref="GeneID:306792"
                     /db_xref="RGD:1583843"
     exon            1..175
                     /gene="S1pr3"
                     /gene_synonym="Edg3; Edg3l; lpb3"
                     /inference="alignment:Splign:2.1.0"
     exon            176..3606
                     /gene="S1pr3"
                     /gene_synonym="Edg3; Edg3l; lpb3"
                     /inference="alignment:Splign:2.1.0"
     CDS             322..1461
                     /gene="S1pr3"
                     /gene_synonym="Edg3; Edg3l; lpb3"
                     /note="endothelial differentiation, sphingolipid
                     G-protein-coupled receptor, 3; cardiac
                     sphingosine-1-phosphate specific receptor"
                     /codon_start=1
                     /product="sphingosine 1-phosphate receptor 3"
                     /protein_id="NP_001258072.1"
                     /db_xref="GeneID:306792"
                     /db_xref="RGD:1583843"
                     /translation="MASTHAQGHPPVLGNDTLREHYDYVGKLAGRLRDPPEGSTLITT
                     ILFLVTCSFIVLENLMVLIAIWKNNKFHNRMYFFIGNLALCDLLAGIAYKVNILMSGR
                     KTFSLSPTVWFLREGSMFVALGASTCSLLAIAIERHLTMIKMRPYDANKKHRVFLLIG
                     MCWLIAFSLGALPILGWNCLENFPDCSTILPLYSKKYIAFLISIFTAILVTIVILYAR
                     IYFLVKSSSRRVANHNSERSMALLRTVVIVVSVFIACWSPLFILFLIDVACRAKECSI
                     LFKSQWFIMLAVLNSAMNPVIYTLASKEMRRAFFRLVCGCLVKGKGTQASPMQPALDP
                     SRSKSSSSNNSSSHSPKVKEDLPHVATSSCVTDKTRSLQNGVLCK"
ORIGIN      
        1 gcaagttcag gggcaggcga caaggtccgg gtgctgagcg aggcggctgg acaagcttag
       61 ccagagagaa acctgaggcc acgagcgacc tccggaggag cccctaaact ggagccttag
      121 ctgagactta gcggtggcag catgcaacca gcccagatga gccttgcaga acgagagcct
      181 gtttccaaca ctcttgctgc agtcaggcct gctgcacgcc ttcaggaacc caccaccgct
      241 gtcccaattg tcccctgaaa tgaacgttcc tggcgcgccc tctcgtggac tgttgaggta
      301 accatccgtc tataggaagt catggcatcc acgcatgcgc agggccaccc gccagtcttg
      361 gggaatgata ctctccggga acattatgat tacgtgggga agctggcagg caggctgcgg
      421 gacccccctg agggtagcac cctcatcacc accatcctct tcttggtcac ctgtagcttc
      481 atcgtcttgg agaacctgat ggttttgatt gccatctgga aaaacaataa atttcataac
      541 cgcatgtact ttttcatcgg caacttggct ctctgcgacc tgctggccgg catagcctac
      601 aaggtcaaca ttctgatgtc cggtaggaag acgttcagcc tgtctccaac agtgtggttc
      661 ctcagggagg gcagtatgtt cgtagccctg ggcgcatcca catgcagctt attggccatt
      721 gccattgagc ggcacctgac catgatcaag atgaggccgt acgacgccaa caagaagcac
      781 cgcgtgttcc ttctgattgg gatgtgctgg ctaattgcct tctcgctggg tgccctgccc
      841 atcctgggct ggaactgcct ggagaacttt cccgactgct ctaccatctt gcccctctac
      901 tccaagaaat acattgcctt tctcatcagc atcttcacag ccattctggt gaccatcgtc
      961 atcttgtacg cgcgcatcta cttcctggtc aagtccagca gccgcagggt ggccaaccac
     1021 aactccgaga gatccatggc ccttctgcgg accgtagtga tcgtggtgag cgtgttcatc
     1081 gcctgttggt cccccctttt catcctcttc ctcatcgatg tggcctgcag ggcgaaggag
     1141 tgctccatcc tcttcaagag tcagtggttc atcatgctgg ctgtcctcaa ctcggccatg
     1201 aaccctgtca tctacacgct ggccagcaaa gagatgcggc gtgctttctt ccggttggtg
     1261 tgcggctgtc tggtcaaggg caaggggacc caggcctccc cgatgcagcc tgctcttgac
     1321 ccgagcagaa gtaaatcaag ctccagtaac aacagcagca gccactctcc aaaggtcaag
     1381 gaagacctgc cccatgtggc tacctcttcc tgcgtcactg acaaaacgag gtcgcttcag
     1441 aatggggtcc tctgcaagtg aatgtctcca caggtcaagc tctgcagcca cacctattta
     1501 ttgcacgcat tcgcttccac gcgaggcctt agagatcttg accctggagg tctgcttgac
     1561 gtggccacca actcctgagg aggagaccca aggagacacc gatacatttc agcccggaca
     1621 tggatgtgcc ttatgggttg caggctccat ccttctgaat gtaccaagct gctgacgttg
     1681 tccactccct ttggatgccg atttccccgg tccagggagg gcaggtagtg atgtgctatg
     1741 cacatgcgct ttgggatgga atcttcctat cttcacacta cattaatttt catagaatgg
     1801 gtgctcctgt atgtgtctgt ccgttgctgt gttgtacaga atgtgtatgc caggttttcc
     1861 caggtggagc ccattacaaa gtgttggtcc ccccacatct tgtgtaacgg ttggtccgaa
     1921 cctgcaggca cagctgtacc ggattcagca tgtgataagg tggtgcgcct ttcccggtgc
     1981 ccttgtgccg gtgtcctagc tcatggctgt gaaaagttac tcaagtattc cttattctca
     2041 aaaagcctca cccaagagca gcccaggtgt gtgggtctca cctttacata cccgtgtccc
     2101 tccctcttgg gtcccttcca taagcttaag tacatctgaa agccagatta tgtgatcgtt
     2161 gaggcatttc tgaaaatcac tgaaaagcca gccaggatct ctcaaaatgc tggcatcact
     2221 gaaggaagag cccatgagga gaggcaaggt gctctccacc gtgggtcacc cttccagggg
     2281 acggcagtct gctgcatgta gagagtttcc agcagtgaca ttcacaagcc agcccttcaa
     2341 ctgtatggta ctgagttcag ttccatgtag agaagcttga ttcgtgtgta gagaagcttg
     2401 atgccagtca gctttgccgc caccttttgc tggcaaggag ctgaagctgt cagcaaagct
     2461 tctcgtctcc ctcaattgtg gaccctgacc aggacccttc agtgagagga atccgccagg
     2521 ctaggaggcg tgatgtggtt ctttgcaccc tcttcagaga gaaccattcc catgcccata
     2581 tgatgggcgc tccaccgctt ggacctgcgt tcctttgtcc atcctgtaag gaaaacgctt
     2641 agaagacacc tctgaaatcc cctccccaag gactctgccc gcgggacaca caggtgggta
     2701 tgttggagag agcagccagc acccatgctc ccagaacagt ctttggaagg actcacactc
     2761 ggggaaactt catgtcagag ctccccataa gttgattagc atcagagaca cacctaccaa
     2821 cctttttaaa gatgattttt ctctcaatgg ttacttgatg gcatttgctc ttgcttaggg
     2881 acacttttcc tgggccctag gtaaccatgg actgactaac gaaagacttc ccctggtgga
     2941 tataggtcac tgccagggaa ttctgctgga tcattggcct atctgtctct tctctacgtc
     3001 accgagaaaa taacttattc tctcatcatg gtgttgacaa aaaacccagg catttctggg
     3061 aaaggaaagc atgcaagtgc tgggctgagg gaaaataaca ggccagtgtg tgggggagtt
     3121 gaggtggaaa atgaatgggg cttgaggacg tgctcttccc taatcggaat gcttcgaggc
     3181 catggatctg ggtcactaat attaataaca cattgtacat gactctgact tctctatatc
     3241 ctcctgtgtc tgctttcatt caacagccct tgcagagggc cacacctacc atccccagct
     3301 aggaggtgac atttgtagaa tgacagagtg tcgagcagtt gaaattagaa atacactaag
     3361 acctaattgc actcacttga tgtatgccaa atggagcaat catccgtgac gccagtgtgc
     3421 gctcctttcc ctagctaagc caccgagaca gcattgagac cgagtgcacc caaaccctca
     3481 ccccgaaggt cggaaacaag agaagccaga gaccctgggg cctgccccag gtagcgagtg
     3541 acctttacta cttgcagttt atgtttgtta ataataaata aaaccaaaag cctttatata
     3601 aaccca
//
