LOCUS       NM_017192               2741 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus sphingosine-1-phosphate receptor 2 (S1pr2), mRNA.
ACCESSION   NM_017192
VERSION     NM_017192.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2741)
  AUTHORS   Xiao,P., Gu,J., Xu,W., Niu,X., Zhang,J., Li,J., Chen,Y., Pei,Z.,
            Zeng,J. and Xing,S.
  TITLE     RTN4/Nogo-A-S1PR2 negatively regulates angiogenesis and secondary
            neural repair through enhancing vascular autophagy in the thalamus
            after cerebral cortical infarction
  JOURNAL   Autophagy 18 (11), 2711-2730 (2022)
   PUBMED   35263212
  REMARK    GeneRIF: RTN4/Nogo-A-S1PR2 negatively regulates angiogenesis and
            secondary neural repair through enhancing vascular autophagy in the
            thalamus after cerebral cortical infarction.
REFERENCE   2  (bases 1 to 2741)
  AUTHORS   Yan,Z., Deng,Y., Zou,Y., Liu,S., Li,K., Yang,J., Guo,X., He,R.,
            Zheng,W. and Xie,H.
  TITLE     Analysis of regulatory effect of miR-149-5p on
            Sphingosine-1-phosphate receptor 2 of pericytes and its
            neuroprotective molecular mechanism after acute cerebral ischemia
            reperfusion in rats
  JOURNAL   Bioengineered 12 (1), 3348-3357 (2021)
   PUBMED   34224319
  REMARK    GeneRIF: Analysis of regulatory effect of miR-149-5p on
            Sphingosine-1-phosphate receptor 2 of pericytes and its
            neuroprotective molecular mechanism after acute cerebral ischemia
            reperfusion in rats.
REFERENCE   3  (bases 1 to 2741)
  AUTHORS   Zhang,T., Guo,D., Zheng,W. and Dai,Q.
  TITLE     Effects of S1PR2 antagonist on blood pressure and angiogenesis
            imbalance in preeclampsia rats
  JOURNAL   Mol Med Rep 23 (6) (2021)
   PUBMED   33880585
  REMARK    GeneRIF: Effects of S1PR2 antagonist on blood pressure and
            angiogenesis imbalance in preeclampsia rats.
REFERENCE   4  (bases 1 to 2741)
  AUTHORS   Shen,X., Zhang,L., Jiang,L., Xiong,W., Tang,Y., Lin,L. and Yu,T.
  TITLE     Alteration of sphingosine-1-phosphate with aging induces
            contractile dysfunction of colonic smooth muscle cells via Ca2+
            -activated K+ channel (BKCa) upregulation
  JOURNAL   Neurogastroenterol Motil 33 (5), e14052 (2021)
   PUBMED   33452855
  REMARK    GeneRIF: Alteration of sphingosine-1-phosphate with aging induces
            contractile dysfunction of colonic smooth muscle cells via Ca(2+)
            -activated K(+) channel (BKCa ) upregulation.
REFERENCE   5  (bases 1 to 2741)
  AUTHORS   Li,Y., Li,H. and Han,J.
  TITLE     Sphingosine-1-phosphate receptor 2 modulates pain sensitivity by
            suppressing the ROS-RUNX3 pathway in a rat model of neuropathy
  JOURNAL   J Cell Physiol 235 (4), 3864-3873 (2020)
   PUBMED   31603252
  REMARK    GeneRIF: Sphingosine-1-phosphate receptor 2 modulates pain
            sensitivity by suppressing the ROS-RUNX3 pathway in a rat model of
            neuropathy.
REFERENCE   6  (bases 1 to 2741)
  AUTHORS   MacLennan,A.J., Carney,P.R., Zhu,W.J., Chaves,A.H., Garcia,J.,
            Grimes,J.R., Anderson,K.J., Roper,S.N. and Lee,N.
  TITLE     An essential role for the H218/AGR16/Edg-5/LP(B2) sphingosine
            1-phosphate receptor in neuronal excitability
  JOURNAL   Eur J Neurosci 14 (2), 203-209 (2001)
   PUBMED   11553273
REFERENCE   7  (bases 1 to 2741)
  AUTHORS   Ancellin,N. and Hla,T.
  TITLE     Differential pharmacological properties and signal transduction of
            the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5
  JOURNAL   J Biol Chem 274 (27), 18997-19002 (1999)
   PUBMED   10383399
REFERENCE   8  (bases 1 to 2741)
  AUTHORS   An,S., Bleu,T., Huang,W., Hallmark,O.G., Coughlin,S.R. and
            Goetzl,E.J.
  TITLE     Identification of cDNAs encoding two G protein-coupled receptors
            for lysosphingolipids
  JOURNAL   FEBS Lett 417 (3), 279-282 (1997)
   PUBMED   9409733
REFERENCE   9  (bases 1 to 2741)
  AUTHORS   MacLennan,A.J., Browe,C.S., Gaskin,A.A., Lado,D.C. and Shaw,G.
  TITLE     Cloning and characterization of a putative G-protein coupled
            receptor potentially involved in development
  JOURNAL   Mol Cell Neurosci 5 (3), 201-209 (1994)
   PUBMED   8087418
REFERENCE   10 (bases 1 to 2741)
  AUTHORS   Okazaki,H., Ishizaka,N., Sakurai,T., Kurokawa,K., Goto,K.,
            Kumada,M. and Takuwa,Y.
  TITLE     Molecular cloning of a novel putative G protein-coupled receptor
            expressed in the cardiovascular system
  JOURNAL   Biochem Biophys Res Commun 190 (3), 1104-1109 (1993)
   PUBMED   8382486
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Nov 26, 2020 this sequence version replaced NM_017192.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U10699.1, SRR26643288.32849.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676785, SAMN16676787
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               JAXUCZ010000008.1  27790244-27790344   c
            102-2741            JAXUCZ010000008.1  27779452-27782091   c
FEATURES             Location/Qualifiers
     source          1..2741
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..2741
                     /gene="S1pr2"
                     /gene_synonym="Edg5; Gpcr13; GPCR18; H218; snGPCR18"
                     /note="sphingosine-1-phosphate receptor 2"
                     /db_xref="GeneID:29415"
                     /db_xref="RGD:68334"
     exon            1..101
                     /gene="S1pr2"
                     /gene_synonym="Edg5; Gpcr13; GPCR18; H218; snGPCR18"
                     /inference="alignment:Splign:2.1.0"
     exon            102..2741
                     /gene="S1pr2"
                     /gene_synonym="Edg5; Gpcr13; GPCR18; H218; snGPCR18"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..1200
                     /gene="S1pr2"
                     /gene_synonym="Edg5; Gpcr13; GPCR18; H218; snGPCR18"
                     /note="S1P2; AGR16; S1P receptor 2; S1P receptor Edg-5;
                     G-protein coupled receptor H218; sphingosine 1-phosphate
                     receptor Edg-5; endothelial differentiation G-protein
                     coupled receptor 5; G-protein coupled receptor 13;
                     endothelial differentiation, sphingolipid
                     G-protein-coupled receptor, 5"
                     /codon_start=1
                     /product="sphingosine 1-phosphate receptor 2"
                     /protein_id="NP_058888.1"
                     /db_xref="GeneID:29415"
                     /db_xref="RGD:68334"
                     /translation="MGGLYSEYLNPEKVQEHYNYTKETLDMQETPSRKVASAFIIILC
                     CAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGPVTLSLTP
                     LQWFAREGSAFITLSASVFSLLAIAIERQVAIAKVKLYGSDKSCRMLMLIGASWLISL
                     ILGGLPILGWNCLDHLEACSTVLPLYAKHYVLCVVTIFSVILLAIVALYVRIYFVVRS
                     SHADVAGPQTLALLKTVTIVLGVFIICWLPAFSILLLDSTCPVRACPVLYKAHYFFAF
                     ATLNSLLNPVIYTWRSRDLRREVLRPLLCWRQGKGATGRRGGNPGHRLLPLRSSSSLE
                     RGLHMPTSPTFLEGNTVV"
ORIGIN      
        1 cgagcacagc caacagtcac caaagtcagc cactggctgt cccggggcgc agacgccaag
       61 gccactcagg ccagggcagg gaccctggcc ggcctagcca gtgctcagtc ccatggcccc
      121 ggccggccac tgagccccac catgggcggt ttatactcag agtacctcaa tcctgagaag
      181 gttcaggaac actacaatta caccaaggag acgctggaca tgcaggagac gccctcccgc
      241 aaggtggcct ccgccttcat catcatttta tgctgtgcca tcgtggtgga gaaccttctg
      301 gtgctaatcg cagtggccag gaacagcaag ttccactcag ccatgtacct gttcctcggc
      361 aacctggcag cctccgacct gctggcaggc gtggccttcg tggccaacac cttgctctcc
      421 ggacctgtca ccctgtcctt aactcccttg cagtggtttg cccgagaggg ttcagccttc
      481 atcacgctct ctgcctcggt cttcagcctc ctggccattg ccatcgagag acaagtggcc
      541 atcgccaagg tcaagctcta cggcagtgac aaaagctgtc gaatgttgat gctcattggg
      601 gcctcttggc tgatatcgct gattctgggt ggcttgccca tcctgggctg gaattgtctg
      661 gaccatctgg aggcttgctc cactgtgctg cccctctatg ctaagcacta tgtgctctgc
      721 gtggtcacca tcttctctgt catcttactg gctatcgtgg ccttgtacgt ccgaatctac
      781 ttcgtagtcc gctcaagcca tgcggacgtt gctggtcctc agacgctggc cctgctcaag
      841 acagtcacca tcgtactggg tgttttcatc atctgctggc tgccggcttt tagcatcctt
      901 ctcttagact ctacctgtcc cgtccgggcc tgtcctgtcc tctacaaagc ccattatttc
      961 tttgccttcg ccaccctcaa ctctctgctc aaccctgtca tctatacatg gcgtagccgg
     1021 gaccttcgga gggaggtact gaggcccctg ctgtgctggc ggcaggggaa gggagcaaca
     1081 gggcgcagag gtgggaaccc tggtcaccga ctcctgcccc tccgcagctc cagctccctg
     1141 gagagaggct tgcatatgcc tacatcgcca acatttctgg agggcaacac agtggtctga
     1201 ggggaaatgt gaactgatct gtaaccaagc cacagagaga gctctgtggg gagagaccag
     1261 gtgacctcat catgtccctc agtgccacag gtctggagga actgaccacg gctcataggt
     1321 caggtggcca acggaggcac tgactaatca gattgtagta ctgtgactgt ggggaccatt
     1381 aagggtctag ggggacagca ggctcgagtt tagggctaga catttgccac ttggtacata
     1441 gggtgtcggc atcctgtctg tcctatcttc cagcttcccg gttcccttcc tgcctcctcc
     1501 ttttaagggc ctctctacat agccccggct ggctagagct tgctgtgcag accaggctga
     1561 cctggacctc ccagagatag atcaactaac tgtgtcctga gtgctgggat tttaaagccg
     1621 tgtgccccca cacccggctc ctgccacctt ccagaagcaa tcttaggcca cttgttgagg
     1681 aaacactctc cccagaggac ccaagccttc ttccctgtct ctctgaggcc tgaatccaca
     1741 gcttccccat tttatcaact gctgcttctt ccctttcctt ctgtgttcag gggaaaccac
     1801 tgtgggggca gggaggggtc ctgggatccc agtttttatg ctcagatctc actgagcact
     1861 tgctttattg gggagcagag aggaatcagc tgaggcagtg tggggcagat gttgaggaga
     1921 atttgggctt cctggtgaga aaactctagg ggaggcgttg gttattcctg gaacccagcc
     1981 tctctcccca cgaactcttc acacccgcag ccttgagctg gatgcaaagg ctgctttcaa
     2041 tttgtctttg tagttttgtt ttgttttgtt ttgttttttt aaattgggac aggatctcac
     2101 gtaccccagg ctggcctccg actcactatg tagccaaggc tggctttgga cttctgaccc
     2161 tcctgcctcc gcttctggag tgcaggtatt acaagggtgt accaccacca ccaccaccac
     2221 caacaacaac aacaacaaca acacctgtct tgaaaactat catgaatgac atggttcaca
     2281 tagccttggg tggccaagga catcccggat actcttatgg catcttccct tgaaggactt
     2341 tgctaaatcc tgtggagaag tagaaaatcc aatacggtac aaacggtatt tatgtgtgtc
     2401 tgtgtatcag tgtggggtct gtgacctcct atcccagtgt gggtgctgtc tgacctctta
     2461 tgtgcacatc cgtgtcaaga ctgctagaga gatggacggg ggtgtgtgtg cttgtggggg
     2521 tctagccatg atcaggcctc ctgggaattg ctgaatcatc tctcccacac acagacacac
     2581 acctccgcct taaagaaatg tgtgaaagaa aaggctgagg aaggggagat ttgggaggca
     2641 aggagccagt cgggagtgtg tctcccctca tacagcttcc cagatgtccc ccttgtgctg
     2701 gaaacccaga actgggccaa taaacagttc aatttctctt g
//
