LOCUS       NM_017301               2596 bp    mRNA    linear   ROD 17-NOV-2024
DEFINITION  Rattus norvegicus sphingosine-1-phosphate receptor 1 (S1pr1), mRNA.
ACCESSION   NM_017301
VERSION     NM_017301.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2596)
  AUTHORS   Zhao,W., Huang,G. and Ye,J.
  TITLE     LINC00707 inhibits myocardial fibrosis and immune disorder in
            rheumatic heart disease by regulating miR-145-5p/S1PR1
  JOURNAL   Biotechnol Genet Eng Rev 40 (4), 3073-3086 (2024)
   PUBMED   37083109
  REMARK    GeneRIF: LINC00707 inhibits myocardial fibrosis and immune disorder
            in rheumatic heart disease by regulating miR-145-5p/S1PR1.
REFERENCE   2  (bases 1 to 2596)
  AUTHORS   Chen,D., Lu,P., Sun,T. and Ding,A.
  TITLE     Long non-coding RNA HOX transcript antisense intergenic RNA
            depletion protects against alcoholic hepatitis through the
            microRNA-148a-3p/sphingosine 1-phosphate receptor 1 axis
  JOURNAL   Cell Tissue Res 394 (3), 471-485 (2023)
   PUBMED   37851113
  REMARK    GeneRIF: Long non-coding RNA HOX transcript antisense intergenic
            RNA depletion protects against alcoholic hepatitis through the
            microRNA-148a-3p/sphingosine 1-phosphate receptor 1 axis.
REFERENCE   3  (bases 1 to 2596)
  AUTHORS   Johansen,V.B.I., Hampson,E., Tsonou,E., Pantarelli,C., Chu,J.Y.,
            Crossland,L., Okkenhaug,H., Massey,A.J., Hornigold,D.C.,
            Welch,H.C.E. and Chetwynd,S.A.
  TITLE     The GPCR adaptor protein Norbin regulates S1PR1 trafficking and the
            morphology, cell cycle and survival of PC12 cells
  JOURNAL   Sci Rep 13 (1), 18237 (2023)
   PUBMED   37880240
  REMARK    GeneRIF: The GPCR adaptor protein Norbin regulates S1PR1
            trafficking and the morphology, cell cycle and survival of PC12
            cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2596)
  AUTHORS   Lauro,F., Giancotti,L.A., Kolar,G., Harada,C.M., Harmon,T.A.,
            Garrett,T.J. and Salvemini,D.
  TITLE     Role of Adenosine Kinase in Sphingosine-1-Phosphate Receptor
            1-Induced Mechano-Hypersensitivities
  JOURNAL   Cell Mol Neurobiol 42 (8), 2909-2918 (2022)
   PUBMED   34773542
  REMARK    GeneRIF: Role of Adenosine Kinase in Sphingosine-1-Phosphate
            Receptor 1-Induced Mechano-Hypersensitivities.
REFERENCE   5  (bases 1 to 2596)
  AUTHORS   Jiang,H., Joshi,S., Liu,H., Mansor,S., Qiu,L., Zhao,H.,
            Whitehead,T., Gropler,R.J., Wu,G.F., Cross,A.H., Benzinger,T.L.S.,
            Shoghi,K.I., Perlmutter,J.S. and Tu,Z.
  TITLE     InVitro and In Vivo Investigation of S1PR1 Expression in the
            Central Nervous System Using [3H]CS1P1 and [11C]CS1P1
  JOURNAL   ACS Chem Neurosci 12 (19), 3733-3744 (2021)
   PUBMED   34516079
  REMARK    GeneRIF: In Vitro and In Vivo Investigation of S1PR1 Expression in
            the Central Nervous System Using [(3)H]CS1P1 and [(11)C]CS1P1.
REFERENCE   6  (bases 1 to 2596)
  AUTHORS   Parrill,A.L., Wang,D., Bautista,D.L., Van Brocklyn,J.R.,
            Lorincz,Z., Fischer,D.J., Baker,D.L., Liliom,K., Spiegel,S. and
            Tigyi,G.
  TITLE     Identification of Edg1 receptor residues that recognize sphingosine
            1-phosphate
  JOURNAL   J Biol Chem 275 (50), 39379-39384 (2000)
   PUBMED   10982820
REFERENCE   7  (bases 1 to 2596)
  AUTHORS   Okamoto,H., Takuwa,N., Yokomizo,T., Sugimoto,N., Sakurada,S.,
            Shigematsu,H. and Takuwa,Y.
  TITLE     Inhibitory regulation of Rac activation, membrane ruffling, and
            cell migration by the G protein-coupled sphingosine-1-phosphate
            receptor EDG5 but not EDG1 or EDG3
  JOURNAL   Mol Cell Biol 20 (24), 9247-9261 (2000)
   PUBMED   11094076
REFERENCE   8  (bases 1 to 2596)
  AUTHORS   Liu,Y., Wada,R., Yamashita,T., Mi,Y., Deng,C.X., Hobson,J.P.,
            Rosenfeldt,H.M., Nava,V.E., Chae,S.S., Lee,M.J., Liu,C.H., Hla,T.,
            Spiegel,S. and Proia,R.L.
  TITLE     Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate,
            is essential for vascular maturation
  JOURNAL   J Clin Invest 106 (8), 951-961 (2000)
   PUBMED   11032855
REFERENCE   9  (bases 1 to 2596)
  AUTHORS   Okamoto,H., Takuwa,N., Gonda,K., Okazaki,H., Chang,K., Yatomi,Y.,
            Shigematsu,H. and Takuwa,Y.
  TITLE     EDG1 is a functional sphingosine-1-phosphate receptor that is
            linked via a Gi/o to multiple signaling pathways, including
            phospholipase C activation, Ca2+ mobilization,
            Ras-mitogen-activated protein kinase activation, and adenylate
            cyclase inhibition
  JOURNAL   J Biol Chem 273 (42), 27104-27110 (1998)
   PUBMED   9765227
REFERENCE   10 (bases 1 to 2596)
  AUTHORS   Lado,D.C., Browe,C.S., Gaskin,A.A., Borden,J.M. and MacLennan,A.J.
  TITLE     Cloning of the rat edg-1 immediate-early gene: expression pattern
            suggests diverse functions
  JOURNAL   Gene 149 (2), 331-336 (1994)
   PUBMED   7959012
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097938.1.
            
            On Jun 12, 2005 this sequence version replaced NM_017301.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097938.1, FQ120434.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2596
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q42"
     gene            1..2596
                     /gene="S1pr1"
                     /gene_synonym="Edg1"
                     /note="sphingosine-1-phosphate receptor 1"
                     /db_xref="GeneID:29733"
                     /db_xref="RGD:61958"
     exon            1..61
                     /gene="S1pr1"
                     /gene_synonym="Edg1"
                     /inference="alignment:Splign:2.1.0"
     exon            62..2571
                     /gene="S1pr1"
                     /gene_synonym="Edg1"
                     /inference="alignment:Splign:2.1.0"
     CDS             227..1378
                     /gene="S1pr1"
                     /gene_synonym="Edg1"
                     /note="endothelial differentiation sphingolipid
                     G-protein-coupled receptor 1; S1P1; S1P receptor 1; S1P
                     receptor Edg-1; sphingosine 1-phosphate receptor Edg-1;
                     endothelial differentiation G-protein coupled receptor 1;
                     EDG1 (Edg1)"
                     /codon_start=1
                     /product="sphingosine 1-phosphate receptor 1"
                     /protein_id="NP_058997.1"
                     /db_xref="GeneID:29733"
                     /db_xref="RGD:61958"
                     /translation="MVSSTSIPVVKALRSQVSDYGNYDIIVRHYNYTGKLNIGVEKDH
                     GIKLTSVVFILICCLIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTAN
                     LLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNSSR
                     SFLLISACWVISLILGGLPIMGWNCISSLSSCSTVLPLYHKHYILFCTTVFTLLLLSI
                     VILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFIL
                     LLLDVGCKAKTCDILYKAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIISCCKCPN
                     GDSAGKFKRPIIPGMEFSRSKSDNSSHPQKDDGDNPETIMSSGNVNSSS"
ORIGIN      
        1 tgcggatcgc gcggtgtaga cccggagccc ggcggacgca gcttcgtccc gcttgagcga
       61 ggctgctgtt tctcggaggc ctctccagcc aaggaaaaac tacataaaaa agcatcggat
      121 tgcttgctga cctggccttg ctgtaactga aggctcgctc aacctcgccc tctagcgttt
      181 gtctggagaa gtaccacccc gggctcctgg ggacacagtt gcggctatgg tgtcctccac
      241 cagcatccca gtggttaagg ctctccgcag ccaagtctcc gactatggca actatgatat
      301 catagtccgg cattacaact acacaggcaa gctgaacatc ggagtggaga aggaccatgg
      361 cattaaactg acttcagtgg tgttcattct catctgctgc ttgatcatcc tagagaatat
      421 atttgtcttg ctaactattt ggaaaaccaa gaagttccac cggcccatgt actatttcat
      481 aggcaaccta gccctctcgg acctgttagc aggagtggct tacacagcta acctgctgtt
      541 gtctggggcc accacctaca agctcacacc tgcccagtgg tttctgcggg aaggaagtat
      601 gtttgtggct ctgtctgcct cagtcttcag cctccttgct atcgccattg agcgctacat
      661 caccatgctg aagatgaaac tacacaacgg cagcaacagc tcgcgctcct ttctgctgat
      721 cagtgcctgc tgggtcatct ccctcatcct gggtgggctg cccatcatgg gctggaactg
      781 catcagctcg ctgtccagct gctccaccgt gctcccgctc taccacaagc actatattct
      841 cttctgcacc accgtcttca ccctgctcct gctttccatc gtcatcctct actgcaggat
      901 ctactccttg gtgaggactc gaagccgccg cctgaccttc cgcaagaaca tctccaaggc
      961 cagccgcagt tccgagaagt ctctggcctt gctgaagaca gtgatcattg tcctgagtgt
     1021 cttcattgcc tgctgggccc ctctcttcat cctactactt ttagatgtgg ggtgcaaggc
     1081 gaagacctgt gacatcctgt acaaagcaga gtacttcctg gttctggctg tgctgaactc
     1141 aggtaccaac cccatcatct acactctgac caataaggag atgcgccggg ccttcatcag
     1201 gatcatatct tgttgcaaat gccccaacgg agactccgct ggcaaattca agaggcccat
     1261 catcccgggc atggaattta gccgcagcaa atcagacaac tcctcccacc cccagaagga
     1321 tgatggggac aatccagaga ccattatgtc ttctggaaac gtcaattctt cttcttaaaa
     1381 ccggaagctg ttgatactgt tgattctggc ttcatcactc actaccctag catttcaaaa
     1441 acatctctct ttctccactg ctgcaaggaa gaagcagccg ggagcctgag agagggaggg
     1501 aagggagaat gtgcggcttg gtgataccat gttgtaggta ggttatgatt atgaacaatg
     1561 ccctgggaag ggtggagatc aggtctggcc tgcagagggt ttcctgcccc cacccctttc
     1621 cccaataccc cggagctttg attttgcact gagccaaagg tctagcattg tcaagctccc
     1681 agagggctca tctggcccct cctcaaagac taaggtccca agagaaagtg tcccgtgagt
     1741 tttgagatgt gctctctcac tgtaatgaca aagtgaatat gtgcccttta gcttggttgg
     1801 gtggtgtgca cgtccccacc ctccatttct tctcatcctg tctccccgcc ccaccccttc
     1861 ttcatattct tttactttat atcttaactg cctgatcttt gttcatcaga aggaggttgt
     1921 agaggggtgt attccttgat tgtctctaac tagcaggctg ttgactggga agactgtttg
     1981 ctgaggccaa agtttccatg gaaggtggat caagttgtcc gggatttggt aggctgtctt
     2041 taagatgaaa atgtattgtt ccttattcct catgtgttcc ttatttccat tacaaccaca
     2101 ttggacatgt gtttgtaatg gaaataacga agtctactct atttgtaatt atattgacca
     2161 ggatcttagg agatatgggt aaagaaaaaa aatgaggtga aatctgaggg ttacttgtgt
     2221 aaaacaagag ctgttgcttg atgtctttct ctaaccccta cgagcatctt tggcactttt
     2281 attggttatt tcagagtgtt gtgtgatctg tgtcaaccaa ctggttgtat tttgtttaaa
     2341 gagcagtttc tgattttcga atgtacttgc ttctttgagg tcattttatt gaatttcttc
     2401 ctaacctgtg ttaacaccat tgaatgtgta gttcttaaga aaatgcctcc ctttgtaccc
     2461 aaaaaagcat tactttaact gacagggaac atcagaaatt cttttcttca gttgtcctta
     2521 ggtattgacc ctggatgtaa atgatacaga gaataaaaat atattactgt caaaaaaaaa
     2581 aaaaaaaaaa aaaaaa
//
