LOCUS       NM_013191               1484 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus S100 calcium binding protein B (S100b), mRNA.
ACCESSION   NM_013191
VERSION     NM_013191.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1484)
  AUTHORS   Ding,S., Wang,C., Wang,W., Yu,H., Chen,B., Liu,L., Zhang,M. and
            Lang,Y.
  TITLE     Autocrine S100B in astrocytes promotes VEGF-dependent inflammation
            and oxidative stress and causes impaired neuroprotection
  JOURNAL   Cell Biol Toxicol 39 (5), 1-25 (2023)
   PUBMED   34792689
  REMARK    GeneRIF: Autocrine S100B in astrocytes promotes VEGF-dependent
            inflammation and oxidative stress and causes impaired
            neuroprotection.
REFERENCE   2  (bases 1 to 1484)
  AUTHORS   Obaid,A.A., Almasmoum,H., Almaimani,R.A., El-Boshy,M., Aslam,A.,
            Idris,S., Ghaith,M.M., El-Readi,M.Z., Ahmad,J., Farrash,W.F.,
            Mujalli,A., Eid,S.Y., Elzubier,M.E. and Refaat,B.
  TITLE     Vitamin D and calcium co-therapy mitigates pre-established cadmium
            nephropathy by regulating renal calcium homeostatic molecules and
            improving anti-oxidative and anti-inflammatory activities in rat
  JOURNAL   J Trace Elem Med Biol 79, 127221 (2023)
   PUBMED   37244046
REFERENCE   3  (bases 1 to 1484)
  AUTHORS   Hamasaki,M.Y., Mendes,C., Batagello,D.S., Hirata,M.H.,
            Britto,L.R.G. and Nogueira,M.I.
  TITLE     Pathophysiological aspects of neonatal anoxia and temporal
            expression of S100beta in different brain regions
  JOURNAL   Neuroreport 34 (11), 575-582 (2023)
   PUBMED   37384931
  REMARK    GeneRIF: Pathophysiological aspects of neonatal anoxia and temporal
            expression of S100beta in different brain regions.
REFERENCE   4  (bases 1 to 1484)
  AUTHORS   Ismail,T.M., Gross,S.R., Lancaster,T., Rudland,P.S. and
            Barraclough,R.
  TITLE     The Role of the C-Terminal Lysine of S100P in S100P-Induced Cell
            Migration and Metastasis
  JOURNAL   Biomolecules 11 (10), 1471 (2021)
   PUBMED   34680103
  REMARK    GeneRIF: The Role of the C-Terminal Lysine of S100P in
            S100P-Induced Cell Migration and Metastasis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1484)
  AUTHORS   Liang,B., Shen,X., Lan,C., Lin,Y., Li,C., Zhong,S. and Yan,S.
  TITLE     Glycolipid toxicity induces osteogenic dysfunction via the
            TLR4/S100B pathway
  JOURNAL   Int Immunopharmacol 97, 107792 (2021)
   PUBMED   34051593
  REMARK    GeneRIF: Glycolipid toxicity induces osteogenic dysfunction via the
            TLR4/S100B pathway.
REFERENCE   6  (bases 1 to 1484)
  AUTHORS   Drohat,A.C., Amburgey,J.C., Abildgaard,F., Starich,M.R.,
            Baldisseri,D. and Weber,D.J.
  TITLE     Solution structure of rat apo-S100B(beta beta) as determined by NMR
            spectroscopy
  JOURNAL   Biochemistry 35 (36), 11577-11588 (1996)
   PUBMED   8794737
REFERENCE   7  (bases 1 to 1484)
  AUTHORS   Maeda,T., Usui,H., Araki,K., Kuwano,R., Takahashi,Y. and Suzuki,Y.
  TITLE     Structure and expression of rat S-100 beta subunit gene
  JOURNAL   Brain Res Mol Brain Res 10 (3), 193-202 (1991)
   PUBMED   1653388
REFERENCE   8  (bases 1 to 1484)
  AUTHORS   Selinfreund,R.H., Barger,S.W., Welsh,M.J. and Van Eldik,L.J.
  TITLE     Antisense inhibition of glial S100 beta production results in
            alterations in cell morphology, cytoskeletal organization, and cell
            proliferation
  JOURNAL   J Cell Biol 111 (5 Pt 1), 2021-2028 (1990)
   PUBMED   2229184
REFERENCE   9  (bases 1 to 1484)
  AUTHORS   Dunn,R., Landry,C., O'Hanlon,D., Dunn,J., Allore,R., Brown,I. and
            Marks,A.
  TITLE     Reduction in S100 protein beta subunit mRNA in C6 rat glioma cells
            following treatment with anti-microtubular drugs
  JOURNAL   J Biol Chem 262 (8), 3562-3566 (1987)
   PUBMED   3818655
REFERENCE   10 (bases 1 to 1484)
  AUTHORS   Kuwano,R., Usui,H., Maeda,T., Fukui,T., Yamanari,N., Ohtsuka,E.,
            Ikehara,M. and Takahashi,Y.
  TITLE     Molecular cloning and the complete nucleotide sequence of cDNA to
            mRNA for S-100 protein of rat brain
  JOURNAL   Nucleic Acids Res 12 (19), 7455-7465 (1984)
   PUBMED   6093041
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Nov 26, 2020 this sequence version replaced NM_013191.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M54919.1, X01090.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840105, SAMN12840106
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               JAXUCZ010000020.1  12380970-12381081   c
            113-258             JAXUCZ010000020.1  12377051-12377196   c
            259-1484            JAXUCZ010000020.1  12372348-12373573   c
FEATURES             Location/Qualifiers
     source          1..1484
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..1484
                     /gene="S100b"
                     /gene_synonym="S100P"
                     /note="S100 calcium binding protein B"
                     /db_xref="GeneID:25742"
                     /db_xref="RGD:3615"
     exon            1..112
                     /gene="S100b"
                     /gene_synonym="S100P"
                     /inference="alignment:Splign:2.1.0"
     exon            113..258
                     /gene="S100b"
                     /gene_synonym="S100P"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..399
                     /gene="S100b"
                     /gene_synonym="S100P"
                     /note="S-100 protein beta chain; S-100 protein subunit
                     beta; S100 calcium-binding protein, beta (neural); S100
                     protein, beta polypeptide, neural"
                     /codon_start=1
                     /product="protein S100-B"
                     /protein_id="NP_037323.1"
                     /db_xref="GeneID:25742"
                     /db_xref="RGD:3615"
                     /translation="MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHF
                     LEEIKEQEVVDKVMETLDEDGDGECDFQEFMAFVSMVTTACHEFFEHE"
     exon            259..1484
                     /gene="S100b"
                     /gene_synonym="S100P"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagtccacac ccagtcctct ctggaggaag aaaaaggagc ttctctgtct accctcctag
       61 tcctcggaca ccgaagccag agaggactcc ggcggcaaaa ggtgaccagg agcctccggg
      121 atgtctgagc tggagaaggc catggttgcc ctcattgatg tcttccatca gtattcaggg
      181 agagagggtg acaagcacaa gctgaagaag tcagaactga aggagctcat caacaacgag
      241 ctctctcact tcctggagga aatcaaagag caggaagtgg tggacaaagt gatggagacg
      301 ctggacgaag atggggatgg ggagtgtgac ttccaggagt ttatggcctt cgtctccatg
      361 gtgaccacag cctgtcatga gttctttgaa catgagtgag acaaaaaaaa aaaagtggct
      421 gagccgtttc cccgtggcag acatgagggc cacgagagga ggcacggcag aaggctcgtg
      481 ggctggaagg agctgcgctc tctagacgca tataactaat taggaagctt gatttgcttc
      541 agggatgaaa ctctgacccc gttcccaagg gctgctttaa gttagcacat cgtttctgct
      601 acactaggta ttcctgtgag ctgaatggtc ccgggaacta ttgataagag tcactgaggg
      661 gacgaaatca acactctgtg ggtatagcac tggttgtaga ccaccatgct cctgtggaag
      721 ggtcacctgt aagaatcaag gcagactacc aatagcacct ccgttggaca gctttcttag
      781 gtgtaatgta tgctgtccat gcatctacag acccacagct ggatccactg ccacccgaag
      841 aggttggctc gcccttacaa ctgcttgtcc tctgtgcaaa cgatgccccg gaaagttaga
      901 cctatcaccc acaccctccc accaccccca gcccaaaagg acagcccact caagtctctt
      961 cttccacagt gaaccgtggt ttgttactaa gtacgtattt gacaccaaca gttctaactg
     1021 gtggaacgat tagatctcgc acactaagta ttagcatcct aactcacgac cgagaatcaa
     1081 aattctgctc agtagacgtc tcctttcagg atgacaccat tgtccccata ggacacggac
     1141 agaggagggc actggagaga gtgtcaggtc tttttctagc tgtatcttcc tctctccctc
     1201 tgctgcccat aatgtgagtg accctctagg gtgagacttg cagggtgagc tgctgaggaa
     1261 tgaagggcca ctgagatgtg tcctttagct gctgggtgtc atgtctgacc tgctggtgcc
     1321 tagggcctgc ttaacactcg gcaaggctgc gagccgagga ctgtgggaag ccggacttga
     1381 tgctttctaa cctgcatatt tgaatgccga aggttcaaac aatccaagtt acagataaat
     1441 aaaaaccgca ttgcaagtat taaaaagcca ttctaggaaa attc
//
