LOCUS       NM_053587                487 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Rattus norvegicus S100 calcium binding protein A9 (S100a9), mRNA.
ACCESSION   NM_053587
VERSION     NM_053587.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Chen,J., Chen,C., Wang,L., Feng,X., Chen,Y., Zhang,R., Cheng,Y.,
            Liu,Z. and Chen,Q.
  TITLE     Identification of S100A8/A9 involved in thromboangiitis obliterans
            development using tandem mass tags-labeled quantitative proteomics
            analysis
  JOURNAL   Cell Signal 120, 111199 (2024)
   PUBMED   38697446
  REMARK    GeneRIF: Identification of S100A8/A9 involved in thromboangiitis
            obliterans development using tandem mass tags-labeled quantitative
            proteomics analysis.
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Naaman,E., Qarawani,A., Ben-Zvi Elimelech,R., Harel,M.,
            Sigal-Dror,S., Safuri,S., Smirnovas,V., Baronaite,I.,
            Romanova,N.V., Morozova-Roche,L.A. and Zayit-Soudry,S.
  TITLE     The Surprising Nonlinear Effects of S100A9 Proteins in the Retina
  JOURNAL   ACS Chem Neurosci 15 (4), 735-744 (2024)
   PUBMED   38324770
  REMARK    GeneRIF: The Surprising Nonlinear Effects of S100A9 Proteins in the
            Retina.
REFERENCE   3  (bases 1 to 487)
  AUTHORS   Wang,J., Lu,L., Zou,G., Ye,Z., Jin,F., Wang,L., Ke,G., Dong,K. and
            Tao,L.
  TITLE     Transcriptomic Analysis of Retinal Gene in Experimental Retinal
            Detachment Rats and Exploration of S100A9 and TLR4 in Human
            Vitreous
  JOURNAL   Curr Eye Res 48 (12), 1170-1178 (2023)
   PUBMED   37846082
  REMARK    GeneRIF: Transcriptomic Analysis of Retinal Gene in Experimental
            Retinal Detachment Rats and Exploration of S100A9 and TLR4 in Human
            Vitreous.
REFERENCE   4  (bases 1 to 487)
  AUTHORS   Cai,X., Hong,L., Liu,Y., Huang,X., Lai,H. and Shao,L.
  TITLE     Salmonella pathogenicity island 1 knockdown confers protection
            against myocardial fibrosis and inflammation in uremic
            cardiomyopathy via down-regulation of S100 Calcium Binding Protein
            A8/A9 transcription
  JOURNAL   Ren Fail 44 (1), 1819-1832 (2022)
   PUBMED   36299239
  REMARK    GeneRIF: Salmonella pathogenicity island 1 knockdown confers
            protection against myocardial fibrosis and inflammation in uremic
            cardiomyopathy via down-regulation of S100 Calcium Binding Protein
            A8/A9 transcription.
REFERENCE   5  (bases 1 to 487)
  AUTHORS   Wang,T., Dai,L., Shen,S., Yang,Y., Yang,M., Yang,X., Qiu,Y. and
            Wang,W.
  TITLE     Comprehensive Molecular Analyses of a Macrophage-Related Gene
            Signature With Regard to Prognosis, Immune Features, and Biomarkers
            for Immunotherapy in Hepatocellular Carcinoma Based on WGCNA and
            the LASSO Algorithm
  JOURNAL   Front Immunol 13, 843408 (2022)
   PUBMED   35693827
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 487)
  AUTHORS   Ryckman,C., Vandal,K., Rouleau,P., Talbot,M. and Tessier,P.A.
  TITLE     Proinflammatory activities of S100: proteins S100A8, S100A9, and
            S100A8/A9 induce neutrophil chemotaxis and adhesion
  JOURNAL   J Immunol 170 (6), 3233-3242 (2003)
   PUBMED   12626582
REFERENCE   7  (bases 1 to 487)
  AUTHORS   Manitz,M.P., Horst,B., Seeliger,S., Strey,A., Skryabin,B.V.,
            Gunzer,M., Frings,W., Schonlau,F., Roth,J., Sorg,C. and Nacken,W.
  TITLE     Loss of S100A9 (MRP14) results in reduced interleukin-8-induced
            CD11b surface expression, a polarized microfilament system, and
            diminished responsiveness to chemoattractants in vitro
  JOURNAL   Mol Cell Biol 23 (3), 1034-1043 (2003)
   PUBMED   12529407
REFERENCE   8  (bases 1 to 487)
  AUTHORS   Striz,I., Jaresova,M., Lacha,J., Sedlacek,J. and Vitko,S.
  TITLE     MRP 8/14 and procalcitonin serum levels in organ transplantations
  JOURNAL   Ann Transplant 6 (2), 6-9 (2001)
   PUBMED   11803621
REFERENCE   9  (bases 1 to 487)
  AUTHORS   Raftery,M.J. and Geczy,C.L.
  TITLE     Identification of posttranslational modifications and cDNA
            sequencing errors in the rat S100 proteins MRP8 and 14 using
            electrospray ionization mass spectrometry
  JOURNAL   Anal Biochem 258 (2), 285-292 (1998)
   PUBMED   9570842
REFERENCE   10 (bases 1 to 487)
  AUTHORS   Imamichi,T., Uchida,I., Wahl,S.M. and McCartney-Francis,N.
  TITLE     Expression and cloning of migration inhibitory factor-related
            protein (MRP)8 and MRP14 in arthritis-susceptible rats
  JOURNAL   Biochem Biophys Res Commun 194 (2), 819-825 (1993)
   PUBMED   8343166
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 26, 2020 this sequence version replaced NM_053587.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L18948.1, FM058504.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676784, SAMN16676806
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                JAXUCZ010000002.1  178490609-178490622 c
            15-176              JAXUCZ010000002.1  178490111-178490272 c
            177-487             JAXUCZ010000002.1  178487941-178488251 c
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..487
                     /gene="S100a9"
                     /gene_synonym="Mrp14"
                     /note="S100 calcium binding protein A9"
                     /db_xref="GeneID:94195"
                     /db_xref="RGD:620267"
     exon            1..14
                     /gene="S100a9"
                     /gene_synonym="Mrp14"
                     /inference="alignment:Splign:2.1.0"
     exon            15..176
                     /gene="S100a9"
                     /gene_synonym="Mrp14"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..365
                     /gene="S100a9"
                     /gene_synonym="Mrp14"
                     /note="myeloid-related protein 14; p14; MRP-14;
                     calgranulin-B; migration inhibitory factor-related protein
                     14; S100 calcium binding protein A9 (calgranulin B);
                     intracellular calcium-binding protein (MRP14)"
                     /codon_start=1
                     /product="protein S100-A9"
                     /protein_id="NP_446039.2"
                     /db_xref="GeneID:94195"
                     /db_xref="RGD:620267"
                     /translation="MAAKTGSQLERSISTIINVFHQYSRKYGHPDTLNKAEFKEMVNK
                     DLPNFLKREKRNENLLRDIMEDLDTNQDNQLSFEECMMLMGKLIFACHEKLHENNPRG
                     HDHSHGKGCGK"
     exon            177..487
                     /gene="S100a9"
                     /gene_synonym="Mrp14"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctccttagc tttgagcaag aagatggctg ccaaaacagg atctcagctg gagcgcagca
       61 taagcaccat catcaatgtt ttccatcagt actctaggaa gtatggacat cctgacaccc
      121 tgaacaaggc ggaattcaaa gaaatggtga ataaggactt gccaaatttt ctgaagaggg
      181 agaaaagaaa tgaaaatctc ctaagagaca tcatggagga cctggacaca aaccaggaca
      241 atcaactgtc ctttgaggag tgtatgatgc tgatgggaaa gttgatcttt gcctgtcatg
      301 agaagctgca tgagaacaac ccacgtgggc atgaccacag ccacggcaaa ggctgtggga
      361 agtaattaag aggtcagcca tgtaacatct gcccaaccaa gtctaaaggg aatagcttac
      421 taaatgacct tggttctggg gctgggaaat aatttaaaaa tgaataaata aagtctttat
      481 ccattcc
//
