LOCUS       NM_053822                357 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus S100 calcium binding protein A8 (S100a8), mRNA.
ACCESSION   NM_053822
VERSION     NM_053822.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 357)
  AUTHORS   An,N., Zhang,Y., Xie,J., Li,J., Lin,J., Li,Q., Wang,Y., Liu,Y. and
            Yang,Y.
  TITLE     Study on the involvement of microglial S100A8 in neuroinflammation
            and microglia activation during migraine attacks
  JOURNAL   Mol Cell Neurosci 130, 103957 (2024)
   PUBMED   39111720
  REMARK    GeneRIF: Study on the involvement of microglial S100A8 in
            neuroinflammation and microglia activation during migraine attacks.
REFERENCE   2  (bases 1 to 357)
  AUTHORS   Chen,J., Chen,C., Wang,L., Feng,X., Chen,Y., Zhang,R., Cheng,Y.,
            Liu,Z. and Chen,Q.
  TITLE     Identification of S100A8/A9 involved in thromboangiitis obliterans
            development using tandem mass tags-labeled quantitative proteomics
            analysis
  JOURNAL   Cell Signal 120, 111199 (2024)
   PUBMED   38697446
  REMARK    GeneRIF: Identification of S100A8/A9 involved in thromboangiitis
            obliterans development using tandem mass tags-labeled quantitative
            proteomics analysis.
REFERENCE   3  (bases 1 to 357)
  AUTHORS   Guo,S., Liu,Q., Tan,T. and Chen,X.
  TITLE     MiR-24 regulates obstructive pulmonary disease in rats via S100A8
  JOURNAL   Exp Lung Res 50 (1), 172-183 (2024)
   PUBMED   39390946
  REMARK    GeneRIF: MiR-24 regulates obstructive pulmonary disease in rats via
            S100A8.
REFERENCE   4  (bases 1 to 357)
  AUTHORS   Wang,M., Zhao,M., Zheng,Z., Pan,W., Zhang,J., Yin,Z., Wei,C., Xu,Y.
            and Wan,J.
  TITLE     TRPA1 deficiency aggravates dilated cardiomyopathy by promoting
            S100A8 expression to induce M1 macrophage polarization in rats
  JOURNAL   FASEB J 37 (6), e22982 (2023)
   PUBMED   37219522
  REMARK    GeneRIF: TRPA1 deficiency aggravates dilated cardiomyopathy by
            promoting S100A8 expression to induce M1 macrophage polarization in
            rats.
            Erratum:[FASEB J. 2023 Aug;37(8):e23065. doi:
            10.1096/fj.202301205.. PMID: 37477922]
REFERENCE   5  (bases 1 to 357)
  AUTHORS   Chen,Y., Dong,Y., Zhang,Z.L., Han,J., Chen,F.S., Tong,X.Y. and
            Ma,H.
  TITLE     Fra-1 induces apoptosis and neuroinflammation by targeting S100A8
            to modulate TLR4 pathways in spinal cord ischemia/reperfusion
            injury
  JOURNAL   Brain Pathol 33 (1), e13113 (2023)
   PUBMED   36634215
  REMARK    GeneRIF: Fra-1 induces apoptosis and neuroinflammation by targeting
            S100A8 to modulate TLR4 pathways in spinal cord
            ischemia/reperfusion injury.
REFERENCE   6  (bases 1 to 357)
  AUTHORS   Signor,L., Tigani,B., Beckmann,N., Falchetto,R. and Stoeckli,M.
  TITLE     Two-dimensional electrophoresis protein profiling and
            identification in rat bronchoalveolar lavage fluid following
            allergen and endotoxin challenge
  JOURNAL   Proteomics 4 (7), 2101-2110 (2004)
   PUBMED   15221771
REFERENCE   7  (bases 1 to 357)
  AUTHORS   Ryckman,C., Vandal,K., Rouleau,P., Talbot,M. and Tessier,P.A.
  TITLE     Proinflammatory activities of S100: proteins S100A8, S100A9, and
            S100A8/A9 induce neutrophil chemotaxis and adhesion
  JOURNAL   J Immunol 170 (6), 3233-3242 (2003)
   PUBMED   12626582
REFERENCE   8  (bases 1 to 357)
  AUTHORS   Raftery,M.J. and Geczy,C.L.
  TITLE     Identification of posttranslational modifications and cDNA
            sequencing errors in the rat S100 proteins MRP8 and 14 using
            electrospray ionization mass spectrometry
  JOURNAL   Anal Biochem 258 (2), 285-292 (1998)
   PUBMED   9570842
REFERENCE   9  (bases 1 to 357)
  AUTHORS   Imamichi,T., Uchida,I., Wahl,S.M. and McCartney-Francis,N.
  TITLE     Expression and cloning of migration inhibitory factor-related
            protein (MRP)8 and MRP14 in arthritis-susceptible rats
  JOURNAL   Biochem Biophys Res Commun 194 (2), 819-825 (1993)
   PUBMED   8343166
REFERENCE   10 (bases 1 to 357)
  AUTHORS   Tao,Y.X.
  TITLE     [Embryonic-origin interferons and maternal recognition of
            pregnancy]
  JOURNAL   Sheng Li Ke Xue Jin Zhan 23 (3), 240-243 (1992)
   PUBMED   1299962
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Dec 23, 2009 this sequence version replaced NM_053822.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CR460662.1, CB701295.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-164               JAXUCZ010000002.1  178464704-178464867
            165-357             JAXUCZ010000002.1  178465031-178465223
FEATURES             Location/Qualifiers
     source          1..357
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..357
                     /gene="S100a8"
                     /gene_synonym="Mrp8"
                     /note="S100 calcium binding protein A8"
                     /db_xref="GeneID:116547"
                     /db_xref="RGD:620265"
     exon            1..164
                     /gene="S100a8"
                     /gene_synonym="Mrp8"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..293
                     /gene="S100a8"
                     /gene_synonym="Mrp8"
                     /note="p8; MRP-8; calgranulin-A; migration inhibitory
                     factor-related protein 8; S100 calcium binding protein A8
                     (calgranulin A)"
                     /codon_start=1
                     /product="protein S100-A8"
                     /protein_id="NP_446274.2"
                     /db_xref="GeneID:116547"
                     /db_xref="RGD:620265"
                     /translation="MATELEKALSNVIEVYHNYSGIKGNHHALYRDDFRKMVTTECPQ
                     FVQNKNTESLFKELDVNSDNAINFEEFLVLVIRVGVAAHKDSHKE"
     exon            165..357
                     /gene="S100a8"
                     /gene_synonym="Mrp8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgaaaggaa atttttatcg acaatggcaa ctgaactgga gaaggccttg agcaacgtca
       61 ttgaagtcta ccacaattat tctggtataa aagggaatca ccatgccctc tacagggatg
      121 acttcaggaa aatggtcact actgagtgcc ctcagtttgt gcagaataaa aataccgaaa
      181 gcttgttcaa agaattggac gtcaatagtg acaacgcaat taacttcgaa gagttccttg
      241 tgttggtgat aagggtgggc gtggcagctc ataaagacag ccacaaggag taacagagct
      301 tctggcctgg ggctgggccc ttggatatgt ctacagaata aagtcgtcat atcttaa
//
