LOCUS       NM_053485                402 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus S100 calcium binding protein A6 (S100a6), mRNA.
ACCESSION   NM_053485
VERSION     NM_053485.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 402)
  AUTHORS   Zhang,X.F., Ma,J.X., Wang,Y.L. and Ma,X.L.
  TITLE     Calcyclin (S100A6) Attenuates Inflammatory Response and Mediates
            Apoptosis of Chondrocytes in Osteoarthritis via the PI3K/AKT
            Pathway
  JOURNAL   Orthop Surg 13 (3), 1094-1101 (2021)
   PUBMED   33942537
  REMARK    GeneRIF: Calcyclin (S100A6) Attenuates Inflammatory Response and
            Mediates Apoptosis of Chondrocytes in Osteoarthritis via the
            PI3K/AKT Pathway.
REFERENCE   2  (bases 1 to 402)
  AUTHORS   Haldar,B., Hamilton,C.L., Solodushko,V., Abney,K.A., Alexeyev,M.,
            Honkanen,R.E., Scammell,J.G. and Cioffi,D.L.
  TITLE     S100A6 is a positive regulator of PPP5C-FKBP51-dependent regulation
            of endothelial calcium signaling
  JOURNAL   FASEB J 34 (2), 3179-3196 (2020)
   PUBMED   31916625
  REMARK    GeneRIF: S100A6 is a positive regulator of PPP5C-FKBP51-dependent
            regulation of endothelial calcium signaling.
REFERENCE   3  (bases 1 to 402)
  AUTHORS   Mofid,A., Newman,N.S., Lee,P.J., Abbasi,C., Matkar,P.N.,
            Rudenko,D., Kuliszewski,M.A., Chen,H.H., Afrasiabi,K.,
            Tsoporis,J.N., Gramolini,A.O., Connelly,K.A., Parker,T.G. and
            Leong-Poi,H.
  TITLE     Cardiac Overexpression of S100A6 Attenuates Cardiomyocyte Apoptosis
            and Reduces Infarct Size After Myocardial Ischemia-Reperfusion
  JOURNAL   J Am Heart Assoc 6 (2), e004738 (2017)
   PUBMED   28174168
  REMARK    GeneRIF: S100A6 overexpression by ultrasound-targeted microbubble
            destruction helps ameliorate myocardial ischemia-reperfusion,
            resulting in lower mortality and improved left ventricular systolic
            function post-ischemia-reperfusion via attenuation of apoptosis,
            reduction in cardiac hypertrophy, and reduced infarct size
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 402)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   5  (bases 1 to 402)
  AUTHORS   Zhou,X., Wang,P., Michal,J.J., Wang,Y., Zhao,J., Jiang,Z. and
            Liu,B.
  TITLE     Molecular characterization of the porcine S100A6 gene and analysis
            of its expression in pigs infected with highly pathogenic porcine
            reproductive and respiratory syndrome virus (HP-PRRSV)
  JOURNAL   J Appl Genet 56 (3), 355-363 (2015)
   PUBMED   25480733
REFERENCE   6  (bases 1 to 402)
  AUTHORS   Deloulme,J.C., Assard,N., Mbele,G.O., Mangin,C., Kuwano,R. and
            Baudier,J.
  TITLE     S100A6 and S100A11 are specific targets of the calcium- and
            zinc-binding S100B protein in vivo
  JOURNAL   J Biol Chem 275 (45), 35302-35310 (2000)
   PUBMED   10913138
REFERENCE   7  (bases 1 to 402)
  AUTHORS   Konrad,L. and Aumuller,G.
  TITLE     Calcyclin is differentially expressed in rat testicular cells
  JOURNAL   Biochim Biophys Acta 1489 (2-3), 440-444 (1999)
   PUBMED   10673048
REFERENCE   8  (bases 1 to 402)
  AUTHORS   Young,L.H., Yang,X. and Voigt,J.M.
  TITLE     Alteration of gene expression in rat mammary tumors induced by
            N-methyl-N-nitrosourea
  JOURNAL   Mol Carcinog 15 (4), 251-260 (1996)
   PUBMED   8634083
REFERENCE   9  (bases 1 to 402)
  AUTHORS   Filipek,A., Heizmann,C.W. and Kuznicki,J.
  TITLE     Calcyclin is a calcium and zinc binding protein
  JOURNAL   FEBS Lett 264 (2), 263-266 (1990)
   PUBMED   2358072
REFERENCE   10 (bases 1 to 402)
  AUTHORS   Murphy,L.C., Murphy,L.J., Tsuyuki,D., Duckworth,M.L. and Shiu,R.P.
  TITLE     Cloning and characterization of a cDNA encoding a highly conserved,
            putative calcium binding protein, identified by an anti-prolactin
            receptor antiserum
  JOURNAL   J Biol Chem 263 (5), 2397-2401 (1988)
   PUBMED   2448309
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF140232.1.
            
            On Jun 9, 2003 this sequence version replaced NM_053485.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF140232.1, BC166598.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..402
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..402
                     /gene="S100a6"
                     /note="S100 calcium binding protein A6"
                     /db_xref="GeneID:85247"
                     /db_xref="RGD:620264"
     exon            1..18
                     /gene="S100a6"
                     /inference="alignment:Splign:2.1.0"
     exon            19..177
                     /gene="S100a6"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..309
                     /gene="S100a6"
                     /note="calcyclin; prolactin receptor-associated protein;
                     calcium binding protein A6 (calcyclin)"
                     /codon_start=1
                     /product="protein S100-A6"
                     /protein_id="NP_445937.1"
                     /db_xref="GeneID:85247"
                     /db_xref="RGD:620264"
                     /translation="MACPLDQAIGLLVAIFHKYSGKEGDKHTLSKKELKELIQKELTI
                     GAKLQDAEIARLMDDLDRNKDQEVNFQEYVAFLGALALIYNEALK"
     exon            178..402
                     /gene="S100a6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttcattgtc gacgtgtgct tctagcccag tggtcagtca tggcatgccc cctggatcag
       61 gccatcggcc ttctcgtggc tatcttccac aagtactctg gcaaggaggg tgacaagcac
      121 accctgagca agaaggagct gaaggagctg atccagaagg agctcaccat tggtgctaag
      181 ctgcaggatg ctgaaattgc aaggctgatg gatgatctgg accgtaacaa ggatcaggaa
      241 gtaaacttcc aggagtatgt tgccttcctg ggggccttgg ctttgatcta caatgaagct
      301 ctgaaataaa atgggaaggc agagatgcct tctgggaggc tatcccagtc aagtccagtg
      361 ggggggtaat tatacaataa atatttcgtt tttgttatgt ct
//
