LOCUS       NM_012618                486 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus S100 calcium-binding protein A4 (S100a4), mRNA.
ACCESSION   NM_012618
VERSION     NM_012618.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Yang,L., Liu,J., Yin,J., Li,Y., Liu,J., Liu,D., Wang,Z.,
            DiSanto,M.E., Zhang,W. and Zhang,X.
  TITLE     S100A4 modulates cell proliferation, apoptosis and fibrosis in the
            hyperplastic prostate
  JOURNAL   Int J Biochem Cell Biol 169, 106551 (2024)
   PUBMED   38360265
  REMARK    GeneRIF: S100A4 modulates cell proliferation, apoptosis and
            fibrosis in the hyperplastic prostate.
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Xi,P., Zhu,W., Zhang,Y., Wang,M., Liang,H., Wang,H. and Tian,D.
  TITLE     Upregulation of hypothalamic TRPV4 via S100a4/AMPKalpha signaling
            pathway promotes the development of diet-induced obesity
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (1), 166883 (2024)
   PUBMED   37683711
  REMARK    GeneRIF: Upregulation of hypothalamic TRPV4 via S100a4/AMPKalpha
            signaling pathway promotes the development of diet-induced obesity.
REFERENCE   3  (bases 1 to 486)
  AUTHORS   Pankratova,S., Klingelhofer,J., Dmytriyeva,O., Owczarek,S.,
            Renziehausen,A., Syed,N., Porter,A.E., Dexter,D.T. and Kiryushko,D.
  TITLE     The S100A4 Protein Signals through the ErbB4 Receptor to Promote
            Neuronal Survival
  JOURNAL   Theranostics 8 (14), 3977-3990 (2018)
   PUBMED   30083275
  REMARK    GeneRIF: These data suggest that the S100-ErbB axis may be an
            important mechanism regulating neuronal survival and plasticity.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 486)
  AUTHORS   Choe,N., Kwon,D.H., Shin,S., Kim,Y.S., Kim,Y.K., Kim,J., Ahn,Y.,
            Eom,G.H. and Kook,H.
  TITLE     The microRNA miR-124 inhibits vascular smooth muscle cell
            proliferation by targeting S100 calcium-binding protein A4 (S100A4)
  JOURNAL   FEBS Lett 591 (7), 1041-1052 (2017)
   PUBMED   28235243
  REMARK    GeneRIF: Data indicate that microRNA miR-124 targets S100
            calcium-binding protein A4 (S100A4) 3' UTR and regulates vascular
            smooth muscle cell proliferation.
REFERENCE   5  (bases 1 to 486)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   6  (bases 1 to 486)
  AUTHORS   Flynn,A.M., Rudland,P.S. and Barraclough,R.
  TITLE     Protein interactions between S100A4 (p9Ka) and other cellular
            proteins identified using in vitro methods
  JOURNAL   Biochem Soc Trans 24 (3), 341S (1996)
   PUBMED   8878885
REFERENCE   7  (bases 1 to 486)
  AUTHORS   De Vouge,M.W. and Mukherjee,B.B.
  TITLE     Transformation of normal rat kidney cells by v-K-ras enhances
            expression of transin 2 and an S-100-related calcium-binding
            protein
  JOURNAL   Oncogene 7 (1), 109-119 (1992)
   PUBMED   1741158
REFERENCE   8  (bases 1 to 486)
  AUTHORS   Barraclough,R., Gibbs,F., Smith,J.A., Haynes,G.A. and Rudland,P.S.
  TITLE     Calcium-ion binding by the potential calcium-ion-binding protein,
            p9Ka
  JOURNAL   Biochem Biophys Res Commun 169 (2), 660-666 (1990)
   PUBMED   2357224
REFERENCE   9  (bases 1 to 486)
  AUTHORS   Masiakowski,P. and Shooter,E.M.
  TITLE     Nerve growth factor induces the genes for two proteins related to a
            family of calcium-binding proteins in PC12 cells
  JOURNAL   Proc Natl Acad Sci U S A 85 (4), 1277-1281 (1988)
   PUBMED   3422491
REFERENCE   10 (bases 1 to 486)
  AUTHORS   Barraclough,R., Savin,J., Dube,S.K. and Rudland,P.S.
  TITLE     Molecular cloning and sequence of the gene for p9Ka. A cultured
            myoepithelial cell protein with strong homology to S-100, a
            calcium-binding protein
  JOURNAL   J Mol Biol 198 (1), 13-20 (1987)
   PUBMED   3430604
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from J03628.1.
            
            On Aug 31, 2012 this sequence version replaced NM_012618.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J03628.1, FQ215053.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-486               J03628.1           2-487
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..486
                     /gene="S100a4"
                     /gene_synonym="18A2; 42A; CAPL; MTS1; P9ka; PEL98; RNP9KA"
                     /note="S100 calcium-binding protein A4"
                     /db_xref="GeneID:24615"
                     /db_xref="RGD:3245"
     exon            1..37
                     /gene="S100a4"
                     /gene_synonym="18A2; 42A; CAPL; MTS1; P9ka; PEL98; RNP9KA"
                     /inference="alignment:Splign:2.1.0"
     exon            38..193
                     /gene="S100a4"
                     /gene_synonym="18A2; 42A; CAPL; MTS1; P9ka; PEL98; RNP9KA"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..358
                     /gene="S100a4"
                     /gene_synonym="18A2; 42A; CAPL; MTS1; P9ka; PEL98; RNP9KA"
                     /note="P9K; placental calcium-binding protein; nerve
                     growth factor-induced protein 42A; calvasculin;
                     metastasin; Protein 9 Ka homologous to calcium-binding
                     protein"
                     /codon_start=1
                     /product="protein S100-A4"
                     /protein_id="NP_036750.1"
                     /db_xref="GeneID:24615"
                     /db_xref="RGD:3245"
                     /translation="MARPLEEALDVIVSTFHKYSGNEGDKFKLNKTELKELLTRELPS
                     FLGRRTDEAAFQKLMNNLDSNRDNEVDFQEYCVFLSCIAMMCNEFFEGCPDKEPRKK"
     exon            194..486
                     /gene="S100a4"
                     /gene_synonym="18A2; 42A; CAPL; MTS1; P9ka; PEL98; RNP9KA"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaacctctct gttcagcact tcctctctct tggtctggtc tcaacggtca ccatggcgag
       61 acccttggag gaggccctgg atgtaatagt gtccaccttc cacaaatact caggcaacga
      121 gggtgacaag ttcaagctga acaagacaga gctcaaggag ctactgacca gggagctgcc
      181 tagcttcctg gggagaagga cagacgaagc tgcattccag aagctgatga acaacttgga
      241 cagcaacagg gacaatgaag ttgacttcca ggagtactgt gtcttcctgt cctgcattgc
      301 catgatgtgc aatgaattct ttgagggctg cccagataag gagccccgga agaagtgaag
      361 actcctcaga tgaagtgttg ggccagtggg ggaatcttcc atgttggctg tgagcatagt
      421 gccttactct ggcttcttca tacatgtgca cagtgctgag caagtttaat aaagagtttt
      481 gaaact
//
