LOCUS       NM_032078              16669 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Rattus norvegicus ryanodine receptor 2 (Ryr2), transcript variant
            1, mRNA.
ACCESSION   NM_032078 XR_006681 XR_008338
VERSION     NM_032078.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 16669)
  AUTHORS   Gao,Y., Li,S., Liu,X., Si,D., Chen,W., Yang,F., Sun,H. and Yang,P.
  TITLE     RyR2 Stabilizer Attenuates Cardiac Hypertrophy by Downregulating
            TNF-alpha/NF-kappaB/NLRP3 Signaling Pathway through Inhibiting
            Calcineurin
  JOURNAL   J Cardiovasc Transl Res 17 (3), 481-495 (2024)
   PUBMED   38652413
  REMARK    GeneRIF: RyR2 Stabilizer Attenuates Cardiac Hypertrophy by
            Downregulating TNF-alpha/NF-kappaB/NLRP3 Signaling Pathway through
            Inhibiting Calcineurin.
REFERENCE   2  (bases 1 to 16669)
  AUTHORS   Dubois,M., Boulghobra,D., Rochebloine,G., Pallot,F., Yehya,M.,
            Bornard,I., Gayrard,S., Coste,F., Walther,G., Meyer,G.,
            Gaillard,J.C., Armengaud,J., Alpha-Bazin,B. and Reboul,C.
  TITLE     Hyperglycemia triggers RyR2-dependent alterations of mitochondrial
            calcium homeostasis in response to cardiac ischemia-reperfusion:
            Key role of DRP1 activation
  JOURNAL   Redox Biol 70, 103044 (2024)
   PUBMED   38266577
  REMARK    GeneRIF: Hyperglycemia triggers RyR2-dependent alterations of
            mitochondrial calcium homeostasis in response to cardiac
            ischemia-reperfusion: Key role of DRP1 activation.
REFERENCE   3  (bases 1 to 16669)
  AUTHORS   Varshney,S., Adela,R., Kachhawa,G., Dada,R., Kulshreshtha,V.,
            Kumari,R., Agarwal,R. and Khadgawat,R.
  TITLE     Disrupted placental vitamin D metabolism and calcium signaling in
            gestational diabetes and pre-eclampsia patients
  JOURNAL   Endocrine 80 (1), 191-200 (2023)
   PUBMED   36477942
REFERENCE   4  (bases 1 to 16669)
  AUTHORS   Vega-Vasquez,I., Lobos,P., Toledo,J., Adasme,T., Paula-Lima,A. and
            Hidalgo,C.
  TITLE     Hippocampal dendritic spines express the RyR3 but not the RyR2
            ryanodine receptor isoform
  JOURNAL   Biochem Biophys Res Commun 633, 96-103 (2022)
   PUBMED   36344175
  REMARK    GeneRIF: Hippocampal dendritic spines express the RyR3 but not the
            RyR2 ryanodine receptor isoform.
REFERENCE   5  (bases 1 to 16669)
  AUTHORS   Harvey,K.E., LaVigne,E.K., Dar,M.S., Salyer,A.E., Pratt,E.P.S.,
            Sample,P.A., Aryal,U.K., Gowher,H. and Hockerman,G.H.
  TITLE     RyR2/IRBIT regulates insulin gene transcript, insulin content, and
            secretion in the insulinoma cell line INS-1
  JOURNAL   Sci Rep 12 (1), 7713 (2022)
   PUBMED   35562179
  REMARK    GeneRIF: RyR2/IRBIT regulates insulin gene transcript, insulin
            content, and secretion in the insulinoma cell line INS-1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 16669)
  AUTHORS   Zhao,M., Li,P., Li,X., Zhang,L., Winkfein,R.J. and Chen,S.R.
  TITLE     Molecular identification of the ryanodine receptor pore-forming
            segment
  JOURNAL   J Biol Chem 274 (37), 25971-25974 (1999)
   PUBMED   10473538
REFERENCE   7  (bases 1 to 16669)
  AUTHORS   Martin,C., Hyvelin,J.M., Chapman,K.E., Marthan,R., Ashley,R.H. and
            Savineau,J.P.
  TITLE     Pregnant rat myometrial cells show heterogeneous ryanodine- and
            caffeine-sensitive calcium stores
  JOURNAL   Am J Physiol 277 (2), C243-C252 (1999)
   PUBMED   10444400
REFERENCE   8  (bases 1 to 16669)
  AUTHORS   Takeshima,H., Komazaki,S., Hirose,K., Nishi,M., Noda,T. and Iino,M.
  TITLE     Embryonic lethality and abnormal cardiac myocytes in mice lacking
            ryanodine receptor type 2
  JOURNAL   EMBO J 17 (12), 3309-3316 (1998)
   PUBMED   9628868
REFERENCE   9  (bases 1 to 16669)
  AUTHORS   Zhang,L., Kelley,J., Schmeisser,G., Kobayashi,Y.M. and Jones,L.R.
  TITLE     Complex formation between junctin, triadin, calsequestrin, and the
            ryanodine receptor. Proteins of the cardiac junctional sarcoplasmic
            reticulum membrane
  JOURNAL   J Biol Chem 272 (37), 23389-23397 (1997)
   PUBMED   9287354
REFERENCE   10 (bases 1 to 16669)
  AUTHORS   Cavallaro,S., Meiri,N., Yi,C.L., Musco,S., Ma,W., Goldberg,J. and
            Alkon,D.L.
  TITLE     Late memory-related genes in the hippocampus revealed by RNA
            fingerprinting
  JOURNAL   Proc Natl Acad Sci U S A 94 (18), 9669-9673 (1997)
   PUBMED   9275181
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Mar 18, 2021 this sequence version replaced NM_032078.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU346200.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760433, SAMN11044071
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-415               JAXUCZ010000017.1  63081527-63081941
            416-535             JAXUCZ010000017.1  63255042-63255161
            536-640             JAXUCZ010000017.1  63284534-63284638
            641-655             JAXUCZ010000017.1  63312200-63312214
            656-730             JAXUCZ010000017.1  63317248-63317322
            731-809             JAXUCZ010000017.1  63319588-63319666
            810-922             JAXUCZ010000017.1  63322606-63322718
            923-1022            JAXUCZ010000017.1  63339551-63339650
            1023-1119           JAXUCZ010000017.1  63340581-63340677
            1120-1194           JAXUCZ010000017.1  63356078-63356152
            1195-1351           JAXUCZ010000017.1  63358056-63358212
            1352-1516           JAXUCZ010000017.1  63377103-63377267
            1517-1638           JAXUCZ010000017.1  63381867-63381988
            1639-1822           JAXUCZ010000017.1  63384958-63385141
            1823-1958           JAXUCZ010000017.1  63387574-63387709
            1959-2054           JAXUCZ010000017.1  63409274-63409369
            2055-2173           JAXUCZ010000017.1  63417611-63417729
            2174-2307           JAXUCZ010000017.1  63418919-63419052
            2308-2549           JAXUCZ010000017.1  63420318-63420559
            2550-2742           JAXUCZ010000017.1  63425569-63425761
            2743-2959           JAXUCZ010000017.1  63427464-63427680
            2960-3064           JAXUCZ010000017.1  63429126-63429230
            3065-3168           JAXUCZ010000017.1  63434316-63434419
            3169-3252           JAXUCZ010000017.1  63440438-63440521
            3253-3412           JAXUCZ010000017.1  63447955-63448114
            3413-3560           JAXUCZ010000017.1  63450618-63450765
            3561-3769           JAXUCZ010000017.1  63462120-63462328
            3770-3944           JAXUCZ010000017.1  63463555-63463729
            3945-4153           JAXUCZ010000017.1  63470837-63471045
            4154-4506           JAXUCZ010000017.1  63472199-63472551
            4507-4621           JAXUCZ010000017.1  63473665-63473779
            4622-4782           JAXUCZ010000017.1  63475425-63475585
            4783-4945           JAXUCZ010000017.1  63477349-63477511
            4946-5032           JAXUCZ010000017.1  63477851-63477937
            5033-5259           JAXUCZ010000017.1  63481431-63481657
            5260-6058           JAXUCZ010000017.1  63485431-63486229
            6059-6259           JAXUCZ010000017.1  63488476-63488676
            6260-6365           JAXUCZ010000017.1  63491674-63491779
            6366-6509           JAXUCZ010000017.1  63493130-63493273
            6510-6783           JAXUCZ010000017.1  63495554-63495827
            6784-6898           JAXUCZ010000017.1  63498054-63498168
            6899-7031           JAXUCZ010000017.1  63499715-63499847
            7032-7135           JAXUCZ010000017.1  63500779-63500882
            7136-7271           JAXUCZ010000017.1  63504046-63504181
            7272-7458           JAXUCZ010000017.1  63505422-63505608
            7459-7564           JAXUCZ010000017.1  63508120-63508225
            7565-7685           JAXUCZ010000017.1  63510798-63510918
            7686-7855           JAXUCZ010000017.1  63513017-63513186
            7856-8076           JAXUCZ010000017.1  63514782-63515002
            8077-8167           JAXUCZ010000017.1  63515151-63515241
            8168-8308           JAXUCZ010000017.1  63516288-63516428
            8309-8472           JAXUCZ010000017.1  63517233-63517396
            8473-8551           JAXUCZ010000017.1  63519453-63519531
            8552-8641           JAXUCZ010000017.1  63522952-63523041
            8642-8779           JAXUCZ010000017.1  63523379-63523516
            8780-8857           JAXUCZ010000017.1  63526607-63526684
            8858-8933           JAXUCZ010000017.1  63528933-63529008
            8934-9057           JAXUCZ010000017.1  63531450-63531573
            9058-9173           JAXUCZ010000017.1  63532467-63532582
            9174-9238           JAXUCZ010000017.1  63534689-63534753
            9239-9360           JAXUCZ010000017.1  63537218-63537339
            9361-9410           JAXUCZ010000017.1  63542552-63542601
            9411-9471           JAXUCZ010000017.1  63548874-63548934
            9472-9710           JAXUCZ010000017.1  63549837-63550075
            9711-9792           JAXUCZ010000017.1  63551771-63551852
            9793-9923           JAXUCZ010000017.1  63552874-63553004
            9924-10244          JAXUCZ010000017.1  63556594-63556914
            10245-10485         JAXUCZ010000017.1  63558592-63558832
            10486-10573         JAXUCZ010000017.1  63559910-63559997
            10574-10666         JAXUCZ010000017.1  63561876-63561968
            10667-10837         JAXUCZ010000017.1  63563067-63563237
            10838-10897         JAXUCZ010000017.1  63564164-63564223
            10898-11032         JAXUCZ010000017.1  63571942-63572076
            11033-11145         JAXUCZ010000017.1  63574899-63575011
            11146-11242         JAXUCZ010000017.1  63577478-63577574
            11243-11346         JAXUCZ010000017.1  63579761-63579864
            11347-11398         JAXUCZ010000017.1  63581624-63581675
            11399-11452         JAXUCZ010000017.1  63584931-63584984
            11453-11476         JAXUCZ010000017.1  63586178-63586201
            11477-11576         JAXUCZ010000017.1  63601960-63602059
            11577-11656         JAXUCZ010000017.1  63603735-63603814
            11657-11733         JAXUCZ010000017.1  63605597-63605673
            11734-11807         JAXUCZ010000017.1  63606439-63606512
            11808-11888         JAXUCZ010000017.1  63617515-63617595
            11889-11977         JAXUCZ010000017.1  63618768-63618856
            11978-12106         JAXUCZ010000017.1  63620970-63621098
            12107-12211         JAXUCZ010000017.1  63624184-63624288
            12212-12293         JAXUCZ010000017.1  63626153-63626234
            12294-13591         JAXUCZ010000017.1  63627377-63628674
            13592-13656         JAXUCZ010000017.1  63630277-63630341
            13657-13804         JAXUCZ010000017.1  63633397-63633544
            13805-13891         JAXUCZ010000017.1  63636510-63636596
            13892-14113         JAXUCZ010000017.1  63637443-63637664
            14114-14244         JAXUCZ010000017.1  63639343-63639473
            14245-14287         JAXUCZ010000017.1  63640735-63640777
            14288-14421         JAXUCZ010000017.1  63644761-63644894
            14422-14482         JAXUCZ010000017.1  63649750-63649810
            14483-14629         JAXUCZ010000017.1  63652514-63652660
            14630-14764         JAXUCZ010000017.1  63654209-63654343
            14765-14921         JAXUCZ010000017.1  63659650-63659806
            14922-14986         JAXUCZ010000017.1  63662149-63662213
            14987-15087         JAXUCZ010000017.1  63663473-63663573
            15088-15139         JAXUCZ010000017.1  63664686-63664737
            15140-16669         JAXUCZ010000017.1  63665609-63667138
FEATURES             Location/Qualifiers
     source          1..16669
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.1"
     gene            1..16669
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /note="ryanodine receptor 2"
                     /db_xref="GeneID:689560"
                     /db_xref="RGD:620314"
     exon            1..415
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             368..15235
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /note="isoform 1 is encoded by transcript variant 1; type
                     2 ryanodine receptor; cardiac muscle ryanodine receptor;
                     cardiac muscle ryanodine receptor-calcium release channel;
                     ryanodine receptor type II; ryanodine receptor 2, cardiac;
                     cardiac-type ryaodine receptor"
                     /codon_start=1
                     /product="ryanodine receptor 2 isoform 1"
                     /protein_id="NP_114467.2"
                     /db_xref="GeneID:689560"
                     /db_xref="RGD:620314"
                     /translation="MADAGEGEDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGN
                     RLCFLESTSNSKNVPPDLSICTFVLEQSLSVRALQEMLANTVEKSEGKFMMKTAQGGG
                     HRTLLYGHAILLRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASK
                     QRSEGEKVRVGDDLILVSVSSERYLHLSYGNSSWRVDAAFQQTLWSVAPISSGSEAAQ
                     GYLIGGDVLRLLHGHMDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVA
                     WSGSHIRWGQPFRLRHVTTGKYLSLMEDKNLLLMDKEKADVKSTAFAFRSSKEKLDAG
                     VRKEVDGMGTSEIKYGDSICYIQHVDTGLWLTYQAVDVKSARMGSIQRKAIMHHEGHM
                     DDGLNLSRSQHEESRTARVIRSTVFLFNRFIRGLDALSKRAKLPTVDLPIESVSLSLQ
                     DLIGYFHPPDEHLEHEDKQNRLRALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFA
                     DVAGREAGESWKSILNSLYELLAALIRGNRKNCAQFSGSLDWLISRLERLEASSGILE
                     VLHCVLVESPEALNIIKEGHIKSIISLLDKHGRNHKVLDVLCSLCVCHGVAVRSNQHL
                     ICDNLLPGRDLLLQTRLVNHVSSMRPNIFLGVSEGSAQYKKWYYELMVDHTEPFVTAE
                     ATHLRVGWASTEGYSPYPGGGEEWGGNGVGDDLFSYGFDGLHLWSGCIARTVSSPNQH
                     LLRTDDVISCCLDLSAPSISFRINGQPVQGMFENFNIDGLFFPVVSFSAGIKVRFLLG
                     GRHGEFKFLPPPGYAACYEAVLPKEKLKVEHSREYKQERTYTRDLLGPTVSLTQAAFT
                     PVPVDTSQIVLPPHLERIRERLAENIHELWVMNKIELGWQYGPVRDDNKRQHPCLVEF
                     CKLPEQERNYNLQMSLETLKTLLALGCHVGIADEHAEEKVKKMKLPKNYQLTSGYKPA
                     PMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNRRNPRLVPYTL
                     LDDRTKKSNKDSLREAVRTLLGYGYHLEAPDQDHASRAEVCSGTGERFRIFRAEKTYA
                     VKAGRWYFEFEAVTAGDMRVGWSRPGCQPDLELGSDERAFAFDGFKAQRWHQGNEHYG
                     RSWQAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFDVGDGFIPVCSLGVAQ
                     VGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQVPSNHEHIE
                     VTRIDGTIDSSPCLKVTQKSFGSQNSNTDIMFYRLSMPIECAEVFSKSVAGGIPGAGF
                     YGPKNDLEDFDVDSDFEVLMKTAHGHLVPDRMDKDKETPKPEFNNHKDYAQEKPSRLK
                     QRFLLRRTKPDYSTSHSARLTEDVLADDRDDYEYLMQTSTYYYSVRIFPGQEPANVWV
                     GWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGRN
                     NSNGLEIGCVVDAASGLLTFIANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELG
                     RIKNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQG
                     WLVQCLDPLQFMSLHIPEENRSVDILELTEQEELLQFHYHTLRLYSAVCALGNHRVAH
                     ALCSHVDEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNNEFIVPMTEE
                     TKSITLFPDENKKHGLPGIGLSTSLRPRMCFSSPSFVSISNECYQYSPEFPLDILKAK
                     TIQMLTEAVKEGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGIFHNEDLKHILQLIEP
                     SVFKEAATPEEEGGAPEKEISIDDSKLEVKEEAKAGKRPKEGLLQMKLPEPVKLQMCL
                     LLQYLCDCQVRHRIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFR
                     SPPQEQINMLLNFKDDKSECPCPEEIRDQLLDFHEDLMTHCGIELDEDGSLDGSNDLT
                     IRGRLLSLVEKVTYLKKKQAEKPVASDSRKSSSLQQLISETMVRWAQESVIEDPELVR
                     AMFVLLHRQYDGIGGLVRALPKTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEK
                     LMIRGLGDIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCR
                     FLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPAMRGSTPLDVAAASVMDNNELALA
                     LREPDLEKVVRYLAGCGLQSCQMLVSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVE
                     ENANVVVRLLIRRPECFGPALRGEGGNGLLAAMEEAIKIAEDPSRDGPSPTSGSSKTL
                     DAEEEEDDTIHMGNAIMTFYAALIDLLGRCAPEMHLIHAGKGEAIRIRSILRSLIPLG
                     DLVGVISIAFQMPTIAKDGKVVEPDMSAGFCPDHKAAMVLFLDRVYGIEVQDFLLHLL
                     EVGFLPDLRAAASLDTAALSATDMALALNRYLCTAVLPLLTRCAPLFAGTEHHASLID
                     SLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQLRPSMMQHLLRRLVFDVPLLNEHAK
                     MPLKLLTNHYERCWKYYCLPGGWSNFGAASEEELHLSRKLFWGIFDALSQKKYEQELF
                     KLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEGNFNPQPVDTSNITIPEKLEYF
                     INKYAEHSHDKWSMDKLANGWIYGEIYSDSSKIQPLMKPYKLLSEKEKEIYRWPIKES
                     LKTMLAWGWRIERTREGDSMALYNRTRRISQTSQVSIDAAHGYSPRAIDMSNVTLSRD
                     LHAMAEMMAENYHNIWAKKKKMELESKGGGNHPLLVPYDTLTAKEKAKDREKAQDIFK
                     FLQISGYAVSRGFKDLDLDTPSIEKRFAYSFLQQLIRYVDEAHQYILEFDGGSRSKGE
                     HFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCTGGHASNKEKEMVTSLFCK
                     LGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLDSVKSALRAFLDNAAEDL
                     EKTMENLKQGQFTHTRSQPKGVTQIINYTTVALLPMLSSLFEHIGQHQFGEDLILEDV
                     QVSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPIAFLETHLDKHNVYSIY
                     NTRSSRERAALSLPANVEDVCPNIPSLEKLMTEIIELAESGIRYTQMPHMMEVVLPML
                     CSYMSRWWEHGPENHPERAEMCCTALNSEHMNTLLGNILKIIYNNLGIDEGAWMKRLA
                     VFSQPIINKVKPQLLKTHFLPLMEKLKKKAAMVVSEEDHLKAEARGDMSEAELLILDE
                     FTTLARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIYWSKSHNFKREE
                     QNFVVQNEINNMSFLITDTKSKMSKAAISDQERKKMKRKGDRYSMQTSLIVAALKRLL
                     PIGLNICAPGDQELIALAKNRFSLKDTEEEVRDVIRSNIHLQGKLEDPAIRWQMALYK
                     DLPNRAEDTSDPERTVERVLDIANVLFHLEQVEHPQRSKKAVWHKLLSKQRKRAVVAC
                     FRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGSELPEEDEAMKR
                     VDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEVTG
                     SQRSKEKEMEKQKLLYQQARLHDRGAAEMVLQTFSASKGETGPMVAATLKLGIAILNG
                     GNSTVQQKMLDYLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSG
                     EKVLQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQES
                     ISDFYWYYSGKDIIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWD
                     AVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMV
                     DMLVESSNNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHY
                     TQSETEFLLSCAETDENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQ
                     TFLELAESVLNYFQPFLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIF
                     DVVNEGGEKEKMELFVNFCEDTIFEMQLAAQISESDLNERSANKEESEKERPEEQAPR
                     MGFFSLLTVQSALFALRYNVLTLVRMLSLKSLKKQMKRMKKMTVKDMVSAFFSSYWSV
                     FVTLLHFVASVCRGFFRIVSSLLLGGSLVEGAKKIKVAELLANMPDPTQDEVRGDEEE
                     GERKPLESALPSEDLTDLKELTEESDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDLM
                     TNPIPVPEVQEKFQEQKVKEEKEGKEETKSEPEKAEGEDGEKEEKAKDDKGKQKLRQL
                     HTHRYGEPEVPESAFWKKIIAYQQKLLNYFARNFYNMRMLALFVAFAINFILLFYKVS
                     TSSVVEGKELPTRTSSDAAKVTTSLDSSPHRIIAVHYVLEESSGYMEPTLRILAILHT
                     IISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTQ
                     SFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFSDAREKKKPKKDSSLSA
                     VLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFAAHLLDIAMGFKTLR
                     TILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGDTPDMKCDDMLTC
                     YMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAF
                     GELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINK
                     DETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN"
     exon            416..535
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            536..640
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            641..655
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            656..730
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            731..809
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            810..922
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1022
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1119
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1194
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1351
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1516
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1638
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1822
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1823..1958
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..2054
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2055..2173
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2307
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2308..2549
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2550..2742
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2743..2959
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2960..3064
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3065..3168
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3169..3252
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3253..3412
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3413..3560
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3561..3769
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3770..3944
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3945..4153
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4154..4506
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4507..4621
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4622..4782
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4783..4945
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4946..5032
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            5033..5259
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            5260..6058
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            6059..6259
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            6260..6365
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            6366..6509
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            6510..6783
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            6784..6898
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            6899..7031
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            7032..7135
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            7136..7271
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            7272..7458
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            7459..7564
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            7565..7685
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            7686..7855
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            7856..8076
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            8077..8167
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            8168..8308
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            8309..8472
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            8473..8551
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            8552..8641
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            8642..8779
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            8780..8857
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            8858..8933
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            8934..9057
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            9058..9173
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            9174..9238
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            9239..9360
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            9361..9410
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            9411..9471
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            9472..9710
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            9711..9792
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            9793..9923
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            9924..10244
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            10245..10485
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            10486..10573
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            10574..10666
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            10667..10837
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            10838..10897
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            10898..11032
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            11033..11145
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            11146..11242
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            11243..11346
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            11347..11398
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            11399..11452
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            11453..11476
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            11477..11576
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            11577..11656
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            11657..11733
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            11734..11807
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            11808..11888
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            11889..11977
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            11978..12106
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            12107..12211
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            12212..12293
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            12294..13591
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            13592..13656
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            13657..13804
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            13805..13891
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            13892..14113
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            14114..14244
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            14245..14287
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            14288..14421
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            14422..14482
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            14483..14629
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            14630..14764
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            14765..14921
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            14922..14986
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            14987..15087
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            15088..15139
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            15140..16669
                     /gene="Ryr2"
                     /gene_synonym="RyR; RYR-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcccgggc cgagtgcgcc gggcagtggg gcctcctccc tgcgtcctca cgccgggctg
       61 ccctcctccc gcaccgtgcg gcgcagggag gccccgcgcc tcggccgccc ccgcgcgccc
      121 gcctccgccg cgctgcaggg ggaccgaccg ctgggctgtc ggcaccagca gcgcggcccc
      181 cggggcgcct cggctcctgg ctgtagccgc cgcaggggta gcgaccggag tagcagccac
      241 cggagccccc agaacatccc gggtagccgt gactggagcg cccagagaag ccgcagcagc
      301 agcataagtg gctacagtct ccgggctccg ccgggctccg gagccggcgg gccaggagcg
      361 cggagccatg gctgatgcgg gcgaaggcga ggacgagatc cagttcctga gaactgatga
      421 tgaggtggtt ctacagtgca ccgcaaccat ccacaaagag cagcagaagc tgtgcttggc
      481 agcagaagga tttggcaaca gactttgctt tttggagtct acttccaatt ctaagaatgt
      541 ccccccggac ctgtccatct gcacctttgt gctggagcag tccctgtcag tacgggccct
      601 gcaggagatg ctagccaaca cagtggaaaa gtcagaaggg aagttcatga tgaagactgc
      661 tcaaggtgga ggccaccgga cactcctcta tggacacgcc atactactac gccattccta
      721 cagtggtatg tatctctgct gtctctccac ctcccggtct tccaccgaca aactggcctt
      781 tgatgttggc cttcaagagg ataccacagg ggaggcttgc tggtggacca tacatcctgc
      841 ctctaagcag agatcagaag gagaaaaggt gcgggttgga gacgacctca tattggtcag
      901 cgtgtcctca gaaaggtact tgcacttgtc atacggcaac agcagctggc gtgtagacgc
      961 agccttccag cagaccctct ggagcgtggc ccctatcagc tcaggaagtg aagcagccca
     1021 agggtatctc attggtggtg atgttctccg gctgctacat ggacacatgg atgaatgtct
     1081 cactgttcct tcaggagaac atggtgaaga acagcggaga acagtccatt atgaaggtgg
     1141 tgctgtatca gttcatgccc gctccctctg gagactagag accctaagag tcgcgtggag
     1201 tggaagtcac ataagatggg gccagccatt ccgactgcgg cacgtcacga caggaaaata
     1261 cttaagcctc atggaagaca agaaccttct actcatggac aaagaaaaag ctgatgtaaa
     1321 atcaacggcg tttgccttcc ggtcttccaa ggaaaaattg gatgcaggtg taaggaaaga
     1381 agtcgatggc atgggaacct cagaaatcaa gtatggagac tccatttgct atatacaaca
     1441 tgtggacaca ggcctgtggc taacctacca ggccgtggat gtcaaatcag cacgaatggg
     1501 atccatacag cgtaaggcta tcatgcacca cgaaggccac atggatgacg gcttgaactt
     1561 atccagatcg cagcacgagg agtcccgcac tgcccgtgtc atccggagca cagtgtttct
     1621 cttcaatagg ttcataaggg gcctggatgc tctcagcaag agagcgaagc tgcccactgt
     1681 tgacttgccc atcgagtctg tgagcctgag tctgcaggac ctcatcggct acttccaccc
     1741 cccagacgag cacctggagc acgaggacaa gcagaacagg ctgcgagccc tgaagaaccg
     1801 gcagaatctc ttccaggaag agggaatgat caacctggtt ctggagtgca tcgaccgcct
     1861 ccatgtctac agcagtgcag cccactttgc agacgttgca ggacgagaag cgggggagtc
     1921 ttggaaatcc atcctgaatt ctctgtatga gttgctggcg gctctaatta gaggaaatcg
     1981 taaaaactgt gctcaatttt ctggctccct cgactggctg atcagcagac tggagagact
     2041 ggaagcgtcc tctggtatcc tggaggtcct ccactgtgtg ttagtggaga gcccggaagc
     2101 tctgaatatc atcaaagaag gacacatcaa gtccattatt tcccttttag acaagcatgg
     2161 gagaaaccac aaggtcctgg atgtgctgtg ttctctctgt gtgtgccatg gagttgccgt
     2221 ccgttctaat cagcatctca tctgtgataa cctcctgccg ggacgagacc tcttactgca
     2281 gacccggctt gtgaatcatg tcagcagcat gaggcctaat attttcctgg gtgtcagcga
     2341 aggatcagca cagtataaga agtggtacta cgagctcatg gtggaccaca cggaaccctt
     2401 tgtgaccgca gaagccactc acctgcgagt gggctgggct tccactgaag ggtattcccc
     2461 gtacccaggt gggggtgaag agtggggtgg caatggcgtt ggtgatgacc tcttctccta
     2521 tgggtttgat ggccttcacc tctggtcagg ttgtatagct cgaacagtga gctcccccaa
     2581 ccagcacctg ctgagaactg atgatgtcat aagttgctgt ttagatctaa gtgccccgag
     2641 catctcgttt cgcattaatg gacaacctgt gcaagggatg tttgagaact tcaatatcga
     2701 tggcctgttc tttccggttg tcagtttctc tgcaggaata aaggttcgct ttttgcttgg
     2761 ggggagacac ggagaattca aatttctccc tccaccgggc tatgcagctt gctatgaagc
     2821 tgttttgccc aaagagaaat tgaaggtgga acacagccga gaatataagc aagagaggac
     2881 gtacacacga gacctgctgg ggcctacagt gtccctgacc caagctgcct tcacacctgt
     2941 tcctgtggac accagccaga ttgtgttgcc tcctcacctg gaaaggataa gagaaagact
     3001 ggcagaaaat atccacgagc tctgggttat gaataaaatt gagcttggct ggcagtatgg
     3061 tccggttaga gatgacaaca agagacagca cccatgtctg gtggagttct gcaagcttcc
     3121 ggaacaggaa cgcaactaca atttgcagat gtctctggaa accctcaaga ctttgctggc
     3181 attaggatgt catgtgggta tagcggatga acatgctgaa gagaaggtga agaaaatgaa
     3241 gctgcccaag aattaccagc tgaccagtgg atacaagcct gcccccatgg atctgagctt
     3301 tataaaactt accccgtctc aggaagcaat ggtggacaag ttggctgaaa atgctcacaa
     3361 cgtgtgggcc cgggaccgaa tccggcaggg ctggacttac ggcatccagc aggatgtgaa
     3421 gaacaggaga aaccctcgtc tggttcccta cactcttctg gatgacagaa ccaagaagtc
     3481 caacaaagac agtctccgag aggcagtgcg aacactgctg ggctacggct accacctgga
     3541 agctcctgat caggaccacg cctcaagagc cgaggtgtgc agcggtactg gggagaggtt
     3601 ccgcatcttc agggcagaga agacctatgc agtaaaggct gggcgctggt actttgaatt
     3661 tgaggccgtc actgctggag acatgagggt gggatggagc aggccaggct gccaaccgga
     3721 tctagaactg ggttctgatg aacgtgcctt cgcttttgac ggctttaagg cccagcggtg
     3781 gcaccagggc aatgaacact acgggcgttc ttggcaagca ggtgatgtcg tgggctgcat
     3841 ggttgatatg aatgaacaca ccatgatgtt cactctgaac ggtgagatcc tgctggatga
     3901 ctcaggctcc gagctggctt tcaaggactt tgatgttggt gacggattca tccctgtgtg
     3961 tagcctcggg gtggcacaag taggcaggat gaactttgga aaggacgtca gcactttgaa
     4021 atactttacc atctgtggct tacaagaggg ctacgagcca tttgcagtta acacaaatag
     4081 ggacatcacc atgtggctga gcaagcggct tcctcagttc ctccaggtcc cctcaaacca
     4141 cgaacacatc gaggtgacca gaatagatgg taccatagac agttctccat gtctgaaggt
     4201 cactcagaag tcctttggtt ctcagaacag caacacagac atcatgtttt accgcctgag
     4261 tatgcccatt gagtgtgctg aggtcttctc aaagtccgtg gctggaggga tccctggcgc
     4321 cggcttctat gggcccaaga atgatttgga ggactttgat gtggattctg actttgaggt
     4381 tctgatgaag acagctcatg gtcatcttgt gcccgaccgc atggacaagg acaaagagac
     4441 ccccaagcca gaattcaata accacaaaga ttatgctcag gaaaagccct cacgcctaaa
     4501 gcaaagattc ttacttagaa ggaccaagcc agattacagc acaagccatt ctgcaagact
     4561 cactgaagac gtccttgctg atgaccggga tgactatgaa tatctgatgc agacatctac
     4621 atactattat tcagtgagga tctttcctgg acaagaacca gctaacgtct gggtgggctg
     4681 gattacatct gacttccacc agtatgacac aggcttcgat ttggacagag tgcgcacagt
     4741 gacagtcacc ctaggagatg aaaaagggaa agtgcacgag agcatcaaac gcagcaactg
     4801 ctatatggtg tgtgcgggag agagcatgag ccccgggcaa ggccgaaaca acagcaatgg
     4861 cttggagatc ggctgtgtgg tggacgctgc cagtgggctg ctcacattca tagccaacgg
     4921 caaggagcta agcacttact atcaggtgga gccaagcacg aagttatttc ctgcggtttt
     4981 cgcgcaagct acaagtccca atgttttcca gtttgagttg ggcagaataa agaatgtgat
     5041 gcctctctca gcgggattgt ttaagagtga gcacaaaaac cccgtgcccc agtgtcctcc
     5101 acgtctgcac gtgcagttcc tgtcacatgt cctgtggagc cggatgccca accagttcct
     5161 caaggtggac gtctctcgaa tcagtgaacg ccaaggctgg ctggtgcagt gtctggatcc
     5221 tctgcagttc atgtccctcc acatccccga ggagaacaga tctgttgata tcttagagct
     5281 gaccgagcag gaggagttgt tgcagtttca ctaccacacc ctccgcctct actctgcagt
     5341 ctgtgccctt gggaatcacc gggtggcgca tgcactgtgc agccacgtgg acgaacctca
     5401 gctgctctat gccattgaga acaagtacat gcctggcttg ctgcgagccg ggtactatga
     5461 cctgctgatt gacatccacc tcagctccta cgccaccgcc aggctcatga tgaacaatga
     5521 gttcatcgtc ccgatgacag aggagacaaa gagcatcacc ctcttccctg atgagaacaa
     5581 gaaacatggc ctcccgggca taggcctcag cacctctctc cgccctcgga tgtgcttttc
     5641 ctcccctagt ttcgtgagca ttagcaacga atgctatcag tatagtcccg agttcccact
     5701 ggacatcctc aaggccaaga ccatccagat gctcacagaa gcggtgaagg agggcagcct
     5761 ccacgcgcgg gatcccgtgg gcgggaccac cgagttcctc tttgtgcctc tcatcaagct
     5821 cttctacacc ctgctcatca tgggcatctt tcacaatgag gatttgaaac acatcctgca
     5881 gttgattgag cctagtgtgt ttaaggaagc tgccactcca gaggaggaag gaggtgcccc
     5941 agagaaggag attagtatag atgactctaa actggaagtc aaagaggaag ccaaagcagg
     6001 caaaaggcct aaggaaggct tactccagat gaaactcccg gagcctgtta aactacagat
     6061 gtgcctcttg cttcagtacc tctgtgactg ccaggttcgg caccggatag aagccattgt
     6121 agccttttca gatgactttg tagccaaact ccaagacaat cagcggttca ggtataatga
     6181 agtcatgcaa gccttaaaca tgtctgctgc actcactgcc aggaaaacca aggagttccg
     6241 gtcaccacca caggagcaga tcaatatgct tctcaatttt aaggatgata aaagtgaatg
     6301 cccctgccct gaagaaatcc gagaccaact cctagatttc catgaggacc tgatgactca
     6361 ctgtggaatt gaactggatg aagatggatc tctagacgga agcaatgact taacaatcag
     6421 aggacgtctg ctgtccctgg tagaaaaggt gacctacctg aagaaaaagc aagctgaaaa
     6481 accagtcgca agtgactcca gaaagtcctc cagcctccag caactcattt ctgagactat
     6541 ggtgcggtgg gctcaagagt ctgtcatcga ggaccctgag ctggtgaggg ctatgtttgt
     6601 gctgctgcac cggcagtatg atggcattgg gggtctcgtt cgagcactgc caaagaccta
     6661 cactatcaac ggcgtctctg tggaggacac catcaatctg cttgcatcac ttggtcagat
     6721 ccgatccctg ctgagtgtga ggatgggcaa agaagaagag aagctgatga tccgaggatt
     6781 aggggatatt atgaataaca aggtgtttta tcagcatccc aatctcatga gggcccttgg
     6841 gatgcacgaa acagtgatgg aagtcatggt gaacgtcctt ggaggtgggg agtccaagga
     6901 aatcaccttc cccaagatgg tggccaactg ctgccgtttt ctctgttact tctgtcgtat
     6961 aagtaggcag aatcagaaag ccatgtttga tcatctcagt tatttactgg aaaacagcag
     7021 tgttggtctt gcctcaccag ccatgagagg ttcaactcca ttagacgtgg ccgcagcgtc
     7081 agtgatggat aacaatgagc ttgcccttgc tctacgagag ccggatctgg agaaggtggt
     7141 tcgctatctg gccggctgtg gtctgcagag ctgccagatg ctggtgtcta agggttaccc
     7201 agacattggg tggaatccag ttgaaggaga acgatatctt gactttctca gatttgccgt
     7261 cttctgtaat ggggagagtg tggaagagaa tgcaaatgtt gtggtgaggt tgctcatccg
     7321 gagaccagag tgctttggcc ctgccttgag aggagaaggt ggtaatggtc tccttgcagc
     7381 catggaagaa gccataaaaa tagctgagga tccttctaga gatggcccct ctccaaccag
     7441 tggatccagc aaaacccttg atgcggaaga ggaggaagac gacaccatcc acatggggaa
     7501 cgcaatcatg accttctacg cagctttgat tgacctgctt ggtcgctgtg ctcctgaaat
     7561 gcatttgatt catgctggaa agggagaagc catccgaatc aggtctattt tgcgatccct
     7621 gattccattg ggagacttgg tgggtgtaat cagcattgca tttcagatgc caacaatagc
     7681 caaagatggg aaggtggtgg agcctgacat gtccgcgggg ttttgcccag atcacaaggc
     7741 agccatggtt ttgttccttg acagggtcta tggaattgag gtgcaagatt tcctcctcca
     7801 tctccttgag gttggctttc tgccagatct tcgcgctgct gcctctctag acacggctgc
     7861 actaagtgct acagacatgg ccttggccct caatcggtac ctctgcacag ctgtcctgcc
     7921 tttgttaacg agatgtgctc ccctgtttgc tggaacagag caccatgctt ccctcattga
     7981 ctctctgcta cacactgtat atagactctc taagggatgt tccctcacca aagctcagcg
     8041 ggactccata gaagtgtgcc tgctctctat atgtggccaa ctgcgacctt ctatgatgca
     8101 gcacctactc cgaaggctgg tgtttgatgt cccactgctg aacgagcacg caaagatgcc
     8161 tctaaagctg ctgaccaatc attatgaaag atgctggaaa tattactgcc tacctggagg
     8221 gtggagcaac tttggtgctg cctcggaaga agaacttcat ttatcaagaa aattattttg
     8281 gggcattttt gatgctttgt ctcaaaagaa atacgaacaa gaacttttca aactggccct
     8341 gccttgcctg agtgcagttg cgggagcttt acctccagac tacatggagt caaactatgt
     8401 cagtatgatg gaaaaacagt catccatgga ctctgaaggg aactttaacc cacaacctgt
     8461 tgatacctca aacattacaa ttcccgagaa gctggaatac ttcattaaca agtatgcgga
     8521 gcattcccat gataaatggt ctatggacaa gttggcgaat ggatggattt atggggaaat
     8581 atattcagac tcttctaaga tccagccact aatgaagcca tataaactct tatctgaaaa
     8641 ggaaaaagaa atttatcgtt ggccaatcaa ggagtcttta aaaacgatgc tggcttgggg
     8701 ttggagaatt gagaggacac gggagggaga cagtatggcc ctttataacc ggactcggcg
     8761 catttctcag actagccagg tgtctataga tgctgcacat gggtatagcc cccgtgctat
     8821 cgacatgagt aacgttaccc tctcgagaga cctgcatgct atggcggaga tgatggctga
     8881 aaactaccac aacatatggg ccaagaaaaa gaaaatggag ctggaatcca aaggaggagg
     8941 aaatcacccc ctgctagtgc cctacgacac actgacagcc aaggagaaag ccaaggacag
     9001 agaaaaggcc caggacatct tcaagttcct acagatcagt ggttatgctg tatccagagg
     9061 gttcaaggac ctggatctgg acacaccttc cattgagaag cgatttgcct acagtttcct
     9121 gcagcagctg atccgatatg tggacgaggc ccatcagtac atcctggagt ttgacggtgg
     9181 cagcagaagc aaaggagagc atttcccgta cgagcaagag atcaagttct tcgccaaagt
     9241 tgttcttcct ttaattgatc agtatttcaa aaaccatcgc ctgtacttct tgtctgctgc
     9301 aagcaggcct ctttgcaccg gaggacatgc gtccaacaag gagaaggaga tggttacaag
     9361 cctgttctgc aaacttggag ttcttgtcag gcataggatt tcactgtttg ggaatgatgc
     9421 tacctcaatt gtgaactgtc ttcatatttt gggtcagact ttggatgcaa ggactgtgat
     9481 gaagacgggt ctggacagcg tgaaaagtgc tctcagggcc tttctggaca atgcggcgga
     9541 ggatctggaa aagacgatgg aaaaccttaa gcagggccag tttactcaca ccaggagcca
     9601 gcccaagggc gtgactcaga tcatcaacta taccaccgtg gcgctcctgc ccatgctctc
     9661 ttccctgttt gagcacattg gccagcatca gtttggagaa gatctgatat tggaggatgt
     9721 gcaggtgtct tgttacagaa ttctgaccag cttgtatgcc ttgggaacca gcaagagcat
     9781 ctatgtggaa aggcaacgtt ctgcacttgg agaatgccta gctgcctttg ctggtgcctt
     9841 ccctatcgcc tttctagaaa cccacctgga caaacataat gtttactcca tctacaacac
     9901 caggtcttca cgagaaagag cagctctcag tttacccgca aatgtggagg atgtctgccc
     9961 aaatatacca tccctggaga agctcatgac tgagatcata gagctggcag agtcaggaat
    10021 ccgttacact cagatgccac acatgatgga ggtggtactg cccatgttat gcagctacat
    10081 gtcaaggtgg tgggagcacg gtcctgagaa ccatccagag agggctgaga tgtgctgcac
    10141 agcgctcaac tcagagcaca tgaacacact gctgggcaac attctcaaga tcatctacaa
    10201 caacctgggg attgatgaag gggcctggat gaagcgctta gctgtatttt cacagccaat
    10261 catcaacaag gtgaaacctc agctcttaaa aactcatttc ttacccttaa tggagaaact
    10321 aaagaaaaag gctgccatgg tagtgtctga ggaagaccac ctaaaagccg aagccagagg
    10381 ggacatgtcc gaagcggagc tgctcattct agatgagttt accacattgg ccagggatct
    10441 ctatgccttc tacccactct tgatccgatt tgtggactat aacagggcaa agtggctgaa
    10501 ggaacccaac ccagaagcag aggagctatt tagaatggta gctgaagtct tcatttactg
    10561 gtccaaatcc cataatttca aaagagagga acagaacttt gtggtgcaga atgaaatcaa
    10621 caacatgtcc ttcctcatca ccgacacaaa gtctaagatg tccaaggcag ccatttctga
    10681 tcaagagagg aagaaaatga agcggaaagg agaccggtat tctatgcaga catctttgat
    10741 tgtggcagct ctgaagcgat tgcttcccat tggactgaac atctgtgccc ctggggacca
    10801 agagctcatt gctctggcca aaaaccgatt tagcttgaaa gacactgagg aggaagtacg
    10861 tgatgtaatc cgcagtaata tacacttgca aggcaagctg gaagaccctg caatcaggtg
    10921 gcagatggct ctatacaaag acttgccaaa cagggcagaa gacacctcag acccagagag
    10981 gacagtggag cgtgtcctgg atatagcgaa tgtgcttttt caccttgaac aggtggagca
    11041 ccctcagaga tcaaagaaag ccgtgtggca caaactgctc tctaagcaga gaaaaagagc
    11101 tgttgttgcc tgtttccgga tggccccttt gtacaatctg ccaaggcatc gggctgtcaa
    11161 tctttttctt cagggatatg aaaagtcttg gattgaaaca gaagagcatt actttgagga
    11221 taaattgatc gaagatttag cgaaaccggg gtctgaactc ccagaagaag atgaagccat
    11281 gaaaagagtt gatcctctgc atcagcttat tcttctgttc agccgcacag ccttaacaga
    11341 gaaatgcaaa ctggaggaag attttctgta catggcgtat gcagacatta tggcaaagag
    11401 ttgtcacgat gaagaagacg atgatggtga agaagaagtg aagagctttg aagtcacagg
    11461 atcccaacgc agcaaggaaa aggaaatgga aaagcagaag cttctgtacc agcaagccag
    11521 actgcatgac cgcggggctg ccgagatggt tctccagacc ttcagtgcca gcaaaggtga
    11581 aactggacca atggtggctg ccactttgaa gctgggtatt gctattttaa atggtgggaa
    11641 ctccacggtg cagcagaaga tgctggatta cctgaaggag aaaaaagatg taggcttctt
    11701 ccagagcctg gcaggcctca tgcagtcttg cagtgtcctg gacctgaatg cctttgagag
    11761 gcaaaacaaa gcagaaggac ttgggatggt gactgaggaa ggatcaggag agaaggtact
    11821 gcaggatgat gagttcacct gtgacctctt ccgattcctg cagctgctct gtgaaggaca
    11881 caactcagat tttcagaatt acctgagaac ccagactggc aacaacacca cagttaatat
    11941 catcatctct actgtggact acctccttcg agtgcaggag tccattagtg atttctattg
    12001 gtactactct ggcaaggaca tcatagatga gcagggccag cgtaactttt ccaaagccat
    12061 ccaagtggcg aagcaggtgt tcaacacact cacggagtac atccagggtc cttgtaccgg
    12121 aaaccagcag agtttggcac acagcaggct ctgggatgct gttgtgggct tccttcatgt
    12181 atttgcacac atgcagatga agctgtctca ggattccagc cagattgagc tcttaaaaga
    12241 actgatggat ctccaaaagg acatggtggt catgctgctg tctatgctag aaggtaatgt
    12301 ggtaaacgga acaataggca agcagatggt ggacatgctt gtggagtcat ccaacaacgt
    12361 ggagatgatc ctcaagttct ttgacatgtt tctgaagcta aaggacttga catcctctga
    12421 cacatttaaa gagtatgacc ctgatggcaa aggcgtcatt tccaagagag acttccacaa
    12481 agccatggag agccacaaac actacaccca gtcagagact gagtttctgt tgtcctgtgc
    12541 agagacagat gagaacgaga cgctggatta tgaagagttt gtcaaaaggt tccacgagcc
    12601 tgccaaggac atcggcttca acgtcgccgt tctgctgacc aacctctcag agcacatgcc
    12661 caatgacacg aggctgcaga ccttcttgga gctggcagag agtgtcctca actacttcca
    12721 acctttcctg ggtcgcatcg agatcatggg cagcgccaag cgcatcgaga gggtctactt
    12781 tgagatcagc gaatccagcc gaacccagtg ggagaagccc caggtcaagg agtccaagag
    12841 gcagttcata ttcgatgtgg tcaatgaggg cggggaaaag gagaagatgg agctctttgt
    12901 gaacttctgt gaggacacca tctttgagat gcagctggca gctcagatct cagagtccga
    12961 cctgaatgag aggtcggcaa ataaagagga gagtgaaaag gagaggccag aggagcaggc
    13021 cccacggatg ggcttcttct ccctgctcac cgtccagtca gccctgtttg cactcaggta
    13081 caatgtccta acccttgtga ggatgctcag cctgaagagc ctgaagaagc agatgaagag
    13141 aatgaagaag atgacagtga aggacatggt ctcagccttc ttctcgtcct actggagtgt
    13201 gtttgtcacc ctcctacact ttgtggccag cgtctgtagg ggcttcttcc gcattgtctc
    13261 cagcctactg ctggggggca gcctggtgga aggtgctaag aaaatcaaag tggcggagct
    13321 tcttgccaac atgccagacc ctactcagga tgaggtgcga ggagatgaag aggagggaga
    13381 gaggaagcca ttagagtcag ccctgccctc tgaagaccta acagacttga aggaactgac
    13441 ggaggaaagt gaccttcttt cagacatatt tggcttggat ctgaagagag aaggagggca
    13501 gtacaaacta attcctcaca acccaaatgc tggtctcagt gacctcatga cgaaccccat
    13561 ccctgtccct gaggtacaag aaaagtttca ggagcagaag gtaaaagaag aaaaggaagg
    13621 aaaggaagaa accaagtctg aaccggagaa ggctgaggga gaggatggag aaaaagaaga
    13681 aaaagccaaa gatgataagg gtaaacagaa gttgaggcag cttcatacac atcgatatgg
    13741 ggagcctgag gtccccgagt cagcattctg gaagaaaatc atagcctacc aacagaagct
    13801 gctgaactat tttgctcgca acttttacaa catgagaatg ctggccctgt ttgtcgcctt
    13861 cgccatcaat ttcatcctgc tcttctacaa ggtctccact tcttctgtgg ttgaaggaaa
    13921 ggagctgcct acccgaactt ccagcgatgc cgctaaagtg accaccagcc tggacagcag
    13981 cccccacaga atcattgcgg ttcactacgt cctggaggag agtagcggct acatggaacc
    14041 caccctgcgc atcctagcca tcctccacac catcatctcc ttcttctgca tcatcggata
    14101 ctactgcctg aaagtcccct tggttatttt taagcgagag aaggaagtgg cacggaagtt
    14161 ggagtttgat gggctttaca ttacggagca gccatcggaa gacgatatca aaggccagtg
    14221 ggacagactg gtgatcaaca cacagtcatt tcccaataac tactgggata aatttgttaa
    14281 aagaaaggta atggataaat atggagagtt ttatgggaga gacagaatca gcgagttact
    14341 gggcatggat aaggctgcac tggatttcag cgatgcaaga gagaagaaga agcccaagaa
    14401 ggacagttcc ttgtctgctg tattgaactc tattgacgtg aagtaccaga tgtggaaact
    14461 tggagtcgtg ttcacagaca attccttcct ctacctagcc tggtatatga ccatgtctgt
    14521 tcttggacac tacaacaact ttttttttgc tgcccacctc cttgacatcg cgatgggctt
    14581 caagaccttg agaactatcc tgtcctcagt tacccataat ggcaaacagc tcgtgttaac
    14641 tgttggcttg ttggctgttg ttgtatacct gtacactgtt gtggcgttca atttcttccg
    14701 aaaattctac aataaaagcg aggatggtga cacgccggac atgaagtgtg acgacatgct
    14761 gacgtgttac atgttccaca tgtatgtggg cgtccgtgct ggagggggca tcggtgatga
    14821 aattgaagac ccagcaggag atgagtacga gatctaccga atcatctttg atatcacatt
    14881 cttcttcttt gtgattgtca tccttttggc tatcatacaa ggtttgatca ttgatgcttt
    14941 tggagaactc agagatcaac aagagcaagt caaggaagac atggagacca agtgcttcat
    15001 ctgtgggata ggcaacgact actttgatac agtgccgcat ggctttgaaa cccatactct
    15061 acaggagcac aacctggcca actacctgtt ttttctgatg tacctcataa acaaggatga
    15121 aacagaacac acgggacagg aatcttatgt ctggaagatg taccaagaga ggtgttggga
    15181 atttttccca gcaggagact gtttccggaa acagtatgag gaccagttaa attaacatcg
    15241 taccttgatt gtctctgaac caaaagcaat ctctctctct ctctttctct ctctctctct
    15301 ctctctctct ctctctctct ctctctctct ctctatttct atctctatct ctatctctct
    15361 ctctccctcc acctttcctc cctccctccc ctccccccac cgttcccttg gaaacacctg
    15421 ctcatatttt ccactaagca gcatcctgtg ctgaggcact gatgctcagt ctcagaggac
    15481 ctgactgttc tccccccacc tcattgtatc ttcactgaga agccaagacc gaagaacaat
    15541 ccaaataagc gttcagacta agcaggaact ctggagagaa attcatcatg gatactctac
    15601 cataccaccc acggacagct tcccctgagg gtcatggagt ctccacaagc tgccagacct
    15661 gtgcagccaa gcatggcagc cacactcacc caggctcttt attttgccat cccagaagga
    15721 agtgtctgag ggtcatagag cactgtagca cttaacaggt taccatggac accagttgca
    15781 aagggaaata gtgccttact ctaagtgggt tgagctatgc agaagataat gtgcatgaca
    15841 aacaccttta cttttctcta catcagcctc ttttcttaga taaaatggtt ttgtgatttt
    15901 ggtttctttt tctttttctt tttttcccct ttattcttta ctttggtgga ggagggtaag
    15961 aaaagctgtc tgtgctattt tcaaaaggag ggtggtgtgt ctcaggagag aaggaggctc
    16021 tcgtcatcca gctacgtaac atttaccctc cccaccttgg taaacactct gatgcaacgt
    16081 ggcaacttat gaaatctttg tatgaaaaat gaagactgca aaaaaaaaat cacaactttc
    16141 aaaagaaata aatcattgca tgtttattat gcaagtttca atgaacaaag aaagccttcg
    16201 gaaacaagtt gatcaacaca ggagaacttt cgtgataatt acatccatag tgacagagct
    16261 gtggactcac tcatatatct ggagtcagtg tcatccaccg acagttggaa ccatcgccaa
    16321 cgtgacagta gtcttgggtt ttcctctttc ttttggccac ctgtgatcat tggttaagga
    16381 cgccttgaca ggccatcttt tgatatccaa gctgaagcaa tatccattca gagatttcat
    16441 tggttgcgtc aaaagacatg ggtgaccatg tacatcgatt cattttatgt ttttctttat
    16501 tccttttttt ttcattttga gtccttttaa tgtaattcta atctttacaa ttaaaaagga
    16561 caggttcaga atggaagcga ggtcattctg cgtacattgg agatctttta ttacaagtct
    16621 gcttgttaat tttagaattg taaaacggct ctaattaaac tatttaact
//
