LOCUS       NM_001419537           15361 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus ryanodine receptor 1 (Ryr1), mRNA.
ACCESSION   NM_001419537 XM_039100851
VERSION     NM_001419537.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 15361)
  AUTHORS   Obaid,A.A., Almasmoum,H., Almaimani,R.A., El-Boshy,M., Aslam,A.,
            Idris,S., Ghaith,M.M., El-Readi,M.Z., Ahmad,J., Farrash,W.F.,
            Mujalli,A., Eid,S.Y., Elzubier,M.E. and Refaat,B.
  TITLE     Vitamin D and calcium co-therapy mitigates pre-established cadmium
            nephropathy by regulating renal calcium homeostatic molecules and
            improving anti-oxidative and anti-inflammatory activities in rat
  JOURNAL   J Trace Elem Med Biol 79, 127221 (2023)
   PUBMED   37244046
REFERENCE   2  (bases 1 to 15361)
  AUTHORS   Varshney,S., Adela,R., Kachhawa,G., Dada,R., Kulshreshtha,V.,
            Kumari,R., Agarwal,R. and Khadgawat,R.
  TITLE     Disrupted placental vitamin D metabolism and calcium signaling in
            gestational diabetes and pre-eclampsia patients
  JOURNAL   Endocrine 80 (1), 191-200 (2023)
   PUBMED   36477942
REFERENCE   3  (bases 1 to 15361)
  AUTHORS   Yamazawa,T., Kobayashi,T., Kurebayashi,N. and Murayama,T.
  TITLE     [Therapeutic effects of novel type1 ryanodine receptor inhibitor on
            skeletal muscle diseases]
  JOURNAL   Nihon Yakurigaku Zasshi 157 (1), 15-22 (2022)
   PUBMED   34980804
REFERENCE   4  (bases 1 to 15361)
  AUTHORS   Yamazawa,T., Kobayashi,T., Kurebayashi,N., Konishi,M., Noguchi,S.,
            Inoue,T., Inoue,Y.U., Nishino,I., Mori,S., Iinuma,H., Manaka,N.,
            Kagechika,H., Uryash,A., Adams,J., Lopez,J.R., Liu,X., Diggle,C.,
            Allen,P.D., Kakizawa,S., Ikeda,K., Lin,B., Ikemi,Y., Nunomura,K.,
            Nakagawa,S., Sakurai,T. and Murayama,T.
  TITLE     A novel RyR1-selective inhibitor prevents and rescues sudden death
            in mouse models of malignant hyperthermia and heat stroke
  JOURNAL   Nat Commun 12 (1), 4293 (2021)
   PUBMED   34257294
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 15361)
  AUTHORS   Agrawal,A., Rathor,R., Kumar,R., Suryakumar,G., Singh,S.N. and
            Kumar,B.
  TITLE     Redox modification of ryanodine receptor contributes to impaired
            Ca2+ homeostasis and exacerbates muscle atrophy under high altitude
  JOURNAL   Free Radic Biol Med 160, 643-656 (2020)
   PUBMED   32916280
  REMARK    GeneRIF: Redox modification of ryanodine receptor contributes to
            impaired Ca(2+) homeostasis and exacerbates muscle atrophy under
            high altitude.
REFERENCE   6  (bases 1 to 15361)
  AUTHORS   Gregg,R.G., Messing,A., Strube,C., Beurg,M., Moss,R., Behan,M.,
            Sukhareva,M., Haynes,S., Powell,J.A., Coronado,R. and Powers,P.A.
  TITLE     Absence of the beta subunit (cchb1) of the skeletal muscle
            dihydropyridine receptor alters expression of the alpha 1 subunit
            and eliminates excitation-contraction coupling
  JOURNAL   Proc Natl Acad Sci U S A 93 (24), 13961-13966 (1996)
   PUBMED   8943043
REFERENCE   7  (bases 1 to 15361)
  AUTHORS   Lynn,S., Morgan,J.M., Lamb,H.K., Meissner,G. and Gillespie,J.I.
  TITLE     Isolation and partial cloning of ryanodine-sensitive Ca2+ release
            channel protein isoforms from human myometrial smooth muscle
  JOURNAL   FEBS Lett 372 (1), 6-12 (1995)
   PUBMED   7556644
REFERENCE   8  (bases 1 to 15361)
  AUTHORS   Takeshima,H., Yamazawa,T., Ikemoto,T., Takekura,H., Nishi,M.,
            Noda,T. and Iino,M.
  TITLE     Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking
            the type-1 ryanodine receptor
  JOURNAL   EMBO J 14 (13), 2999-3006 (1995)
   PUBMED   7621815
REFERENCE   9  (bases 1 to 15361)
  AUTHORS   Futatsugi,A., Kuwajima,G. and Mikoshiba,K.
  TITLE     Tissue-specific and developmentally regulated alternative splicing
            in mouse skeletal muscle ryanodine receptor mRNA
  JOURNAL   Biochem J 305 (Pt 2) (Pt 2), 373-378 (1995)
   PUBMED   7832748
REFERENCE   10 (bases 1 to 15361)
  AUTHORS   Takeshima,H., Iino,M., Takekura,H., Nishi,M., Kuno,J., Minowa,O.,
            Takano,H. and Noda,T.
  TITLE     Excitation-contraction uncoupling and muscular degeneration in mice
            lacking functional skeletal muscle ryanodine-receptor gene
  JOURNAL   Nature 369 (6481), 556-559 (1994)
   PUBMED   7515481
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 7, 2023 this sequence version replaced XM_039100851.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression, longest
                                         protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-188               JAXUCZ010000001.1  93551118-93551305   c
            189-308             JAXUCZ010000001.1  93543307-93543426   c
            309-413             JAXUCZ010000001.1  93541887-93541991   c
            414-488             JAXUCZ010000001.1  93540683-93540757   c
            489-567             JAXUCZ010000001.1  93540525-93540603   c
            568-680             JAXUCZ010000001.1  93540147-93540259   c
            681-774             JAXUCZ010000001.1  93539770-93539863   c
            775-868             JAXUCZ010000001.1  93536384-93536477   c
            869-943             JAXUCZ010000001.1  93535860-93535934   c
            944-1100            JAXUCZ010000001.1  93535274-93535430   c
            1101-1265           JAXUCZ010000001.1  93534908-93535072   c
            1266-1387           JAXUCZ010000001.1  93534126-93534247   c
            1388-1583           JAXUCZ010000001.1  93533613-93533808   c
            1584-1719           JAXUCZ010000001.1  93529333-93529468   c
            1720-1815           JAXUCZ010000001.1  93529157-93529252   c
            1816-1934           JAXUCZ010000001.1  93528956-93529074   c
            1935-2068           JAXUCZ010000001.1  93528689-93528822   c
            2069-2310           JAXUCZ010000001.1  93527771-93528012   c
            2311-2503           JAXUCZ010000001.1  93527129-93527321   c
            2504-2720           JAXUCZ010000001.1  93525547-93525763   c
            2721-2825           JAXUCZ010000001.1  93524597-93524701   c
            2826-2929           JAXUCZ010000001.1  93524313-93524416   c
            2930-3013           JAXUCZ010000001.1  93523155-93523238   c
            3014-3321           JAXUCZ010000001.1  93521807-93522114   c
            3322-3524           JAXUCZ010000001.1  93520149-93520351   c
            3525-3699           JAXUCZ010000001.1  93518469-93518643   c
            3700-3908           JAXUCZ010000001.1  93518151-93518359   c
            3909-4303           JAXUCZ010000001.1  93514125-93514519   c
            4304-4436           JAXUCZ010000001.1  93512093-93512225   c
            4437-4597           JAXUCZ010000001.1  93510840-93511000   c
            4598-4763           JAXUCZ010000001.1  93509989-93510154   c
            4764-4850           JAXUCZ010000001.1  93507769-93507855   c
            4851-5077           JAXUCZ010000001.1  93507436-93507662   c
            5078-5690           JAXUCZ010000001.1  93505953-93506565   c
            5691-5954           JAXUCZ010000001.1  93504187-93504450   c
            5955-6155           JAXUCZ010000001.1  93503683-93503883   c
            6156-6267           JAXUCZ010000001.1  93503040-93503151   c
            6268-6414           JAXUCZ010000001.1  93499005-93499151   c
            6415-6688           JAXUCZ010000001.1  93497839-93498112   c
            6689-6803           JAXUCZ010000001.1  93496449-93496563   c
            6804-6936           JAXUCZ010000001.1  93496228-93496360   c
            6937-7031           JAXUCZ010000001.1  93495616-93495710   c
            7032-7167           JAXUCZ010000001.1  93494538-93494673   c
            7168-7354           JAXUCZ010000001.1  93494145-93494331   c
            7355-7463           JAXUCZ010000001.1  93493956-93494064   c
            7464-7584           JAXUCZ010000001.1  93492219-93492339   c
            7585-7754           JAXUCZ010000001.1  93491972-93492141   c
            7755-7975           JAXUCZ010000001.1  93490978-93491198   c
            7976-8066           JAXUCZ010000001.1  93490785-93490875   c
            8067-8207           JAXUCZ010000001.1  93489781-93489921   c
            8208-8371           JAXUCZ010000001.1  93489257-93489420   c
            8372-8450           JAXUCZ010000001.1  93489069-93489147   c
            8451-8540           JAXUCZ010000001.1  93488806-93488895   c
            8541-8681           JAXUCZ010000001.1  93488248-93488388   c
            8682-8756           JAXUCZ010000001.1  93487796-93487870   c
            8757-8832           JAXUCZ010000001.1  93487643-93487718   c
            8833-8956           JAXUCZ010000001.1  93487251-93487374   c
            8957-9072           JAXUCZ010000001.1  93486756-93486871   c
            9073-9140           JAXUCZ010000001.1  93485885-93485952   c
            9141-9262           JAXUCZ010000001.1  93485671-93485792   c
            9263-9312           JAXUCZ010000001.1  93484954-93485003   c
            9313-9373           JAXUCZ010000001.1  93484486-93484546   c
            9374-9612           JAXUCZ010000001.1  93484056-93484294   c
            9613-9694           JAXUCZ010000001.1  93480187-93480268   c
            9695-9825           JAXUCZ010000001.1  93479558-93479688   c
            9826-10158          JAXUCZ010000001.1  93477900-93478232   c
            10159-10399         JAXUCZ010000001.1  93477567-93477807   c
            10400-10487         JAXUCZ010000001.1  93474835-93474922   c
            10488-10580         JAXUCZ010000001.1  93474604-93474696   c
            10581-10595         JAXUCZ010000001.1  93473978-93473992   c
            10596-10766         JAXUCZ010000001.1  93472129-93472299   c
            10767-10826         JAXUCZ010000001.1  93470735-93470794   c
            10827-10964         JAXUCZ010000001.1  93470264-93470401   c
            10965-11077         JAXUCZ010000001.1  93469798-93469910   c
            11078-11174         JAXUCZ010000001.1  93469543-93469639   c
            11175-11281         JAXUCZ010000001.1  93469245-93469351   c
            11282-11333         JAXUCZ010000001.1  93466534-93466585   c
            11334-11408         JAXUCZ010000001.1  93466327-93466401   c
            11409-11508         JAXUCZ010000001.1  93464749-93464848   c
            11509-11588         JAXUCZ010000001.1  93464326-93464405   c
            11589-11665         JAXUCZ010000001.1  93464129-93464205   c
            11666-11739         JAXUCZ010000001.1  93462915-93462988   c
            11740-11757         JAXUCZ010000001.1  93462228-93462245   c
            11758-11838         JAXUCZ010000001.1  93461170-93461250   c
            11839-11927         JAXUCZ010000001.1  93457137-93457225   c
            11928-12056         JAXUCZ010000001.1  93456914-93457042   c
            12057-12161         JAXUCZ010000001.1  93456722-93456826   c
            12162-12243         JAXUCZ010000001.1  93454467-93454548   c
            12244-12431         JAXUCZ010000001.1  93452769-93452956   c
            12432-12773         JAXUCZ010000001.1  93440397-93440738   c
            12774-13565         JAXUCZ010000001.1  93436940-93437731   c
            13566-13636         JAXUCZ010000001.1  93436217-93436287   c
            13637-13787         JAXUCZ010000001.1  93435331-93435481   c
            13788-13874         JAXUCZ010000001.1  93434500-93434586   c
            13875-14126         JAXUCZ010000001.1  93432601-93432852   c
            14127-14257         JAXUCZ010000001.1  93430457-93430587   c
            14258-14300         JAXUCZ010000001.1  93428906-93428948   c
            14301-14431         JAXUCZ010000001.1  93426642-93426772   c
            14432-14492         JAXUCZ010000001.1  93426488-93426548   c
            14493-14639         JAXUCZ010000001.1  93426047-93426193   c
            14640-14774         JAXUCZ010000001.1  93425364-93425498   c
            14775-14931         JAXUCZ010000001.1  93422344-93422500   c
            14932-14996         JAXUCZ010000001.1  93421487-93421551   c
            14997-15097         JAXUCZ010000001.1  93421146-93421246   c
            15098-15149         JAXUCZ010000001.1  93420490-93420541   c
            15150-15361         JAXUCZ010000001.1  93420078-93420289   c
FEATURES             Location/Qualifiers
     source          1..15361
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..15361
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /note="ryanodine receptor 1"
                     /db_xref="GeneID:114207"
                     /db_xref="RGD:1586637"
     exon            1..188
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..15245
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /note="ryanodine receptor 1-like, skeletal muscle;
                     ryanodine receptor 1, skeletal muscle; type 1 ryanodine
                     receptor; skeletal muscle ryanodine receptor; ryanodine
                     receptor 1 (skeletal); skeletal muscle calcium release
                     channel; skeletal muscle-type ryanodine receptor"
                     /codon_start=1
                     /product="ryanodine receptor 1"
                     /protein_id="NP_001406466.1"
                     /db_xref="GeneID:114207"
                     /db_xref="RGD:1586637"
                     /translation="MGDGGGEGEDEVQFLRTDDEVVLQCSATVLKEQLKLCLAAEGFG
                     NRLCFLEPTSNAQNVPPDLAICCFILEQSLSVRALQEMLANTVEAGVESSQGGGHRTL
                     LYGHAILLRHAHSRMYLSCLTTSRSMTDKLAFDVGLQEDATGEACWWTMHPASKQRSE
                     GEKVRVGDDLILVSVSSERYLHLSTASGELQVDASFMQTLWNMNPICSCCEEGFVTGG
                     HVLRLFHGHMDECLTISPSDSDDQRRLVYYEGGPVCTHARSLWRLEPLRISWSGSHLR
                     WGQPLRIRHVTTGRYLALTEDQGLVVVDASKAHTKATSFCFRISKEKLDVAPKRDVEG
                     MGPPEIKYGESLCFVQHVASGLWLTYAAPDPKALRLGVLKKKAMLHQEGHMDDALSLT
                     RCQQEESQAARMIYSTAGLYNQFIKGLDSFSGKPRGSGPPAGSALPIEGVILSLQDLI
                     GYFEPPSEELQHEEKQTKLRSLRNRQSLFQEEGMLSLVLNCIDRLNVYTTAAHFAEFA
                     GEEAAESWKEIVNLLYELLASLIRGNRTNCALFSTNLDWLVSKLDRLEASSGILEVLY
                     CVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVLDVLCSLCVCNGVAVRSNQDLITE
                     NLLPGRELLLQTNLINYVTSIRPNIFVGRAEGSTQYGKWYFEVMVDEVAPFLTAQATH
                     LRVGWALSEGYSPYPGGGEGWGGNGVGDDLYSYGFDGLHLWTGHVARPVTSPGQHLLG
                     PEDVVSCCLDLSVPSISFRINGCPVQGVFESFNLDGLFFPVVSFSAGIKVRFLLGGRH
                     GEFKFLPPPGYAPCHEAVLPRERLHLQPIKEYRREGPRGPHLVGPSRCLSHLDFVPCP
                     VDTIQIVLPPHLERIREKLAENIHELWALTRIEQGWTYGPVRDDNKRLHPCLVDFHSL
                     PEPERNYNLQMSGETLKTLLALGCHVGMADEKAEDNLKKTKLPKTYMMNNGYKPAPLD
                     LSHVRLTPAQTTLVDRLAENGHNVWARDRVAQGWSYSAVQDIPARRNPRLVPYRLLDE
                     ATKRSNRDSLCQAVRTLLGYGYNIEPPDQEPSQVDSQSRGDRARIFRAEKSYAVQSGR
                     WYFEFEAVTTGEMRVGWARPELRPDVELGADDLAYVFNGHRGQRWHLGSEPFGRPWQS
                     GDVVGCMIDLTENTIIFTLNGEVLMSDSGSETAFREIEIGDGFLPVCSLGPGQVGHLN
                     LGQDVSSLRFFAICGLQEGFEPFAINMQRPVTTWFSKSLPQFEPVPLEHPHYEVARMD
                     GTVDTPPCLRLTHRTWGSQNSLVEMLFLRLSLPVQFHQHFRCTAGATPLASPGLQPPA
                     EDEARAAEPDTDYENLRRSAGGWGEAEAGKDGTAKEGTPGGAAQPGVEAQPARAENEK
                     DATTEKNKKRGFLFKAKKVAMMTQPPSTPALPRLPRDVVPADNRDDPEIILNTTTYYY
                     SVRVFAGQEPSCVWVGWVTPDYHQHDMSFDLSKVRAVTVTMGDEQGNVHSSLKCSNCY
                     MVWGGDFVSPGQQGRISHTDLVIGCLVDLATGLMTFTANGKESNTFFQVEPNTKLFPA
                     VFVLPTHQNVVQFELGKQKNIMPLSAAMFLSERKNPAPQCPPRLEVQMLMPVSWSRMP
                     NHFLHVDTRRAGERLGWAVQCQEPLMMMALHIPEENRCMDILELSERLDLQRFHSHTL
                     SLYRSVCALGNNRVAHALCSHVDQAQLLHALEDAHLPGPLRAGYYDLLISIHLESACR
                     SRRSMLSEYIVPLTEETRAITLFPPGRSAEDGPRRHGLPGVGVTTSLRPPHHFSPPCF
                     VVALPAAGAAEAPARLSPAIPLEALRDKALRMLGEAVRDGGQHARDPVGGSVEFQFVP
                     VLKLVSTLLVMGVFSDEDVKQILKMIEPEVFTEEEEVEEEEEEEEEDEEEKEEDEEEE
                     AHEKEDEEKEEAEEAAEEEKEELEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVES
                     LAAFAERYVDKLQSNQRGRYGLLMKAFTMSAAETARRTREFRSPPQEQINMLLQFKNG
                     ADEEDCPLPEEIREDLVNFHQDLLAHCGIQLEGEEEEPEEESTLGSRLMSLLEKVRLV
                     KKKEEKPEEEPAAEEHKPQSLQELVSHTVVRWAQEDFVQSPELVRAMFSLLHRQYDGL
                     GELLRALPRAYTISLSSVEDTMSLLECLGQIRSLLIVQMGPQEENLMIQSIGNIMNNK
                     VFYQHPNLMRALGMHETVMEVMVNVLGGGESKEIRFPKMVTSCCRFLCYFCRISRQNQ
                     RSMFDHLSYLLENSGIGLGMQGSTPLDVAAASVIDNNELALALQEQDLEKVVSYLAGC
                     GLQSCPMLLAKGYPDIGWNPCGGERYLDFLRFAVFVNGESVEENANVVVRLLIRKPEC
                     FGPALRGEGGSGLLAAIEEAIRISEDPARDGPGVRRDRRREHFGEEPPEENRVHLGHA
                     IMSFYAALIDLLGRCAPEMHLIQAGKGEALRIRAILRSLVPLDDLVGIISLPLQIPTL
                     GKDGALVQPKMSASFVPDHKASMVLFLDRVYGIENQDFLLHVLDVGFLPDMRAAASLD
                     TATFSTTEMALALNRYLCLAVLPLITKCAPLFAGTEHRAIMVDSMLHTVYRLSRGRSL
                     TKAQRDVIEDCLMALCRYIRPSMLQHLLRRLVFDVPILNEFAKMPLKLLTNHYERCWK
                     YYCLPTGWANFGVTSEEELHLTRKLFWGIFDSLAHKKYDQELYRIAMPCLCAIAGALP
                     PDYVDASYSSKTEKKATVDAEGNFDPRPVETLNVIIPEKLDSFINKFAEYAHEKWAFD
                     KIQNNWSYGENIDEELKTHPMLRPYKTFSEKDKEIYRWPIKESLKAMIAWEWTVEKAR
                     EGEEEKTEKKKTRKISQTAQTYDPREGYNPQPPDLSVVTLSRELQAMAEQLAENYHNT
                     WGRKKKQELEAKGGGSHPLLVPYDTLTAKEKARDREKAQELLKFLQMNGYAVTRGLKD
                     MELDTSSIEKRFAFGFLQQLLRWMDISQEFIAHLEAVVSSGRVEKSPHEQEIKFFAKI
                     LLPLINQYFTNHCLYFLSTPAKVLGSGGHASNKEKEMITSLFCKLAALVRHRVSLFGT
                     DAPAVVNCLHILARSLDARTVMKSGPEIVKAGLRSFFESASEDIEKMVENLRLGKVSQ
                     ARTQVKGVGQNLTYTTVALLPVLTTLFQHIAQHQFGDDVILDDVQVSCYRTLCSIYSL
                     GTTRNPYVEKLRPALGECLARLAAAMPVAFLEPELNEYNACSVYTTKSPRERAILGLP
                     NSVEEMCPDIPVLERLMAEIGGLAESGARYTEMPHVIEITLPMLCSYLPRWWERGPEA
                     PPPALPAGAPPPCTAVTSDHLNSLLGNILRIIVNNLGIDEASWMKRLAVFAQPIVSRA
                     RPELLRSHFIPTIGRLRKRAGKVVAEEEQLRLEAKAEAEEGELLVRDEFSVLCRDLYA
                     LYPLLIRYVDNNRAHWLTEPNPNSEELFRMVGEIFIYWSKSHNFKREEQNFVVQNEIN
                     NMSFLTADNKSKMAKAGDVQSGGSDQERTKKKRRGDRYSVQTSLIVATLKKMLPIGLN
                     MCAPTDQDLIVLAKARYALKDTDEEVREFLQNNLNLQGKVEGSPSLRWQMALYRGVPG
                     REEDADDPEKIVRRVQEVSAVLYHLDQTEHPYKSKKAVWHKLLSKQRRRAVVACFRMT
                     PLYNLPTHRACNMFLESYKASWILTEDHSFEDRMIDDLSKAGEQEEEEEEVEEKKPDP
                     LHQLVLHFSRTALTEKSKLDEDYLYMAYADIMAKSCHLEEGGENVEEGGEEEEVEVSF
                     EEKEMEKQRLLYQQSRLHNRGAAEMVLQMISACKGETGAMVSSTLKLGISILNGGNAE
                     VQQKMLDYLKDKKEVGFFQSIQALMQTCSVLDLNAFERQNKAEGLGMVNEDGTVINRQ
                     NGEKVMADDEFTQDLFRFLQLLCEGHNNDFQNYLRTQTGNTTTINIIICTVDYLLRLQ
                     ESISDFYWYYSGKDVIEEQGKRNFSKAMSVAKQVFNSLTEYIQGPCTGNQQSLAHSRL
                     WDAVVGFLHVFAHMMMKLAQDSSQIELLKELLDLQKDMVVMLLSLLEGNVVNGMIARQ
                     MVDMLVESSSNVEMILKFFDMFLKLKDIVGSEAFQDYVTDPRGLISKKDFQKAMDSQK
                     QFTGPEIQFLLSCSEADENEMINCEEFANRFQEPARDIGFNVAVLLTNLSEHVPHDPR
                     LRNFLELAESILDYFRPYLGRIEIMGASRRIERIYFEISETNRAQWEMPQVKESKRQF
                     IFDVVNEGGESEKMELFVSFCEDTIFEMQIAAQISEPEGEPEEDDDEGAEEAEEGAAG
                     PDGSGSAAAAGVWTWLATAAGRTLRGLSYRSLRRRVRRLRRLTAREAATAVAVLLWAM
                     VARAGGAGAGAAAGVLRLLWGSLFGGGLVDSAKKVTVTELLAGMPDPTGDEVHGQQPS
                     GAGSDAEGEGQGEGEGDAAEGVGDEEVAADQAGTGGADRTVAVADGSPFRPEGAGGLG
                     DMGDTTPVEPPTPEGSPILKRKLGVDGEEEEPQPEPEPEPEPEPEKADTENGEKEVPE
                     PPPEPPKKAPPPPPPKKEEAGGAGLEEFWGELEVQRVKFLNYLSRNFYTLRFLALFLA
                     FAINFILLFYKVSDSPPGEDDIEGSGAGDMSGAGSGDGSGWGSRASEEVEGDEDENMV
                     YYFLEESTGYMEPALRCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKELARKLEFDGL
                     YITEQPEDDDVKGQWDRLVLNTPSFPSNYWDKFVKRKVLDKHGDIFGRERIAELLGMD
                     LASLEITAHNERKPDPPPGLLTWIMSIDVKYQIWKFGVIFTDNSFLYLGWYMVMSLLG
                     HYNNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFFR
                     KFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDI
                     TFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFE
                     THTLEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYED
                     QLG"
     exon            189..308
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            309..413
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            414..488
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            489..567
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            568..680
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            681..774
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            775..868
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            869..943
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1100
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1265
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1387
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1583
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1719
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..1815
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..1934
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1935..2068
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2069..2310
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2311..2503
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2504..2720
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2721..2825
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2826..2929
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2930..3013
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            3014..3321
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            3322..3524
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            3525..3699
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            3700..3908
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            3909..4303
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            4304..4436
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            4437..4597
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            4598..4763
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            4764..4850
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            4851..5077
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            5078..5690
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            5691..5954
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            5955..6155
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            6156..6267
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            6268..6414
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            6415..6688
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            6689..6803
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            6804..6936
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            6937..7031
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            7032..7167
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            7168..7354
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            7355..7463
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            7464..7584
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            7585..7754
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            7755..7975
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            7976..8066
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            8067..8207
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            8208..8371
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            8372..8450
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            8451..8540
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            8541..8681
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            8682..8756
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            8757..8832
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            8833..8956
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            8957..9072
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            9073..9140
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            9141..9262
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            9263..9312
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            9313..9373
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            9374..9612
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            9613..9694
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            9695..9825
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            9826..10158
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            10159..10399
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            10400..10487
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            10488..10580
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            10581..10595
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            10596..10766
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            10767..10826
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            10827..10964
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            10965..11077
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            11078..11174
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            11175..11281
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            11282..11333
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            11334..11408
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            11409..11508
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            11509..11588
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            11589..11665
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            11666..11739
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            11740..11757
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            11758..11838
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            11839..11927
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            11928..12056
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            12057..12161
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            12162..12243
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            12244..12431
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            12432..12773
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            12774..13565
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            13566..13636
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            13637..13787
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            13788..13874
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            13875..14126
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            14127..14257
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            14258..14300
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            14301..14431
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            14432..14492
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            14493..14639
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            14640..14774
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            14775..14931
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            14932..14996
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            14997..15097
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            15098..15149
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
     exon            15150..15361
                     /gene="Ryr1"
                     /gene_synonym="RYR-1; Ryr1l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttccatct ccctcgcggg tgcctctggc tcccctagag gtctcggacc ccagcccgcc
       61 ctcaacccac ccgcccagcc tgcagccctc tctcgccatc ctcagacctt agcccgggac
      121 acccggggat tgccatcatg ggtgatggag gaggtgaagg cgaggacgag gtccagtttt
      181 tgcggacgga cgacgaagtg gtcctgcagt gcagcgccac cgtgctcaag gagcagctca
      241 agttgtgtct ggccgctgag ggtttcggta atcgcctctg cttcctcgaa cccaccagca
      301 acgcgcagaa tgtaccccct gatctggcca tctgctgctt tatcctggag cagtctctgt
      361 cagttcgagc cctgcaggag atgctggcca atactgtgga ggccggtgta gagtcatccc
      421 agggcggggg acacaggaca ctcttgtatg gccatgccat cctgctccgg cacgcacaca
      481 gccgtatgta cctgagttgc ctcaccacct cccgatccat gactgacaag ttggcctttg
      541 atgtgggatt acaggaagac gccacagggg aggcctgttg gtggacgatg cacccagcct
      601 cgaagcagag gtctgaagga gagaaggttc gagttgggga tgacctcatc cttgtgagtg
      661 tctcctctga gcgatacctg cacctgtcaa ccgcaagtgg ggaactccag gtggatgcct
      721 ccttcatgca gactctgtgg aatatgaacc ctatctgctc ctgctgtgaa gaaggctttg
      781 tgactggagg acatgtcctc cgcctctttc atggacatat ggatgaatgt ctgaccattt
      841 ccccttctga cagtgatgac caacgcagac ttgtctacta cgagggaggg cctgtgtgca
      901 cccatgcccg ctccctgtgg aggctggagc cactgagaat cagctggagt ggaagccatc
      961 tccgctgggg ccagccacta agaatcaggc atgtgaccac agggaggtac cttgcgctca
     1021 ctgaggacca aggccttgtg gtggttgatg ccagcaaggc ccacaccaag gccacttcct
     1081 tttgcttccg catctccaag gagaagctgg atgtggcccc caagagagat gtggagggca
     1141 tggggccccc tgagatcaag tatggagagt cactctgctt tgtgcagcat gtggcctcag
     1201 gtctgtggct cacctatgcg gccccagacc ccaaggccct gaggcttggg gtactcaaga
     1261 agaaggccat gctgcaccag gaaggccaca tggatgatgc gctatcactg acgcgatgcc
     1321 agcaggagga gtcccaggct gcccggatga tatacagcac tgcgggcctg tacaaccagt
     1381 tcataaaggg tctcgatagc ttcagcggga agccacgggg ttcggggcca ccggctgggt
     1441 cagcactgcc catcgagggc gtcatcctga gcctacaaga cctcatcggc tatttcgagc
     1501 cgccttcgga ggagctgcag cacgaggaga agcagaccaa gctccgcagc ctgcgcaacc
     1561 gacaaagcct cttccaggag gaggggatgc tctccctggt cctgaattgc attgatcgcc
     1621 tcaatgtcta caccaccgca gcccattttg ctgaatttgc aggggaggag gcagctgaat
     1681 cctggaaaga gattgtgaac ctgctctatg aacttctagc ttctctgatc cgtggcaatc
     1741 gcaccaactg tgccctcttt tccacaaact tggattggct ggtcagcaaa ctggatcgtc
     1801 tggaggcctc atctggcatc ctggaggtgt tgtactgtgt tctgattgag agtcctgagg
     1861 tgctaaacat catccaggag aaccacatca agtctatcat ctccctctta gacaagcatg
     1921 ggaggaatca caaggtcctg gatgtgctat gctcactctg tgtgtgcaat ggtgtagctg
     1981 tgcgctccaa ccaggatctc attactgaga acttgctccc gggccgtgaa cttctgctgc
     2041 agacaaacct tatcaactac gtcaccagca tccgtcccaa catctttgtg ggccgagcag
     2101 agggctccac gcagtatggc aagtggtact tcgaggtgat ggtggacgag gtggctccgt
     2161 ttctgacagc tcaggccacc cacctgcggg tgggctgggc cctcagcgag ggctacagtc
     2221 cctaccctgg aggtggcgag ggctggggcg gcaacggggt cggcgatgac ctctattctt
     2281 acggctttga tgggctgcac ctctggacag ggcatgtggc acgcccagtg acttctcccg
     2341 gacaacacct cttgggcccg gaggatgtgg tcagctgctg cctggacctc agcgtaccat
     2401 ccatctcctt tcgtatcaat ggctgccccg tgcagggtgt ctttgaatcc ttcaacctcg
     2461 atgggctctt tttccccgtc gtgagcttct ccgctggtat caaagtgcgc ttcctccttg
     2521 gcgggcgcca cggtgaattt aagttcctgc ccccacctgg ctatgcccca tgccatgaag
     2581 ctgtgcttcc tcgggagcgg ctccatctcc aaccaatcaa agagtatcgc agggaagggc
     2641 ctcgggggcc ccacctggtg ggccccagtc gctgcctctc acatctggac tttgtgccct
     2701 gccctgtgga caccatccag atcgtcttgc ccccccacct ggagcgaatt cgggagaagc
     2761 tggcagagaa cattcatgaa ctctgggcac tgactcgcat tgagcaggga tggacctatg
     2821 gtccggttcg ggatgacaac aagaggctgc acccatgtct tgtggatttt cacagcttgc
     2881 cagagcctga gcggaattac aacttgcaga tgtcagggga gacactcaag actctgctgg
     2941 ccctgggctg ccatgtcggc atggcagatg agaaggcaga ggacaacctg aagaagacga
     3001 agctccctaa gacgtatatg atgaacaacg gatataagcc ggctcctctg gacctgagcc
     3061 acgtgaggct gacgcctgcg cagacgactc tggtggaccg gctggcagag aacgggcaca
     3121 atgtatgggc gagagaccgg gtggcacagg gctggagcta tagcgctgtg caggacatcc
     3181 ctgcacgcag aaaccctcgc ctcgtgccct accgcctgct tgacgaggcc accaagcgca
     3241 gcaaccggga cagcctctgc caggctgtgc gcacactctt gggctatggc tacaacatcg
     3301 agccacctga ccaggagccc agtcaggtgg acagccagtc tcgaggcgac cgggcccgca
     3361 tcttccgggc ggagaagtcc tatgcagtcc agagcggccg ctggtacttc gagtttgaag
     3421 cagtcaccac aggagagatg cgagtggggt gggcaagacc tgagctgaga cctgacgtgg
     3481 agctgggggc tgatgatctg gcctatgtct tcaatgggca ccgaggccag cgctggcact
     3541 tgggcagtga gccattcgga cgtccctggc agtcgggtga tgtcgttggc tgcatgattg
     3601 atctcacgga gaacaccatc atcttcaccc tcaatggcga ggtcctcatg tctgactcgg
     3661 gctcggaaac agccttccga gaaattgaga ttggggacgg cttcctgcca gtctgcagct
     3721 tgggacctgg tcaggtgggc cacctgaacc tgggccagga tgtgagctcc ctgaggtttt
     3781 ttgccatctg tggcctccag gaaggctttg agccgttcgc catcaacatg caacgcccag
     3841 tgaccacctg gtttagcaag agccttcctc agtttgagcc tgtgcccctc gaacaccccc
     3901 actatgaggt ggcccgcatg gatggcactg tggatacacc tccctgcctg cgcttgactc
     3961 accgtacctg gggctcacag aacagtctgg tggagatgct gtttctccgg ctaagccttc
     4021 cggtccagtt ccaccagcac ttccgctgca ccgcaggggc cacacccctc gcatcccctg
     4081 gcctgcagcc gcctgcggaa gatgaggccc gggcagcaga accggatacg gactatgaga
     4141 acctgcgccg ctctgctgga ggctggggag aggctgaggc gggcaaggat ggaactgcca
     4201 aggaggggac acccggaggc gctgcccagc caggggtaga ggctcagcct gcaagggcgg
     4261 agaatgagaa agacgccacc acggagaaga acaagaagag agggttctta ttcaaggcca
     4321 agaaggttgc catgatgacc caaccacctt ccaccccggc tcttccccga ctccctcgag
     4381 atgtagtacc tgctgacaac cgtgacgacc ctgagatcat cctcaacacc accacgtact
     4441 attactctgt gagggtcttc gcgggtcagg agcccagctg cgtgtgggtg ggctgggtca
     4501 ctcctgacta ccatcaacat gacatgagct tcgacctcag caaggtccgg gcggtgacag
     4561 tgaccatggg ggatgaacaa ggcaatgtcc acagcagcct caagtgtagc aactgttaca
     4621 tggtgtgggg cggggatttc gtgagtccgg gacagcaagg ccgcatcagc cacacggacc
     4681 tagtcattgg atgcctggtg gatctggcca ccggcttgat gacctttaca gccaatggca
     4741 aagaaagcaa caccttcttc caggtggagc ccaacacaaa gctgtttcct gccgtctttg
     4801 tcctgcccac ccaccagaac gtggtccagt ttgagttggg gaagcaaaag aacatcatgc
     4861 cgctgtcagc cgccatgttc ctcagcgagc gcaagaatcc agccccgcag tgcccaccaa
     4921 ggctggaggt gcagatgctg atgcctgtct cctggagccg aatgcccaac cacttcctac
     4981 atgtggacac gcggcgtgct ggcgagcggc tgggctgggc tgtgcagtgc caggagccgc
     5041 tgatgatgat ggcgctacac atcccggagg agaacaggtg catggacatc ctggagctgt
     5101 ctgagcggct ggatctacag cgcttccact cgcacacgct ctcgctctac cgctccgtgt
     5161 gcgccctggg caacaaccgc gtggctcatg ccctgtgcag ccacgtggac caggcacagc
     5221 tgctgcatgc tctggaagac gcgcacttgc cgggtcctct gcgtgcaggc tactatgacc
     5281 tcctcatcag catccacctc gaaagcgcct gccgcagccg tcgctccatg ctctctgagt
     5341 acattgtgcc gctcacagag gagacccgag ccatcacgct tttcccaccc ggtcgtagcg
     5401 cggaagatgg cccccgccgc catggcctgc ctggcgttgg ggtcacaacc tccctgagac
     5461 ctccacacca cttctcaccc ccgtgttttg tggtcgccct gccagctgct ggggccgcag
     5521 aagctccggc tcgcctcagc cctgccatcc ctctggaggc tctgcgagac aaggcgctga
     5581 gaatgttggg ggaagccgtg cgtgacggag gacagcatgc tcgcgaccca gtagggggct
     5641 ctgtggagtt ccagtttgtg ccggtgctca agcttgtgtc taccctcctg gtgatgggtg
     5701 tctttagcga cgaggatgtg aagcagatcc tgaagatgat agagcctgaa gtcttcaccg
     5761 aggaagaaga ggtggaggag gaggaagagg aggaagagga agatgaggag gagaaagagg
     5821 aggacgagga ggaagaggca cacgagaagg aagatgagga aaaagaagag gcagaggagg
     5881 ccgcagagga ggagaaggaa gagctggagg aggggctgct gcagatgaag ttgcctgagt
     5941 ctgtgaaatt acagatgtgc cacctcctgg agtatttctg tgaccaagag ctgcagcacc
     6001 gggtggagtc cttggcagcc tttgcggagc gatatgtgga caagctgcag agcaatcagc
     6061 ggggtcgcta cggcctcctc atgaaagcct tcaccatgag cgcggccgag actgcaaggc
     6121 gcacgcggga gttccgctct ccgccccaag agcagatcaa catgctattg caattcaaaa
     6181 atggtgccga tgaggaagat tgtcctctcc ctgaagagat ccgagaggat ttagttaact
     6241 ttcaccaaga cctgttggca cattgtggaa tccagctgga gggagaggag gaggagccag
     6301 aggaagagag cactctgggc agccgcctca tgagcctgtt ggagaaggtg cggctggtga
     6361 agaagaaaga ggagaagcct gaggaggagc cggcagctga ggagcacaag cctcagtcct
     6421 tgcaggagct ggtgtcgcac acagtggtgc gctgggccca ggaggacttc gttcagagcc
     6481 cagagctggt ccgagccatg ttcagcctcc tgcaccggca gtacgatgga ctcggcgagc
     6541 tgctgcgtgc cctgcctcgg gcctacacga tctctctgtc ctcagtggag gacaccatga
     6601 gcctgctgga gtgtctgggc cagatacgct cactgcttat tgtgcagatg ggtccccagg
     6661 aggagaacct catgatccag agcattggga acatcatgaa taacaaagtc ttctaccagc
     6721 acccaaacct gatgagagcg ctcggtatgc acgaaactgt catggaggtc atggtgaatg
     6781 tcctcggggg cggcgagtca aaggagatcc gcttccccaa gatggtgaca agctgctgcc
     6841 gtttcctctg ctacttctgc cggatcagcc ggcagaacca gcgctctatg tttgaccacc
     6901 tgagctacct gctggagaac agtggcattg gcctggggat gcagggctcc acgcccctgg
     6961 atgtagcagc tgcttctgtc attgacaaca atgagctggc cttggcatta caggagcaag
     7021 acctggaaaa ggttgtgtca tacttggcag ggtgtggctt acaaagctgc cccatgctcc
     7081 tggccaaagg ctatcctgac atcggatgga atccctgtgg gggcgagcgc tacctggact
     7141 tcctgcgctt tgccgtcttt gtcaacggtg agagcgtgga agagaacgct aatgtggtag
     7201 tgcggctgtt gatccgaaag cccgagtgct ttggacctgc cctgcggggt gagggtggct
     7261 cagggctgct ggctgccatc gaagaagcca tccgcatctc cgaggaccct gcacgggatg
     7321 ggccgggtgt ccgcagggac cggcgacgtg agcactttgg tgaggaaccc cctgaagaga
     7381 accgggtaca tctaggacac gccatcatgt ccttctatgc tgctttgatt gacctgctgg
     7441 gacgctgtgc tcctgagatg catctgattc aagccggtaa gggtgaggcc ctgaggatcc
     7501 gtgctatcct tcggtccctc gtgcctttgg atgaccttgt gggcatcatc agcctcccac
     7561 tgcagatccc caccctgggc aaagatggcg cactggttca gccaaagatg tctgcatcct
     7621 tcgtgcctga ccacaaggca tccatggtgc ttttcctgga ccgagtgtat ggcattgaga
     7681 accaggactt cttgctgcat gtgctggatg tggggttcct tcctgacatg agggcagctg
     7741 cctcactgga cacggctact ttcagcacca cggagatggc gctggcactt aaccgctact
     7801 tgtgcctggc tgtgctgccg ctcatcacca agtgcgcgcc actctttgcg ggcaccgagc
     7861 accgcgccat catggtggac tccatgctgc acacagtata ccgactgtcg cggggccgct
     7921 cgctcaccaa agcacagcgc gacgtcattg aggactgcct catggcgctg tgcaggtata
     7981 tccgcccgtc catgctgcag cacctgcttc gacgcctggt gttcgatgtg cccatcctca
     8041 atgagtttgc caagatgcct ctcaagctcc ttaccaacca ctacgagcgt tgctggaagt
     8101 actactgcct tcccacaggc tgggccaact tcggggtcac ctctgaggaa gagctgcacc
     8161 tcacacgcaa gctcttctgg ggcatctttg attctctggc gcataagaaa tacgaccagg
     8221 agctttaccg aatagccatg ccgtgtctct gtgccattgc gggggcactg ccccccgact
     8281 atgtggatgc ctcatactcc tccaagacgg agaaaaaagc cacagtggat gcggaaggca
     8341 actttgatcc ccggcctgtg gagaccctca atgtcatcat cccagagaag ctggactcct
     8401 tcattaacaa gttcgcagaa tatgcccatg agaagtgggc ctttgacaag attcagaaca
     8461 actggtccta tggcgagaac attgatgaag aactgaagac ccaccccatg ctgagaccct
     8521 acaagacctt ctcagagaag gacaaagaga tttaccgctg gcccatcaag gagtccttga
     8581 aggccatgat tgcctgggaa tggacggtcg agaaggccag ggaaggtgag gaggaaaaga
     8641 ccgaaaagaa aaaaacaaga aagatatccc aaacggccca gacatatgac cctcgagaag
     8701 gctacaatcc ccagccacca gacctcagtg tggttacgtt gtcccgggag ctgcaggcca
     8761 tggctgaaca attggcagag aattatcaca acacttgggg gcgaaagaag aagcaagagc
     8821 tggaggctaa agggggtggg tcccatcctc tgctggtccc ctacgacacg cttacggcca
     8881 aggagaaggc gcgggaccgg gagaaggccc aggagttgct gaagtttctg cagatgaatg
     8941 gctatgctgt caccaggggt cttaaggaca tggaactgga cacatcttcc attgagaaac
     9001 gatttgcctt tggcttcctg cagcagctgc tgcgctggat ggacatctcc caggagttta
     9061 tcgcccactt ggaggctgtg gtcagcagtg gacgggtaga gaaatcccca catgaacagg
     9121 agattaaatt ctttgctaag attctgctgc ctttaatcaa ccaatacttc accaaccact
     9181 gtctctactt cctatccaca ccggccaaag tgctgggcag tggtggccat gcctccaaca
     9241 aggagaagga aatgatcacc agcctcttct gtaaacttgc tgctcttgtc cgccaccgag
     9301 tctccctctt tgggacggat gccccagctg tggtcaactg tcttcatata ttggcacgtt
     9361 ccctggatgc caggacggtg atgaaatcgg gccctgagat cgtaaaggcg ggtctgcgct
     9421 ccttcttcga gagtgcctcg gaggacattg agaagatggt ggagaacctg cggctaggca
     9481 aggtgtccca ggcacgcacg caggtgaagg gtgtgggcca gaacctcacc tacaccacag
     9541 tggctctgct gcctgtcctc accaccctct tccagcacat cgcccagcac cagttcggag
     9601 atgatgtcat cctggatgac gttcaagttt cttgctaccg aacactatgc agtatctact
     9661 ctctgggaac caccaggaac ccctacgtgg aaaagctgcg gccagccctg ggggaatgcc
     9721 tggcccgcct ggccgcagcc atgccagtgg cattcctgga gcctgagctg aatgaataca
     9781 acgcctgctc tgtctacacc accaagtctc ctcgagagcg ggccatcctg gggcttccca
     9841 acagtgtgga agagatgtgt ccagacatcc cggtgctaga acggcttatg gcagagatcg
     9901 gggggctggc cgagtccggg gcgcgctaca ccgagatgcc gcacgtcatc gagatcacac
     9961 tgcctatgct gtgcagctac ctgccccgct ggtgggagcg agggcctgag gcgcccccac
    10021 cagccctgcc tgcaggagcc ccaccaccct gtacagccgt cacctccgat cacctcaatt
    10081 ccctactggg gaacatcctt cgaatcatcg tcaataacct gggcatcgat gaggcctcgt
    10141 ggatgaagcg gttggctgtg tttgcccagc ccatcgtgag ccgtgccagg ccagagctcc
    10201 tacgctccca cttcatccct actatcgggc gactgcgtaa gcgggcaggg aaggtggtgg
    10261 ctgaggagga gcagctgcgc ctggaggcca aggcagaggc tgaggagggt gagctcctgg
    10321 tccgggatga gttctccgtg ctctgccgtg acctgtatgc cctctaccca ctgctcatcc
    10381 gctacgtaga caacaacagg gcacactggc tgacagagcc caatcccaac tcggaggagc
    10441 tgttcaggat ggtgggagaa atcttcatct actggtccaa gtcccacaac tttaagcgtg
    10501 aagaacagaa cttcgtggtc cagaacgaga ttaacaacat gtcctttttg accgctgaca
    10561 ataagagcaa aatggccaag gcaggagacg tacagtcagg tggctcggac caggaacgca
    10621 ccaagaagaa acgccggggg gaccgctact cggtgcagac atccttgatc gtggccacgc
    10681 tcaagaagat gttaccgata ggactaaaca tgtgtgctcc cactgaccag gacctcattg
    10741 tgctggccaa ggcccgctat gcgctgaaag atacagatga ggaggttcgt gaattccttc
    10801 aaaacaacct taaccttcag ggaaaggtgg aaggctcacc atctcttcgc tggcaaatgg
    10861 cactgtaccg cggcgttcca ggccgcgagg aagatgccga tgatcctgag aaaatcgtgc
    10921 gcagagtcca ggaagtgtcc gctgtgctct atcacctaga ccagacggag catccttaca
    10981 agtccaagaa ggcggtgtgg cataaacttt tgtccaagca acgccggagg gcagtggtgg
    11041 cctgtttccg catgacgccc ctatacaact tacccacgca ccgagcatgc aacatgttct
    11101 tggagagcta caaagcctcc tggatcctga ctgaggacca cagtttcgag gaccgcatga
    11161 tagatgacct atcaaaagct ggggagcagg aggaagagga ggaagaagtg gaggagaaga
    11221 agccagaccc cctacaccag ttggtcctac acttcagccg gacagctctg actgaaaaga
    11281 gcaaactgga tgaggactac ctgtacatgg cttacgctga catcatggca aagagctgcc
    11341 acctggagga gggcggggaa aatgtcgaag aaggaggtga agaagaggaa gtggaggtgt
    11401 cctttgagga gaaggagatg gagaagcaga ggctcctgta ccagcagtcg aggctgcaca
    11461 accggggtgc cgccgagatg gtactgcaga tgatcagtgc ttgcaaagga gagacgggtg
    11521 ccatggtgtc ttccaccctg aagctgggca tctccatcct caacggaggg aacgctgaag
    11581 tgcagcagaa aatgctggat tacctgaagg acaagaagga agtgggcttc ttccagagta
    11641 tccaggcgct aatgcaaacg tgcagcgtcc tggacctcaa tgcctttgag aggcagaaca
    11701 aggcggaggg gctgggcatg gtgaatgaag acgggactgt catcaatcgc cagaacggag
    11761 agaaagtcat ggcagatgat gagttcacac aggacctgtt ccgcttcctg cagctgctct
    11821 gcgagggcca taacaacgat ttccaaaact acctacggac acagactggg aacaccacca
    11881 ccatcaatat catcatctgc acagtggact acctcctgcg gctgcaggaa tccatcagtg
    11941 acttctactg gtactactcg ggcaaggatg tcattgagga gcagggaaag agaaacttct
    12001 ccaaagccat gtcggtagcg aaacaagtgt tcaacagcct cactgagtac atccagggac
    12061 cctgcaccgg aaaccagcag agtctagcgc acagtcgcct ctgggatgct gtggtgggct
    12121 tcctgcacgt gttcgcacac atgatgatga agctggctca ggactctagc cagatagagc
    12181 tgctgaagga gctgctggac ctgcaaaagg acatggtggt gatgttgctg tcccttctgg
    12241 aaggaaatgt ggtgaacggc atgatcgcac ggcagatggt ggacatgctc gtggagtctt
    12301 cgtccaatgt ggagatgatc ctcaagttct tcgacatgtt tctgaagctc aaggacatcg
    12361 tgggctctga ggccttccag gactacgtca ccgatccccg tggcctcatc tccaagaagg
    12421 acttccagaa ggccatggac agccagaagc agttcactgg cccagagatc cagttcctgc
    12481 tttcgtgttc agaagcagat gagaatgaga tgatcaattg tgaagagttt gcgaaccgct
    12541 tccaggaacc agcgcgggac attggcttca acgtggcagt gctgctcacc aacctgtcag
    12601 agcatgtgcc ccacgacccg cgcctgcgca acttcctgga gttggctgag agcatcctgg
    12661 attacttccg gccttacctg ggccgcatcg aaatcatggg cgcatcgcgt cgcatagaac
    12721 ggatctactt cgaaatctca gaaaccaacc gtgcccagtg ggagatgccc caggtgaagg
    12781 agtctaagcg ccagttcatc ttcgacgtgg tgaacgaggg cggcgagtcc gagaagatgg
    12841 agctgttcgt gagcttctgc gaggacacga tcttcgagat gcagatcgct gctcagatct
    12901 ctgagccgga gggcgagccg gaggaggacg atgatgaggg cgctgaggag gctgaggagg
    12961 gcgcagcggg tcccgacggg tcgggctctg cagcggccgc aggggtgtgg acgtggctgg
    13021 cgacggcggc gggccgaacg ctgcggggtc tgagctaccg gagcctgcgg cgacgtgtgc
    13081 ggaggctgcg gcggctgacg gcgcgggagg ctgccacggc cgtggccgtg ttgctctggg
    13141 cgatggtggc ccgcgcgggg ggcgcgggcg cgggcgcggc ggccggggta ctgcggctgc
    13201 tctggggctc gctgttcggt ggtgggctgg tagacagcgc caagaaggtg actgtgaccg
    13261 agctcttggc aggcatgccg gaccccactg gcgacgaggt gcacggtcag cagcctagcg
    13321 gcgctggcag cgatgcggag ggcgagggcc agggtgaggg cgaaggggat gcggctgaag
    13381 gcgtcggaga tgaagaggtg gcagcggacc aggctggcac gggaggtgct gaccggacgg
    13441 tggccgtagc cgatgggagc cccttcaggc cagaaggagc cggtggtctc ggggatatgg
    13501 gtgacacgac accagtggag cccccaacgc cagagggctc gcccatcctc aagaggaagc
    13561 tgggggtgga cggagaagaa gaggagccgc agccagagcc agagccggag ccagagcctg
    13621 aaccggaaaa agctgatacc gagaatggag agaaggaagt ccctgagccg cctccggagc
    13681 cccccaagaa ggcacctcct ccaccccctc caaagaagga ggaagctgga ggtgcaggcc
    13741 tggaagaatt ctggggtgaa ctggaagtgc agagggtgaa attcttgaac tacttgtcga
    13801 ggaacttcta cacgctgcga ttcctggccc tcttcctggc atttgccatc aactttatct
    13861 tattgtttta taaggtttca gactctccgc caggggagga tgacatagaa ggttccggag
    13921 ctggggacat gtcaggggca gggtctggtg atggctctgg ctggggctcc agagccagcg
    13981 aggaggtaga gggtgatgaa gatgagaaca tggtgtacta cttcctggag gagagcaccg
    14041 gctacatgga acctgccctg aggtgcttga gcctgctgca taccctggtg gcctttctct
    14101 gcatcattgg ctacaactgt ctcaaggtgc cccttgtgat ctttaagagg gagaaggagc
    14161 tggcccggaa gctggagttc gatggtctct acattacaga gcagccagag gatgatgatg
    14221 tgaagggaca gtgggatcgc ctggtgctca acacaccgtc tttccccagc aactactggg
    14281 acaagtttgt caagcggaag gttctggaca aacacgggga catcttcggg cgggagcgga
    14341 ttgcagagct gctgggcatg gatctggcct ctctggagat cacagcccac aatgagcgca
    14401 aacctgaccc tccaccaggc ctgctgacat ggatcatgtc catcgatgtc aaataccaga
    14461 tctggaagtt tggagtcatc ttcacagaca actctttcct gtatctgggc tggtacatgg
    14521 tgatgtccct cctgggccac tacaataact tcttcttcgc tgcccacctc ttggatatcg
    14581 ccatgggagt caagacgctg cgcaccatcc tttcatccgt cactcacaac ggaaagcagc
    14641 tggtgatgac agtagggctc ctggctgtag tggtctactt gtatacggtg gtggccttca
    14701 acttcttccg caagttctac aacaagagcg aagatgagga cgagcctgac atgaagtgtg
    14761 acgacatgat gacgtgctac ctgttccaca tgtatgtggg cgtccgggcc ggtggtggca
    14821 tcggggacga gatcgaggac ccggctggtg atgaatatga actgtaccgg gtcgtcttcg
    14881 acatcacctt tttcttcttc gtcattgtca tcctactggc tatcatccag ggtctgatta
    14941 ttgatgcttt cggggagctc cgagaccaac aagagcaagt gaaggaagac atggagacca
    15001 agtgcttcat ctgtgggata ggcagtgact acttcgacac gaccccacat gggtttgaga
    15061 cccacactct ggaagagcac aacctagcca attacatgtt tttcctgatg tatttgataa
    15121 ataaggatga gacagagcac accggtcagg agtcatatgt ctggaagatg taccaggaga
    15181 ggtgctggga cttcttccct gctggagact gtttccgaaa gcagtatgag gaccagcttg
    15241 gctgaggtct gcagctggcc ctcccccacc tcaagtgcct tctcccactg caagctcctc
    15301 cccaggcagc tggggacagg tgatcctgaa ctagaccaat aaagcctctg ctacaccccc
    15361 a
//
