LOCUS       NM_080402               2236 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus receptor-like tyrosine kinase (Ryk), mRNA.
ACCESSION   NM_080402 XM_343458
VERSION     NM_080402.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2236)
  AUTHORS   Yang QO, Yang WJ, Li J, Liu FT, Yuan H and Ou Yang YP.
  TITLE     Ryk receptors on unmyelinated nerve fibers mediate excitatory
            synaptic transmission and CCL2 release during neuropathic pain
            induced by peripheral nerve injury
  JOURNAL   Mol Pain 13, 1744806917709372 (2017)
   PUBMED   28565999
  REMARK    GeneRIF: These studies demonstrate the existence of critical
            crosstalk between astrocytes and unmyelinated fibers, which
            indicate the presynaptic mechanism of Ryk in cytokine transmission
            of neuropathic pain and the therapeutic potential for Wnt/Ryk
            signaling pathway in the treatment of neuropathic pain.
REFERENCE   2  (bases 1 to 2236)
  AUTHORS   Rao KS, Aronshtam A, McElory-Yaggy KL, Bakondi B, VanBuren P, Sobel
            BE and Spees JL.
  TITLE     Human epicardial cell-conditioned medium contains HGF/IgG complexes
            that phosphorylate RYK and protect against vascular injury
  JOURNAL   Cardiovasc Res 107 (2), 277-286 (2015)
   PUBMED   26025956
  REMARK    GeneRIF: Early treatment with HGF/IgG complexes after myocardial
            ischaemia with reperfusion may rescue tissue through vasoprotection
REFERENCE   3  (bases 1 to 2236)
  AUTHORS   Blakely BD, Bye CR, Fernando CV, Prasad AA, Pasterkamp RJ, Macheda
            ML, Stacker SA and Parish CL.
  TITLE     Ryk, a receptor regulating Wnt5a-mediated neurogenesis and axon
            morphogenesis of ventral midbrain dopaminergic neurons
  JOURNAL   Stem Cells Dev 22 (15), 2132-2144 (2013)
   PUBMED   23517308
REFERENCE   4  (bases 1 to 2236)
  AUTHORS   Gonzalez P, Fernandez-Martos CM, Arenas E and Rodriguez FJ.
  TITLE     The Ryk receptor is expressed in glial and fibronectin-expressing
            cells after spinal cord injury
  JOURNAL   J Neurotrauma 30 (10), 806-817 (2013)
   PUBMED   23320533
  REMARK    GeneRIF: we demonstrate that Ryk is expressed in the unlesioned
            spinal cord and that, after spinal cord injury, its spatiotemporal
            and cellular expression pattern changed dramatically, being
            expressed in cells involved in the spinal cord response to damage.
REFERENCE   5  (bases 1 to 2236)
  AUTHORS   Lyu J, Yamamoto V and Lu W.
  TITLE     Cleavage of the Wnt receptor Ryk regulates neuronal differentiation
            during cortical neurogenesis
  JOURNAL   Dev Cell 15 (5), 773-780 (2008)
   PUBMED   19000841
REFERENCE   6  (bases 1 to 2236)
  AUTHORS   Kamitori K, Machide M, Osumi N and Kohsaka S.
  TITLE     Expression of receptor tyrosine kinase RYK in developing rat
            central nervous system
  JOURNAL   Brain Res Dev Brain Res 114 (1), 149-160 (1999)
   PUBMED   10209253
REFERENCE   7  (bases 1 to 2236)
  AUTHORS   Serfas MS and Tyner AL.
  TITLE     Ryk is expressed in a differentiation-specific manner in epithelial
            tissues and is strongly induced in decidualizing uterine stroma
  JOURNAL   Oncogene 17 (26), 3435-3444 (1998)
   PUBMED   10030667
REFERENCE   8  (bases 1 to 2236)
  AUTHORS   Simoneaux DK, Fletcher FA, Jurecic R, Shilling HG, Van NT, Patel P
            and Belmont JW.
  TITLE     The receptor tyrosine kinase-related gene (ryk) demonstrates
            lineage and stage-specific expression in hematopoietic cells
  JOURNAL   J Immunol 154 (3), 1157-1166 (1995)
   PUBMED   7822791
REFERENCE   9  (bases 1 to 2236)
  AUTHORS   Yee K, Bishop TR, Mather C and Zon LI.
  TITLE     Isolation of a novel receptor tyrosine kinase cDNA expressed by
            developing erythroid progenitors
  JOURNAL   Blood 82 (4), 1335-1343 (1993)
   PUBMED   8394755
REFERENCE   10 (bases 1 to 2236)
  AUTHORS   Hovens CM, Stacker SA, Andres AC, Harpur AG, Ziemiecki A and Wilks
            AF.
  TITLE     RYK, a receptor tyrosine kinase-related molecule with unusual
            kinase domain motifs
  JOURNAL   Proc Natl Acad Sci U S A 89 (24), 11818-11822 (1992)
   PUBMED   1334548
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000200.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_080402.3.
            
            On Jun 8, 2021 this sequence version replaced NM_080402.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY669340.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-346               JACYVU010000200.1  6378121-6378466
            347-468             JACYVU010000200.1  6405504-6405625
            469-568             JACYVU010000200.1  6411340-6411439
            569-703             JACYVU010000200.1  6412435-6412569
            704-757             JACYVU010000200.1  6415295-6415348
            758-902             JACYVU010000200.1  6418829-6418973
            903-1003            JACYVU010000200.1  6424860-6424960
            1004-1138           JACYVU010000200.1  6429797-6429931
            1139-1225           JACYVU010000200.1  6432170-6432256
            1226-1295           JACYVU010000200.1  6434910-6434979
            1296-1428           JACYVU010000200.1  6439961-6440093
            1429-1538           JACYVU010000200.1  6441201-6441310
            1539-1698           JACYVU010000200.1  6441415-6441574
            1699-1835           JACYVU010000200.1  6448633-6448769
            1836-2236           JACYVU010000200.1  6449784-6450184
FEATURES             Location/Qualifiers
     source          1..2236
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..2236
                     /gene="Ryk"
                     /note="receptor-like tyrosine kinase"
                     /db_xref="GeneID:140585"
                     /db_xref="RGD:620549"
     exon            1..346
                     /gene="Ryk"
                     /inference="alignment:Splign:2.1.0"
     CDS             163..1947
                     /gene="Ryk"
                     /EC_number="2.7.10.1"
                     /note="tyrosine-protein kinase RYK"
                     /codon_start=1
                     /product="tyrosine-protein kinase RYK precursor"
                     /protein_id="NP_536327.1"
                     /db_xref="GeneID:140585"
                     /db_xref="RGD:620549"
                     /translation="MRAGRGGVPGTGGLRAPPPPLLLLLLAMLPAAAPRSPALAAAPA
                     GPSVSLYLSEDEVRRLLGLDAELYYVRNDLISHYALSFNLLVPSETNFLHFTWHAKSK
                     VEYKLGFQVDNFVAMGMPQVNISAQGEVPRTLSVFRVELSCTGKVDSEVMILMQLNLT
                     VNSSKNFTVLNFKRRKMCYKKLEEVKTSALDKNTSRTIYDPVHAAPTTSTRVFYISVG
                     VCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQPSTQTTQYLRADTPNNA
                     TPVTSSSGYPTLRIEKNDLRSVTLLEAKAKVKDIAISRERVTLKDVLQEGTFGRIFHG
                     ILVDEKDPNKEKQTFVKTVKDQASEVQVTMMLTESCKLRGLHHRNLLPITHVCIEEGE
                     KPMVISPYMNWGNLKLFLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIH
                     KDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSS
                     ASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCW
                     ALDPEERPKFQQLVQCLTEFHAALGAYV"
     exon            347..468
                     /gene="Ryk"
                     /inference="alignment:Splign:2.1.0"
     exon            469..568
                     /gene="Ryk"
                     /inference="alignment:Splign:2.1.0"
     exon            569..703
                     /gene="Ryk"
                     /inference="alignment:Splign:2.1.0"
     exon            704..757
                     /gene="Ryk"
                     /inference="alignment:Splign:2.1.0"
     exon            758..902
                     /gene="Ryk"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1003
                     /gene="Ryk"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1138
                     /gene="Ryk"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1225
                     /gene="Ryk"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1295
                     /gene="Ryk"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1428
                     /gene="Ryk"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1538
                     /gene="Ryk"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1698
                     /gene="Ryk"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..1835
                     /gene="Ryk"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..2236
                     /gene="Ryk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcacccccc cccccccctc ccgttctcgg gcggcgggtc tgaagcggcg gcgcgatgag
       61 ctggccggcc gcccccggct cggggctgtg aggcgctcgg ggccggggtg cgcggcggcg
      121 cggcgggcgg cgggcggcgg acgctcctgc tcggcggcgg ccatgcgcgc gggccggggc
      181 ggcgtcccgg ggaccggcgg cctgagggcc ccgccgccgc cgctgctcct gctgctgctg
      241 gcgatgctgc ccgccgccgc cccgcggtcc ccggccctgg ccgccgctcc tgcgggaccc
      301 agcgtgagcc tctacctgag cgaggacgag gtgcgccggc tgctcggtct tgatgcagaa
      361 ctttactatg tgagaaatga cctcatcagt cactacgctc tgtcctttaa cctgctagtg
      421 cccagtgaga caaacttcct gcacttcact tggcatgcaa agtccaaggt tgaatataag
      481 ctgggattcc aagtagacaa ctttgtggcc atgggcatgc cccaggtcaa tatttctgct
      541 caaggggagg tcccacgcac tttatcagtg tttcgggtcg agctttcgtg taccggcaaa
      601 gtagactcgg aagtcatgat actaatgcag ctcaatctga cagtgaattc ttcaaaaaat
      661 tttacagttt taaattttaa acgaaggaaa atgtgctaca aaaaacttga agaagtaaaa
      721 acttcagcct tggacaaaaa cactagcaga actatttatg atcctgtaca cgcagctcca
      781 actacttcca cacgtgtgtt ttacatcagt gtgggggttt gttgtgcagt aatatttctt
      841 gtagcaataa tattagcagt tttgcacctt catagtatga aaaggattga actggatgac
      901 agcatcagcg ccagcagcag ttcacagggg ctgtctcagc cgtccaccca gacgacccag
      961 tatctgagag ctgacacacc caacaatgca actcctgtca ccagctcctc aggttaccct
     1021 accttgcgga tagagaagaa cgacttgcga agtgtcactc ttttggaagc caaagccaag
     1081 gtgaaggata ttgcaatatc cagggaaagg gtcacactga aagatgtact tcaagaaggt
     1141 acttttgggc gtattttcca tgggatttta gtagatgaaa aagatccaaa taaagaaaaa
     1201 caaacattcg taaaaacagt taaagaccaa gcttctgaag ttcaggtgac catgatgctt
     1261 actgagagct gcaagctgcg aggtctgcac cacagaaacc tccttcctat tactcatgtg
     1321 tgcatagaag aaggagaaaa gcctatggtg atatcgccat atatgaactg ggggaatctt
     1381 aaattatttc tacggcagtg caaattagta gaagccaata atccacaggc aatttcccaa
     1441 caagatctgg tacatatggc tattcagatt gcctgcggaa tgagctacct ggccagaagg
     1501 gaagtgattc ataaagacct ggctgctagg aactgcgtca tcgacgacac tcttcaagta
     1561 aaaatcacag acaatgccct ttccagagac ctgtttccga tggactacca ctgtctgggg
     1621 gacaacgaga acaggccagt gagatggatg gctctggaaa gcctggtcaa caatgagttc
     1681 tctagtgcta gtgacgtgtg ggcctttgga gtgacactgt gggagctcat gactctgggc
     1741 cagacgccct acgtggacat cgaccccttt gagatggccg cttacctgaa agatggttac
     1801 cgaatagccc agccaatcaa ctgccctgac gaactgtttg ctgtgatggc ctgttgctgg
     1861 gccttggacc cagaggagcg gcctaagttt cagcagctgg tccagtgcct cacagagttc
     1921 catgctgccc tgggcgccta cgtctgactt ctctcccagc tctaccactc agaagaaagt
     1981 gcctgtctgt cgcagttgct tcgtgtgcag cgcagtgcct gtaggagccc tctgtctcct
     2041 agaacacaca gccttaggaa tgctttcaga ccgaaccttt aaagacaact taataatgca
     2101 gagtattttc tagataccac ttttactagg ttgaaccaaa aggggttttg taaatttttt
     2161 ggccaaaaat tttttaaaat atagttactt tggactaggg gttgcattct ttaaaaataa
     2221 acagttttaa agatta
//
